Organizational Approach

Mechanism-Specific Approach to Sleep Disorders

• Identify Symptoms:
  - primary insomnia vs. secondary insomnia
  - excessive daytime sleepiness
  - obstructive sleep apnea
  
  
• Separate therapy responders and non-responders
  
  
• Identify biomarkers for heritable signs
  
  
• Develop pre-clinical phenotypes:
  - behavioral
  - neurochemical
  - electrographic
  - metabolic