WP_WNTBETACATENIN_SIGNALING_PATHWAY_IN_LEUKEMIA Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKT1 RAC-alpha serine/threonine-protein kinase [1] -1.56[2] -0.76[3] -2.24[4] -0.93[5] -0.74[6] -1.14[7]
2 CTNNB1 Catenin beta-1 [8] -0.02[9] 0.51[10] 1.00[11] -0.13[12] 0.28[13] 0.21[14]
3 MYC Myc proto-oncogene protein [15] -1.21[16] -0.51[17] -2.94[18] -3.67[19] -1.12[20] -2.89[21]
4 CCND1 G1/S-specific cyclin-D1 [22] 1.41[23] -0.06[24] 0.37[25] 1.00[26] -0.30[27] 0.16[28]
5 CSNK1A1 Casein kinase I isoform alpha [29] -1.30[30] -0.28[31] -0.91[32] -0.05[33] 0.23[34] -0.20[35]
6 JUP Junction plakoglobin [36] -0.65[37] -0.83[38] -0.95[39] -1.44[40] -1.94[41] -0.49[42]
7 LRP5 Low-density lipoprotein receptor-related protein 5 [43] 0.47[44] 1.22[45] 1.45[46] 0.86[47] -0.43[48] 1.26[49]
8 PPARD Peroxisome proliferator-activated receptor delta [50] -2.00[51] -1.52[52] -2.18[53] -0.80[54] -0.21[55] -2.52[56]
9 TCF3 Transcription factor E2-alpha [57] 0.50[58] 0.85[59] 1.04[60] 0.50[61] 0.84[62] -2.04[63]
10 RARA Retinoic acid receptor alpha [64] -1.03[65] -1.42[66] -1.28[67] 0.28[68] -0.08[69] -0.74[70]
11 GSK3B Glycogen synthase kinase-3 beta [71] -0.37[72] 0.30[73] 0.47[74] 0.93[75] 0.94[76] 0.27[77]
12 AXIN2 Axin-2 [78] 1.83[79] 0.47[80] -3.98[81] -1.97[82] -2.17[83] -3.24[84]
13 PML Protein PML [85] -1.40[86] -1.38[87] -0.08[88] 1.00[89] 0.67[90] -0.65[91]
14 ZBTB16 Zinc finger and BTB domain-containing protein 16 [92] -11.10[93] -10.46[94] -1.74[95] [96] -0.15[97] 2.99[98]
15 DKK1 Dickkopf-related protein 1 [99] 3.64[100] 1.02[101] 1.08[102] 0.45[103] 3.39[104] -6.33[105]
16 LRP6 Low-density lipoprotein receptor-related protein 6 [106] 0.18[107] 1.88[108] 2.83[109] 0.98[110] 1.70[111] 3.89[112]
17 FZD6 Frizzled-6 [113] 0.15[114] 2.00[115] -0.90[116] 3.85[117] 2.79[118] 0.22[119]
18 APC Adenomatous polyposis coli protein [120] -1.07[121] 1.64[122] 1.08[123] 1.34[124] 2.16[125] 2.84[126]
19 BCL9 B-cell CLL/lymphoma 9 protein [127] 0.37[128] 1.18[129] 2.43[130] 3.18[131] 1.54[132] 0.31[133]
20 SALL4 Sal-like protein 4 [134] -1.63[135] -2.37[136] 2.81[137] -1.61[138] -1.04[139] 0.29[140]
21 LEF1 Lymphoid enhancer-binding factor 1 [141] 1.02[142] -4.88[143] 2.64[144] 0.20[145] -1.33[146] 0.19[147]
22 FLT3 Receptor-type tyrosine-protein kinase FLT3 [148] [149] [150] -4.50[151] -3.67[152] [153] 2.03[154]
23 RUNX1T1 Protein CBFA2T1 [155] [156] -2.15[157] -4.30[158] 1.20[159] 2.58[160] 4.74[161]
24 PYGO1 Pygopus homolog 1 [162] -0.47[163] [164] 1.05[165] 4.30[166] 4.74[167] -0.20[168]
25 WIF1 Wnt inhibitory factor 1 [169] [170] [171] [172] [173] [174] [175]
26 WNT1 Proto-oncogene Wnt-1 [176] [177] [178] [179] [180] [181] [182]
[1]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[2]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[3]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[4]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[5]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[6]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[7]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[8]
ref_hepatocyte CTNNB1
Mean 37.2
Standard deviation 16
Values 22 31 23 57 53
[9]
HepG2 CTNNB1
Mean 252
Standard deviation 27
Values 2.7e+02 2.3e+02
[10]
HepG2.C3A CTNNB1
Mean 158
Standard deviation 34
Values 1.8e+02 1.3e+02
[11]
HuH.7 CTNNB1
Mean 282
Standard deviation 64
Values 3.1e+02 2.1e+02 3.3e+02
[12]
SNU475 CTNNB1
Mean 115
Standard deviation 10
Values 1.1e+02 1.2e+02
[13]
THLE CTNNB1
Mean 151
Standard deviation 19
Values 1.4e+02 1.6e+02
[14]
liver CTNNB1
Mean 114
Standard deviation 15
Values 1.1e+02 1.3e+02 98 1.2e+02
[15]
ref_hepatocyte MYC
Mean 29.9
Standard deviation 34
Values 89 1.4 23 15 20
[16]
HepG2 MYC
Mean 88.8
Standard deviation 53
Values 52 1.3e+02
[17]
HepG2.C3A MYC
Mean 62.6
Standard deviation 15
Values 52 73
[18]
HuH.7 MYC
Mean 14.7
Standard deviation 2.6
Values 14 18 13
[19]
SNU475 MYC
Mean 7.93
Standard deviation 1.4
Values 8.9 6.9
[20]
THLE MYC
Mean 46
Standard deviation 10
Values 39 53
[21]
liver MYC
Mean 10.6
Standard deviation 6
Values 5.5 5.9 18 13
[22]
ref_hepatocyte CCND1
Mean 23
Standard deviation 14
Values 19 12 11 44 28
[23]
HepG2 CCND1
Mean 421
Standard deviation 48
Values 3.9e+02 4.5e+02
[24]
HepG2.C3A CCND1
Mean 66.1
Standard deviation 12
Values 74 58
[25]
HuH.7 CCND1
Mean 113
Standard deviation 31
Values 1.2e+02 79 1.4e+02
[26]
SNU475 CCND1
Mean 155
Standard deviation 66
Values 2e+02 1.1e+02
[27]
THLE CCND1
Mean 62.5
Standard deviation 6.4
Values 67 58
[28]
liver CCND1
Mean 67.8
Standard deviation 49
Values 25 1.1e+02 26 1.1e+02
[29]
ref_hepatocyte CSNK1A1
Mean 20.7
Standard deviation 9.8
Values 35 14 10 20 24
[30]
HepG2 CSNK1A1
Mean 57.9
Standard deviation 0.1
Values 58 58
[31]
HepG2.C3A CSNK1A1
Mean 51.1
Standard deviation 2
Values 53 50
[32]
HuH.7 CSNK1A1
Mean 41.8
Standard deviation 2.9
Values 41 39 45
[33]
SNU475 CSNK1A1
Mean 67.7
Standard deviation 7.6
Values 62 73
[34]
THLE CSNK1A1
Mean 81.2
Standard deviation 5.1
Values 78 85
[35]
liver CSNK1A1
Mean 47.5
Standard deviation 6.3
Values 47 56 41 47
[36]
ref_hepatocyte JUP
Mean 20.2
Standard deviation 11
Values 35 25 17 17 6.8
[37]
HepG2 JUP
Mean 88.5
Standard deviation 10
Values 81 96
[38]
HepG2.C3A JUP
Mean 34
Standard deviation 9.3
Values 27 41
[39]
HuH.7 JUP
Mean 39.4
Standard deviation 2.2
Values 40 37 42
[40]
SNU475 JUP
Mean 25.2
Standard deviation 4.4
Values 22 28
[41]
THLE JUP
Mean 17.6
Standard deviation 5.7
Values 14 22
[42]
liver JUP
Mean 38
Standard deviation 16
Values 33 19 56 45
[43]
ref_hepatocyte LRP5
Mean 11.4
Standard deviation 3.9
Values 7.3 13 17 8.8 10
[44]
HepG2 LRP5
Mean 108
Standard deviation 24
Values 91 1.3e+02
[45]
HepG2.C3A LRP5
Mean 79.2
Standard deviation 20
Values 65 93
[46]
HuH.7 LRP5
Mean 117
Standard deviation 36
Values 1.2e+02 81 1.5e+02
[47]
SNU475 LRP5
Mean 69.8
Standard deviation 26
Values 52 88
[48]
THLE LRP5
Mean 28.3
Standard deviation 7.2
Values 23 33
[49]
liver LRP5
Mean 71.8
Standard deviation 33
Values 1.1e+02 93 39 50
[50]
ref_hepatocyte PPARD
Mean 10.1
Standard deviation 15
Values 37 2.2 7.9 1.4 2.3
[51]
HepG2 PPARD
Mean 17.4
Standard deviation 8.1
Values 12 23
[52]
HepG2.C3A PPARD
Mean 10.6
Standard deviation 2.3
Values 8.9 12
[53]
HuH.7 PPARD
Mean 8.45
Standard deviation 0.13
Values 8.3 8.5 8.5
[54]
SNU475 PPARD
Mean 19.7
Standard deviation 2.2
Values 18 21
[55]
THLE PPARD
Mean 29.3
Standard deviation 0.077
Values 29 29
[56]
liver PPARD
Mean 4.66
Standard deviation 1.3
Values 5.3 2.7 4.8 5.8
[57]
ref_hepatocyte TCF3
Mean 5.47
Standard deviation 3.2
Values 8.6 2.2 2.2 8.4 5.9
[58]
HepG2 TCF3
Mean 53.2
Standard deviation 13
Values 44 62
[59]
HepG2.C3A TCF3
Mean 29.6
Standard deviation 3.1
Values 27 32
[60]
HuH.7 TCF3
Mean 42.6
Standard deviation 12
Values 48 29 51
[61]
SNU475 TCF3
Mean 26.2
Standard deviation 5.9
Values 22 30
[62]
THLE TCF3
Mean 32.8
Standard deviation 0.23
Values 33 33
[63]
liver TCF3
Mean 3.51
Standard deviation 0.15
Values 3.6 3.7 3.3 3.4
[64]
ref_hepatocyte RARA
Mean 5.02
Standard deviation 3.8
Values 5.4 7.5 9.8 1.1 1.3
[65]
HepG2 RARA
Mean 16.9
Standard deviation 3.5
Values 14 19
[66]
HepG2.C3A RARA
Mean 5.59
Standard deviation 2.4
Values 3.9 7.3
[67]
HuH.7 RARA
Mean 7.81
Standard deviation 0.69
Values 7 8.3 8.1
[68]
SNU475 RARA
Mean 20.7
Standard deviation 2.1
Values 19 22
[69]
THLE RARA
Mean 15.9
Standard deviation 0.29
Values 16 16
[70]
liver RARA
Mean 7.93
Standard deviation 1
Values 7.3 7.1 8 9.3
[71]
ref_hepatocyte GSK3B
Mean 4.16
Standard deviation 1.7
Values 4.9 2.1 2.7 5.2 5.9
[72]
HepG2 GSK3B
Mean 22.1
Standard deviation 6
Values 26 18
[73]
HepG2.C3A GSK3B
Mean 15.3
Standard deviation 2.3
Values 17 14
[74]
HuH.7 GSK3B
Mean 21.8
Standard deviation 5.6
Values 15 26 24
[75]
SNU475 GSK3B
Mean 26.9
Standard deviation 2.6
Values 25 29
[76]
THLE GSK3B
Mean 26.7
Standard deviation 2.9
Values 25 29
[77]
liver GSK3B
Mean 13.2
Standard deviation 3.2
Values 16 15 14 8.6
[78]
ref_hepatocyte AXIN2
Mean 3.77
Standard deviation 8.1
Values 0.16 0.24 0.14 18 0
[79]
HepG2 AXIN2
Mean 92
Standard deviation 17
Values 80 1e+02
[80]
HepG2.C3A AXIN2
Mean 15.6
Standard deviation 6.3
Values 20 11
[81]
HuH.7 AXIN2
Mean 0.905
Standard deviation 0.058
Values 0.84 0.91 0.96
[82]
SNU475 AXIN2
Mean 3.25
Standard deviation 0.69
Values 2.8 3.7
[83]
THLE AXIN2
Mean 2.82
Standard deviation 0.56
Values 3.2 2.4
[84]
liver AXIN2
Mean 1.06
Standard deviation 0.52
Values 1.7 1.2 0.68 0.59
[85]
ref_hepatocyte PML
Mean 3.77
Standard deviation 3.1
Values 8.7 2.3 2.5 0.6 4.7
[86]
HepG2 PML
Mean 9.79
Standard deviation 1.6
Values 8.6 11
[87]
HepG2.C3A PML
Mean 4.34
Standard deviation 1.3
Values 3.4 5.2
[88]
HuH.7 PML
Mean 13.5
Standard deviation 2.4
Values 12 12 16
[89]
SNU475 PML
Mean 25.6
Standard deviation 4.6
Values 22 29
[90]
THLE PML
Mean 20.2
Standard deviation 3.6
Values 18 23
[91]
liver PML
Mean 6.32
Standard deviation 2.7
Values 4.7 4.1 10 6.5
[92]
ref_hepatocyte ZBTB16
Mean 2.29
Standard deviation 2
Values 2.8 1.2 5.3 0 2.1
[93]
HepG2 ZBTB16
Mean 0.00716
Standard deviation 0.002
Values 0.0086 0.0057
[94]
HepG2.C3A ZBTB16
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[95]
HuH.7 ZBTB16
Mean 2.6
Standard deviation 1.1
Values 1.3 3.1 3.4
[96]
SNU475 ZBTB16
Mean 0
Standard deviation 0
Values 0 0
[97]
THLE ZBTB16
Mean 6.95
Standard deviation 0.69
Values 6.5 7.4
[98]
liver ZBTB16
Mean 48.1
Standard deviation 9.3
Values 60 50 38 45
[99]
ref_hepatocyte DKK1
Mean 2
Standard deviation 4.1
Values 0 0.089 0 9.3 0.59
[100]
HepG2 DKK1
Mean 172
Standard deviation 31
Values 1.9e+02 1.5e+02
[101]
HepG2.C3A DKK1
Mean 12.2
Standard deviation 9
Values 19 5.8
[102]
HuH.7 DKK1
Mean 16.1
Standard deviation 6.9
Values 21 8.2 19
[103]
SNU475 DKK1
Mean 9.29
Standard deviation 1.1
Values 10 8.5
[104]
THLE DKK1
Mean 70.4
Standard deviation 23
Values 54 87
[105]
liver DKK1
Mean 0.0656
Standard deviation 0.079
Values 0.04 0.043 0 0.18
[106]
ref_hepatocyte LRP6
Mean 1.95
Standard deviation 0.83
Values 0.7 1.9 1.7 2.8 2.6
[107]
HepG2 LRP6
Mean 15.2
Standard deviation 4.8
Values 19 12
[108]
HepG2.C3A LRP6
Mean 21.5
Standard deviation 0.56
Values 22 21
[109]
HuH.7 LRP6
Mean 52.6
Standard deviation 14
Values 37 64 58
[110]
SNU475 LRP6
Mean 13
Standard deviation 2
Values 12 14
[111]
THLE LRP6
Mean 21.2
Standard deviation 0.26
Values 21 21
[112]
liver LRP6
Mean 76.1
Standard deviation 40
Values 1.1e+02 1.1e+02 42 40
[113]
ref_hepatocyte FZD6
Mean 1.28
Standard deviation 0.91
Values 1.9 0.28 0.49 2.4 1.3
[114]
HepG2 FZD6
Mean 9.74
Standard deviation 0.56
Values 10 9.3
[115]
HepG2.C3A FZD6
Mean 15.4
Standard deviation 0.43
Values 16 15
[116]
HuH.7 FZD6
Mean 2.59
Standard deviation 0.88
Values 2.1 3.6 2.1
[117]
SNU475 FZD6
Mean 62.6
Standard deviation 37
Values 36 89
[118]
THLE FZD6
Mean 29.7
Standard deviation 3.7
Values 27 32
[119]
liver FZD6
Mean 3.95
Standard deviation 1.6
Values 4.7 5.8 3 2.3
[120]
ref_hepatocyte APC
Mean 1.09
Standard deviation 0.39
Values 1 0.97 0.53 1.4 1.5
[121]
HepG2 APC
Mean 3.57
Standard deviation 1.5
Values 4.6 2.5
[122]
HepG2.C3A APC
Mean 10.1
Standard deviation 2.6
Values 12 8.3
[123]
HuH.7 APC
Mean 8.67
Standard deviation 2.6
Values 5.7 11 9.7
[124]
SNU475 APC
Mean 9.33
Standard deviation 3.4
Values 12 6.9
[125]
THLE APC
Mean 16.3
Standard deviation 4.6
Values 20 13
[126]
liver APC
Mean 20.6
Standard deviation 6.3
Values 22 28 20 12
[127]
ref_hepatocyte BCL9
Mean 0.849
Standard deviation 0.58
Values 1.8 0.88 0.62 0.45 0.46
[128]
HepG2 BCL9
Mean 7.54
Standard deviation 0.81
Values 7 8.1
[129]
HepG2.C3A BCL9
Mean 5.75
Standard deviation 0.025
Values 5.8 5.7
[130]
HuH.7 BCL9
Mean 17.3
Standard deviation 3.4
Values 14 16 21
[131]
SNU475 BCL9
Mean 26
Standard deviation 0.97
Values 25 27
[132]
THLE BCL9
Mean 8.29
Standard deviation 1.9
Values 6.9 9.7
[133]
liver BCL9
Mean 2.79
Standard deviation 0.22
Values 2.7 2.6 2.7 3.1
[134]
ref_hepatocyte SALL4
Mean 0.222
Standard deviation 0.31
Values 0.74 0.25 0.078 0 0.034
[135]
HepG2 SALL4
Mean 0.491
Standard deviation 0.25
Values 0.32 0.66
[136]
HepG2.C3A SALL4
Mean 0.128
Standard deviation 0.016
Values 0.14 0.12
[137]
HuH.7 SALL4
Mean 5.9
Standard deviation 0.89
Values 5.5 6.9 5.3
[138]
SNU475 SALL4
Mean 0.247
Standard deviation 0.14
Values 0.34 0.15
[139]
THLE SALL4
Mean 0.363
Standard deviation 0.18
Values 0.49 0.23
[140]
liver SALL4
Mean 0.714
Standard deviation 0.24
Values 1 0.74 0.66 0.44
[141]
ref_hepatocyte LEF1
Mean 0.0478
Standard deviation 0.085
Values 0.2 0 0.043 0 0
[142]
HepG2 LEF1
Mean 0.663
Standard deviation 0.44
Values 0.35 0.97
[143]
HepG2.C3A LEF1
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[144]
HuH.7 LEF1
Mean 1.13
Standard deviation 0.42
Values 0.77 1.6 1
[145]
SNU475 LEF1
Mean 0.186
Standard deviation 0.2
Values 0.33 0.042
[146]
THLE LEF1
Mean 0.0639
Standard deviation 0.015
Values 0.053 0.074
[147]
liver LEF1
Mean 0.144
Standard deviation 0.047
Values 0.13 0.13 0.21 0.1
[148]
ref_hepatocyte FLT3
Mean 0.0374
Standard deviation 0.084
Values 0 0.19 0 0 0
[149]
HepG2 FLT3
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A FLT3
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 FLT3
Mean 0.00625
Standard deviation 0.011
Values 0.019 0 0
[152]
SNU475 FLT3
Mean 0.00992
Standard deviation 0.0075
Values 0.015 0.0046
[153]
THLE FLT3
Mean 0
Standard deviation 0
Values 0 0
[154]
liver FLT3
Mean 0.402
Standard deviation 0.15
Values 0.57 0.44 0.21 0.39
[155]
ref_hepatocyte RUNX1T1
Mean 0.0223
Standard deviation 0.027
Values 0 0.033 0 0.064 0.016
[156]
HepG2 RUNX1T1
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A RUNX1T1
Mean 0.0151
Standard deviation 0.0062
Values 0.011 0.019
[158]
HuH.7 RUNX1T1
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[159]
SNU475 RUNX1T1
Mean 0.174
Standard deviation 0.21
Values 0.32 0.028
[160]
THLE RUNX1T1
Mean 0.447
Standard deviation 0.03
Values 0.43 0.47
[161]
liver RUNX1T1
Mean 1.57
Standard deviation 0.56
Values 1.3 1 2.4 1.6
[162]
ref_hepatocyte PYGO1
Mean 0.013
Standard deviation 0.029
Values 0 0.065 0 0 0
[163]
HepG2 PYGO1
Mean 0.0644
Standard deviation 0.067
Values 0.11 0.017
[164]
HepG2.C3A PYGO1
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 PYGO1
Mean 0.102
Standard deviation 0.062
Values 0.056 0.077 0.17
[166]
SNU475 PYGO1
Mean 0.866
Standard deviation 0.18
Values 0.74 0.99
[167]
THLE PYGO1
Mean 1.17
Standard deviation 0.075
Values 1.1 1.2
[168]
liver PYGO1
Mean 0.0298
Standard deviation 0.035
Values 0.079 0.014 0 0.026
[169]
ref_hepatocyte WIF1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 WIF1
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A WIF1
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[172]
HuH.7 WIF1
Mean 0.33
Standard deviation 0.13
Values 0.27 0.24 0.48
[173]
SNU475 WIF1
Mean 0.0146
Standard deviation 0.00091
Values 0.015 0.014
[174]
THLE WIF1
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[175]
liver WIF1
Mean 0.0128
Standard deviation 0.026
Values 0 0 0 0.051
[176]
ref_hepatocyte WNT1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[177]
HepG2 WNT1
Mean 0.043
Standard deviation 0.036
Values 0.017 0.069
[178]
HepG2.C3A WNT1
Mean 0
Standard deviation 0
Values 0 0
[179]
HuH.7 WNT1
Mean 0.37
Standard deviation 0.12
Values 0.47 0.23 0.41
[180]
SNU475 WNT1
Mean 0.00464
Standard deviation 0.0066
Values 0 0.0093
[181]
THLE WNT1
Mean 0
Standard deviation 0
Values 0 0
[182]
liver WNT1
Mean 0.0351
Standard deviation 0.032
Values 0.04 0 0.024 0.077