Project Description

Post-translational regulation of Sf1 in adrenal development

Sf1 (NR5A1) is an essential nuclear receptor in adrenal development and homeostasis. While it is well established that Sf1 dosage be critical for the proliferation of adrenocortical cells, recently, Sf1 post-translational modification has also been shown to regulate its function and activity. Previous study suggested that SUMOylation of Sf1 could influence its binding activity with CDK7, phosphorylation status, and thus change downstream gene transcription. Current projects focus on using different mouse models to study the roles of phosphorylation and SUMOylation on Sf1 and how they influence adrenal development and homeostasis in vivo.