Hereditary spastic paraplegia

Treatment of hereditary spastic paraplegia

Currently, there is no specific treatment to prevent, retard, or reverse HSP's progressive disability. Nonetheless, treatment approaches used for chronic paraplegia from other causes are useful. Patients in relatively early stages of the illness have obtained symptomatic improvement with oral and intrathecal baclofen and oral dantrolene. Zanaflex has also provided some reduction of spasticity. Bladder spasticity has been improved with oxybutynin (Ditropan).

Regular physical therapy is important to maintain and improve range of motion and muscle strength. Furthermore, physical therapy is necessary to maintain aerobic conditioning of the cardiovascular system. While physical therapy does not reduce the degenerative process within the spinal cord, it is considered important that HSP subjects maintain a physical therapy exercise regimen at least several times each week.

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