WP_UREA_CYCLE_AND_ASSOCIATED_PATHWAYS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ASS1 Argininosuccinate synthase [1] -1.73[2] -2.11[3] -1.10[4] -2.20[5] -2.74[6] -1.76[7]
2 ARG1 Arginase-1 [8] -8.31[9] -9.11[10] -2.02[11] -9.75[12] -10.99[13] 0.33[14]
3 GLUD1 Glutamate dehydrogenase 1, mitochondrial [15] 0.66[16] 1.38[17] 0.87[18] -0.71[19] -0.54[20] 0.31[21]
4 CPS1 Carbamoyl-phosphate synthase [ammonia], mitochondrial [22] -2.44[23] -3.00[24] -2.51[25] -9.08[26] -3.10[27] 1.82[28]
5 MDH2 Malate dehydrogenase, mitochondrial [29] 0.42[30] -0.78[31] 0.43[32] 1.15[33] -0.11[34] -1.20[35]
6 ALDH4A1 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [36] 0.53[37] 1.54[38] -2.04[39] -1.20[40] -2.88[41] 0.21[42]
7 ASL Argininosuccinate lyase [43] -0.67[44] -1.30[45] 0.26[46] -0.21[47] -2.36[48] -0.59[49]
8 GOT1 Aspartate aminotransferase, cytoplasmic [50] 0.21[51] 1.15[52] 0.33[53] -1.13[54] -0.90[55] -0.34[56]
9 MDH1 Malate dehydrogenase, cytoplasmic [57] 0.87[58] 0.78[59] 0.94[60] 2.19[61] 1.13[62] -1.32[63]
10 GOT2 Aspartate aminotransferase, mitochondrial [64] 1.10[65] -0.05[66] 0.87[67] 0.96[68] 1.32[69] -0.01[70]
11 FH Fumarate hydratase, mitochondrial [71] -0.06[72] -0.54[73] 0.40[74] 1.88[75] 0.68[76] -0.60[77]
12 GPT Alanine aminotransferase 1 [78] -4.51[79] -3.90[80] -4.40[81] -4.24[82] -7.69[83] -1.30[84]
13 OTC Ornithine carbamoyltransferase, mitochondrial [85] -8.65[86] -8.45[87] -2.45[88] -10.23[89] -9.64[90] -1.42[91]
14 OAT Ornithine aminotransferase, mitochondrial [92] 1.25[93] 1.64[94] 0.77[95] 1.74[96] 2.11[97] -0.54[98]
15 SLC25A13 Calcium-binding mitochondrial carrier protein Aralar2 [99] 1.27[100] 1.05[101] 2.03[102] 2.23[103] 0.29[104] 0.71[105]
16 GLS2 Glutaminase liver isoform, mitochondrial [106] -0.98[107] -1.09[108] -4.70[109] -4.39[110] -4.57[111] -0.25[112]
17 LDHB L-lactate dehydrogenase B chain [113] -7.45[114] -8.24[115] -5.92[116] -0.54[117] 5.10[118] -1.87[119]
18 NAGS N-acetylglutamate synthase, mitochondrial [120] -1.30[121] -0.60[122] 0.18[123] -3.89[124] -3.00[125] -0.50[126]
19 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial [127] 5.00[128] 4.34[129] 4.31[130] 3.38[131] 1.42[132] -2.62[133]
20 SLC25A15 Mitochondrial ornithine transporter 1 [134] 1.93[135] 1.47[136] 2.39[137] 1.23[138] 1.23[139] 2.25[140]
21 NOS2 Nitric oxide synthase, inducible [141] 1.53[142] [143] -4.69[144] -2.15[145] -3.74[146] -8.04[147]
22 SLC25A12 Calcium-binding mitochondrial carrier protein Aralar1 [148] 3.70[149] 3.17[150] 1.23[151] 5.88[152] 5.43[153] -0.47[154]
23 NOS3 Nitric oxide synthase, endothelial [155] 6.28[156] 2.68[157] 2.87[158] 2.76[159] 3.40[160] 2.04[161]
24 NOS1 Nitric oxide synthase, brain [162] -0.04[163] 1.22[164] 0.38[165] 2.03[166] 1.23[167] -0.04[168]
[1]
ref_hepatocyte ASS1
Mean 312
Standard deviation 3.6e+02
Values 56 8.5e+02 5.1e+02 57 90
[2]
HepG2 ASS1
Mean 73
Standard deviation 14
Values 63 83
[3]
HepG2.C3A ASS1
Mean 81.4
Standard deviation 45
Values 50 1.1e+02
[4]
HuH.7 ASS1
Mean 94.9
Standard deviation 22
Values 86 1.2e+02 79
[5]
SNU475 ASS1
Mean 19.2
Standard deviation 7
Values 14 24
[6]
THLE ASS1
Mean 23.8
Standard deviation 0.31
Values 24 24
[7]
liver ASS1
Mean 218
Standard deviation 27
Values 1.9e+02 2.5e+02 2.3e+02 2e+02
[8]
ref_hepatocyte ARG1
Mean 190
Standard deviation 2.6e+02
Values 15 5.4e+02 3.9e+02 0.48 1.9
[9]
HepG2 ARG1
Mean 0.462
Standard deviation 0.059
Values 0.42 0.5
[10]
HepG2.C3A ARG1
Mean 0.387
Standard deviation 0.27
Values 0.58 0.19
[11]
HuH.7 ARG1
Mean 30.5
Standard deviation 25
Values 18 60 14
[12]
SNU475 ARG1
Mean 0.062
Standard deviation 0.03
Values 0.041 0.083
[13]
THLE ARG1
Mean 0.0476
Standard deviation 0.00039
Values 0.047 0.048
[14]
liver ARG1
Mean 562
Standard deviation 3.3e+02
Values 1.8e+02 4.1e+02 7.7e+02 8.9e+02
[15]
ref_hepatocyte GLUD1
Mean 132
Standard deviation 1.1e+02
Values 15 2.7e+02 1.4e+02 2.2e+02 24
[16]
HepG2 GLUD1
Mean 161
Standard deviation 65
Values 2.1e+02 1.2e+02
[17]
HepG2.C3A GLUD1
Mean 386
Standard deviation 27
Values 3.7e+02 4.1e+02
[18]
HuH.7 GLUD1
Mean 157
Standard deviation 18
Values 1.5e+02 1.8e+02 1.5e+02
[19]
SNU475 GLUD1
Mean 22.7
Standard deviation 0.64
Values 22 23
[20]
THLE GLUD1
Mean 46.4
Standard deviation 7.4
Values 41 52
[21]
liver GLUD1
Mean 386
Standard deviation 1.2e+02
Values 3.1e+02 4.1e+02 5.5e+02 2.7e+02
[22]
ref_hepatocyte CPS1
Mean 128
Standard deviation 1.9e+02
Values 1.6 4.2e+02 2e+02 7.7 8.2
[23]
HepG2 CPS1
Mean 18.3
Standard deviation 4.2
Values 21 15
[24]
HepG2.C3A CPS1
Mean 18
Standard deviation 4.7
Values 21 15
[25]
HuH.7 CPS1
Mean 14.7
Standard deviation 2.6
Values 12 17 15
[26]
SNU475 CPS1
Mean 0.0667
Standard deviation 0.042
Values 0.096 0.037
[27]
THLE CPS1
Mean 7.64
Standard deviation 0.35
Values 7.4 7.9
[28]
liver CPS1
Mean 1.06e+03
Standard deviation 4.4e+02
Values 1e+03 1.7e+03 7.5e+02 7.9e+02
[29]
ref_hepatocyte MDH2
Mean 104
Standard deviation 75
Values 77 1.3e+02 2.2e+02 38 53
[30]
HepG2 MDH2
Mean 107
Standard deviation 16
Values 96 1.2e+02
[31]
HepG2.C3A MDH2
Mean 67.7
Standard deviation 5.8
Values 64 72
[32]
HuH.7 MDH2
Mean 91.1
Standard deviation 31
Values 98 57 1.2e+02
[33]
SNU475 MDH2
Mean 64.7
Standard deviation 14
Values 55 74
[34]
THLE MDH2
Mean 49
Standard deviation 8.8
Values 43 55
[35]
liver MDH2
Mean 107
Standard deviation 92
Values 29 26 1.7e+02 2e+02
[36]
ref_hepatocyte ALDH4A1
Mean 76.6
Standard deviation 93
Values 7.4 2.1e+02 1.4e+02 7.7 17
[37]
HepG2 ALDH4A1
Mean 85.5
Standard deviation 16
Values 96 74
[38]
HepG2.C3A ALDH4A1
Mean 251
Standard deviation 61
Values 2.1e+02 2.9e+02
[39]
HuH.7 ALDH4A1
Mean 12.1
Standard deviation 3.6
Values 14 8 14
[40]
SNU475 ALDH4A1
Mean 9.43
Standard deviation 4.6
Values 6.2 13
[41]
THLE ALDH4A1
Mean 5.31
Standard deviation 0.91
Values 4.7 6
[42]
liver ALDH4A1
Mean 209
Standard deviation 57
Values 1.7e+02 1.5e+02 2.6e+02 2.5e+02
[43]
ref_hepatocyte ASL
Mean 75.2
Standard deviation 60
Values 35 1.4e+02 1.3e+02 8.2 57
[44]
HepG2 ASL
Mean 36.6
Standard deviation 1.9
Values 38 35
[45]
HepG2.C3A ASL
Mean 34.4
Standard deviation 3
Values 32 37
[46]
HuH.7 ASL
Mean 58.5
Standard deviation 21
Values 77 36 63
[47]
SNU475 ASL
Mean 18.3
Standard deviation 1.6
Values 17 19
[48]
THLE ASL
Mean 7.49
Standard deviation 0.63
Values 7 7.9
[49]
liver ASL
Mean 118
Standard deviation 52
Values 81 67 1.7e+02 1.5e+02
[50]
ref_hepatocyte GOT1
Mean 75.1
Standard deviation 57
Values 62 1.1e+02 1.5e+02 6.4 44
[51]
HepG2 GOT1
Mean 67.6
Standard deviation 26
Values 49 86
[52]
HepG2.C3A GOT1
Mean 188
Standard deviation 68
Values 1.4e+02 2.4e+02
[53]
HuH.7 GOT1
Mean 61.7
Standard deviation 15
Values 75 45 65
[54]
SNU475 GOT1
Mean 9.68
Standard deviation 0.11
Values 9.8 9.6
[55]
THLE GOT1
Mean 20.6
Standard deviation 1.6
Values 20 22
[56]
liver GOT1
Mean 140
Standard deviation 1e+02
Values 51 1.1e+02 1.1e+02 2.8e+02
[57]
ref_hepatocyte MDH1
Mean 74.5
Standard deviation 43
Values 9.2 1.1e+02 1e+02 99 52
[58]
HepG2 MDH1
Mean 106
Standard deviation 36
Values 1.3e+02 80
[59]
HepG2.C3A MDH1
Mean 144
Standard deviation 49
Values 1.8e+02 1.1e+02
[60]
HuH.7 MDH1
Mean 93.1
Standard deviation 25
Values 1.2e+02 67 96
[61]
SNU475 MDH1
Mean 95.9
Standard deviation 44
Values 65 1.3e+02
[62]
THLE MDH1
Mean 83.2
Standard deviation 9.4
Values 77 90
[63]
liver MDH1
Mean 70.6
Standard deviation 50
Values 22 34 1.2e+02 1.1e+02
[64]
ref_hepatocyte GOT2
Mean 58.1
Standard deviation 35
Values 29 1e+02 86 32 39
[65]
HepG2 GOT2
Mean 96.4
Standard deviation 0.81
Values 97 96
[66]
HepG2.C3A GOT2
Mean 63.2
Standard deviation 7.6
Values 69 58
[67]
HuH.7 GOT2
Mean 69
Standard deviation 13
Values 72 55 80
[68]
SNU475 GOT2
Mean 31.9
Standard deviation 2.4
Values 30 34
[69]
THLE GOT2
Mean 74.4
Standard deviation 6.4
Values 70 79
[70]
liver GOT2
Mean 136
Standard deviation 87
Values 50 77 1.8e+02 2.4e+02
[71]
ref_hepatocyte FH
Mean 43.1
Standard deviation 38
Values 8.7 78 91 17 21
[72]
HepG2 FH
Mean 32
Standard deviation 8
Values 38 26
[73]
HepG2.C3A FH
Mean 33.4
Standard deviation 7.2
Values 39 28
[74]
HuH.7 FH
Mean 37.1
Standard deviation 6.3
Values 43 31 38
[75]
SNU475 FH
Mean 44.6
Standard deviation 4.8
Values 41 48
[76]
THLE FH
Mean 35.3
Standard deviation 6.3
Values 31 40
[77]
liver FH
Mean 67.3
Standard deviation 23
Values 42 55 82 90
[78]
ref_hepatocyte GPT
Mean 40.1
Standard deviation 56
Values 1.4 1.3e+02 48 1.8 15
[79]
HepG2 GPT
Mean 1.37
Standard deviation 0.59
Values 1.8 0.95
[80]
HepG2.C3A GPT
Mean 3.02
Standard deviation 1.1
Values 2.2 3.8
[81]
HuH.7 GPT
Mean 1.23
Standard deviation 0.39
Values 1.3 1.6 0.81
[82]
SNU475 GPT
Mean 0.599
Standard deviation 0.6
Values 0.17 1
[83]
THLE GPT
Mean 0.0994
Standard deviation 0.035
Values 0.12 0.074
[84]
liver GPT
Mean 38.4
Standard deviation 12
Values 30 27 45 51
[85]
ref_hepatocyte OTC
Mean 32.4
Standard deviation 50
Values 2.1 1.2e+02 41 1.7 0.78
[86]
HepG2 OTC
Mean 0.0623
Standard deviation 0.015
Values 0.073 0.052
[87]
HepG2.C3A OTC
Mean 0.104
Standard deviation 0.065
Values 0.15 0.058
[88]
HuH.7 OTC
Mean 3.85
Standard deviation 0.39
Values 3.7 3.6 4.3
[89]
SNU475 OTC
Mean 0.0076
Standard deviation 0.011
Values 0.015 0
[90]
THLE OTC
Mean 0.0207
Standard deviation 0.029
Values 0.041 0
[91]
liver OTC
Mean 28.5
Standard deviation 16
Values 19 19 52 24
[92]
ref_hepatocyte OAT
Mean 20.8
Standard deviation 20
Values 1.5 49 17 31 5.3
[93]
HepG2 OAT
Mean 38.4
Standard deviation 12
Values 47 30
[94]
HepG2.C3A OAT
Mean 72.9
Standard deviation 11
Values 81 65
[95]
HuH.7 OAT
Mean 23.1
Standard deviation 2.5
Values 23 26 21
[96]
SNU475 OAT
Mean 19.6
Standard deviation 6.9
Values 15 25
[97]
THLE OAT
Mean 45.9
Standard deviation 12
Values 37 54
[98]
liver OAT
Mean 33.7
Standard deviation 22
Values 24 14 65 32
[99]
ref_hepatocyte SLC25A13
Mean 18.3
Standard deviation 9.3
Values 5.8 31 21 17 16
[100]
HepG2 SLC25A13
Mean 34.3
Standard deviation 3.3
Values 37 32
[101]
HepG2.C3A SLC25A13
Mean 42.6
Standard deviation 0.73
Values 43 42
[102]
HuH.7 SLC25A13
Mean 48.8
Standard deviation 4.2
Values 46 47 54
[103]
SNU475 SLC25A13
Mean 24.1
Standard deviation 1.4
Values 23 25
[104]
THLE SLC25A13
Mean 11.4
Standard deviation 2.6
Values 9.6 13
[105]
liver SLC25A13
Mean 70.5
Standard deviation 11
Values 61 62 85 73
[106]
ref_hepatocyte GLS2
Mean 17.1
Standard deviation 20
Values 2.5 43 36 1.3 3.2
[107]
HepG2 GLS2
Mean 6.74
Standard deviation 0.93
Values 7.4 6.1
[108]
HepG2.C3A GLS2
Mean 9.03
Standard deviation 1.6
Values 10 7.9
[109]
HuH.7 GLS2
Mean 0.429
Standard deviation 0.081
Values 0.37 0.52 0.4
[110]
SNU475 GLS2
Mean 0.231
Standard deviation 0.061
Values 0.19 0.27
[111]
THLE GLS2
Mean 0.37
Standard deviation 0.071
Values 0.42 0.32
[112]
liver GLS2
Mean 33.9
Standard deviation 12
Values 20 35 31 50
[113]
ref_hepatocyte LDHB
Mean 16.5
Standard deviation 16
Values 13 14 10 1.7 43
[114]
HepG2 LDHB
Mean 0.073
Standard deviation 0.043
Values 0.043 0.1
[115]
HepG2.C3A LDHB
Mean 0.0613
Standard deviation 0.0043
Values 0.064 0.058
[116]
HuH.7 LDHB
Mean 0.177
Standard deviation 0.097
Values 0.066 0.24 0.22
[117]
SNU475 LDHB
Mean 3.19
Standard deviation 2.5
Values 1.4 4.9
[118]
THLE LDHB
Mean 288
Standard deviation 43
Values 2.6e+02 3.2e+02
[119]
liver LDHB
Mean 10.6
Standard deviation 5.8
Values 6.2 6.5 19 11
[120]
ref_hepatocyte NAGS
Mean 11.3
Standard deviation 9.6
Values 13 23 17 0.8 2.6
[121]
HepG2 NAGS
Mean 3.57
Standard deviation 2.1
Values 2.1 5
[122]
HepG2.C3A NAGS
Mean 8.44
Standard deviation 4.2
Values 5.5 11
[123]
HuH.7 NAGS
Mean 8.34
Standard deviation 1.5
Values 8.5 9.8 6.8
[124]
SNU475 NAGS
Mean 0.215
Standard deviation 0.075
Values 0.27 0.16
[125]
THLE NAGS
Mean 0.725
Standard deviation 0.054
Values 0.76 0.69
[126]
liver NAGS
Mean 19
Standard deviation 5.9
Values 13 15 26 21
[127]
ref_hepatocyte PYCR1
Mean 8.14
Standard deviation 7
Values 12 2 6.7 18 1.6
[128]
HepG2 PYCR1
Mean 202
Standard deviation 52
Values 1.7e+02 2.4e+02
[129]
HepG2.C3A PYCR1
Mean 185
Standard deviation 66
Values 1.4e+02 2.3e+02
[130]
HuH.7 PYCR1
Mean 105
Standard deviation 35
Values 1.4e+02 68 1.1e+02
[131]
SNU475 PYCR1
Mean 24
Standard deviation 8.4
Values 18 30
[132]
THLE PYCR1
Mean 11.2
Standard deviation 2.1
Values 13 9.7
[133]
liver PYCR1
Mean 3.12
Standard deviation 1.6
Values 2.7 1 4.7 4
[134]
ref_hepatocyte SLC25A15
Mean 7.49
Standard deviation 4.7
Values 1.6 13 12 5.2 6.2
[135]
HepG2 SLC25A15
Mean 22.1
Standard deviation 0.4
Values 22 22
[136]
HepG2.C3A SLC25A15
Mean 23.4
Standard deviation 2.2
Values 25 22
[137]
HuH.7 SLC25A15
Mean 25.5
Standard deviation 6.9
Values 29 18 30
[138]
SNU475 SLC25A15
Mean 4.94
Standard deviation 0.17
Values 4.8 5.1
[139]
THLE SLC25A15
Mean 9
Standard deviation 1.6
Values 7.9 10
[140]
liver SLC25A15
Mean 83.8
Standard deviation 25
Values 56 1.1e+02 69 1e+02
[141]
ref_hepatocyte NOS2
Mean 0.74
Standard deviation 1.6
Values 3.7 0.024 0 0 0
[142]
HepG2 NOS2
Mean 1.66
Standard deviation 0.53
Values 2 1.3
[143]
HepG2.C3A NOS2
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 NOS2
Mean 0.0187
Standard deviation 0.017
Values 0.0094 0.039 0.0082
[145]
SNU475 NOS2
Mean 0.0469
Standard deviation 0.027
Values 0.066 0.028
[146]
THLE NOS2
Mean 0.0284
Standard deviation 0.01
Values 0.035 0.021
[147]
liver NOS2
Mean 0.00662
Standard deviation 0.013
Values 0.026 0 0 0
[148]
ref_hepatocyte SLC25A12
Mean 0.736
Standard deviation 0.42
Values 0.78 0.48 0.17 1 1.3
[149]
HepG2 SLC25A12
Mean 7.39
Standard deviation 0.38
Values 7.7 7.1
[150]
HepG2.C3A SLC25A12
Mean 7.45
Standard deviation 1.3
Values 8.3 6.6
[151]
HuH.7 SLC25A12
Mean 1.12
Standard deviation 0.072
Values 1.2 1.2 1
[152]
SNU475 SLC25A12
Mean 12.2
Standard deviation 1.1
Values 11 13
[153]
THLE SLC25A12
Mean 16.3
Standard deviation 1.1
Values 15 17
[154]
liver SLC25A12
Mean 1.26
Standard deviation 0.66
Values 2.2 1.3 0.68 0.87
[155]
ref_hepatocyte NOS3
Mean 0.251
Standard deviation 0.22
Values 0.014 0.18 0.12 0.58 0.37
[156]
HepG2 NOS3
Mean 15.1
Standard deviation 1.3
Values 16 14
[157]
HepG2.C3A NOS3
Mean 1.81
Standard deviation 0.061
Values 1.9 1.8
[158]
HuH.7 NOS3
Mean 1.2
Standard deviation 0.2
Values 1.2 1 1.4
[159]
SNU475 NOS3
Mean 0.48
Standard deviation 0.28
Values 0.28 0.68
[160]
THLE NOS3
Mean 1.36
Standard deviation 0.21
Values 1.5 1.2
[161]
liver NOS3
Mean 2.44
Standard deviation 1.3
Values 4.3 2.3 1.5 1.6
[162]
ref_hepatocyte NOS1
Mean 0.0628
Standard deviation 0.06
Values 0.033 0.024 0.086 0.16 0.013
[163]
HepG2 NOS1
Mean 0.0472
Standard deviation 0.042
Values 0.077 0.017
[164]
HepG2.C3A NOS1
Mean 0.165
Standard deviation 0.04
Values 0.19 0.14
[165]
HuH.7 NOS1
Mean 0.0531
Standard deviation 0.054
Values 0.11 0.039 0.0082
[166]
SNU475 NOS1
Mean 0.0724
Standard deviation 0.07
Values 0.12 0.023
[167]
THLE NOS1
Mean 0.0754
Standard deviation 0.069
Values 0.12 0.027
[168]
liver NOS1
Mean 0.144
Standard deviation 0.1
Values 0.16 0.19 0 0.23