WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -1.77[2] | -1.79[3] | -1.84[4] | -1.81[5] | -1.32[6] | -1.67[7] |
2 | JUN | Transcription factor AP-1 | [8] | -1.32[9] | -2.39[10] | -2.39[11] | -2.29[12] | -1.69[13] | -2.16[14] |
3 | CTNNB1 | Catenin beta-1 | [15] | 0.78[16] | 0.75[17] | 1.38[18] | 0.17[19] | 0.43[20] | 0.76[21] |
4 | MYC | Myc proto-oncogene protein | [22] | -0.40[23] | -0.27[24] | -2.56[25] | -3.37[26] | -0.97[27] | -2.35[28] |
5 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | -0.03[29] | 0.27[30] | -0.08[31] | 0.62[32] | -0.02[33] | -0.20[34] | |
6 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | -0.56[35] | 0.01[36] | -0.89[37] | 0.16[38] | 0.30[39] | -0.45[40] | |
7 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | -1.23[41] | -1.09[42] | -1.28[43] | -1.04[44] | -1.11[45] | -1.34[46] | |
8 | CCND1 | G1/S-specific cyclin-D1 | [47] | 2.22[48] | 0.19[49] | 0.75[50] | 1.30[51] | -0.15[52] | 0.71[53] |
9 | CTNND1 | Catenin delta-1 | [54] | -4.61[55] | -4.64[56] | -4.34[57] | -4.68[58] | -5.01[59] | -4.09[60] |
10 | CTBP1 | C-terminal-binding protein 1 | [61] | -0.78[62] | -0.19[63] | -0.18[64] | -0.17[65] | -1.10[66] | -0.61[67] |
11 | FOSL1 | Fos-related antigen 1 | [68] | -2.57[69] | -3.56[70] | -6.67[71] | -1.44[72] | -0.63[73] | -7.48[74] |
12 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isofor | -1.14[75] | 0.21[76] | -0.36[77] | 0.36[78] | 0.19[79] | -0.54[80] | |
13 | LDLR | Low-density lipoprotein receptor | [81] | -0.64[82] | 0.67[83] | 1.41[84] | -1.48[85] | -0.26[86] | 0.88[87] |
14 | CD44 | CD44 antigen | [88] | -7.90[89] | -8.92[90] | -2.77[91] | 1.18[92] | 1.66[93] | -1.63[94] |
15 | DVL1 | Segment polarity protein dishevelled homolog DVL-1 | [95] | -0.03[96] | 0.90[97] | -0.49[98] | -0.51[99] | -0.45[100] | -1.11[101] |
16 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | -0.38[102] | -0.43[103] | -0.28[104] | -0.31[105] | -0.50[106] | 2.58[107] | |
17 | LRP5 | Low-density lipoprotein receptor-related protein 5 | [108] | 1.27[109] | 1.47[110] | 1.82[111] | 1.16[112] | -0.28[113] | 1.80[114] |
18 | PPARD | Peroxisome proliferator-activated receptor delta | [115] | -1.20[116] | -1.27[117] | -1.80[118] | -0.50[119] | -0.06[120] | -1.97[121] |
19 | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha | [122] | -0.05[123] | 0.54[124] | 0.22[125] | 1.56[126] | 1.45[127] | 0.49[128] |
20 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [129] | -0.93[130] | 0.61[131] | 0.21[132] | -0.09[133] | 0.12[134] | -0.10[135] |
21 | WNT11 | Protein Wnt-11 | [136] | -2.26[137] | -7.49[138] | -6.73[139] | -7.12[140] | -7.51[141] | -3.43[142] |
22 | PRKCZ | Protein kinase C zeta type | [143] | -0.36[144] | 0.50[145] | -1.78[146] | -2.88[147] | -5.05[148] | -1.99[149] |
23 | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isofor | -0.48[150] | 0.14[151] | 0.27[152] | 0.29[153] | 0.21[154] | -0.37[155] | |
24 | CSNK1E | Casein kinase I isoform epsilon | [156] | 0.53[157] | 0.64[158] | 1.03[159] | -0.11[160] | 0.98[161] | -1.17[162] |
25 | FZD5 | Frizzled-5 | [163] | 0.14[164] | 1.48[165] | 2.20[166] | -1.72[167] | -3.00[168] | 2.24[169] |
26 | DVL3 | Segment polarity protein dishevelled homolog DVL-3 | [170] | 0.65[171] | 1.34[172] | 0.47[173] | 0.89[174] | 0.99[175] | -0.04[176] |
27 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isofor | -0.72[177] | -0.06[178] | -0.80[179] | 0.28[180] | 0.09[181] | -0.15[182] | |
28 | TP53 | Cellular tumor antigen p53 | [183] | 0.80[184] | 0.84[185] | 1.33[186] | 0.71[187] | 0.40[188] | -0.39[189] |
29 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [190] | -0.13[191] | 0.98[192] | -0.09[193] | 0.62[194] | 0.05[195] | 0.72[196] |
30 | AXIN1 | Axin-1 | [197] | 0.52[198] | 1.31[199] | -0.52[200] | -9.28[201] | -0.40[202] | -1.00[203] |
31 | POU5F1 | POU domain, class 5, transcription factor 1 | [204] | -4.42[205] | -1.93[206] | -4.48[207] | -4.40[208] | -4.64[209] | -3.96[210] |
32 | MAPK9 | Mitogen-activated protein kinase 9 | [211] | 0.39[212] | 1.10[213] | 0.89[214] | 1.13[215] | 0.62[216] | 0.16[217] |
33 | PRKCI | Protein kinase C iota type | [218] | 0.22[219] | 1.38[220] | 2.71[221] | 0.57[222] | 1.01[223] | -0.10[224] |
34 | GSK3B | Glycogen synthase kinase-3 beta | [225] | 0.43[226] | 0.55[227] | 0.85[228] | 1.23[229] | 1.09[230] | 0.81[231] |
35 | NFYA | Nuclear transcription factor Y subunit alpha | [232] | 0.72[233] | 1.41[234] | 1.02[235] | 0.85[236] | 0.34[237] | 0.12[238] |
36 | AXIN2 | Axin-2 | [239] | 2.63[240] | 0.71[241] | -3.60[242] | -1.67[243] | -2.02[244] | -2.69[245] |
37 | CCND3 | G1/S-specific cyclin-D3 | [246] | 0.12[247] | -0.47[248] | -2.37[249] | 3.08[250] | 2.28[251] | 0.31[252] |
38 | PRKCD | Protein kinase C delta type | [253] | 0.26[254] | 0.99[255] | 0.20[256] | -1.09[257] | 0.10[258] | -1.42[259] |
39 | FBXW2 | F-box/WD repeat-containing protein 2 | [260] | 1.60[261] | 1.74[262] | 2.47[263] | 1.46[264] | 2.07[265] | 2.52[266] |
40 | ZBTB33 | Transcriptional regulator Kaiso | [267] | -0.32[268] | 0.85[269] | 1.53[270] | 0.74[271] | 0.57[272] | 1.40[273] |
41 | FZD4 | Frizzled-4 | [274] | 3.25[275] | 2.67[276] | 1.44[277] | 0.11[278] | -0.53[279] | 2.60[280] |
42 | EP300 | Histone acetyltransferase p300 | [281] | 1.89[282] | 1.96[283] | 2.58[284] | 1.99[285] | 2.07[286] | 2.41[287] |
43 | PRKCA | Protein kinase C alpha type | [288] | 2.00[289] | 2.52[290] | 2.61[291] | 1.57[292] | 1.96[293] | 1.57[294] |
44 | TCF7L2 | Transcription factor 7-like 2 | [295] | 0.03[296] | 1.28[297] | 1.21[298] | 0.11[299] | 0.12[300] | 1.37[301] |
45 | NLK | Serine/threonine-protein kinase NLK | [302] | -0.56[303] | 0.48[304] | 0.71[305] | 0.13[306] | -0.08[307] | 0.46[308] |
46 | DVL2 | Segment polarity protein dishevelled homolog DVL-2 | [309] | 1.28[310] | 1.51[311] | 2.23[312] | 1.64[313] | 1.31[314] | -0.34[315] |
47 | RACGAP1 | Rac GTPase-activating protein 1 | [316] | 1.26[317] | 2.21[318] | 2.18[319] | 2.59[320] | 3.17[321] | -1.06[322] |
48 | LRP6 | Low-density lipoprotein receptor-related protein 6 | [323] | 0.99[324] | 2.13[325] | 3.21[326] | 1.28[327] | 1.85[328] | 4.43[329] |
49 | TCF7L1 | Transcription factor 7-like 1 | [330] | -3.89[331] | -1.60[332] | 0.32[333] | -2.40[334] | -2.25[335] | -0.06[336] |
50 | CREBBP | CREB-binding protein | [337] | 2.07[338] | 1.76[339] | 2.10[340] | 2.17[341] | 2.21[342] | 2.89[343] |
51 | TCF7 | Transcription factor 7 | [344] | 1.60[345] | 0.73[346] | -0.48[347] | -0.42[348] | -0.70[349] | -0.72[350] |
52 | NKD1 | Protein naked cuticle homolog 1 | [351] | 5.21[352] | 3.98[353] | -4.66[354] | -3.13[355] | -4.01[356] | -0.04[357] |
53 | PPP2R3B | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta | [358] | [359] | [360] | [361] | [362] | [363] | |
54 | FRAT1 | Proto-oncogene FRAT1 | [364] | -0.14[365] | 0.09[366] | 1.93[367] | -3.14[368] | -1.92[369] | 0.13[370] |
55 | PLAU | Urokinase-type plasminogen activator | [371] | -0.57[372] | -4.21[373] | -3.32[374] | 1.74[375] | -0.21[376] | -2.35[377] |
56 | FZD6 | Frizzled-6 | [378] | 0.95[379] | 2.25[380] | -0.52[381] | 4.15[382] | 2.94[383] | 0.77[384] |
57 | CTBP2 | C-terminal-binding protein 2 | [385] | -2.90[386] | -1.99[387] | 1.47[388] | 2.70[389] | 3.01[390] | 1.20[391] |
58 | APC | Adenomatous polyposis coli protein | [392] | -0.26[393] | 1.88[394] | 1.45[395] | 1.64[396] | 2.31[397] | 3.39[398] |
59 | FZD8 | Frizzled-8 | [399] | -3.96[400] | -8.82[401] | -1.72[402] | -3.55[403] | -2.31[404] | -0.55[405] |
60 | WNT3 | Proto-oncogene Wnt-3 | [406] | -1.22[407] | 0.21[408] | -1.98[409] | -1.15[410] | -2.46[411] | -0.17[412] |
61 | PPM1J | Protein phosphatase 1J | [413] | -3.42[414] | -2.46[415] | -1.98[416] | -3.55[417] | -1.88[418] | -4.97[419] |
62 | WNT5B | Protein Wnt-5b | [420] | -5.77[421] | -6.47[422] | -0.18[423] | 0.99[424] | -2.79[425] | -1.55[426] |
63 | PRKCE | Protein kinase C epsilon type | [427] | -0.19[428] | -1.23[429] | 0.99[430] | 0.40[431] | 0.79[432] | 3.21[433] |
64 | CCND2 | G1/S-specific cyclin-D2 | [434] | 2.31[435] | 1.37[436] | -5.11[437] | -5.03[438] | -2.09[439] | 1.51[440] |
65 | PRKCH | Protein kinase C eta type | [441] | -1.20[442] | -4.53[443] | -3.15[444] | 1.69[445] | 3.35[446] | 2.76[447] |
66 | PPP2R3A | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha | -2.83[448] | -3.96[449] | -2.09[450] | 1.37[451] | 1.37[452] | 1.88[453] | |
67 | FZD7 | Frizzled-7 | [454] | 1.37[455] | -2.19[456] | 3.54[457] | 3.98[458] | 1.41[459] | -0.33[460] |
68 | NANOG | Homeobox protein NANOG | [461] | -0.42[462] | -0.79[463] | -2.51[464] | -2.86[465] | -3.75[466] | -0.43[467] |
69 | LRRK2 | Leucine-rich repeat serine/threonine-protein kinase 2 | [468] | [469] | -5.20[470] | [471] | -1.16[472] | 2.99[473] | 4.29[474] |
70 | WNT4 | Protein Wnt-4 | [475] | -4.52[476] | -3.19[477] | -4.56[478] | -1.95[479] | -3.24[480] | -0.14[481] |
71 | FZD1 | Frizzled-1 | [482] | 0.72[483] | -0.77[484] | 2.64[485] | 1.83[486] | 2.99[487] | 2.44[488] |
72 | WNT5A | Protein Wnt-5a | [489] | -4.03[490] | -3.54[491] | -2.64[492] | 6.01[493] | 7.61[494] | 0.96[495] |
73 | PRKCB | Protein kinase C beta type | [496] | -7.65[497] | -5.97[498] | [499] | 1.90[500] | -3.38[501] | 3.19[502] |
74 | MMP7 | Matrilysin | [503] | -0.41[504] | -2.72[505] | [506] | 1.96[507] | -3.27[508] | 0.36[509] |
75 | SOX2 | Transcription factor SOX-2 | [510] | -3.17[511] | [512] | -0.43[513] | 2.36[514] | -6.59[515] | -5.01[516] |
76 | WNT7B | Protein Wnt-7b | [517] | 1.85[518] | 0.51[519] | -0.01[520] | -0.25[521] | -1.17[522] | -1.18[523] |
77 | FZD3 | Frizzled-3 | [524] | 2.10[525] | 3.51[526] | 4.94[527] | 3.21[528] | 2.47[529] | 3.30[530] |
78 | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform | -3.26[531] | -5.48[532] | 2.55[533] | 3.79[534] | -4.35[535] | -0.84[536] | |
79 | WNT9B | Protein Wnt-9b | [537] | -4.88[538] | -5.23[539] | -1.95[540] | [541] | [542] | -5.20[543] |
80 | PRKD1 | Serine/threonine-protein kinase D1 | [544] | 1.08[545] | 1.47[546] | 3.58[547] | 4.06[548] | 4.06[549] | 2.79[550] |
81 | NKD2 | Protein naked cuticle homolog 2 | [551] | 1.84[552] | 1.41[553] | 1.21[554] | 0.81[555] | 2.46[556] | 0.12[557] |
82 | FZD2 | Frizzled-2 | [558] | 0.31[559] | -0.82[560] | 1.62[561] | 6.30[562] | 3.79[563] | -0.71[564] |
83 | FZD9 | Frizzled-9 | [565] | 0.59[566] | 1.25[567] | 0.73[568] | 1.55[569] | -0.72[570] | -0.75[571] |
84 | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isofo | 3.63[572] | 4.37[573] | -2.63[574] | 5.03[575] | -0.70[576] | -5.45[577] | |
85 | PRKCQ | Protein kinase C theta type | [578] | 0.07[579] | -3.01[580] | [581] | 1.54[582] | 3.07[583] | 1.74[584] |
86 | WNT2B | Protein Wnt-2b | [585] | -1.47[586] | -0.21[587] | -0.49[588] | 2.02[589] | 1.36[590] | 0.58[591] |
87 | LEF1 | Lymphoid enhancer-binding factor 1 | [592] | 1.82[593] | -4.63[594] | 3.02[595] | 0.50[596] | -1.18[597] | 0.73[598] |
88 | WNT16 | Protein Wnt-16 | [599] | [600] | [601] | [602] | 0.76[603] | -3.08[604] | -0.20[605] |
89 | ESRRB | Steroid hormone receptor ERR2 | [606] | -2.45[607] | -3.17[608] | -0.88[609] | [610] | [611] | -0.86[612] |
90 | WNT10A | Protein Wnt-10a | [613] | 0.42[614] | -2.45[615] | -5.43[616] | 2.96[617] | -2.78[618] | -1.83[619] |
91 | PRKCG | Protein kinase C gamma type | [620] | -1.66[621] | -0.51[622] | -3.15[623] | -1.65[624] | -1.71[625] | [626] |
92 | FOXD3 | Forkhead box protein D3 | [627] | -4.16[628] | [629] | 0.24[630] | 1.29[631] | [632] | [633] |
93 | WNT2 | Protein Wnt-2 | [634] | [635] | [636] | -2.63[637] | 0.35[638] | -3.56[639] | 5.87[640] |
94 | MAPK10 | Mitogen-activated protein kinase 10 | [641] | -2.32[642] | [643] | [644] | 8.32[645] | 4.09[646] | 6.90[647] |
95 | PTPA | Serine/threonine-protein phosphatase 2A activator | [648] | [649] | [650] | [651] | [652] | [653] | [654] |
96 | MIR1281 | [655] | [656] | [657] | [658] | [659] | [660] | [661] | |
97 | MIR6808 | [662] | [663] | [664] | [665] | [666] | [667] | [668] | |
98 | WNT3A | Protein Wnt-3a | [669] | [670] | [671] | [672] | [673] | [674] | [675] |
99 | MIR6886 | [676] | [677] | [678] | [679] | [680] | [681] | [682] | |
100 | FZD10 | Frizzled-10 | [683] | [684] | [685] | [686] | [687] | [688] | [689] |
101 | WNT7A | Protein Wnt-7a | [690] | [691] | [692] | [693] | [694] | [695] | [696] |
102 | WNT1 | Proto-oncogene Wnt-1 | [697] | [698] | [699] | [700] | [701] | [702] | [703] |
103 | TPTEP2-CSNK1E | [704] | [705] | [706] | [707] | [708] | [709] | [710] | |
104 | MIR4683 | [711] | [712] | [713] | [714] | [715] | [716] | [717] | |
105 | WNT10B | Protein Wnt-10b | [718] | [719] | [720] | [721] | [722] | [723] | [724] |
106 | WNT6 | Protein Wnt-6 | [725] | [726] | [727] | [728] | [729] | [730] | [731] |