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C.S. Mott Children's Hospital


Vivian Cheung, M.D.
In the Cheung lab, we combine computational and experimental methods to study normal variation in human traits and genetics of complex diseases. We assess the extent of individual differences in cellular phenotypes such as gene expression and organelle function. Then, we treat the variable phenotypes as quantitative traits to map and characterize molecularly their regulators. We are particularly interested in regulators that affect transcription and RNA processing. Our studies focus on normal human cells at baseline homeostatic states; however, we are also interested in cellular responses to stress including DNA damage, protein load and metabolic perturbations. By studying regulation in normal cells, we gain insights into how dysregulations lead to diseases. While our interest is in human biology, recently, we have taken advantage of yeast genetics to complement our studies.

Timothy Hoban, M.D.

Dr. Hoban's research interest focuses on identifying the causes of sleep disorders in children, and on improving their treatment .

Sucheta Joshi, M.D.

Dr. Joshi is a pediatric epileptologist. Her research focuses on understanding the impact of epilepsy on quality of life in adolescents.

Steven Leber, M.D., Ph.D.

Dr. Leber is interested in the application of the Internet in medicine. He also is interested in pediatric headache, including evaluation of referral patterns from primary physicians and in headache treatment.

Patricia Robertson, M.D.

Dr. Robertson's research interests focus on development of more effective therapies for pediatric brain tumors. Related research focuses on refining clinical methods for the evaluation of response to treatment, for the assessment of outcomes, and for analyzing late effects of therapy on children with these tumors.

Renée Shellhaas, M.D.
Dr. Shellhaas is a pediatric epileptologist. Her clinical interests include the evaluation and treatment of infants and children with epilepsy. Her research is focused on seizures and encephalopathy in newborn infants. She is studying the use of conventional EEG, as well as newer tools such as near-infrared spectroscopy and amplitude integrated EEG, in the neonatal intensive care unit.

Faye Silverstein, M.D.

Dr. Silverstein's research program focuses on the pathogenesis of neonatal brain injury, and, in particular, on the complex roles of inflammatory mediators in modulating susceptibility to both neuronal and glial damage. Her laboratory primarily uses in vivo rodent models of neonatal ischemic and excitotoxic brain injury to study cellular and molecular mechanisms of cell death, to identify mechanisms that are particularly important in the pathogenesis of brain injury in the immature nervous system, and to develop more effective therapeutic intervention strategies.