WP_TRANSCRIPTIONAL_ACTIVATION_BY_NRF2_IN_RESPONSE_TO_PHYTOCHEMICALS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GSTA2 Glutathione S-transferase A2 [1] -6.78[2] -9.14[3] -4.43[4] -10.55[5] -11.87[6] -2.07[7]
2 HMOX1 Heme oxygenase 1 [8] -0.52[9] -1.30[10] -2.11[11] -2.70[12] -0.72[13] -0.72[14]
3 NQO1 NAD(P)H dehydrogenase [quinone] 1 [15] 2.71[16] 2.54[17] 2.46[18] 3.00[19] 1.37[20] -3.88[21]
4 CEBPB CCAAT/enhancer-binding protein beta [22] -1.21[23] -1.70[24] -1.37[25] -2.51[26] 0.64[27] -0.31[28]
5 GCLC Glutamate--cysteine ligase catalytic subunit [29] -0.40[30] 0.11[31] -0.80[32] -0.15[33] -0.65[34] 1.78[35]
6 GCLM Glutamate--cysteine ligase regulatory subunit [36] -1.01[37] -1.64[38] -0.87[39] -0.25[40] 0.14[41] 0.52[42]
7 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 -1.11[43] -1.24[44] -1.52[45] -2.85[46] -0.67[47] 0.11[48]
8 NFE2L2 Nuclear factor erythroid 2-related factor 2 [49] 0.72[50] 1.80[51] 1.71[52] -0.63[53] 1.82[54] 1.53[55]
9 KEAP1 Kelch-like ECH-associated protein 1 [56] 0.17[57] 0.22[58] 0.26[59] -1.91[60] 1.29[61] 1.91[62]
10 MAPK8 Mitogen-activated protein kinase 8 [63] -1.49[64] 0.07[65] -0.75[66] -2.00[67] 0.07[68] 0.85[69]
11 MAF Transcription factor Maf [70] -2.93[71] -5.82[72] 1.61[73] -0.95[74] 0.33[75] 3.77[76]
12 PRKCA Protein kinase C alpha type [77] 2.80[78] 2.98[79] 3.65[80] 1.05[81] 3.62[82] 3.28[83]
13 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.42[84] 1.36[85] 1.86[86] 0.03[87] 2.45[88] 3.28[89]
14 SLC7A11 Cystine/glutamate transporter [90] 2.63[91] 3.62[92] 3.77[93] 3.78[94] 4.80[95] 0.34[96]
15 EPHB2 Ephrin type-B receptor 2 [97] -0.87[98] -5.79[99] 0.94[100] 1.27[101] 4.23[102] -0.21[103]
[1]
ref_hepatocyte GSTA2
Mean 199
Standard deviation 3.4e+02
Values 1.1 8e+02 1.2e+02 27 48
[2]
HepG2 GSTA2
Mean 4.11
Standard deviation 1.5
Values 5.2 3.1
[3]
HepG2.C3A GSTA2
Mean 0.647
Standard deviation 0.13
Values 0.74 0.55
[4]
HuH.7 GSTA2
Mean 13.1
Standard deviation 7.6
Values 10 22 7.6
[5]
SNU475 GSTA2
Mean 0.525
Standard deviation 0.65
Values 0.066 0.98
[6]
THLE GSTA2
Mean 0.0506
Standard deviation 0.0038
Values 0.053 0.048
[7]
liver GSTA2
Mean 26.3
Standard deviation 39
Values 0.29 20 0.73 84
[8]
ref_hepatocyte HMOX1
Mean 45.4
Standard deviation 44
Values 1.2e+02 37 47 19 4.5
[9]
HepG2 HMOX1
Mean 71.8
Standard deviation 29
Values 52 92
[10]
HepG2.C3A HMOX1
Mean 33.6
Standard deviation 4.7
Values 37 30
[11]
HuH.7 HMOX1
Mean 14.9
Standard deviation 6.3
Values 12 22 10
[12]
SNU475 HMOX1
Mean 27.6
Standard deviation 4.6
Values 31 24
[13]
THLE HMOX1
Mean 26.2
Standard deviation 9.7
Values 19 33
[14]
liver HMOX1
Mean 15.2
Standard deviation 2.1
Values 15 13 16 18
[15]
ref_hepatocyte NQO1
Mean 42.1
Standard deviation 85
Values 1.6 0.37 1.4 1.9e+02 13
[16]
HepG2 NQO1
Mean 625
Standard deviation 2.7e+02
Values 4.3e+02 8.1e+02
[17]
HepG2.C3A NQO1
Mean 447
Standard deviation 1.2e+02
Values 5.3e+02 3.6e+02
[18]
HuH.7 NQO1
Mean 329
Standard deviation 90
Values 4e+02 2.3e+02 3.5e+02
[19]
SNU475 NQO1
Mean 1.32e+03
Standard deviation 2.1e+02
Values 1.2e+03 1.5e+03
[20]
THLE NQO1
Mean 103
Standard deviation 3.8
Values 1.1e+02 1e+02
[21]
liver NQO1
Mean 1.58
Standard deviation 1.1
Values 0.97 1.8 0.49 3.1
[22]
ref_hepatocyte CEBPB
Mean 37.2
Standard deviation 25
Values 24 62 65 9 26
[23]
HepG2 CEBPB
Mean 36.4
Standard deviation 26
Values 18 55
[24]
HepG2.C3A CEBPB
Mean 20.9
Standard deviation 13
Values 12 30
[25]
HuH.7 CEBPB
Mean 20.5
Standard deviation 6.4
Values 23 25 13
[26]
SNU475 CEBPB
Mean 25.6
Standard deviation 11
Values 33 18
[27]
THLE CEBPB
Mean 55
Standard deviation 10
Values 48 62
[28]
liver CEBPB
Mean 16.5
Standard deviation 5.6
Values 22 16 18 9.1
[29]
ref_hepatocyte GCLC
Mean 23.9
Standard deviation 11
Values 36 37 16 14 17
[30]
HepG2 GCLC
Mean 41.2
Standard deviation 0.21
Values 41 41
[31]
HepG2.C3A GCLC
Mean 47.1
Standard deviation 0.68
Values 47 48
[32]
HuH.7 GCLC
Mean 19.4
Standard deviation 7.4
Values 15 28 15
[33]
SNU475 GCLC
Mean 84.8
Standard deviation 9.1
Values 78 91
[34]
THLE GCLC
Mean 14.4
Standard deviation 0.55
Values 15 14
[35]
liver GCLC
Mean 45.3
Standard deviation 20
Values 64 59 37 22
[36]
ref_hepatocyte GCLM
Mean 20.7
Standard deviation 17
Values 32 5.2 8.4 12 45
[37]
HepG2 GCLM
Mean 23.3
Standard deviation 15
Values 13 34
[38]
HepG2.C3A GCLM
Mean 12.1
Standard deviation 3.1
Values 14 9.9
[39]
HuH.7 GCLM
Mean 16.1
Standard deviation 2.7
Values 13 19 16
[40]
SNU475 GCLM
Mean 68.3
Standard deviation 0.053
Values 68 68
[41]
THLE GCLM
Mean 21.6
Standard deviation 2.7
Values 20 24
[42]
liver GCLM
Mean 16.4
Standard deviation 8.1
Values 7 14 18 27
[43]
ref_hepatocyte AIMP2
Mean 17.4
Standard deviation 5.5
Values 23 11 16 13 23
[44]
HepG2 AIMP2
Mean 18.3
Standard deviation 2.5
Values 17 20
[45]
HepG2.C3A AIMP2
Mean 13.5
Standard deviation 2.6
Values 15 12
[46]
HuH.7 AIMP2
Mean 8.59
Standard deviation 2.3
Values 10 5.9 9.7
[47]
SNU475 AIMP2
Mean 9.46
Standard deviation 0.75
Values 10 8.9
[48]
THLE AIMP2
Mean 10.4
Standard deviation 1.5
Values 9.3 11
[49]
liver AIMP2
Mean 10.4
Standard deviation 6.3
Values 4.6 5.3 15 17
[50]
ref_hepatocyte NFE2L2
Mean 15.6
Standard deviation 4.9
Values 11 19 21 18 9.4
[51]
HepG2 NFE2L2
Mean 58.6
Standard deviation 25
Values 76 41
[52]
HepG2.C3A NFE2L2
Mean 99.8
Standard deviation 19
Values 1.1e+02 86
[53]
HuH.7 NFE2L2
Mean 72.7
Standard deviation 3
Values 74 75 69
[54]
SNU475 NFE2L2
Mean 39.6
Standard deviation 2.1
Values 41 38
[55]
THLE NFE2L2
Mean 52.3
Standard deviation 3.2
Values 55 50
[56]
liver NFE2L2
Mean 25
Standard deviation 9.2
Values 15 21 28 36
[57]
ref_hepatocyte KEAP1
Mean 14.9
Standard deviation 4.1
Values 17 15 20 11 11
[58]
HepG2 KEAP1
Mean 38
Standard deviation 2.6
Values 36 40
[59]
HepG2.C3A KEAP1
Mean 31.6
Standard deviation 0.82
Values 32 31
[60]
HuH.7 KEAP1
Mean 25.2
Standard deviation 5.2
Values 30 20 26
[61]
SNU475 KEAP1
Mean 15.5
Standard deviation 1.8
Values 17 14
[62]
THLE KEAP1
Mean 34.5
Standard deviation 4.9
Values 31 38
[63]
liver KEAP1
Mean 30.9
Standard deviation 7.7
Values 29 23 31 41
[64]
ref_hepatocyte MAPK8
Mean 7.1
Standard deviation 4.4
Values 15 4.7 3.8 6.5 5.6
[65]
HepG2 MAPK8
Mean 5.76
Standard deviation 1
Values 6.5 5.1
[66]
HepG2.C3A MAPK8
Mean 13.6
Standard deviation 4
Values 17 11
[67]
HuH.7 MAPK8
Mean 5.99
Standard deviation 0.68
Values 5.2 6.2 6.5
[68]
SNU475 MAPK8
Mean 6.98
Standard deviation 0.5
Values 6.6 7.3
[69]
THLE MAPK8
Mean 7.08
Standard deviation 1
Values 6.4 7.8
[70]
liver MAPK8
Mean 7.08
Standard deviation 1
Values 7.6 7.8 7.3 5.6
[71]
ref_hepatocyte MAF
Mean 2.64
Standard deviation 1.4
Values 0.9 4.9 2.4 2.6 2.4
[72]
HepG2 MAF
Mean 0.788
Standard deviation 0.5
Values 1.1 0.44
[73]
HepG2.C3A MAF
Mean 0.0853
Standard deviation 0.11
Values 0.16 0.0097
[74]
HuH.7 MAF
Mean 11.4
Standard deviation 8.2
Values 7.3 21 6.2
[75]
SNU475 MAF
Mean 5.39
Standard deviation 2.7
Values 3.5 7.3
[76]
THLE MAF
Mean 3.15
Standard deviation 0.074
Values 3.2 3.1
[77]
liver MAF
Mean 19.9
Standard deviation 6.7
Values 16 17 30 17
[78]
ref_hepatocyte PRKCA
Mean 2.45
Standard deviation 2.1
Values 1.1 1.2 1.2 2.7 6
[79]
HepG2 PRKCA
Mean 38.7
Standard deviation 5.6
Values 43 35
[80]
HepG2.C3A PRKCA
Mean 35.5
Standard deviation 4.5
Values 39 32
[81]
HuH.7 PRKCA
Mean 43.7
Standard deviation 11
Values 33 44 54
[82]
SNU475 PRKCA
Mean 20
Standard deviation 4.3
Values 23 17
[83]
THLE PRKCA
Mean 28.8
Standard deviation 11
Values 21 36
[84]
liver PRKCA
Mean 13.2
Standard deviation 7.1
Values 21 17 11 4.7
[85]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 0.94 1.2 2.3 2.6
[86]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 4.3 2.1
[87]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 9.6 8
[88]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 7 12 10
[89]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 6.8 8.1
[90]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[91]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 13 15 6.1 6
[92]
ref_hepatocyte SLC7A11
Mean 1.16
Standard deviation 1.5
Values 1.1 0.081 0.13 0.84 3.6
[93]
HepG2 SLC7A11
Mean 16.2
Standard deviation 8
Values 11 22
[94]
HepG2.C3A SLC7A11
Mean 26.1
Standard deviation 9.4
Values 19 33
[95]
HuH.7 SLC7A11
Mean 22.5
Standard deviation 3.7
Values 18 24 25
[96]
SNU475 SLC7A11
Mean 62.6
Standard deviation 14
Values 72 53
[97]
THLE SLC7A11
Mean 30.6
Standard deviation 10
Values 38 24
[98]
liver SLC7A11
Mean 0.81
Standard deviation 0.61
Values 0.54 0.77 1.7 0.26
[99]
ref_hepatocyte EPHB2
Mean 0.766
Standard deviation 0.96
Values 2 0.065 0.15 0 1.7
[100]
HepG2 EPHB2
Mean 0.949
Standard deviation 0.65
Values 0.49 1.4
[101]
HepG2.C3A EPHB2
Mean 0.0253
Standard deviation 0.0055
Values 0.021 0.029
[102]
HuH.7 EPHB2
Mean 2.09
Standard deviation 1.4
Values 2.5 0.54 3.2
[103]
SNU475 EPHB2
Mean 7.27
Standard deviation 2.9
Values 9.3 5.2
[104]
THLE EPHB2
Mean 13.6
Standard deviation 2
Values 12 15
[105]
liver EPHB2
Mean 0.366
Standard deviation 0.19
Values 0.62 0.37 0.19 0.28