WP_UNFOLDED_PROTEIN_RESPONSE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HSPA5 78 kDa glucose-regulated protein [1] 0.01[2] -0.24[3] -1.06[4] -0.26[5] -0.48[6] -0.11[7]
2 ATF4 Cyclic AMP-dependent transcription factor ATF-4 [8] -0.70[9] 0.08[10] -0.10[11] -1.98[12] -0.85[13] -1.99[14]
3 XBP1 X-box-binding protein 1 [15] -1.08[16] -1.12[17] 0.48[18] -1.86[19] -2.44[20] 0.60[21]
4 PPP1R15A Protein phosphatase 1 regulatory subunit 15A [22] -1.29[23] -2.56[24] -2.12[25] -1.17[26] -0.53[27] -3.40[28]
5 DDIT3 DNA damage-inducible transcript 3 protein [29] -1.52[30] -1.06[31] -1.32[32] -1.06[33] -0.49[34] -1.97[35]
6 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 [36] 0.74[37] 0.35[38] 0.01[39] 1.65[40] 1.80[41] 0.62[42]
7 NFE2L2 Nuclear factor erythroid 2-related factor 2 [43] 1.23[44] 1.84[45] 1.37[46] 1.51[47] 1.44[48] 0.39[49]
8 TNFRSF10B Tumor necrosis factor receptor superfamily member 10B [50] 2.45[51] 2.01[52] 1.73[53] 0.71[54] 2.01[55] 0.25[56]
9 BID BH3-interacting domain death agonist [57] 0.19[58] -0.02[59] -0.48[60] 0.75[61] -0.09[62] 0.39[63]
10 MBTPS1 Membrane-bound transcription factor site-1 protease [64] 2.05[65] 1.54[66] 1.46[67] 2.43[68] 2.18[69] 1.54[70]
11 TXNIP Thioredoxin-interacting protein [71] 1.32[72] 1.72[73] 2.26[74] 3.39[75] 3.09[76] 2.76[77]
12 CASP8 Caspase-8 [78] 0.48[79] 0.74[80] -0.17[81] 0.96[82] -0.09[83] -1.20[84]
13 TP53 Cellular tumor antigen p53 [85] 2.10[86] 1.35[87] 2.03[88] 2.33[89] 1.69[90] 0.18[91]
14 ATF6 Cyclic AMP-dependent transcription factor ATF-6 alpha [92] 2.21[93] 1.92[94] 1.44[95] 3.50[96] 3.29[97] 2.92[98]
15 BBC3 Bcl-2-binding component 3 [99] 1.20[100] 0.77[101] 0.19[102] -1.76[103] -1.31[104] -4.11[105]
16 EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 [106] 1.00[107] 1.51[108] 1.60[109] 1.23[110] 1.45[111] 1.97[112]
17 IL1B Interleukin-1 beta [113] -8.23[114] -8.42[115] -4.17[116] -2.55[117] 2.73[118] -4.98[119]
18 MBTPS2 Membrane-bound transcription factor site-2 protease [120] 1.41[121] 1.44[122] 2.16[123] 3.14[124] 2.73[125] 1.77[126]
19 PMAIP1 Phorbol-12-myristate-13-acetate-induced protein 1 [127] 0.51[128] -3.17[129] 0.30[130] 3.33[131] 2.24[132] -4.08[133]
20 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 [134] 0.29[135] 0.55[136] 0.47[137] 0.07[138] 1.09[139] 2.39[140]
21 BCL2L11 Bcl-2-like protein 11 [141] 1.97[142] 1.66[143] 1.91[144] 2.91[145] 1.57[146] 2.21[147]
22 CASP2 Caspase-2 [148] 2.16[149] 1.48[150] 2.20[151] 2.92[152] 3.04[153] 1.80[154]
23 BCL2 Apoptosis regulator Bcl-2 [155] -2.39[156] 2.70[157] -4.79[158] 2.82[159] 2.22[160] 3.45[161]
24 MIR3191 [162] [163] [164] [165] [166] [167] [168]
25 RTCB tRNA-splicing ligase RtcB homolog [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte HSPA5
Mean 323
Standard deviation 1.8e+02
Values 4.7e+02 2.1e+02 5.6e+02 2.1e+02 1.7e+02
[2]
HepG2 HSPA5
Mean 522
Standard deviation 17
Values 5.3e+02 5.1e+02
[3]
HepG2.C3A HSPA5
Mean 488
Standard deviation 22
Values 4.7e+02 5e+02
[4]
HuH.7 HSPA5
Mean 279
Standard deviation 1e+02
Values 2.3e+02 4e+02 2.1e+02
[5]
SNU475 HSPA5
Mean 240
Standard deviation 1.2e+02
Values 1.6e+02 3.2e+02
[6]
THLE HSPA5
Mean 287
Standard deviation 62
Values 2.4e+02 3.3e+02
[7]
liver HSPA5
Mean 365
Standard deviation 1.6e+02
Values 2.9e+02 3.1e+02 2.5e+02 6.1e+02
[8]
ref_hepatocyte ATF4
Mean 212
Standard deviation 1.7e+02
Values 4.8e+02 1.3e+02 2.7e+02 76 1.1e+02
[9]
HepG2 ATF4
Mean 208
Standard deviation 25
Values 1.9e+02 2.3e+02
[10]
HepG2.C3A ATF4
Mean 397
Standard deviation 1.4e+02
Values 3e+02 4.9e+02
[11]
HuH.7 ATF4
Mean 356
Standard deviation 84
Values 4.5e+02 3.1e+02 3.1e+02
[12]
SNU475 ATF4
Mean 47.8
Standard deviation 2.6
Values 46 50
[13]
THLE ATF4
Mean 145
Standard deviation 1.3
Values 1.5e+02 1.4e+02
[14]
liver ATF4
Mean 64.9
Standard deviation 27
Values 46 44 1e+02 68
[15]
ref_hepatocyte XBP1
Mean 168
Standard deviation 1.5e+02
Values 60 3.8e+02 2.9e+02 56 56
[16]
HepG2 XBP1
Mean 127
Standard deviation 20
Values 1.4e+02 1.1e+02
[17]
HepG2.C3A XBP1
Mean 137
Standard deviation 17
Values 1.3e+02 1.5e+02
[18]
HuH.7 XBP1
Mean 422
Standard deviation 17
Values 4.3e+02 4.3e+02 4e+02
[19]
SNU475 XBP1
Mean 41.4
Standard deviation 13
Values 32 51
[20]
THLE XBP1
Mean 38.5
Standard deviation 6.1
Values 34 43
[21]
liver XBP1
Mean 311
Standard deviation 1.9e+02
Values 1.9e+02 1.8e+02 5.8e+02 3e+02
[22]
ref_hepatocyte PPP1R15A
Mean 46.5
Standard deviation 53
Values 1.4e+02 5.3 19 18 55
[23]
HepG2 PPP1R15A
Mean 30.6
Standard deviation 24
Values 14 47
[24]
HepG2.C3A PPP1R15A
Mean 14
Standard deviation 6.7
Values 9.2 19
[25]
HuH.7 PPP1R15A
Mean 19.2
Standard deviation 5.6
Values 18 25 14
[26]
SNU475 PPP1R15A
Mean 18.4
Standard deviation 6.4
Values 23 14
[27]
THLE PPP1R15A
Mean 40
Standard deviation 0.53
Values 40 40
[28]
liver PPP1R15A
Mean 5.39
Standard deviation 1.5
Values 5.8 3.3 5.7 6.8
[29]
ref_hepatocyte DDIT3
Mean 23.4
Standard deviation 23
Values 17 15 64 7.5 13
[30]
HepG2 DDIT3
Mean 13.1
Standard deviation 8.7
Values 7 19
[31]
HepG2.C3A DDIT3
Mean 19.9
Standard deviation 9
Values 14 26
[32]
HuH.7 DDIT3
Mean 16.9
Standard deviation 6.4
Values 18 23 10
[33]
SNU475 DDIT3
Mean 10
Standard deviation 0.8
Values 11 9.5
[34]
THLE DDIT3
Mean 20.6
Standard deviation 4
Values 23 18
[35]
liver DDIT3
Mean 7.31
Standard deviation 5.6
Values 2.3 2.7 12 12
[36]
ref_hepatocyte EIF2S1
Mean 16
Standard deviation 10
Values 18 8 11 10 33
[37]
HepG2 EIF2S1
Mean 42.6
Standard deviation 3.9
Values 45 40
[38]
HepG2.C3A EIF2S1
Mean 36.2
Standard deviation 14
Values 46 26
[39]
HuH.7 EIF2S1
Mean 29
Standard deviation 6.1
Values 34 22 31
[40]
SNU475 EIF2S1
Mean 44.7
Standard deviation 5.8
Values 49 41
[41]
THLE EIF2S1
Mean 69.1
Standard deviation 4.7
Values 66 72
[42]
liver EIF2S1
Mean 30
Standard deviation 9.6
Values 21 25 32 43
[43]
ref_hepatocyte NFE2L2
Mean 15.6
Standard deviation 4.9
Values 11 19 21 18 9.4
[44]
HepG2 NFE2L2
Mean 58.6
Standard deviation 25
Values 76 41
[45]
HepG2.C3A NFE2L2
Mean 99.8
Standard deviation 19
Values 1.1e+02 86
[46]
HuH.7 NFE2L2
Mean 72.7
Standard deviation 3
Values 74 75 69
[47]
SNU475 NFE2L2
Mean 39.6
Standard deviation 2.1
Values 41 38
[48]
THLE NFE2L2
Mean 52.3
Standard deviation 3.2
Values 55 50
[49]
liver NFE2L2
Mean 25
Standard deviation 9.2
Values 15 21 28 36
[50]
ref_hepatocyte TNFRSF10B
Mean 14.6
Standard deviation 7.1
Values 23 5.4 9.2 17 19
[51]
HepG2 TNFRSF10B
Mean 128
Standard deviation 33
Values 1e+02 1.5e+02
[52]
HepG2.C3A TNFRSF10B
Mean 105
Standard deviation 32
Values 82 1.3e+02
[53]
HuH.7 TNFRSF10B
Mean 87.5
Standard deviation 7.5
Values 86 95 81
[54]
SNU475 TNFRSF10B
Mean 21.3
Standard deviation 2.9
Values 23 19
[55]
THLE TNFRSF10B
Mean 73
Standard deviation 11
Values 81 66
[56]
liver TNFRSF10B
Mean 21.3
Standard deviation 4.6
Values 27 22 21 16
[57]
ref_hepatocyte BID
Mean 12.3
Standard deviation 4.8
Values 17 12 15 4.5 12
[58]
HepG2 BID
Mean 22.5
Standard deviation 0.74
Values 23 22
[59]
HepG2.C3A BID
Mean 21.5
Standard deviation 4.7
Values 25 18
[60]
HuH.7 BID
Mean 15.9
Standard deviation 4.6
Values 21 12 15
[61]
SNU475 BID
Mean 18.5
Standard deviation 1.4
Values 17 19
[62]
THLE BID
Mean 14.3
Standard deviation 1.7
Values 13 15
[63]
liver BID
Mean 19.7
Standard deviation 11
Values 10 9.4 30 29
[64]
ref_hepatocyte MBTPS1
Mean 12.1
Standard deviation 4.1
Values 9.9 9 9.7 19 13
[65]
HepG2 MBTPS1
Mean 80.3
Standard deviation 2.9
Values 78 82
[66]
HepG2.C3A MBTPS1
Mean 62.7
Standard deviation 9.8
Values 56 70
[67]
HuH.7 MBTPS1
Mean 59.9
Standard deviation 6.7
Values 62 53 65
[68]
SNU475 MBTPS1
Mean 58.2
Standard deviation 23
Values 42 75
[69]
THLE MBTPS1
Mean 67.8
Standard deviation 8.7
Values 62 74
[70]
liver MBTPS1
Mean 42.8
Standard deviation 5.9
Values 45 46 34 46
[71]
ref_hepatocyte TXNIP
Mean 11
Standard deviation 11
Values 4.9 13 29 6.2 1.1
[72]
HepG2 TXNIP
Mean 44
Standard deviation 36
Values 19 69
[73]
HepG2.C3A TXNIP
Mean 64.3
Standard deviation 30
Values 43 85
[74]
HuH.7 TXNIP
Mean 94.3
Standard deviation 8.4
Values 94 1e+02 86
[75]
SNU475 TXNIP
Mean 102
Standard deviation 25
Values 1.2e+02 84
[76]
THLE TXNIP
Mean 115
Standard deviation 45
Values 1.5e+02 83
[77]
liver TXNIP
Mean 90.5
Standard deviation 29
Values 1.1e+02 66 1.2e+02 65
[78]
ref_hepatocyte CASP8
Mean 8.88
Standard deviation 6.8
Values 8.9 2.8 1.9 18 13
[79]
HepG2 CASP8
Mean 19.9
Standard deviation 3.1
Values 18 22
[80]
HepG2.C3A CASP8
Mean 26.3
Standard deviation 13
Values 35 17
[81]
HuH.7 CASP8
Mean 14.2
Standard deviation 3.6
Values 18 11 14
[82]
SNU475 CASP8
Mean 15.4
Standard deviation 0.7
Values 15 16
[83]
THLE CASP8
Mean 10.3
Standard deviation 0.97
Values 9.6 11
[84]
liver CASP8
Mean 4.72
Standard deviation 0.87
Values 5 5.2 3.4 5.3
[85]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 6.2 5.5 5.5 5.5 3.7
[86]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[87]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 25 23
[88]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 46 20 50
[89]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 19 28
[90]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[91]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 5.6 5 9 9.5
[92]
ref_hepatocyte ATF6
Mean 4.13
Standard deviation 1.9
Values 5.6 3.6 6.5 1.9 3
[93]
HepG2 ATF6
Mean 30.5
Standard deviation 4.7
Values 34 27
[94]
HepG2.C3A ATF6
Mean 27.9
Standard deviation 2.3
Values 29 26
[95]
HuH.7 ATF6
Mean 20.2
Standard deviation 4.2
Values 16 24 21
[96]
SNU475 ATF6
Mean 41.5
Standard deviation 2.3
Values 40 43
[97]
THLE ATF6
Mean 49.9
Standard deviation 3.5
Values 47 52
[98]
liver ATF6
Mean 38.1
Standard deviation 7
Values 36 48 35 33
[99]
ref_hepatocyte BBC3
Mean 4.09
Standard deviation 4.3
Values 11 1.3 3.2 3.6 0.92
[100]
HepG2 BBC3
Mean 15.1
Standard deviation 11
Values 7 23
[101]
HepG2.C3A BBC3
Mean 12.4
Standard deviation 9.8
Values 5.5 19
[102]
HuH.7 BBC3
Mean 8.39
Standard deviation 3.1
Values 7.8 12 5.7
[103]
SNU475 BBC3
Mean 1.08
Standard deviation 0.44
Values 0.77 1.4
[104]
THLE BBC3
Mean 2.04
Standard deviation 0.082
Values 2.1 2
[105]
liver BBC3
Mean 0.288
Standard deviation 0.11
Values 0.44 0.3 0.24 0.18
[106]
ref_hepatocyte EIF2AK3
Mean 3.27
Standard deviation 0.7
Values 3.8 2.3 2.9 3.2 4.1
[107]
HepG2 EIF2AK3
Mean 10.5
Standard deviation 4.8
Values 14 7.1
[108]
HepG2.C3A EIF2AK3
Mean 16.6
Standard deviation 3.7
Values 14 19
[109]
HuH.7 EIF2AK3
Mean 17.9
Standard deviation 5
Values 15 24 15
[110]
SNU475 EIF2AK3
Mean 6.86
Standard deviation 1.2
Values 6 7.7
[111]
THLE EIF2AK3
Mean 11.1
Standard deviation 0.36
Values 11 11
[112]
liver EIF2AK3
Mean 15.7
Standard deviation 9.3
Values 21 26 5.8 10
[113]
ref_hepatocyte IL1B
Mean 3.09
Standard deviation 5.4
Values 13 0.76 2 0 0.08
[114]
HepG2 IL1B
Mean 0.0165
Standard deviation 0.017
Values 0.0043 0.029
[115]
HepG2.C3A IL1B
Mean 0.0161
Standard deviation 0.023
Values 0.032 0
[116]
HuH.7 IL1B
Mean 0.309
Standard deviation 0.06
Values 0.3 0.37 0.25
[117]
SNU475 IL1B
Mean 0.472
Standard deviation 0.21
Values 0.62 0.32
[118]
THLE IL1B
Mean 25.4
Standard deviation 8.5
Values 31 19
[119]
liver IL1B
Mean 0.12
Standard deviation 0.051
Values 0.17 0.11 0.14 0.051
[120]
ref_hepatocyte MBTPS2
Mean 2.91
Standard deviation 1.1
Values 1.3 3.2 2.3 4.3 3.5
[121]
HepG2 MBTPS2
Mean 12.4
Standard deviation 2.3
Values 14 11
[122]
HepG2.C3A MBTPS2
Mean 14.1
Standard deviation 0.19
Values 14 14
[123]
HuH.7 MBTPS2
Mean 23.4
Standard deviation 5.3
Values 17 27 25
[124]
SNU475 MBTPS2
Mean 22.8
Standard deviation 3.1
Values 21 25
[125]
THLE MBTPS2
Mean 23.9
Standard deviation 2.4
Values 22 26
[126]
liver MBTPS2
Mean 12.1
Standard deviation 2.3
Values 9.9 12 11 15
[127]
ref_hepatocyte PMAIP1
Mean 2.2
Standard deviation 2.9
Values 6.7 0.54 0.22 0.061 3.5
[128]
HepG2 PMAIP1
Mean 5.03
Standard deviation 2.9
Values 3 7.1
[129]
HepG2.C3A PMAIP1
Mean 0.435
Standard deviation 0.037
Values 0.46 0.41
[130]
HuH.7 PMAIP1
Mean 4.88
Standard deviation 0.84
Values 4.2 5.8 4.6
[131]
SNU475 PMAIP1
Mean 19.7
Standard deviation 2.1
Values 21 18
[132]
THLE PMAIP1
Mean 12.8
Standard deviation 1
Values 14 12
[133]
liver PMAIP1
Mean 0.159
Standard deviation 0.092
Values 0.053 0.11 0.21 0.26
[134]
ref_hepatocyte ERN1
Mean 1.88
Standard deviation 2.4
Values 6.1 0.8 0.7 0.53 1.3
[135]
HepG2 ERN1
Mean 3.66
Standard deviation 1.4
Values 2.7 4.6
[136]
HepG2.C3A ERN1
Mean 4.9
Standard deviation 1.2
Values 4.1 5.7
[137]
HuH.7 ERN1
Mean 4.68
Standard deviation 2.5
Values 2.2 7.2 4.7
[138]
SNU475 ERN1
Mean 1.75
Standard deviation 0.041
Values 1.8 1.7
[139]
THLE ERN1
Mean 4.95
Standard deviation 1.4
Values 4 5.9
[140]
liver ERN1
Mean 12
Standard deviation 5.2
Values 19 12 9.1 7.5
[141]
ref_hepatocyte BCL2L11
Mean 1.6
Standard deviation 0.72
Values 1.7 1.5 2 2.4 0.45
[142]
HepG2 BCL2L11
Mean 10.1
Standard deviation 0.76
Values 9.5 11
[143]
HepG2.C3A BCL2L11
Mean 9.01
Standard deviation 0.3
Values 9.2 8.8
[144]
HuH.7 BCL2L11
Mean 10.8
Standard deviation 1
Values 9.7 12 11
[145]
SNU475 BCL2L11
Mean 10.7
Standard deviation 3
Values 8.6 13
[146]
THLE BCL2L11
Mean 5.92
Standard deviation 0.75
Values 5.4 6.4
[147]
liver BCL2L11
Mean 9.03
Standard deviation 4.2
Values 15 6.5 7.8 6.5
[148]
ref_hepatocyte CASP2
Mean 1.49
Standard deviation 0.81
Values 1.5 1.1 0.94 2.9 1
[149]
HepG2 CASP2
Mean 10.7
Standard deviation 1.9
Values 12 9.4
[150]
HepG2.C3A CASP2
Mean 7.41
Standard deviation 0.75
Values 7.9 6.9
[151]
HuH.7 CASP2
Mean 12.4
Standard deviation 4.7
Values 15 6.9 15
[152]
SNU475 CASP2
Mean 10
Standard deviation 0.13
Values 10 9.9
[153]
THLE CASP2
Mean 15.2
Standard deviation 2.5
Values 13 17
[154]
liver CASP2
Mean 6.36
Standard deviation 2.4
Values 3.8 5.2 7.2 9.2
[155]
ref_hepatocyte BCL2
Mean 0.0984
Standard deviation 0.087
Values 0.15 0.2 0.12 0.019 0
[156]
HepG2 BCL2
Mean 0.0301
Standard deviation 0.0061
Values 0.026 0.034
[157]
HepG2.C3A BCL2
Mean 1.13
Standard deviation 0.21
Values 0.99 1.3
[158]
HuH.7 BCL2
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[159]
SNU475 BCL2
Mean 0.618
Standard deviation 0.094
Values 0.68 0.55
[160]
THLE BCL2
Mean 0.568
Standard deviation 0.0088
Values 0.56 0.57
[161]
liver BCL2
Mean 1.31
Standard deviation 1
Values 2.5 1.8 0.49 0.49
[162]
ref_hepatocyte MIR3191
Missing
[163]
HepG2 MIR3191
Missing
[164]
HepG2.C3A MIR3191
Missing
[165]
HuH.7 MIR3191
Missing
[166]
SNU475 MIR3191
Missing
[167]
THLE MIR3191
Missing
[168]
liver MIR3191
Missing
[169]
ref_hepatocyte RTCB
Missing
[170]
HepG2 RTCB
Missing
[171]
HepG2.C3A RTCB
Missing
[172]
HuH.7 RTCB
Missing
[173]
SNU475 RTCB
Missing
[174]
THLE RTCB
Missing
[175]
liver RTCB
Missing