WP_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ASS1 Argininosuccinate synthase [1] -1.57[2] -1.86[3] -1.36[4] -1.56[5] -1.66[6] -1.57[7]
2 GATM Glycine amidinotransferase, mitochondrial [8] -8.26[9] -3.80[10] -4.05[11] -8.91[12] -9.81[13] -0.23[14]
3 ARG1 Arginase-1 [15] -8.15[16] -8.86[17] -2.28[18] -9.12[19] -9.91[20] 0.52[21]
4 GLUD1 Glutamate dehydrogenase 1, mitochondrial [22] 0.82[23] 1.63[24] 0.60[25] -0.07[26] 0.55[27] 0.50[28]
5 CPS1 Carbamoyl-phosphate synthase [ammonia], mitochondrial [29] -2.27[30] -2.75[31] -2.77[32] -8.44[33] -2.01[34] 2.01[35]
6 GAMT Guanidinoacetate N-methyltransferase [36] -0.66[37] -0.63[38] -0.24[39] -0.95[40] -1.16[41] -0.85[42]
7 ODC1 Ornithine decarboxylase [43] 1.45[44] 1.48[45] 0.50[46] 1.27[47] 1.92[48] -2.49[49]
8 ASL Argininosuccinate lyase [50] -0.51[51] -1.05[52] -0.01[53] 0.43[54] -1.27[55] -0.40[56]
9 ACY1 Aminoacylase-1 [57] -4.36[58] -4.29[59] -3.49[60] -5.29[61] -5.07[62] -5.76[63]
10 SMS Spermine synthase [64] 0.83[65] -0.01[66] 0.51[67] 2.60[68] 2.36[69] -3.14[70]
11 OTC Ornithine carbamoyltransferase, mitochondrial [71] -8.49[72] -8.20[73] -2.72[74] -9.59[75] -8.56[76] -1.23[77]
12 SRM Spermidine synthase [78] 1.14[79] 1.19[80] -0.05[81] 2.32[82] 2.39[83] -2.81[84]
13 OAT Ornithine aminotransferase, mitochondrial [85] 1.42[86] 1.89[87] 0.51[88] 2.38[89] 3.20[90] -0.35[91]
14 SARDH Sarcosine dehydrogenase, mitochondrial [92] 0.87[93] 0.65[94] 0.65[95] -2.35[96] -0.90[97] 1.44[98]
15 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase [99] 3.12[100] 3.64[101] 4.14[102] 3.02[103] 2.92[104] -0.58[105]
16 NAGS N-acetylglutamate synthase, mitochondrial [106] -1.14[107] -0.35[108] -0.09[109] -3.25[110] -1.91[111] -0.30[112]
17 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial [113] 5.17[114] 4.59[115] 4.04[116] 4.02[117] 2.51[118] -2.43[119]
18 CKB Creatine kinase B-type [120] 5.03[121] 3.42[122] 6.01[123] 5.00[124] 3.68[125] -0.82[126]
19 ARG2 Arginase-2, mitochondrial [127] 2.89[128] 2.63[129] 1.48[130] 2.13[131] 2.29[132] -1.74[133]
20 CKM Creatine kinase M-type [134] 6.28[135] 4.75[136] 0.29[137] 0.86[138] -0.30[139] -1.68[140]
21 PYCR3 Pyrroline-5-carboxylate reductase 3 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte ASS1
Mean 312
Standard deviation 3.6e+02
Values 56 8.5e+02 5.1e+02 57 90
[2]
HepG2 ASS1
Mean 73
Standard deviation 14
Values 63 83
[3]
HepG2.C3A ASS1
Mean 81.4
Standard deviation 45
Values 50 1.1e+02
[4]
HuH.7 ASS1
Mean 94.9
Standard deviation 22
Values 86 1.2e+02 79
[5]
SNU475 ASS1
Mean 19.2
Standard deviation 7
Values 14 24
[6]
THLE ASS1
Mean 23.8
Standard deviation 0.31
Values 24 24
[7]
liver ASS1
Mean 218
Standard deviation 27
Values 1.9e+02 2.5e+02 2.3e+02 2e+02
[8]
ref_hepatocyte GATM
Mean 270
Standard deviation 4.7e+02
Values 12 1.1e+03 1.9e+02 0.68 50
[9]
HepG2 GATM
Mean 0.609
Standard deviation 0.19
Values 0.74 0.48
[10]
HepG2.C3A GATM
Mean 18.3
Standard deviation 1.2
Values 19 17
[11]
HuH.7 GATM
Mean 12.8
Standard deviation 4.6
Values 17 7.8 14
[12]
SNU475 GATM
Mean 0.101
Standard deviation 0.065
Values 0.15 0.056
[13]
THLE GATM
Mean 0.0721
Standard deviation 0.018
Values 0.059 0.085
[14]
liver GATM
Mean 474
Standard deviation 2.1e+02
Values 3.5e+02 3.2e+02 7.7e+02 4.5e+02
[15]
ref_hepatocyte ARG1
Mean 190
Standard deviation 2.6e+02
Values 15 5.4e+02 3.9e+02 0.48 1.9
[16]
HepG2 ARG1
Mean 0.462
Standard deviation 0.059
Values 0.42 0.5
[17]
HepG2.C3A ARG1
Mean 0.387
Standard deviation 0.27
Values 0.58 0.19
[18]
HuH.7 ARG1
Mean 30.5
Standard deviation 25
Values 18 60 14
[19]
SNU475 ARG1
Mean 0.062
Standard deviation 0.03
Values 0.041 0.083
[20]
THLE ARG1
Mean 0.0476
Standard deviation 0.00039
Values 0.047 0.048
[21]
liver ARG1
Mean 562
Standard deviation 3.3e+02
Values 1.8e+02 4.1e+02 7.7e+02 8.9e+02
[22]
ref_hepatocyte GLUD1
Mean 132
Standard deviation 1.1e+02
Values 15 2.7e+02 1.4e+02 2.2e+02 24
[23]
HepG2 GLUD1
Mean 161
Standard deviation 65
Values 2.1e+02 1.2e+02
[24]
HepG2.C3A GLUD1
Mean 386
Standard deviation 27
Values 3.7e+02 4.1e+02
[25]
HuH.7 GLUD1
Mean 157
Standard deviation 18
Values 1.5e+02 1.8e+02 1.5e+02
[26]
SNU475 GLUD1
Mean 22.7
Standard deviation 0.64
Values 22 23
[27]
THLE GLUD1
Mean 46.4
Standard deviation 7.4
Values 41 52
[28]
liver GLUD1
Mean 386
Standard deviation 1.2e+02
Values 3.1e+02 4.1e+02 5.5e+02 2.7e+02
[29]
ref_hepatocyte CPS1
Mean 128
Standard deviation 1.9e+02
Values 1.6 4.2e+02 2e+02 7.7 8.2
[30]
HepG2 CPS1
Mean 18.3
Standard deviation 4.2
Values 21 15
[31]
HepG2.C3A CPS1
Mean 18
Standard deviation 4.7
Values 21 15
[32]
HuH.7 CPS1
Mean 14.7
Standard deviation 2.6
Values 12 17 15
[33]
SNU475 CPS1
Mean 0.0667
Standard deviation 0.042
Values 0.096 0.037
[34]
THLE CPS1
Mean 7.64
Standard deviation 0.35
Values 7.4 7.9
[35]
liver CPS1
Mean 1.06e+03
Standard deviation 4.4e+02
Values 1e+03 1.7e+03 7.5e+02 7.9e+02
[36]
ref_hepatocyte GAMT
Mean 94.4
Standard deviation 1.2e+02
Values 11 2.6e+02 1.8e+02 15 6
[37]
HepG2 GAMT
Mean 41.4
Standard deviation 4.1
Values 38 44
[38]
HepG2.C3A GAMT
Mean 57.7
Standard deviation 8.1
Values 52 63
[39]
HuH.7 GAMT
Mean 62.6
Standard deviation 22
Values 78 38 72
[40]
SNU475 GAMT
Mean 8.87
Standard deviation 1.8
Values 7.6 10
[41]
THLE GAMT
Mean 10.1
Standard deviation 0.71
Values 11 9.6
[42]
liver GAMT
Mean 108
Standard deviation 90
Values 32 31 2e+02 1.7e+02
[43]
ref_hepatocyte ODC1
Mean 80.4
Standard deviation 64
Values 1.3e+02 20 54 34 1.7e+02
[44]
HepG2 ODC1
Mean 152
Standard deviation 16
Values 1.6e+02 1.4e+02
[45]
HepG2.C3A ODC1
Mean 213
Standard deviation 1.3e+02
Values 3e+02 1.2e+02
[46]
HuH.7 ODC1
Mean 89.1
Standard deviation 41
Values 1.2e+02 42 1e+02
[47]
SNU475 ODC1
Mean 35.1
Standard deviation 2.2
Values 34 37
[48]
THLE ODC1
Mean 73.4
Standard deviation 18
Values 60 87
[49]
liver ODC1
Mean 29.6
Standard deviation 18
Values 20 50 10 39
[50]
ref_hepatocyte ASL
Mean 75.2
Standard deviation 60
Values 35 1.4e+02 1.3e+02 8.2 57
[51]
HepG2 ASL
Mean 36.6
Standard deviation 1.9
Values 38 35
[52]
HepG2.C3A ASL
Mean 34.4
Standard deviation 3
Values 32 37
[53]
HuH.7 ASL
Mean 58.5
Standard deviation 21
Values 77 36 63
[54]
SNU475 ASL
Mean 18.3
Standard deviation 1.6
Values 17 19
[55]
THLE ASL
Mean 7.49
Standard deviation 0.63
Values 7 7.9
[56]
liver ASL
Mean 118
Standard deviation 52
Values 81 67 1.7e+02 1.5e+02
[57]
ref_hepatocyte ACY1
Mean 72.1
Standard deviation 60
Values 22 1.5e+02 1.2e+02 21 45
[58]
HepG2 ACY1
Mean 2.42
Standard deviation 0.67
Values 2 2.9
[59]
HepG2.C3A ACY1
Mean 3.49
Standard deviation 0.8
Values 4.1 2.9
[60]
HuH.7 ACY1
Mean 5.02
Standard deviation 1.4
Values 5.3 3.5 6.3
[61]
SNU475 ACY1
Mean 0.334
Standard deviation 0.16
Values 0.22 0.45
[62]
THLE ACY1
Mean 0.518
Standard deviation 0.013
Values 0.51 0.53
[63]
liver ACY1
Mean 2.74
Standard deviation 2.8
Values 0.26 0.36 5.1 5.2
[64]
ref_hepatocyte SMS
Mean 48.6
Standard deviation 41
Values 65 18 12 35 1.1e+02
[65]
HepG2 SMS
Mean 60
Standard deviation 5.2
Values 56 64
[66]
HepG2.C3A SMS
Mean 45.7
Standard deviation 8.7
Values 52 40
[67]
HuH.7 SMS
Mean 54.1
Standard deviation 17
Values 69 35 59
[68]
SNU475 SMS
Mean 53.5
Standard deviation 0.37
Values 54 53
[69]
THLE SMS
Mean 60.3
Standard deviation 9.2
Values 54 67
[70]
liver SMS
Mean 11.4
Standard deviation 7.2
Values 4.4 6 16 19
[71]
ref_hepatocyte OTC
Mean 32.4
Standard deviation 50
Values 2.1 1.2e+02 41 1.7 0.78
[72]
HepG2 OTC
Mean 0.0623
Standard deviation 0.015
Values 0.073 0.052
[73]
HepG2.C3A OTC
Mean 0.104
Standard deviation 0.065
Values 0.15 0.058
[74]
HuH.7 OTC
Mean 3.85
Standard deviation 0.39
Values 3.7 3.6 4.3
[75]
SNU475 OTC
Mean 0.0076
Standard deviation 0.011
Values 0.015 0
[76]
THLE OTC
Mean 0.0207
Standard deviation 0.029
Values 0.041 0
[77]
liver OTC
Mean 28.5
Standard deviation 16
Values 19 19 52 24
[78]
ref_hepatocyte SRM
Mean 28.1
Standard deviation 25
Values 70 16 33 6.5 15
[79]
HepG2 SRM
Mean 42.7
Standard deviation 0.29
Values 43 43
[80]
HepG2.C3A SRM
Mean 60.7
Standard deviation 5.5
Values 65 57
[81]
HuH.7 SRM
Mean 21.2
Standard deviation 10
Values 27 9.7 27
[82]
SNU475 SRM
Mean 25.5
Standard deviation 6.7
Values 30 21
[83]
THLE SRM
Mean 35.3
Standard deviation 5.7
Values 31 39
[84]
liver SRM
Mean 8.26
Standard deviation 6.7
Values 2.5 2.4 14 14
[85]
ref_hepatocyte OAT
Mean 20.8
Standard deviation 20
Values 1.5 49 17 31 5.3
[86]
HepG2 OAT
Mean 38.4
Standard deviation 12
Values 47 30
[87]
HepG2.C3A OAT
Mean 72.9
Standard deviation 11
Values 81 65
[88]
HuH.7 OAT
Mean 23.1
Standard deviation 2.5
Values 23 26 21
[89]
SNU475 OAT
Mean 19.6
Standard deviation 6.9
Values 15 25
[90]
THLE OAT
Mean 45.9
Standard deviation 12
Values 37 54
[91]
liver OAT
Mean 33.7
Standard deviation 22
Values 24 14 65 32
[92]
ref_hepatocyte SARDH
Mean 15.9
Standard deviation 20
Values 0.51 42 32 4.6 0.76
[93]
HepG2 SARDH
Mean 20.2
Standard deviation 1.3
Values 21 19
[94]
HepG2.C3A SARDH
Mean 23.7
Standard deviation 3.8
Values 21 26
[95]
HuH.7 SARDH
Mean 19.6
Standard deviation 4.3
Values 18 16 24
[96]
SNU475 SARDH
Mean 0.567
Standard deviation 0.057
Values 0.53 0.61
[97]
THLE SARDH
Mean 2.05
Standard deviation 0.015
Values 2.1 2
[98]
liver SARDH
Mean 88.9
Standard deviation 39
Values 1.5e+02 80 71 59
[99]
ref_hepatocyte ALDH18A1
Mean 15.8
Standard deviation 13
Values 9.2 11 11 40 9
[100]
HepG2 ALDH18A1
Mean 95.7
Standard deviation 18
Values 1.1e+02 83
[101]
HepG2.C3A ALDH18A1
Mean 187
Standard deviation 39
Values 1.6e+02 2.1e+02
[102]
HuH.7 ALDH18A1
Mean 218
Standard deviation 2
Values 2.2e+02 2.2e+02 2.2e+02
[103]
SNU475 ALDH18A1
Mean 23.3
Standard deviation 5.2
Values 20 27
[104]
THLE ALDH18A1
Mean 28.8
Standard deviation 5.2
Values 25 33
[105]
liver ALDH18A1
Mean 21.9
Standard deviation 5.3
Values 20 25 15 27
[106]
ref_hepatocyte NAGS
Mean 11.3
Standard deviation 9.6
Values 13 23 17 0.8 2.6
[107]
HepG2 NAGS
Mean 3.57
Standard deviation 2.1
Values 2.1 5
[108]
HepG2.C3A NAGS
Mean 8.44
Standard deviation 4.2
Values 5.5 11
[109]
HuH.7 NAGS
Mean 8.34
Standard deviation 1.5
Values 8.5 9.8 6.8
[110]
SNU475 NAGS
Mean 0.215
Standard deviation 0.075
Values 0.27 0.16
[111]
THLE NAGS
Mean 0.725
Standard deviation 0.054
Values 0.76 0.69
[112]
liver NAGS
Mean 19
Standard deviation 5.9
Values 13 15 26 21
[113]
ref_hepatocyte PYCR1
Mean 8.14
Standard deviation 7
Values 12 2 6.7 18 1.6
[114]
HepG2 PYCR1
Mean 202
Standard deviation 52
Values 1.7e+02 2.4e+02
[115]
HepG2.C3A PYCR1
Mean 185
Standard deviation 66
Values 1.4e+02 2.3e+02
[116]
HuH.7 PYCR1
Mean 105
Standard deviation 35
Values 1.4e+02 68 1.1e+02
[117]
SNU475 PYCR1
Mean 24
Standard deviation 8.4
Values 18 30
[118]
THLE PYCR1
Mean 11.2
Standard deviation 2.1
Values 13 9.7
[119]
liver PYCR1
Mean 3.12
Standard deviation 1.6
Values 2.7 1 4.7 4
[120]
ref_hepatocyte CKB
Mean 4.4
Standard deviation 5.3
Values 4.9 0.89 1.8 13 1
[121]
HepG2 CKB
Mean 99.7
Standard deviation 12
Values 91 1.1e+02
[122]
HepG2.C3A CKB
Mean 44.6
Standard deviation 6.7
Values 49 40
[123]
HuH.7 CKB
Mean 222
Standard deviation 17
Values 2.4e+02 2.1e+02 2.1e+02
[124]
SNU475 CKB
Mean 25.4
Standard deviation 1.2
Values 25 26
[125]
THLE CKB
Mean 13.5
Standard deviation 1.3
Values 14 13
[126]
liver CKB
Mean 5.14
Standard deviation 6.3
Values 1.5 0.56 14 4.3
[127]
ref_hepatocyte ARG2
Mean 3.18
Standard deviation 1.9
Values 6.5 2.5 2 3.3 1.7
[128]
HepG2 ARG2
Mean 16.3
Standard deviation 5.8
Values 12 20
[129]
HepG2.C3A ARG2
Mean 18.6
Standard deviation 2.3
Values 17 20
[130]
HuH.7 ARG2
Mean 6.92
Standard deviation 0.27
Values 6.6 7 7.1
[131]
SNU475 ARG2
Mean 2.53
Standard deviation 0.049
Values 2.6 2.5
[132]
THLE ARG2
Mean 3.75
Standard deviation 0.28
Values 4 3.6
[133]
liver ARG2
Mean 1.96
Standard deviation 0.4
Values 1.9 2.5 1.8 1.6
[134]
ref_hepatocyte CKM
Mean 0.0455
Standard deviation 0.065
Values 0 0 0.086 0.14 0
[135]
HepG2 CKM
Mean 2.45
Standard deviation 2
Values 1 3.9
[136]
HepG2.C3A CKM
Mean 1.16
Standard deviation 0.28
Values 1.4 0.96
[137]
HuH.7 CKM
Mean 0.0437
Standard deviation 0.0097
Values 0.047 0.051 0.033
[138]
SNU475 CKM
Mean 0.015
Standard deviation 0.015
Values 0.025 0.0046
[139]
THLE CKM
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[140]
liver CKM
Mean 0.0294
Standard deviation 0.034
Values 0.066 0 0 0.051
[141]
ref_hepatocyte PYCR3
Missing
[142]
HepG2 PYCR3
Missing
[143]
HepG2.C3A PYCR3
Missing
[144]
HuH.7 PYCR3
Missing
[145]
SNU475 PYCR3
Missing
[146]
THLE PYCR3
Missing
[147]
liver PYCR3
Missing