Recent News

Santiago Schnell appointed dean of Notre Dame’s College of Science

If you are interested in our research, this is how you can do to join our group.

Santiago Schnell, D.Phil., has been appointed chair of the Department of Molecular & Integrative Physiology in the Medical School, …


We work at the interface between biophysical chemistry, the mathematical and engineering sciences, and pathophysiology

Dr. Schnell and his research group develop methods and models to obtain high-quality measurements with rigor, reproducibility, and robustness in the biomedical sciences. Our research departs from the premise that there is a continuum between health and disease. If we are capable of measuring this continuum, we will be in the position of detecting disease earlier and understanding it better to intervene more precisely. Below you will find some of our current projects.


We are deriving rate equations and developing standard based approaches to measure enzyme kinetic parameters.

We are developing Standards for Reporting Enzymology Data (STRENDA) in collaboration with an international committee sponsored by the Beilstein-Institut.

The EnzymeML language is an open standard based on the XML markup language.

We are deciphering the control mechanism of the unfolded protein response and protein homeostasis to open new therapeutic avenues for age-associated and protein folding diseases

The study of macromolecular crowding is indispensable for understanding cellular physiology and biochemistry. We are investigating how crowding affects quantitatively the cellular biochemistry, and qualitatively cellular physiology.

We investigate complex biomedical systems comprising many interacting components, where modeling and theory may aid in the identification of the key mechanisms underlying the behavior of the system as a whole.

We are developing new metrics and models to measure and improve performance of scientists, research universities, and academic policies.

We are developing standard-based guidelines to evaluate computational protein disorder predictions.


Meet the team working at the Schnell Lab. Our research group embodies physiologists, biophysicists, engineers, and mathematical scientists, working on lively and multidisciplinary teams with other research groups within the university, the USA and abroad.

If you are interested in joining the lab, please read this post.

Principal Investigator


Santiago Schnell

John A. Jacquez Collegiate Professor of Physiology

Postdoctoral Fellows


Justin Eilertsen

Postdoctoral Fellow

Dynamical Systems, Nonlinear Phenomena, Applied Mathematics



Joseph Cavataio

Research Associate

Mathematical Biology, Metrology


Sofia Medina

Research Associate

Dynamical Systems, Applied Mathematics, Mathematical Biology

Support our research

If you would like to support our research efforts, please consider making a tax deductible donation to the Schnell Lab through the Leaders & Best Online Giving at Michigan. All donations are used to support our research efforts to advance on how to detect disease earlier, understand it better to intervene more precisely.

Donate Learn more about our projects


Contact Dr. Santiago Schnell