WP_VALPROIC_ACID_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2C9 Cytochrome P450 2C9 [1] [2] -15.04[3] -7.92[4] -13.24[5] -12.57[6] 0.21[7]
2 CYP2A6 Cytochrome P450 2A6 [8] -15.86[9] [10] -8.16[11] -10.32[12] -12.87[13] -2.42[14]
3 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 [15] -0.72[16] -1.35[17] -0.88[18] 0.40[19] 1.05[20] -1.78[21]
4 HADHA Trifunctional enzyme subunit alpha, mitochondrial [22] 1.81[23] 1.75[24] 1.99[25] 1.71[26] 1.85[27] -0.18[28]
5 HADHB Trifunctional enzyme subunit beta, mitochondrial [29] 1.72[30] 1.43[31] 1.16[32] 1.63[33] 1.55[34] 0.32[35]
6 ABAT 4-aminobutyrate aminotransferase, mitochondrial [36] 1.45[37] 0.81[38] -0.70[39] -6.41[40] -4.71[41] 0.36[42]
7 CYP2B6 Cytochrome P450 2B6 [43] -7.64[44] -4.58[45] -2.98[46] -8.11[47] -9.24[48] 1.59[49]
8 ACADSB Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial 0.30[50] 2.46[51] 2.23[52] -0.57[53] -0.90[54] 1.25[55]
9 EHHADH Peroxisomal bifunctional enzyme [56] -0.88[57] -0.48[58] 0.34[59] -0.28[60] -1.09[61] 0.83[62]
10 HDAC1 Histone deacetylase 1 [63] 2.51[64] 2.15[65] 3.06[66] 3.60[67] 3.26[68] -1.27[69]
11 IVD Isovaleryl-CoA dehydrogenase, mitochondrial [70] 2.33[71] 2.10[72] 0.66[73] 2.40[74] 2.15[75] 0.99[76]
12 UGT1A3 UDP-glucuronosyltransferase 1-3 [77] -0.96[78] [79] -7.77[80] -3.46[81] -8.69[82] 0.43[83]
13 ACSM1 Acyl-coenzyme A synthetase ACSM1, mitochondrial [84] 2.15[85] -0.45[86] 0.41[87] -2.18[88] -2.57[89] -0.78[90]
[1]
ref_hepatocyte CYP2C9
Mean 285
Standard deviation 4.1e+02
Values 21 9.2e+02 4.7e+02 0.064 20
[2]
HepG2 CYP2C9
Mean 0
Standard deviation 0
Values 0 0
[3]
HepG2.C3A CYP2C9
Mean 0.00536
Standard deviation 0.0076
Values 0.011 0
[4]
HuH.7 CYP2C9
Mean 0.616
Standard deviation 0.63
Values 0.25 1.3 0.25
[5]
SNU475 CYP2C9
Mean 0.00696
Standard deviation 0.0098
Values 0 0.014
[6]
THLE CYP2C9
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[7]
liver CYP2C9
Mean 822
Standard deviation 5.3e+02
Values 2.9e+02 6.1e+02 8.6e+02 1.5e+03
[8]
ref_hepatocyte CYP2A6
Mean 231
Standard deviation 3e+02
Values 38 5.5e+02 5.6e+02 0 4.6
[9]
HepG2 CYP2A6
Mean 0.00214
Standard deviation 0.003
Values 0.0043 0
[10]
HepG2.C3A CYP2A6
Mean 0
Standard deviation 0
Values 0 0
[11]
HuH.7 CYP2A6
Mean 0.421
Standard deviation 0.53
Values 0.12 1 0.11
[12]
SNU475 CYP2A6
Mean 0.0428
Standard deviation 0.025
Values 0.025 0.06
[13]
THLE CYP2A6
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[14]
liver CYP2A6
Mean 107
Standard deviation 1e+02
Values 13 1.8e+02 29 2.1e+02
[15]
ref_hepatocyte HSD17B10
Mean 85.5
Standard deviation 74
Values 31 1.7e+02 1.7e+02 14 52
[16]
HepG2 HSD17B10
Mean 28.7
Standard deviation 2
Values 30 27
[17]
HepG2.C3A HSD17B10
Mean 21.3
Standard deviation 2.8
Values 23 19
[18]
HuH.7 HSD17B10
Mean 24.2
Standard deviation 9.3
Values 32 14 26
[19]
SNU475 HSD17B10
Mean 26.6
Standard deviation 1.5
Values 28 26
[20]
THLE HSD17B10
Mean 51.1
Standard deviation 6
Values 47 55
[21]
liver HSD17B10
Mean 61.9
Standard deviation 43
Values 24 25 95 1e+02
[22]
ref_hepatocyte HADHA
Mean 82.4
Standard deviation 46
Values 20 69 1.1e+02 1.4e+02 71
[23]
HepG2 HADHA
Mean 159
Standard deviation 5.6
Values 1.6e+02 1.6e+02
[24]
HepG2.C3A HADHA
Mean 176
Standard deviation 53
Values 1.4e+02 2.1e+02
[25]
HuH.7 HADHA
Mean 170
Standard deviation 6.3
Values 1.6e+02 1.7e+02 1.8e+02
[26]
SNU475 HADHA
Mean 63.8
Standard deviation 14
Values 54 74
[27]
THLE HADHA
Mean 86
Standard deviation 10
Values 79 93
[28]
liver HADHA
Mean 182
Standard deviation 42
Values 1.6e+02 1.5e+02 1.7e+02 2.4e+02
[29]
ref_hepatocyte HADHB
Mean 57.6
Standard deviation 50
Values 7 97 1.2e+02 47 15
[30]
HepG2 HADHB
Mean 105
Standard deviation 34
Values 1.3e+02 80
[31]
HepG2.C3A HADHB
Mean 98.3
Standard deviation 0.9
Values 99 98
[32]
HuH.7 HADHB
Mean 67
Standard deviation 10
Values 75 56 70
[33]
SNU475 HADHB
Mean 42.1
Standard deviation 15
Values 32 52
[34]
THLE HADHB
Mean 48.7
Standard deviation 2.2
Values 47 50
[35]
liver HADHB
Mean 179
Standard deviation 83
Values 92 1.2e+02 2.5e+02 2.5e+02
[36]
ref_hepatocyte ABAT
Mean 56.9
Standard deviation 75
Values 8.5 1.8e+02 74 15 6
[37]
HepG2 ABAT
Mean 86
Standard deviation 44
Values 1.2e+02 55
[38]
HepG2.C3A ABAT
Mean 63.3
Standard deviation 4.5
Values 66 60
[39]
HuH.7 ABAT
Mean 18.3
Standard deviation 4.1
Values 16 23 16
[40]
SNU475 ABAT
Mean 0.158
Standard deviation 0.027
Values 0.18 0.14
[41]
THLE ABAT
Mean 0.628
Standard deviation 0.091
Values 0.69 0.56
[42]
liver ABAT
Mean 182
Standard deviation 14
Values 1.9e+02 2e+02 1.8e+02 1.7e+02
[43]
ref_hepatocyte CYP2B6
Mean 49.6
Standard deviation 62
Values 12 1e+02 1.3e+02 0 4.1
[44]
HepG2 CYP2B6
Mean 0.138
Standard deviation 0.15
Values 0.034 0.24
[45]
HepG2.C3A CYP2B6
Mean 1.32
Standard deviation 0.56
Values 0.92 1.7
[46]
HuH.7 CYP2B6
Mean 3.27
Standard deviation 2.3
Values 1.9 5.9 2.1
[47]
SNU475 CYP2B6
Mean 0.0424
Standard deviation 0.04
Values 0.071 0.014
[48]
THLE CYP2B6
Mean 0.0237
Standard deviation 0.033
Values 0.047 0
[49]
liver CYP2B6
Mean 372
Standard deviation 5.3e+02
Values 7.4 3.2e+02 23 1.1e+03
[50]
ref_hepatocyte ACADSB
Mean 36.4
Standard deviation 43
Values 2.3 1.1e+02 34 31 4.8
[51]
HepG2 ACADSB
Mean 24.8
Standard deviation 16
Values 36 14
[52]
HepG2.C3A ACADSB
Mean 127
Standard deviation 7.3
Values 1.2e+02 1.3e+02
[53]
HuH.7 ACADSB
Mean 89
Standard deviation 9.8
Values 80 99 87
[54]
SNU475 ACADSB
Mean 5.81
Standard deviation 1.1
Values 5 6.6
[55]
THLE ACADSB
Mean 5.65
Standard deviation 0.82
Values 5.1 6.2
[56]
liver ACADSB
Mean 215
Standard deviation 71
Values 1.1e+02 2.3e+02 2.6e+02 2.6e+02
[57]
ref_hepatocyte EHHADH
Mean 33.3
Standard deviation 41
Values 4.6 1e+02 36 13 9
[58]
HepG2 EHHADH
Mean 10
Standard deviation 5.1
Values 14 6.4
[59]
HepG2.C3A EHHADH
Mean 15.2
Standard deviation 3.7
Values 18 13
[60]
HuH.7 EHHADH
Mean 22
Standard deviation 3.4
Values 22 19 25
[61]
SNU475 EHHADH
Mean 6.51
Standard deviation 1.9
Values 5.1 7.9
[62]
THLE EHHADH
Mean 4.51
Standard deviation 0.22
Values 4.4 4.7
[63]
liver EHHADH
Mean 147
Standard deviation 40
Values 1.8e+02 1e+02 1.9e+02 1.2e+02
[64]
ref_hepatocyte HDAC1
Mean 20.8
Standard deviation 4.1
Values 19 18 18 22 28
[65]
HepG2 HDAC1
Mean 65.4
Standard deviation 11
Values 58 73
[66]
HepG2.C3A HDAC1
Mean 58.9
Standard deviation 2.3
Values 60 57
[67]
HuH.7 HDAC1
Mean 90.9
Standard deviation 22
Values 1.1e+02 68 94
[68]
SNU475 HDAC1
Mean 59.8
Standard deviation 8
Values 54 65
[69]
THLE HDAC1
Mean 57.8
Standard deviation 6.8
Values 53 63
[70]
liver HDAC1
Mean 21.5
Standard deviation 6.8
Values 14 18 25 29
[71]
ref_hepatocyte IVD
Mean 18
Standard deviation 19
Values 3.9 46 30 4.4 5.2
[72]
HepG2 IVD
Mean 49.8
Standard deviation 10
Values 57 42
[73]
HepG2.C3A IVD
Mean 49
Standard deviation 0.63
Values 49 49
[74]
HuH.7 IVD
Mean 14.8
Standard deviation 4.7
Values 18 9.4 16
[75]
SNU475 IVD
Mean 22.4
Standard deviation 4.6
Values 19 26
[76]
THLE IVD
Mean 23.1
Standard deviation 2.9
Values 21 25
[77]
liver IVD
Mean 88.7
Standard deviation 47
Values 38 69 99 1.5e+02
[78]
ref_hepatocyte UGT1A3
Mean 4.24
Standard deviation 4.8
Values 0.37 11 7.9 0 2.3
[79]
HepG2 UGT1A3
Mean 1.2
Standard deviation 0.2
Values 1.1 1.3
[80]
HepG2.C3A UGT1A3
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 UGT1A3
Mean 0.0101
Standard deviation 0.0024
Values 0.0094 0.013 0.0082
[82]
SNU475 UGT1A3
Mean 0.0911
Standard deviation 0.029
Values 0.071 0.11
[83]
THLE UGT1A3
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[84]
liver UGT1A3
Mean 14.2
Standard deviation 12
Values 5.8 21 2.5 28
[85]
ref_hepatocyte ACSM1
Mean 0.231
Standard deviation 0.35
Values 0 0.041 0.83 0.29 0
[86]
HepG2 ACSM1
Mean 0.567
Standard deviation 0.19
Values 0.7 0.44
[87]
HepG2.C3A ACSM1
Mean 0.107
Standard deviation 0.00023
Values 0.11 0.11
[88]
HuH.7 ACSM1
Mean 0.159
Standard deviation 0.053
Values 0.19 0.19 0.098
[89]
SNU475 ACSM1
Mean 0.012
Standard deviation 0.0027
Values 0.01 0.014
[90]
THLE ACSM1
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[91]
liver ACSM1
Mean 0.334
Standard deviation 0.18
Values 0.32 0.6 0.19 0.23