Here’s a list of selected publications of the Lab.

Clicking on the PubMed logo on the right here should automatically perform a search for our publications.

mTORC1 signaling and regulation of pancreatic β-cell mass.
Blandino-Rosano M, Chen AY, Scheys JO, Alejandro EU, Gould AP, Taranukha T, Elghazi L, Cras-Méneur C, Bernal-Mizrachi E.
Cell Cycle. 2012 May 15;11(10):1892-902. Epub 2012 May 15.
PMID: 22544327
Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.
Tanabe K, Liu Y, Hasan SD, Martinez SC, Cras-Méneur C, Welling CM, Bernal-Mizrachi E, Tanizawa Y, Rhodes CJ, Zmuda E, Hai T, Abumrad NA, Permutt MA.
PLoS One. 2011 Apr 26;6(4):e18146.
PMID: 21541314
Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice.
Liu Y, Tanabe K, Baronnier D, Patel S, Woodgett J, Cras-Méneur C, Permutt MA.
Diabetologia. 2010 Dec;53(12):2600-10. Epub 2010 Sep 7.
PMID: 20821187

Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia.
Bernal-Mizrachi E, Cras-Méneur C, Ye BR, Johnson JD, Permutt MA.
PLoS One. 2010 Aug 3;5(8):e11969.
PMID: 20689817

Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells.
Elghazi L, Balcazar N, Blandino-Rosano M, Cras-Méneur C, Fatrai S, Gould AP, Chi MM, Moley KH, Bernal-Mizrachi E.
Diabetes. 2010 Oct;59(10):2390-9. Epub 2010 Jul 9.
PMID: 20622167

Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.
Cras-Méneur C, Li L, Kopan R, Permutt MA.
Genes Dev. 2009 Sep 1;23(17):2088-101.
PMID: 19723764

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA.
PLoS Biol. 2008 Feb;6(2):e37.
PMID: 18288891
Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.
Martinez SC, Tanabe K, Cras-Méneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA.
Diabetes. 2008 Apr;57(4):846-59. Epub 2008 Jan 3.
PMID: 18174526
Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway.
Elghazi L, Rachdi L, Weiss AJ, Cras-Méneur C, Bernal-Mizrachi E.
Diabetes Obes Metab. 2007 Nov;9 Suppl 2:147-57. Review.
PMID: 17919189

A global approach to identify differentially expressed genes in cDNA (two-color) microarray experiments.
Zhou Y, Cras-Méneur C, Ohsugi M, Stormo GD, Permutt MA.
Bioinformatics. 2007 Aug 15;23(16):2073-9. Epub 2007 Jun 5.
PMID: 17550914

Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell.
Martinez SC, Cras-Méneur C, Bernal-Mizrachi E, Permutt MA.
Diabetes. 2006 Jun;55(6):1581-91.
PMID: 16731820

Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity.
Fatrai S, Elghazi L, Balcazar N, Cras-Méneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E.
Diabetes. 2006 Feb;55(2):318-25.
PMID: 16443763

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.
Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Méneur C, Permutt MA, Imai S.
Cell Metab. 2005 Aug;2(2):105-17.
PMID: 16098828

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.
Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.
J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.
PMID: 15546857

Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes.
Ohsugi M, Cras-Méneur C, Zhou Y, Warren W, Bernal-Mizrachi E, Permutt MA.
Diabetes. 2004 Jun;53(6):1496-508.
PMID: 15161754

An expression profile of human pancreatic islet mRNAs by Serial Analysis of Gene Expression (SAGE).
Cras-Méneur C, Inoue H, Zhou Y, Ohsugi M, Bernal-Mizrachi E, Pape D, Clifton SW, Permutt MA.
Diabetologia. 2004 Feb;47(2):284-99. Epub 2004 Jan 13.
PMID: 14722648

[Control of pancreatic development].
Scharfmann R, Cras-Méneur C, Basmaciogullari A, Duvillié B.
Journ Annu Diabetol Hotel Dieu. 2003:17-22. Review. French. No abstract available.
PMID: 12868297

Transcriptional program of the endocrine pancreas in mice and humans.
Kaestner KH, Lee CS, Scearce LM, Brestelli JE, Arsenlis A, Le PP, Lantz KA, Crabtree J, Pizarro A, Mazzarelli J, Pinney D, Fischer S, Manduchi E, Stoeckert CJ Jr, Gradwohl G, Clifton SW, Brown JR, Inoue H, Cras-Méneur C, Permutt MA.
Diabetes. 2003 Jul;52(7):1604-10.
PMID: 12829622
Gene expression profiling in islet biology and diabetes research.
Bernal-Mizrachi E, Cras-Méneur C, Ohsugi M, Permutt MA.
Diabetes Metab Res Rev. 2003 Jan-Feb;19(1):32-42. Review.
PMID: 12592642

FGFR1-IIIb is a putative marker of pancreatic progenitor cells.
Cras-Méneur C, Scharfmann R.
Mech Dev. 2002 Aug;116(1-2):205-8.
PMID: 12128225

Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation.
Elghazi L, Cras-Méneur C, Czernichow P, Scharfmann R.
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3884-9. Epub 2002 Mar 12.
PMID: 11891329

Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: a balance between proliferation and differentiation.
Cras-Méneur C, Elghazi L, Czernichow P, Scharfmann R.
Diabetes. 2001 Jul;50(7):1571-9.
PMID: 11423478

No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes.
Dupont S, Hani EH, Cras-Méneur C, De Matos F, Lobbens S, Lecoeur C, Vaxillaire M, Scharfmann R, Froguel P.
Diabetes. 2001 May;50(5):1219-21.
PMID: 11334431
Pancreatic pattern of expression of thyrotropin-releasing hormone during rat embryonic development.
Basmaciogullari A,
Cras-Meneur C, Czernichow P, Scharfmann R.
J Endocrinol. 2000 Sep;166(3):481-8.
PMID: 10974642