We combine chemical kinetics, mathematical, computational and statistical methods to develop standard-based approaches to measure the rates of enzyme catalyzed reactions and distinguish their molecular mechanisms under diverse experimental conditions.
Most of our research focuses on deriving mathematical approximations of the governing rate law equations for progress curves of enzyme catalyzed reactions. After deriving those approximation, we investigate the experimental conditions they can be effectively used to model the progress curves of enzyme catalyzed reactions and estimate their kinetic parameters.
In addition, we are also interested in developing and implementing algorithms for the accurate estimation of enzyme kinetic parameters from progress curve experiments.
