2019 Publications

Beltran H, Hruszkewycz A, Scher H, Hildesheim J, Isaacs J, Yu E, Kelly K, Lin D, Dicker A, Arnold J, Hecht T, Wicha M, Sears R, Rowley D, White R, Gulley J, Lee J, Diaz-Meco M, Small E, Shen M, Knudsen K, Goodrich D, Lotan T, Zoubeidi A, Sawyers C, Rudin C, Loda M, Thompson T, Rubin M, Tawab-Amiri A, Dahut W, Nelson P. A perspective on the role of lineage plasticity in prostate cancer therapy resistance. Clin Can Res 2019 July [In press]

Lee E, Ouzounova M, Piranlioglu R, Ma MT, Guzel M, Marasco D, Chadli A, Gestwicki JE, Cowell JK, Wicha MS, Hassan KA, Korkaya H. Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20. Oncogene. 2019 June 13. doi: 10.1038/s41388-019-0838-y PMID: 31197211

Hill EM, Esper RM, Sen A, Simon BR, Aslam MN, Jiang Y, Dame MK, McClintock SD, Colacino JA, Djuric Z, Wicha MS, Smith WL, Brenner, DE. Dietary polyunsaturated fatty acids modulates adipose Secretome and is associated with changes in mammary epithelial stem cell self-renewal. The Journal of Nutritional Biochemistry. [In Press] Available online 24 May 2019. DOI: 10.1016/j.jnutbio.2019.05.007

Chen YH, Chen YC, Lin E, Brien R, Jung S, Chen YT, Lee W, Hao Z, Sahoo S, Min Kang H, Cong J, Burness M, Nagrath S, Wicha MS, Yoon E. Hydro-Seq enables contamination-free high-throughput single-cell RNA- sequencing for circulating tumor cells. Nat Commun. 2019 May 15;10(1):2163. doi: 10.1038/s41467-019-10122-2. PMID: 31092822; PMCID: PMC5520360.

Lee E, Piranlioglu R, Wicha M, Korkaya H. Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development. Cancer Research. Int J Mol Sci. 2019 May 13;20(9). pii: E2357. Review. DOI: 10.3390/ijms20092357 PMID: 31085991

Bushnell G, Hardas T, Hartfield R, Zhang Y, Oakes R, Ronquist S, Chen H, Rajapakse I, Wicha M, Jeruss J, Shea L. Biomaterial scaffolds recruit an aggressive population of metastatic tumor cells in vivo. Cancer Research Cancer Research 2019 Feb 26, pii: canres.2502.2018. DOI: 10.3390/ijms20092357 PMID: 31085991

Piranlioglu R, Lee E, Ouzounova M, Bollag R, Vinyard A, Arbab A, Marasco D, Guzel M, Cowell J, Thangaraju M, Chadli A, Hassan K, Wicha M, Celis E, Korkaya H. Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model. Nature Communications. 2019 May 15;10(1):2163. DOI: 10.3390/ijms20092357. PMID: 30926774, PMCID: PMC6441000

Luo M, Wicha MS. Targeting Cancer Stem Cell Redox Metabolism to Enhance Therapy Responses. Seminars in Radiation Oncology 2019 Jan;29(1) 42-54. doi: 10.1016/j.semradonc.2018.10.003. Review. [Epub ahead of print] PMID 30573183

2018 Publications

Zhang Z, Chen L, Humphries B, Brien R, Wicha MS, Luker KE, Luker GD, Chen YC, Yoon E. Morphology-based prediction of cancer cell migration using an artificial neural network and a random decision forest. Integr Biol (Camb). 2018 Nov 13. doi: 10.1039/c8ib00106e [Epub ahead of print] PMID: 30420987 [PubMed - as supplied by publisher]

Sehl ME, Wicha MS. Modeling of Interactions between Cancer Stem Cells and their Microenvironment: Predicting Clinical Response. Metholds Mol Biol. 2018:1711:333-349. doi: 10.1007/978-1-4939-7493-1_16. PMID 29344897 [PubMed-indexed for MEDLINE]

Andrews A, Warner K, Rodrigues-Ramirez C, Pearson A, Nor F, Zhang Z, Kerk A, Kulkarni A, Helman J, Brenner JC, Wicha M, Wang, S, Nor J. Ablation of cancer stem cells by therapeutic inhibition of the MDM2-p53 interaction in mucoepidermoid carecinoma. Clinical Cancer Research. 2018 Nov 29. pii:clincanres.2730.2017 doi: 10.1158/1078-0432.CCR-17-2730 [Epub ahead of print] PMID: 30498096 [PubMed-as supplied by publisher]

Jiagge E, Souleiman Jibril A, Davis M, Murga-Zamalloa C, Kleer CG, Gyan K, Divine G, Hoenerhoff M, Bensenhave J, Awuah B, Oppong J, Adjei E, Salem B, Toy K, Merajver S, Wicha MS, Newman L. Androgen Receptor and ALDH1 Expression Among Internationally Diverse Patient Populations J Glob Oncol.2018 Oct;(4):1-8. doi: 10.1200/JGO.18.00056 DOI: 10.1200/JGO.18.00056 PMID: 30307804

Jiagge E, Bensenhaver J, Celina K, Hoenerhoff MJ, Gilani R, Kyei I, Oppong J, Awuah B, Adjei E, Wicha MS, Newman L, Merajver S. Creating Models to Identify New Therapeutic Options for Aggressive African Breast Cancers. Journal of Global Oncology, no. 4_suppl_2 (October 1 2018) 00-00. DOI: 10.1200/jgo.18.83500

Feinber TY, Zheng H, Liu R, Wicha MS, Yu SM, Weiss SJ. Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary pithelial Cell Invasion Programs. Dev Cell. 2018 Sep 24. pii: S1534-5807(18)30698. doi.org/10.1016/j.devcel.2018.08.025 [Epub ahead of print]. PMID: 30269950 [PubMed – as supplied by publisher]

Zeinali M, Nagrath S, Hafner M, Simeone D, Wicha MS, Cuneo K, Bankhead III A, Shi J, Zhao L, Sahai B, Mdhar V, Fouladdel S, Shao S, Cameron H, Harouaka R, Kozminsky M, Grafton M, Attari A, Noroozi S. Profiling heterogeneous circulating tumor cells (CTC) populations in pancreatic cancer using a serial microfluidic CTC Carpet Chip. Advanced Biosystems - Wiley Online Library. doi: 10.1002/adbi.201800228.

Zheng F, Dang J, Zhang H, Xu F, Ba D, Zhang B, Cheng F, Chang AE, Wicha MS, Li Q. Cancer Stem Cell Vacination with PD-L1 and CTLA-4 Blockades Enhances the Eradication of Melanoma Stem Cells in a Mouse Tumor Model. Journal of Immunotherapy. doi: 10.1097/CJI.0000000000000242 PMID: 30063587; PMICID: PMC6128768

Korkaya H, Lee E, Ouzounova M, Prianlioglu R, Ma M, Guzel M, Marasco D, Chadli A, Gestwicki J, Cowell J, Wicha M, Hassan K. The pleiotropic effect of TNF in breast cancer subtypes is regulated by TNFAIP3/A20. Oncogene 30 August 2018; doi:10.1038/s41388-018-0472-0; PMID: 30166590.

Luo M, Shang L, Brooks M, Jiagge E, Zhu Y, Buschhaus J, Conley S, Fath M, Davis A, Gheordunescu E, Wang Y, Harouaka R, Lozier A, Triner D, McDermott S, Merajver SD, Luker GD, Spitz DR, Wicha M. Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling. Cell Metabolism 28, 69-86, July 3, 2018. doi: 10.1016/j.cmet.2018.06.006; PMID: 29972798

Li W, Tanikawa T, Kryczek I, Xia H, Li G, Wu K, Wei S, Zhao L, Vatan L, Wen B, Shu P, Sun D, Kleer C, Wicha B, Sabel M, Tao K, Wang G, Zou W. Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer.Cell Metabolism, Published online May 24, 2018 doi:10.1016/j.cmet.2018.04.022. PMID: 29805099

Luo M, Brooks, M, Wicha MS. Asparagine and Glutamine: Con-conspirators Fueling Metastasis. Cell Metabolism, Volume 27, Issue 5, 1 May 2018, pages 947-949. doi: 10.1016/j.cmet.2018.04.012. PMID: 29719230

Nor J, McDermott SC, Rodriguez-Ramirez C, McDermott S, Wicha M. FGFR signaling regulates resistance of head and neck cancer stem cells to Cisplatin. Oncotarget, 2018; 9:25148-25165 doi: 10.18632/oncotarget.25358. PMID: 29861860; PMCID: PMC5982758

Burness ML, Wicha MS; Tamoxifen and ERα36: Fertilizing the seeds of breast cancer. Cell Research, Published online 21 March 2018; doi: 10.1038/s41422-018-0028-4. PMID: 29563540

Liu M, Liu Y, Deng L, Wang D, He X, Zhou L, Wicha MD, Bai F, Liu S. Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer. Mol Cancer. 2018 Feb 23;17(1):65. doi: 10.1186/s12943-018-0809-x. PMID: 29471829; PMCID: PMC5824475

Colacino JA, Azizi E, Brooks MD, Harouaka R, Fouladdel S, McDermott S, Lee M, Hill D, Madden J, Boerner J, Cote ML, Sartor MA, Rozek LS, Wicha MS; Heterogeneity of human breast stem and progenitor cells as revealed by transcriptional profiling. Stem Cell Reports, Published online 29 Mar 2018 [Epub ahead of print]; doi: 10.1101/109751 PMID: 29606612 [PubMed - as supplied by publisher]

Dame MK, Attili D, McClintock SD, Dedhia PH, Ouilette P, Hardt O, Chin, AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai Y, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson L, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA; Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma Cells. Development. 2018 Feb 21. pii:dev.153049. doi:10.1242/dev.153049 PMID: 29467240; PMCID: PMC5897593

Sehl ME, Wicha MS; (2018) Modeling of Interactions between Cancer Stem Cells and their Microenvironment: Predicting Clinical Response. In: von Stechow L. (eds) Cancer Systems Biology, vol 1711. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7493-1_16. PMID:29344897

Lin H, Hurt EM, Zhao L, Szeliga W, Harms P, Vats P, Lao C, Wicha MS, Mandai M, Zou W, Wei S, Green MD, Vatan L, Herbst R, Fecher L, Chinnaiyan AM, Lawrence T, Hamanishi J, Kryczek I; Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression. Journal of Clinical Investigation, January 2018. doi: 10.1172/JCI12803; PMID: 29608143; PMCID: PMC5873851

2017 Publications

Azizi E, Granger J, Harouaka R, Luther T, Wicha MS, Stem Cells in Breast Development and Cancer; The Breast (Fifth Edition) 5 September 2017 (online); DOI: 10.1016/B978-0-323-35955-9.00023-4

Ronquist S, Patterson G, Muir LA, Lindsly S, Chen H, Brown M, Wicha MS, Bloch A, Brockett R, Rajapakse I; Algorithm for cellular reprogramming; Proceedings of the National Academy of Sciences; 2017 November 7, vol. 114 no. 46; doi: 10.1073/pnas.1712350114

Lin M, Chang AE, Wicha MS, Li Q, Huang S; Development and Application of Cancer Stem Cell-Targeted Vaccine in Cancer Immuotherapy; Journal of Vaccines & Vaccination. 2017 Oct 31: 8(6): 371; doi:10.4172/2157-7560.1000371 PMID: 29423335; PMCID: PMC5800506

Halperin RF, Carpten JD, Manojlovic Z, Aldrich J, Keats J, Byron S, Liang WS, Russell M, Enriquez D, Claasen A, Cherni I, Awuah B, Oppong J, Wicha MS, Newman LA, Jaigge E, Kim S, Craig DW. A method to reduce ancestry related germline false positives in tumor only somatic variant calling. BMC Med Genomics. 2017 Oct 19;10(1):61. doi: 10.1186/s12920-017-0296-8. PMID: 29052513 PMIC: PMC5649057

Lin E*, Rivera-Baez L*, Fouladdel, S*, Yoon H, Guthrie S, Wieger J, Deol Y, Keller E, Sahai B, Simeone D, Burness ML, Azizi E, Wicha M, Nagrath S; High Throughput Microfluidic Labyrinth for the Label Free Isolation of CTCs for Single Cell Gene Expression Profiling; Cell Systems, 2017 September 20; DOI:10.1016/j.cels.2017.08.12  PMID: 28941584 *these authors contributed equally

Wang D, Zu J, Liu B, He X, Zhou L, Hu X, Qiao F, Zhang, A, Xu X, Zhang H, Wicha M, Zhang L, Shao Z, Liu S, IL6 blockade potentiates the anti-tumor effects of y–secretase inhibitors in Notch3-expressing breast cancer; Cell Death and Differentiation, 13 October 2017 DOI: 10.1038/cdd.2017.162. PMID: 29027990

Jiagge EM, Jibril A, Divine G, Gyan KK, Bensenhaver JM, Oppong JK, Awuah B, Adjei E, Merajver S, Wicha M, Newman LA, Beyond triple-negative breast cancer and African ancestry: Tumor phenotypes among internationally diverse patient populations; Journal of Clinical Oncology 35, no.15_suppl (May 2017) 1101-1101; DOI:10.1200/JCO.2017.35.15

Kerk SA, Finkel KA, Pearson AT, Warner KA, Zhang Z, Nor F, Wagner VP, Vargas PA, Wicha MS, Hurt EM, Hollingsworth RE, Tice DA, Nor JE, 5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Aquamous Cell Carcinoma; Clinical Cancer Research 2017 May 15;23((10):2516-2527. doi: 10.1158/1078-0432.CCR-16-1834. Epub 2066 Oct 25. PMID: 27780858

Zhang XF, Weng DSH, Pan K, Zhou ZQ, Pan QZ, Zhao JJ, Tang Y, Jiang SS, Chen CL, Li YQ, Zhang HX, Chang AE, Wicha MS, Zeng YX, Li Q, Xia JC, Dendritic-cell-based immunotherapy evokes potent anti-tumor immune responses in CD105+ human renal cancer stem cells; Molecular Carcinogenesis, 16 June 2017 doi/10.1002/mc.22697

Nagrath S, Murlidhar V, Reddy R, Fouladdel S, Zhao L, Ishikawa MK, Grabauskiene S, Zhang Z, Lin J, Chang AC, Carrott PW Jr, Lynch WR, Orringer MB, Kumar-Sinha C, Palanisamy N, Beer DG, Wicha MS, Ramnath N, Azizi E, Poor Prognosis Indicated by Venout Circulating Tumor Cell Clusters in Early Stage Lung Cancer; Cancer Research - DOI: 10:1158/0008-5472.CAN-16-2072; 17 July 2017

Schott AF, Goldstein L, Cristofanilli M, Wicha MS, Phase 1b pilot study to evaluate reparixin in combination with weekly paclitaxel in patients with HER-2 negative metastatic breast cancer (MBC); Clinical Cancer Research; 2017 May; doi:10.1158/1078-0432.CCR-16-2748. PMID: 28539464 PMICD: PMC5600824

Kolev VN, Tam WF, Wright Q, McDermott SP, Vidal CM, Shapiro IM, Xu Q, Wicha M, Pachter JA, Weaver DT, Inhibition of FAK kinase activity preferentially targets cancer stem cells; Oncotarget June 2017. - doi: 10.18632/oncotarget.18517; PMID: 25486195 PMCID:PMC4614818

Burnett JP, Lim G, Li Y, Shah RB, Lim R, Paholak HJ, McDermott SP, Sun L, Tsume Y, Bai S, Wicha MS, Sun D, Zhang T. Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells. Proceedings of the National Academy of Sciences. 2017 May 28;394:52-64. doi: 10.1016/j.canlet.2017.02.023. Epub 2017 Feb 27. PMID: 28254410

Chen YC, Baac H, Lee KT, Fouladdel S, Teichert K, Ok J G, Cheng YH, Ingram P, Hart A J, Azizi E, Guo L J, Wicha M, Yoon E, Selective Photomechanical Detachment and Retrieval of Divided Sister Cells from Enclosed Microfluidics for Downstream Analysis; ACS Nano, 2017 May 23. doi:10.1021/scsnano.7b00413. Epub 2017 May 8. PMID: 28480715

Wadehra M, Kiyohara M, Dillard C, Kim S, Lu J, Sachdev D, Goodglick L, Tao M, Torous V, Wang W, Gordon L, Braun J, McDermott S, Wicha M, Aryasomayajula C, Najafzadeh P, Tsui J, EMP2 is a novel therapeutic target for endometrial cancer cells; Oncogene - doi: 10.1038/onc2017.142. PMID: 28604744. PMCID: PMC5648618

Zou W, Nagarsheth N, Wicha M. Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy; Nature Reviews Immunology - May 2017, doi:10.1038/nri.2017.49. PMID: 28555670

Tan Z, Nie S, McDermott SP, Wicha MS, Lubman DM. Single Amino Acid Variant Profilesof Subpopulations in the MCF-7 Breast Cancer Cell Line. J Proteome Res. 2017 Feb 3;16(2):842-851. doi: 10.1021/acs.jproteome.6b00824. Epub 2017 Jan 20. PMID: 28076950

Liu Y, Burness ML, Martin-Trevino R, Guy J, Bai S, Harouaka R, Brooks MD, Shang L, Fox A, Luther TK, Davis A, Baker TL, Colacino J, Clouthier SG, Shao ZM, Wicha MS, Liu S. RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer; Clinical Cancer Research. 2017 Jan 15;23(2):514-522. doi: 10.1158/1078-0432.CCR-15-1348. Epub 2016 Dec 29. PMID: 28034904

Jack RM, Hussain, K, Rodrigues D, Azizi, E, Wicha MS, Simeone D, Nagrath S. Microfluidic Continuum Sorting of Sub-Populations of Tumor Cells via Surface Antibody Expression Levels; Lab on a Chip, 2017, DOI: 10.1039/C6LC01496H. PMID: 28294230

2016 Publications

Prince M, Zhou L, Moyera J, Tao H, Lua L, Owen J, Etigena M, Zheng F, Chang A, Xia J, Wolf G, Max S Wicha, Huang S, Ren X, Li Q. Evaluation of the immunogenicity of ALDH high human head and neck squamous cell carcinoma cancer stem cells in vitro. Oral Oncology, 59:30-42, 2016 August. doi:10.1016/j.oraloncology.2016.05.013. PMID: 27424180

Hu Y, Lu L, Xia Y, Chen X, Chang A, Hollingsworth  R, Hurt E, Owen J, Moyer J, Prince M, Dai F, Bao Y, Wang Y, Whitfield J, Xia J, Huang S, Wicha M, Li Q. Therapeutic efficacy of cancer stem cell vaccines in the adjuvant setting. Cancer Research, 76(16):4661-72 2016, Aug 15. doi: 10.1158/0008-5472.CAN-15-2664. PMID: 27325649

Paholak H, Stevers N, Chen H, Burnett J, He M, Korkaya H, McDermott S, Deol Y, Clouthier S, Luther T, Li Q, Wicha MS, Sun, D. Elimination of epithelial-like and mesenchymal-like breast cancer stem cells to inhibit metastasis following nanoparticle-mediated phototermal therapy. Biomaterials, 104:145-57, 2016 June 23. doi: 10.1016/j.biomaterials.2016.06.045. PMID: 27450902

Chen Y, Zhang Z, Fouladdel S, Deol Y, Ingram P, McDermott S, Azizi E, Wicha M, Yoon E. Single Cell Dual Adherent-Suspension Co-Culture Micro-Environment for Studying Tumor-Stormal Interactions with Functionally Selected Cancer Stem-like Cells. Lab Chip, 16, 2935-2945, 2016. PMID: 27381658

Chen Y, Ingram P, Fouladdel S, McDermottS, Azizi E, Wicha M, Yoon E. High-Throughput Single-Cell Derived Sphere Formation for Cancer Stem-Like Cell Identification and Analysis. Scientific Reports, 2016 June 13;6:27301. doi: 10.1038/srep27301; PMID: 27292795 PMCID:PMC4904376

Sun L, Burnett J, Gasparyan M, Xu F, Jiang H, Lin C, Myers I, Korkaya H, Liu Y,  Connarn J, He H, Zhang N, Wicha M, Sun D. Novel Cancer Stem Cell Targets during Epithelial to Mesenchymal Transition in PTEN-deficient Trastuzumab-resistant. Breast Cancer. Oncotarget. 2016 Jun 6. doi: 10.18632/oncotarget.9839. PMID: 27285982

Colacino JA, McDermott SP, Sartor MA, Wicha MS, Rozek LS. Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention. Breast Cancer Research and Treatment, pp 1-13, June 15, 2016. PMID: 27306423

Hsu E, Kulp S, Huang H, Tu H, Chao M, Tseng Y, Yang M, Salunke S, Sullivan N, Chen W, Zhang J, Teng C, Fu W, Sun D, Wicha M, Shapiro C, Chen C. Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer. Carcinogenesis, 37(4) pp 430-442, April 1, 2016. PMID: 26905583

Finkel K, Warner, Kerk S, Bradford C, McLean S, Prince M, Zhong H, Hurt E, Hollingsworth R, Wicha M, Tice D, Nör J. IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence. Neoplasia, 18(5) pp 273-281, May 31, 2016. PMID: 27237319

Peng D, Tanikawa T, Li W, Zhao L, Vatan L, Szeliga W, Wan S, Wei S, Wang Y, Liu Y, Staroslawska E, Szubstarski F, Rolinski J, Grywalska E, Stanisławek A, Polkowski W, Kurylcio A, Kleer C, Chang A, Wicha M, Sabel M, Zou W, Kryczek I. Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling. Cancer Research, 76 (11) pp 3156-3165, June 1, 2016. PMID: 27197152

Murthy P, Kidwell KM, Schott AF, Merajver SD, Griggs JJ, Smerage JD, Van Poznak CH, Wicha MS, Hayes DF, Henry NL. Clinical predictors of long-term survival in HER2-positive metastatic breast cancer. Breast Cancer Research and Treatment. 2016 Feb 13. PMID: 26875184

Yoon HJ, Shanker A, Wang Y, Kozminsky M, Jin Q, Palanisamy N, Burness ML, Azizi E, Simeone D, Wicha MS, Kim J, Nagrath S. Tunable Thermal-Sensitive Polymer-Graphene Oxide Composity for Efficient capture and release of circulating tumor cells by temperature-sensitive polymer-graphene oxide composite. Advanced Materials, 2016 Apr 26; DOI:10.1002/adma.201600658 , PMID: 27115557 PMCID: PMC5680542

Jack R, Grafton M, Rodrigues D,. Giraldez M,Griffith C, Cieslak R, Zenali M, Kumar-Sinha C, Azizi E, Wicha M,  Tewari M, Simeone D, and Nagrath S. Ultra-Specific Isolation of Circulating Tumor Cells Enables Rare-Cell RNA Profiling. Advanced Science, DOI: 10.1002/advs.201600063, 2016.

Zhong H, Davis A, Ouzounova M, Carrasco RA, Chen C, Breen S, Chang YS, Huang J, Liu Z, Yao Y, Hurt E, Moisan J, Fung M, Tice DA, Clouthier SG, Xiao Z, Wicha MS, Korkaya H, Hollingsworth RE. A novel IL6 antibody sensitizes multiple tumor types to chemotherapy including trastuzumab-resistant tumors. Cancer Research, 76(2):480-490, 2016. PMID: 26744529

2015 Publications

Hsu E, Kulp S, Huang H, Tu H, Salunke S, Sullivan N, Sun D, Wicha M, Shapiro C, Chen C. Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6-Abundant Breast Cancer Cells by Regulating y-Secretase-Mediated Notch1 Activation in Caveolae. Neoplasia. 2015 June 30; 17(6), 497-508. PMID: 26152358

Kim G, Ouzounova M, Quraishi AA, Davis A, Tawakkol N, Clouthier S, Malik F, Paulson AK, D'Angelo RC, Korkaya S, Baker TL, Esen ES, Prat A, Liu S, Kleer CG, Thomas DG, Wicha MS, Korkaya H. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. Oncogene. 2015 Feb; 34 (6), 671-680. PMID: 24531711

Proctor E, Kidwell K, Jiagge E, Bensenhaver J, Awuah B, Gyan K, Toy K, Kwaku Oppong J, Kyei I, Aitpillah F, Osei-Bonsu E, Adjei E, l Ohene-Yeboah M, Newman Brewer R, Ahenkorah Fondjo L, Owusu-Afriyie O, Wicha MS, Merajver S, Kleer C, Newman L. Characterizing Breast Cancer in Population with Increased Prevalence of Triple-Negative Breast Cancer: Androgen Receptor and ALDH1 Expression in Ghanaian Women. Annals of surgical oncology. 2015 March 6, 1-5. PMID: 25743329

Malik F, Korkaya H, Clouthier S, Wicha MS. Regulation of Breast Cancer Stem Cells by Mesenchymal Stem Cells in Metastatic Niche. Principles of Stem Cell Biology and cancer, Future Applications and Therapeutics. 2015 May 1, 123-143.

Pan Q, Wang Q, Dan J, Pan K, Li Y, Zhang Y , Zhao J, Weng D, Tang Y, Huang L, He J, Chen S, Ke M, CHen M, Wicha MS, Chang A, Zeng Y, Li Q, Xia J. A Nomogram for Predicting the Benefit of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Hepatocellular Carcinoma. Scientific reports. 2015 March 17; 5:9202 DOI: 10.1038/srep09202. PMID: 25776856

Brooks M, Wicha MS. Tumor Twitter: Cellular Communication in the Breast Cancer Stem Cell Niche. Cancer Discovery. 2015 May 4; 5(5), 469-71. DOI:10.1158/2159-8290.CD-15-0327

Lu L, Tao H, Chang A, Hu Y, Shu G, Chen Q, Egenti M, Owen J, Moyer J, Prince M, Huang S, Wicha MS, Xia J, Li Q. Cancer stem cells vaccine inhibits metastases of primary tumors and induces humoral immue responses against cancer stem cells. OncoImmunology. 2015 May 1; 4:3, e990767, DOI: 10.4161/2162402X.2014.990767

Pan Q, Li Q, Liu S, Ning N, Zhang Z, Xu, Chang AE, Wicha MS. Targeting Cancer Stem Cells Using Immunologic Approaches. Stem Cells. 2015 Apr 15. PubMed PMID: 25873269

Conley SJ, Baker TL, Burnett JP, Theisen RL, Lazarus D, Peters CG, Clouthier SG, Eliasof S, Wicha MS. CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer. Breast Cancer Res Treat. 2015 Apr 2. PubMed PMID: 25833208

Ke J, Zhao Z, Hong SH, Bai S, He Z, Malik F, Xu J, Zhou L, Chen W, Martin-Trevino R, Wu X, Lan P, Yi Y, Ginestier C, Ibarra I, Shang L, McDermott S, Luther T, Clouthier SG, Wicha MS, Liu S. Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells.Oncotarget. 2015 Jan 21. PubMed PMID: 2568682

D'Angelo RC, Ouzounova M, Davis A, Choi D, Tchuenkam SM, Kim G, Luther T, Quraishi AA, Senbabaoglu Y, Conley SJ, Clouthier SG, Hassan KA, Wicha MS, Korkaya H. Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity. Mol Cancer Ther. 2015 Feb 11. PubMed PMID: 25673823.

Liu Y, Chen C, Qian P, Lu X, Sun B, Zhang X, Wang L, Gao X, Li H, Chen Z, Tang J, Zhang W, Dong J, Bai R, Lobie PE, Wu Q, Liu S, Zhang H, Zhao F, Wicha MS, Zhu T, Zhao Y. Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nat Commun. 2015 Jan 23. PubMed PMID: 25612916