WP_TRYPTOPHAN_CATABOLISM_LEADING_TO_NAD_PRODUCTION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 TDO2 Tryptophan 2,3-dioxygenase [1] -13.07[2] -11.57[3] -7.28[4] -5.47[5] -9.42[6] 0.71[7]
2 KYNU Kynureninase [8] -1.22[9] -1.09[10] -3.31[11] -1.92[12] -4.19[13] -2.96[14]
3 NAMPT Nicotinamide phosphoribosyltransferase [15] -1.07[16] -0.93[17] 0.33[18] 1.53[19] 2.43[20] 0.58[21]
4 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] [22] 2.10[23] 1.72[24] 2.17[25] 1.06[26] -2.11[27] -0.86[28]
5 HAAO 3-hydroxyanthranilate 3,4-dioxygenase [29] -1.87[30] -1.25[31] -2.56[32] -8.71[33] -12.16[34] -1.08[35]
6 AFMID Kynurenine formamidase [36] 0.99[37] 1.78[38] 0.77[39] -1.72[40] -2.65[41] 0.07[42]
7 NADSYN1 Glutamine-dependent NAD(+) synthetase [43] 2.78[44] 2.19[45] 1.53[46] 2.29[47] 0.59[48] 0.10[49]
8 AADAT Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [50] -0.23[51] -0.46[52] -1.50[53] -0.60[54] -1.66[55] -0.17[56]
9 KMO Kynurenine 3-monooxygenase [57] -7.29[58] -6.11[59] -3.15[60] -0.99[61] -7.43[62] 1.27[63]
10 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 [64] 1.93[65] 3.04[66] 1.61[67] 3.00[68] 1.02[69] -0.09[70]
11 NMNAT3 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 [71] 1.86[72] 1.93[73] -5.34[74] 0.25[75] -4.03[76] -1.32[77]
12 IDO1 Indoleamine 2,3-dioxygenase 1 [78] 0.27[79] 0.62[80] 0.37[81] 4.15[82] -0.69[83] -0.03[84]
13 NMNAT2 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 [85] -1.20[86] -1.73[87] -1.82[88] 7.39[89] 5.96[90] 0.40[91]
14 NMRK1 Nicotinamide riboside kinase 1 [92] [93] [94] [95] [96] [97] [98]
15 NAPRT Nicotinate phosphoribosyltransferase [99] [100] [101] [102] [103] [104] [105]
16 NMRK2 Nicotinamide riboside kinase 2 [106] [107] [108] [109] [110] [111] [112]
[1]
ref_hepatocyte TDO2
Mean 130
Standard deviation 1.9e+02
Values 5.3 4.3e+02 2e+02 0 18
[2]
HepG2 TDO2
Mean 0.0107
Standard deviation 0.0091
Values 0.0043 0.017
[3]
HepG2.C3A TDO2
Mean 0.037
Standard deviation 0.039
Values 0.064 0.0097
[4]
HuH.7 TDO2
Mean 0.435
Standard deviation 0.39
Values 0.26 0.89 0.16
[5]
SNU475 TDO2
Mean 1.01
Standard deviation 0.68
Values 1.5 0.53
[6]
THLE TDO2
Mean 0.203
Standard deviation 0.19
Values 0.34 0.069
[7]
liver TDO2
Mean 397
Standard deviation 2.8e+02
Values 1.8e+02 1.8e+02 7.8e+02 4.4e+02
[8]
ref_hepatocyte KYNU
Mean 90.5
Standard deviation 1.2e+02
Values 70 24 31 22 3.1e+02
[9]
HepG2 KYNU
Mean 27.4
Standard deviation 17
Values 16 39
[10]
HepG2.C3A KYNU
Mean 36.6
Standard deviation 14
Values 47 26
[11]
HuH.7 KYNU
Mean 4.72
Standard deviation 2.1
Values 3.2 7.1 3.9
[12]
SNU475 KYNU
Mean 8.24
Standard deviation 5.2
Values 12 4.6
[13]
THLE KYNU
Mean 5.29
Standard deviation 2.8
Values 7.2 3.3
[14]
liver KYNU
Mean 21.7
Standard deviation 3.4
Values 21 18 26 22
[15]
ref_hepatocyte NAMPT
Mean 74.5
Standard deviation 39
Values 57 89 95 16 1.2e+02
[16]
HepG2 NAMPT
Mean 25.1
Standard deviation 8.5
Values 31 19
[17]
HepG2.C3A NAMPT
Mean 33.9
Standard deviation 3.2
Values 36 32
[18]
HuH.7 NAMPT
Mean 48.4
Standard deviation 12
Values 38 62 44
[19]
SNU475 NAMPT
Mean 74.1
Standard deviation 15
Values 85 63
[20]
THLE NAMPT
Mean 427
Standard deviation 55
Values 4.7e+02 3.9e+02
[21]
liver NAMPT
Mean 209
Standard deviation 33
Values 1.9e+02 2.5e+02 1.8e+02 2.2e+02
[22]
ref_hepatocyte QPRT
Mean 54.6
Standard deviation 24
Values 18 83 60 66 46
[23]
HepG2 QPRT
Mean 166
Standard deviation 13
Values 1.8e+02 1.6e+02
[24]
HepG2.C3A QPRT
Mean 155
Standard deviation 28
Values 1.4e+02 1.7e+02
[25]
HuH.7 QPRT
Mean 127
Standard deviation 6.4
Values 1.2e+02 1.3e+02 1.2e+02
[26]
SNU475 QPRT
Mean 39.2
Standard deviation 20
Values 25 54
[27]
THLE QPRT
Mean 13.5
Standard deviation 0.43
Values 13 14
[28]
liver QPRT
Mean 56.2
Standard deviation 29
Values 34 31 92 68
[29]
ref_hepatocyte HAAO
Mean 49.4
Standard deviation 65
Values 9.1 1.5e+02 72 8.2 3.8
[30]
HepG2 HAAO
Mean 9.61
Standard deviation 2.4
Values 11 7.9
[31]
HepG2.C3A HAAO
Mean 18
Standard deviation 2.2
Values 16 20
[32]
HuH.7 HAAO
Mean 4.33
Standard deviation 0.95
Values 4.9 3.2 4.8
[33]
SNU475 HAAO
Mean 0.0405
Standard deviation 0.021
Values 0.025 0.056
[34]
THLE HAAO
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[35]
liver HAAO
Mean 43.7
Standard deviation 25
Values 23 21 64 67
[36]
ref_hepatocyte AFMID
Mean 27.8
Standard deviation 20
Values 4.8 35 51 41 7.6
[37]
HepG2 AFMID
Mean 39
Standard deviation 12
Values 47 31
[38]
HepG2.C3A AFMID
Mean 82.2
Standard deviation 14
Values 72 92
[39]
HuH.7 AFMID
Mean 24.5
Standard deviation 7.7
Values 32 17 25
[40]
SNU475 AFMID
Mean 2.9
Standard deviation 0.18
Values 2.8 3
[41]
THLE AFMID
Mean 4.73
Standard deviation 0.045
Values 4.7 4.8
[42]
liver AFMID
Mean 54.5
Standard deviation 41
Values 28 23 1.1e+02 54
[43]
ref_hepatocyte NADSYN1
Mean 6.84
Standard deviation 2.5
Values 3.2 6.5 9.5 8.9 6.1
[44]
HepG2 NADSYN1
Mean 33.2
Standard deviation 0.013
Values 33 33
[45]
HepG2.C3A NADSYN1
Mean 27
Standard deviation 8
Values 21 33
[46]
HuH.7 NADSYN1
Mean 10.2
Standard deviation 0.43
Values 10 9.8 11
[47]
SNU475 NADSYN1
Mean 11.5
Standard deviation 5
Values 8 15
[48]
THLE NADSYN1
Mean 11
Standard deviation 0.13
Values 11 11
[49]
liver NADSYN1
Mean 13.7
Standard deviation 3.8
Values 10 12 19 14
[50]
ref_hepatocyte AADAT
Mean 6.3
Standard deviation 9.1
Values 0.67 22 6.3 1.3 1.3
[51]
HepG2 AADAT
Mean 3.81
Standard deviation 2.5
Values 5.6 2
[52]
HepG2.C3A AADAT
Mean 3.96
Standard deviation 1.1
Values 4.7 3.2
[53]
HuH.7 AADAT
Mean 1.15
Standard deviation 0.46
Values 1.5 0.62 1.4
[54]
SNU475 AADAT
Mean 1.43
Standard deviation 0.11
Values 1.3 1.5
[55]
THLE AADAT
Mean 2.12
Standard deviation 0.11
Values 2 2.2
[56]
liver AADAT
Mean 10.5
Standard deviation 4.6
Values 6 7.2 16 13
[57]
ref_hepatocyte KMO
Mean 3.63
Standard deviation 4.2
Values 0.79 8.8 7.5 0.026 0.95
[58]
HepG2 KMO
Mean 0.0165
Standard deviation 0.0071
Values 0.021 0.011
[59]
HepG2.C3A KMO
Mean 0.0452
Standard deviation 0.018
Values 0.032 0.058
[60]
HuH.7 KMO
Mean 0.212
Standard deviation 0.072
Values 0.17 0.3 0.17
[61]
SNU475 KMO
Mean 0.629
Standard deviation 0.51
Values 0.99 0.27
[62]
THLE KMO
Mean 0.0225
Standard deviation 0.0017
Values 0.024 0.021
[63]
liver KMO
Mean 16.3
Standard deviation 7.3
Values 9.6 14 27 15
[64]
ref_hepatocyte NMNAT1
Mean 2.87
Standard deviation 1.2
Values 1.6 2 2.6 4.6 3.6
[65]
HepG2 NMNAT1
Mean 7.76
Standard deviation 0.7
Values 8.2 7.3
[66]
HepG2.C3A NMNAT1
Mean 20.4
Standard deviation 2.1
Values 22 19
[67]
HuH.7 NMNAT1
Mean 4.53
Standard deviation 0.81
Values 5.1 3.6 4.9
[68]
SNU475 NMNAT1
Mean 7.88
Standard deviation 1.8
Values 6.6 9.2
[69]
THLE NMNAT1
Mean 6.18
Standard deviation 0.82
Values 5.6 6.8
[70]
liver NMNAT1
Mean 5.02
Standard deviation 0.66
Values 4.2 5.3 4.9 5.8
[71]
ref_hepatocyte NMNAT3
Mean 1.31
Standard deviation 1.8
Values 0 0.87 1.1 4.5 0.13
[72]
HepG2 NMNAT3
Mean 3.36
Standard deviation 0.041
Values 3.4 3.3
[73]
HepG2.C3A NMNAT3
Mean 4.31
Standard deviation 0.33
Values 4.1 4.5
[74]
HuH.7 NMNAT3
Mean 0.0168
Standard deviation 0.015
Values 0 0.026 0.025
[75]
SNU475 NMNAT3
Mean 0.536
Standard deviation 0.28
Values 0.34 0.73
[76]
THLE NMNAT3
Mean 0.0855
Standard deviation 0.038
Values 0.11 0.059
[77]
liver NMNAT3
Mean 0.977
Standard deviation 0.36
Values 0.87 0.91 1.5 0.64
[78]
ref_hepatocyte IDO1
Mean 0.512
Standard deviation 0.3
Values 0.35 0.33 0.22 0.8 0.86
[79]
HepG2 IDO1
Mean 0.438
Standard deviation 0.012
Values 0.45 0.43
[80]
HepG2.C3A IDO1
Mean 0.68
Standard deviation 0.23
Values 0.51 0.85
[81]
HuH.7 IDO1
Mean 0.343
Standard deviation 0.071
Values 0.26 0.4 0.37
[82]
SNU475 IDO1
Mean 3.13
Standard deviation 1.9
Values 1.8 4.4
[83]
THLE IDO1
Mean 0.339
Standard deviation 0.014
Values 0.35 0.33
[84]
liver IDO1
Mean 0.937
Standard deviation 0.19
Values 1.1 1.1 0.85 0.72
[85]
ref_hepatocyte NMNAT2
Mean 0.0372
Standard deviation 0.07
Values 0.16 0 0.026 0 0
[86]
HepG2 NMNAT2
Mean 0.0114
Standard deviation 0.0081
Values 0.017 0.0057
[87]
HepG2.C3A NMNAT2
Mean 0.00972
Standard deviation 0.014
Values 0 0.019
[88]
HuH.7 NMNAT2
Mean 0.00547
Standard deviation 0.0095
Values 0 0 0.016
[89]
SNU475 NMNAT2
Mean 2.15
Standard deviation 1.4
Values 3.2 1.1
[90]
THLE NMNAT2
Mean 2.47
Standard deviation 0.39
Values 2.2 2.8
[91]
liver NMNAT2
Mean 0.092
Standard deviation 0.085
Values 0.12 0.2 0.024 0.026
[92]
ref_hepatocyte NMRK1
Missing
[93]
HepG2 NMRK1
Mean 1.99
Standard deviation 0.23
Values 2.1 1.8
[94]
HepG2.C3A NMRK1
Mean 5.23
Standard deviation 1.4
Values 4.3 6.2
[95]
HuH.7 NMRK1
Mean 6.35
Standard deviation 1.5
Values 7.9 6.3 4.8
[96]
SNU475 NMRK1
Mean 1.52
Standard deviation 0.84
Values 0.93 2.1
[97]
THLE NMRK1
Mean 4.92
Standard deviation 0.086
Values 4.9 5
[98]
liver NMRK1
Mean 7.63
Standard deviation 5.5
Values 3.3 2.9 14 10
[99]
ref_hepatocyte NAPRT
Missing
[100]
HepG2 NAPRT
Missing
[101]
HepG2.C3A NAPRT
Missing
[102]
HuH.7 NAPRT
Missing
[103]
SNU475 NAPRT
Missing
[104]
THLE NAPRT
Missing
[105]
liver NAPRT
Missing
[106]
ref_hepatocyte NMRK2
Missing
[107]
HepG2 NMRK2
Mean 0.00573
Standard deviation 0.0081
Values 0 0.011
[108]
HepG2.C3A NMRK2
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 NMRK2
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 NMRK2
Mean 0.00464
Standard deviation 0.0066
Values 0 0.0093
[111]
THLE NMRK2
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[112]
liver NMRK2
Mean 0.00642
Standard deviation 0.013
Values 0 0 0 0.026