Peer-Reviewed Publications

• Dobrosotskaya IY, Hammer GD, Schteingart DE, Maturen KE, and Worden FP. Mebendazole Monotherapy and Long-Term Disease Control in Metastatic Adrenocortical Carcinoma. Endocrine Practice. May-June;17(3); e59-62 (2011).
• Scheys JOA, Heaton JH, and Hammer GD. Evidence of Adrenal Failure in Aging Dax1-deficient Mice. Endocrinology Sep;152(9):3430-9 (2011).
• Nasonkin OI, Ward RD, Bavers DL, Beuschlein F, Mortensen AH, Keegan CE, Hammer GD, and Camper SA. Prop1 Deficient Dwarf Mice Maintain ACTH Production. PLOS 6(12) e28355. (2011).
• Simon DP, and Hammer GD. Adrenocortical Stem and Progenitor Cells - Implications for Adrenocortical Carcinoma. Molecular and Cellular Endocrinology. March 31;351(1);2-11. (2012).
• Simon DP, Giordano TJ and Hammer GD. Upregulated JAG1 Enhances Cell Proliferation in Adrenocortical Carcinoma. Clinical Cancer Research. 18(9):2452-64 (Highlighted on Cover) (2012).
• Miller BS, Ignatoski KM, Daignault S, Lindland C, Doherty M, Gauger PG, Hammer GD, Wang SC, Doherty GM, and The University of Michigan Analytical Morphomics Group. Worsening Central Sarcopenia and Increasing Intra-Abdominal Fat Correlate with Decreased Survival in Patients with Adrenocortical Carcinoma. World Journal of Surgery. July;36(7):1509-16. (2012).
• Wood MA, Hammer, GD. Adrenocortical stem and progenitor cells: Unifying model of two proposed origins. Mol Cell Endocrinol. 2010 Nov 20. [Epub ahead of print] PMID:21094677
• Kelly, VR, Xu, B, Koenig, RJ and Hammer, GD. Dax1 upregulates OCT4 expression in mouse embryonic stem cells via LRH-1 and SRA. Mol Cell Endocrinol. 2010 Dec; 24(12):2281-91.
• Sabolch A., Feng, M. Griffith K, Hammer, G, Doherty G. and Ben-Josef E. Adjuvant and Definitive Radiotherapy for Adrenocortical Carcinoma. Int J Radiat Oncol Biol Phys. 2010 Jul 31.
• Miller BS Gauger PG, Hammer GD, Giordano TJ and Doherty GM (2010) Ann Arbor Proposal for modification of the ENSAT staging system for adrenocortical carcinoma using tumor grade, Langenbecks Arch Surg. Sep; 395(7):955-61. (2010).
• Miller BS, Ammori JB, Gauger PG, Broome JT, Hammer GD, Doherty GM. Laparoscopic resection is inappropriate in patients with known or suspected adrenocortical carcinoma. World J Surg. 34(6):1380-5 (2010).
• Garcia-Perez, JL, Morell, M, Scheys, JO, Kulpa, DA, Morell, S, Carter, CC, Hammer, GD, Collins, KL, O'Shea, KS, Menendez, P and Moran JV. Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells. Nature. Aug 5;466(7307):769-73. (2010)
• Watson, RL, Spalding, AC, Zielske, SP, Morgan, , A. Kim, M. Bommer, GT, Eldar-Finkelman, H, Giordano, T, Fearon, ER, Hammer, GD Lawrence, TS and Ben-Josef, E. GSK3 Beta and Beta-catenin Modulate Radiation Cytotoxicity in Pancreatic Cancer. Neoplasia 12(5): 357-365 (2010).
• Looyenga, BD, Wiaters, E, Vale, WW and Hammer GD. Inhibin-A Antagonizes TGFß2 Signaling by Downregulating Cell Surface Expression of the TGFß Co-receptor Betaglycan. Molecular Endocrinology 24(3): 608-620 (2010).
• Haluska P, Worden F, Olmos D, Yinv D, Schteingart D, Batzel GN, Paccagnella ML, de Bono JS, Richardson RL, Gualberto AG and Hammer GD. Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody CP-751,871 in patients with refractory adrenocortical carcinoma. Cancer Chemotherapy and Pharmacology 65(4):765-73 (2010).
• Strosberg, JR, Hammer, GD and Doherty, GM. Management of Adrenocortical Carcinoma. (invited, peer-reviewed) Journal of the National Comprehensive Cancer Network 7(7):752-9 (2009).

• Else, T, Kim, AC, Trovoto, A, Ferguson, DO, Lucas, PC and Hammer, GD. Genetic p53 deficiency partially rescues adrencortial dysplasia (acd) phenotype at the expense of increased tumorigenicity. Cancer Cell 15(6): 465-476 (2009).
• Kim AC, Barlaskar FM, Heaton JH, Else T, Kelly VR, Krill KT, Scheys JO, Simon DP, Trovato A, Yang W-H, and Hammer GD. In Search of Adrenocortical Stem and Progenitor Cells. (invited, peer-reviewed) Endocrine Reviews 30 (3): 241-263 (2009).
• Xu, B, Yang, W-H, Gerin, I, Hu, C-D, Hammer, GD and Koenig, RJ. DAX-1 and Steroid Receptor RNA Activator (SRA) Function as Transcriptional Coactivators for Steroidogenic Factor-1 in Steroidogenesis. Molecular and Cellular Biology 29(7):1719-34 (2009).
• Yang WH, Heaton JH, Brevig H, Mukherjee S, Iñiguez-Lluhí JA, Hammer GD Sumoylation inhibits SF-1 activity by reducing CDK7 mediated Ser 203 phosphorylation MCB. 29(3): 613-25 (2009).
• Barlaskar, FM, Spalding, AC, Heaton, JH, Davis, MA, Ben-Josef, E. and Hammer, GD. The Type 1 Insulin-like Growth Factor Receptor as a Novel Therapeutic Target in Adrenocortical Carcinomas. JCEM. 94(1): 204-12 (2009).
• Giordano, TJ, Kuick, R, Else, T, Gauger, PG, Vinco, M, Bauersfeld, J, Sanders, D, Thomas, DG, Doherty, G and Hammer, GD. Molecular Classification and Prognostication of Adrenocortical Tumors by Transcriptome Profiling. Clinical Cancer Research. 15(2): 668-76 (2009).
• White ML, Cho KJ, Gauger PG, Doherty GM, Hammer GD, Miller BS. The Role of Radiologic Studies in the Evaluation and Management of Primary Hyperaldosteronism. Surgery 2008 Surgery. 144(6):926-33 (2008) (Role: Participated in the evaluation of many of the patients included in the analysis and assisted in writing of manuscript)

• Kim, AC, Reuter, AL Zubair, M, Serecky, K, Else, T, Bingham, NC, Lavery, GG, Parker, KL and Hammer GD. Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex. Development 135 (15): 2593-602 (2008).
• Rui X, Tsao J, Scheys JO, Hammer GD, Schimmer BP. Contributions of Sp1 and Steroidogenic Factor 1 to Adcy4 Expression in Y1 Mouse Adrenal Cells. Endocrinology 149(7) 3668-78. (2008) (Role: Performed ChIP assays and assisted in writing of manuscript)
• Else T, Giordano TJ, Hammer GD. Evaluation of telomere length maintenance mechanisms in adrenocortical carcinoma. J Clin Endocrinol Metab. Apr;93(4):1442-9 (2008).
• Barlaskar FM and Hammer, GD. The molecular genetics of adrenocortical carcinoma. Rev Endocr Metab Disord 8(4): 343-8 (2007) (invited, peer-reviewed)
• Else, T, Theisen, BK, Hutz, JE, Keegan, CE, Hammer, GD and Ferguson, DO. Tpp1/Acd maintains genomic stability through a complex role in telomere protection. Chromosome Research 15(8): 1001-13 (2007).
• Looyenga, BD and Hammer GD. Genetic Removal of Smad3 from Inhibin-null Mice Attenuates Tumor Progression by Uncoupling Extracellular Mitogenic Signals from the Cell Cycle Machinery. Molecular Endocrinology 21: 2440-2457 (2007).
• Hockemeyer, D, Else, T, Daniels, J-P., Palm, W, Ye, JZ-S., deLange, T, and Hammer, GD. Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nature Structural and Molecular Biology 14(8): 754-61 (2007).
• Keegan, CE, Hutz, JE, Krause, AS, Koehler, K, Metherell, LA, Boikos, S, Stergiopoulos, S, Clark, AJ, Stratakis, CA, Huebner, A, and Hammer, GD. Novel polymorphisms and lack of mutations in the ACD gene in patients with ACTH resistance syndromes. Clinical Endocrinology; 67(2): 168-174 (2007).
• Kim, A and Hammer, GD. Functional Characterization of Undifferentiated Adrenocortical Cells with Stem/Progenitor Cell Properties: Review of Literature and Recent Advances. (invited, peer-reviewed) Molecular and Cellular Endocrinology 265-266: 10-16 (2007).

• Lichtenauer U, Duchniewicz M, Kolanczyk M, Höflich, A, Hahner S, Else T, Bicknell AB, Tomasz Zemojtel T, Stallings NR, Hammer GD, Scheele J and Beuschlein F. Pbx-1 and SF-1 synergistically affect adrenocortical growth and steroidogenesis. Endocrinology 148 (2): 693-704 (2007).
• Gummow BM, Scheys JO, Cancelli VR and Hammer GD. Reciprocal Regulation of a GR-SF-1 Transcription Complex on the Dax-1 Promoter by Glucocorticoids and ACTH in the Adrenal Cortex. Molecular Endocrinology 20 (11): 2711-23 (2006).
• Looyenga BD and Hammer GD. Origin and Identity of Adrenocortical Tumors in Inhibin Knockout Mice: Implications for Cellular Plasticity in the Adrenal Cortex. Molecular Endocrinology 20 (11): 2848-63 (2006).
• Beuschlein F, Slawik M, Shapiro I, Hartmann M, Wudy S, Hammer GD and Reincke M. Gonadectomy in mice of the inbred strain CE/J induces proliferation of subcapsular adrenal cells expressing gonadal marker genes. Journal of Endocrinology 190 (1): 47-57 (2006).
• Martin M and Hammer GD. Pheochromocytoma: Risk Groups, Diagnosis and Management in Primary Care. Hospital Physician 42 (2): 17-24 (2006).
• Hutz JE, Krause AS, Achermannm J, Vilain E, Tauber M, Lecointre C, McCabe ERB, Hammer GD and Keegan CE. IMAGe association and congenital adrenal hypoplasia: No disease-causing mutations found in the ACD gene. Molecular Genetics and Metabolism 88 (1): 66-70 (2006).
• Winnay JN and Hammer GD. ACTH-mediated signaling cascades coordinate a cyclic pattern of SF-1-dependent transcriptional activation. Mol Endocrinol. 20 (1): 147-166 (2006).
• Winnay JN, Xu Z, O'Malley BW and Hammer GD. Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function.. Endocrinology. 147 (3): 1322-32 (2006).
• Else T and Hammer GD. Genetic analysis of adrenal absence: agenesis and aplasia. Trends in Endocrinology and Metabolism 16 (10): 458-468 (2005).
• Schteingart DE, Doherty GM, Gauger PG, Giordano TJ, Hammer GD, Korobkin, M and Worden F. Management of Patients with Adrenal Cancer: Recommendations of an International Consensus Conference. Endocrine-Related Cancer 12 (3): 667-680 (2005).

• Park SY, Raverot G, Meeks JJ, Pfaff LE, Weiss J, Hammer GD and Jameson JL. Nuclear Receptors Sf1 and Dax1 Function Cooperatively to Mediate Somatic Cell Differentiation During Testis. Development 132 (10): 2415-2423 (2005).
• Hammer GD, Parker KL and Schimmer BP. Transcriptional Control of Adrenocortical Development. (invited, peer-reviewed) Endocrinology 146 (3): 1018-24 (2005).
• Keegan CE, Hutz JE, Else T, Adamska M, Sah SP, Kent AE, Howes J, Beamer WG and Hammer GD. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Human Molecular Genetics 14 (1): 113-123 (2005).
• Hammer GD, Tyrrell JB, Lamborn KR, Applebury CB, Hannegan ET, Bell S, Rahl R., Lu A and Wilson CB. Transphenoidal Microsurgery for Cushing's Disease: Initial Outcome and Long Term Results. Journal of Clinical Endocrinology and Metabolism 89 (12): 6348-6357 (2004).
• Beuschlein F, Looyenga BD, Reincke M and Hammer GD. Role of the Inhibin/activin System and Luteinizing Hormone in Adrenocortical Tumorigenesis. (invited, peer-reviewed) Hormone and Metabolic Research 36: 392-396 (2004).
• 1. Kennell JA, OLeary EE, Gummow BM, Hammer GD and MacDougald OA. 2003. T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Molecular and Cellular Biology 23 (15): 5366-75 (2003).
• Gummow BM, Winnay JN and Hammer GD. Convergence of Wnt signaling and SF-1 on transcription of the rat inhibin alpha gene. Journal of Biological Chemistry 278 (29): 26572-26579 (2003).
• Beuschlein F, Looyenga BD, Mutch C, Bleasdale S, Bavers DL, Parlow AF, Nilson JH and Hammer GD. Activin induces X-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin deficient mice. Molecular and Cellular Biology 23 (11): 3951-3964 (2003).
Michelle Wood, Ph.D., is doing tissue culture work.
• Beuschlein F and Hammer GD. Ectopic POMC Syndromes in Endocrine Manifestations of Systemic Disease. (invited, peer-reviewed) Endocrinology Clinics of North America 31: 1-44 (2002).
• Keegan CE and Hammer GD. Recent Insights into Organogenesis of the Adrenal Cortex. (invited, peer-reviewed) Trends in Endocrinology and Metabolism 13 (5): 200-208 (2002).
• Beuschlein F, Mutch C, Bavers DL, Ulrich-Lai Y, Engeland WC, Keegan C and Hammer GD. Steroidogenic Factor-1 is essential for compensatory adrenal growth following unilateral adrenalectomy. Endocrinology 143 (8): 3122-35 (2002).
• Babu PS, Bavers DL, Beuschlein F, Shah S, Jeffs B, Jameson JL and Hammer GD. Interaction between Dax-1 and SF-1 in vivo: Increased adrenal responsiveness to ACTH in the Absence of Dax-1. Endocrinology 143 (2): 665-673 (2002).
• Hammer GD and Ingraham HA. Steroidogenic Factor 1: Its role in endocrine organ development and differentiation. (invited, peer-reviewed) Frontiers in Neuroendocrinology 20: 199-223 (1999).
• Hammer GD, Kylova I, Zhang Y, Darimont BD, Simpson K, Weigel NL and Ingraham HA. Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: Integration of hormone signaling in reproduction and stress. Molecular Cell 3 (4): 521-526 (1999).
• Nachtigal MW, Horokawa Y, Enyeart Van Houten DL, Flanagan JN, Hammer GD and Ingraham HA. Wilms' Tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. Cell 93 (3): 445-454 (1998).
• Low MJ, Liu B, Hammer GD, Rubinstein M and Allen RG. Posttranslational processing of proopiomelanocortin (POMC) in mouse pituitary melanotroph tumors induced by a POMC-simian virus 40 large T antigen transgene. Journal of Biological Chemistry 268 (33): 24967-24975 (1993).
• Asa SL, Kovacs K, Hammer GD, Liu B, Roos BA and Low MJ. Pituitary corticotroph hyperplasia in rats implanted with a medullary thyroid carcinoma cell line transfected with a corticotropin-releasing hormone cDNA expression vector. Endocrinology 131 (2): 715-720 (1992).
• Liu B, Hammer GD, Rubinstein M, Mortrud M and Low MJ. Identification of DNA elements cooperatively activating proopiomelanocortin gene expression in the pituitary gland of transgenic mice. Molecular and Cellular Biology. 12 (9): 3978-3900 (1992).
• Hammer GD, Muller G, Liu B, Petrides JS, Roos BA and Low MJ. Ectopic corticotropin-releasing hormone produced by a transfected cell line chronically activates the pituitary-adrenal axis in trankaryotic rats. Endocrinology 130 (4): 1975-1985 (1992).
• Hammer GD, Fairchild-Huntress V and Low MJ. Pituitary-specific and hormonally regulated gene expression directed by the rat proopiomelanocortin promoter in transgenic mice. Molecular Endocrinology 4 (11): 1689-1697 (1990).
• Hammer, GD and Kapp, BS. The effects of naloxone administered into the periaqueductal gray on the shock-elicited freezing behavior in the rat. Behavioral and Neural Biology 46: 189-195 (1986).