WP_TOLLLIKE_RECEPTOR_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | LBP | Lipopolysaccharide-binding protein | [1] | -11.17[2] | -13.95[3] | -6.11[4] | -12.55[5] | -17.43[6] | 0.10[7] |
2 | CD14 | Monocyte differentiation antigen CD14 | [8] | -7.85[9] | -7.67[10] | -4.61[11] | -4.22[12] | -5.09[13] | -0.47[14] |
3 | NFKBIA | NF-kappa-B inhibitor alpha | [15] | -0.57[16] | -2.11[17] | -2.24[18] | -2.94[19] | -0.74[20] | -1.10[21] |
4 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [22] | 0.10[23] | 0.02[24] | 0.98[25] | 0.60[26] | 0.90[27] | -0.93[28] |
5 | JUN | Transcription factor AP-1 | [29] | 0.00[30] | -1.29[31] | -0.77[32] | -1.12[33] | -0.24[34] | -1.77[35] |
6 | FOS | Proto-oncogene c-Fos | [36] | -5.52[37] | -4.01[38] | -4.42[39] | -5.58[40] | -4.20[41] | -1.27[42] |
7 | AKT1 | RAC-alpha serine/threonine-protein kinase | [43] | 0.57[44] | 0.59[45] | -0.24[46] | 0.53[47] | 0.87[48] | -0.21[49] |
8 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [50] | -0.73[51] | -0.18[52] | -1.03[53] | -1.24[54] | -1.06[55] | -1.40[56] |
9 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [57] | -0.44[58] | -0.52[59] | 0.31[60] | 0.04[61] | 0.86[62] | -1.16[63] |
10 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [64] | 0.54[65] | 0.47[66] | 1.59[67] | -0.26[68] | 0.54[69] | -1.67[70] |
11 | SPP1 | Osteopontin | [71] | 3.67[72] | 2.68[73] | -5.57[74] | 2.48[75] | -5.27[76] | -1.05[77] |
12 | IKBKG | NF-kappa-B essential modulator | [78] | -0.40[79] | 0.00[80] | -2.00[81] | -0.27[82] | -1.17[83] | -0.57[84] |
13 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [85] | 1.91[86] | 1.55[87] | 0.78[88] | 1.38[89] | 2.06[90] | -0.65[91] |
14 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [92] | 0.42[93] | -0.25[94] | 1.11[95] | 3.11[96] | 1.16[97] | 0.99[98] |
15 | TOLLIP | Toll-interacting protein | [99] | 0.22[100] | 0.36[101] | 0.61[102] | -0.45[103] | -0.97[104] | 1.18[105] |
16 | RELA | Transcription factor p65 | [106] | 0.62[107] | 0.37[108] | 0.76[109] | 0.53[110] | 0.75[111] | -0.85[112] |
17 | NFKBIB | NF-kappa-B inhibitor beta | [113] | -0.67[114] | -0.60[115] | -0.02[116] | -1.23[117] | -0.57[118] | -1.69[119] |
18 | IFNAR2 | Interferon alpha/beta receptor 2 | [120] | -0.72[121] | -0.82[122] | 0.12[123] | -0.81[124] | -0.50[125] | -0.74[126] |
19 | MYD88 | Myeloid differentiation primary response protein MyD88 | [127] | 0.30[128] | 0.61[129] | 0.29[130] | -0.45[131] | 0.16[132] | 0.83[133] |
20 | IRF7 | Interferon regulatory factor 7 | [134] | -8.74[135] | -7.50[136] | -6.14[137] | -2.57[138] | -2.51[139] | -0.04[140] |
21 | MAPK1 | Mitogen-activated protein kinase 1 | [141] | 2.20[142] | 2.58[143] | 2.67[144] | 2.43[145] | 2.39[146] | 1.81[147] |
22 | AKT2 | RAC-beta serine/threonine-protein kinase | [148] | 1.45[149] | 1.97[150] | 2.35[151] | 1.44[152] | 1.55[153] | 1.17[154] |
23 | IRF3 | Interferon regulatory factor 3 | [155] | 0.79[156] | 1.21[157] | 2.19[158] | 0.94[159] | 0.84[160] | -1.15[161] |
24 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [162] | 0.85[163] | 1.27[164] | 1.79[165] | 2.28[166] | 2.06[167] | 0.28[168] |
25 | FADD | FAS-associated death domain protein | [169] | 0.53[170] | 0.07[171] | 1.05[172] | 2.52[173] | 0.64[174] | -1.74[175] |
26 | CASP8 | Caspase-8 | [176] | 0.51[177] | 1.33[178] | 0.75[179] | 0.50[180] | 0.07[181] | -1.38[182] |
27 | MAPK14 | Mitogen-activated protein kinase 14 | [183] | 1.96[184] | 2.28[185] | 2.11[186] | 2.27[187] | 2.05[188] | 1.32[189] |
28 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [190] | 0.39[191] | 1.71[192] | 1.83[193] | 1.07[194] | 1.57[195] | 0.28[196] |
29 | IFNAR1 | Interferon alpha/beta receptor 1 | [197] | 0.55[198] | 1.27[199] | 1.23[200] | 1.57[201] | 1.87[202] | 2.47[203] |
30 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [204] | 0.02[205] | 0.38[206] | 1.73[207] | 2.65[208] | 2.47[209] | 3.04[210] |
31 | MAPK8 | Mitogen-activated protein kinase 8 | [211] | -0.96[212] | 0.70[213] | -0.17[214] | -0.32[215] | -0.15[216] | -0.48[217] |
32 | TBK1 | Serine/threonine-protein kinase TBK1 | [218] | -0.15[219] | 1.78[220] | 1.18[221] | 1.07[222] | 1.47[223] | 0.51[224] |
33 | TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | [225] | 0.55[226] | 2.74[227] | 3.09[228] | 0.93[229] | 2.45[230] | 0.86[231] |
34 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [232] | 1.16[233] | 1.08[234] | 1.13[235] | 0.34[236] | 1.56[237] | 0.49[238] |
35 | CCL3 | C-C motif chemokine 3 | [239] | [240] | [241] | [242] | -7.61[243] | [244] | -4.38[245] |
36 | CCL4 | C-C motif chemokine 4 | [246] | [247] | [248] | [249] | [250] | [251] | -3.37[252] |
37 | MAPK13 | Mitogen-activated protein kinase 13 | [253] | 2.83[254] | 3.48[255] | 1.06[256] | -1.30[257] | 0.53[258] | -1.68[259] |
38 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [260] | 2.36[261] | 2.83[262] | 3.70[263] | 1.29[264] | 2.16[265] | -0.26[266] |
39 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [267] | 1.19[268] | 2.07[269] | 1.53[270] | 1.79[271] | 1.50[272] | 1.10[273] |
40 | CD40 | Tumor necrosis factor receptor superfamily member 5 | [274] | -0.31[275] | -1.26[276] | -9.26[277] | -2.24[278] | -0.59[279] | -0.90[280] |
41 | TICAM1 | TIR domain-containing adapter molecule 1 | [281] | -0.22[282] | -1.08[283] | 0.11[284] | -0.64[285] | 0.72[286] | -0.47[287] |
42 | MAPK9 | Mitogen-activated protein kinase 9 | [288] | 1.72[289] | 2.19[290] | 2.50[291] | 2.30[292] | 2.07[293] | 0.54[294] |
43 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [295] | 0.78[296] | 1.19[297] | 1.12[298] | 1.66[299] | 1.50[300] | 1.52[301] |
44 | CCL5 | C-C motif chemokine 5 | [302] | -4.27[303] | -3.48[304] | -3.07[305] | -3.12[306] | -4.00[307] | 0.76[308] |
45 | MAPK3 | Mitogen-activated protein kinase 3 | [309] | 2.34[310] | 2.63[311] | 2.93[312] | 1.01[313] | 1.34[314] | -1.01[315] |
46 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [316] | 1.39[317] | 2.86[318] | 3.07[319] | 1.23[320] | 2.36[321] | 1.55[322] |
47 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [323] | 1.45[324] | 1.85[325] | 2.67[326] | 0.87[327] | 1.73[328] | -0.72[329] |
48 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [330] | 1.14[331] | 2.03[332] | 2.36[333] | 0.59[334] | 1.24[335] | 0.26[336] |
49 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [337] | 1.01[338] | 1.32[339] | 1.67[340] | 0.84[341] | 1.25[342] | 1.22[343] |
50 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1.70[344] | 2.46[345] | 2.87[346] | 1.63[347] | 2.10[348] | 1.19[349] | |
51 | IL1B | Interleukin-1 beta | [350] | -8.21[351] | -7.83[352] | -3.25[353] | -3.01[354] | 2.90[355] | -5.16[356] |
52 | LY96 | Lymphocyte antigen 96 | [357] | -2.16[358] | -2.30[359] | -8.47[360] | -0.78[361] | -4.08[362] | -1.33[363] |
53 | TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein | [364] | 0.35[365] | 0.57[366] | 0.92[367] | 0.86[368] | 0.00[369] | 0.30[370] |
54 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.11[371] | 2.00[372] | 2.44[373] | 1.71[374] | 2.23[375] | 1.95[376] | |
55 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.38[377] | 3.71[378] | 0.15[379] | 0.86[380] | 1.94[381] | 0.33[382] | |
56 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [383] | 2.24[384] | 2.49[385] | 1.93[386] | 0.69[387] | 2.32[388] | 0.52[389] |
57 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [390] | 0.78[391] | -2.19[392] | 2.92[393] | 1.59[394] | -2.13[395] | -1.58[396] |
58 | TLR2 | Toll-like receptor 2 | [397] | -3.05[398] | -1.39[399] | -8.14[400] | -4.39[401] | 2.68[402] | 1.28[403] |
59 | CXCL10 | C-X-C motif chemokine 10 | [404] | -8.65[405] | -6.10[406] | -0.73[407] | -0.98[408] | -8.25[409] | -2.35[410] |
60 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | [411] | 0.75[412] | 2.36[413] | 2.89[414] | 2.00[415] | 2.07[416] | 1.81[417] |
61 | IL6 | Interleukin-6 | [418] | -7.95[419] | [420] | -3.84[421] | -0.27[422] | 2.56[423] | [424] |
62 | TRAF3 | TNF receptor-associated factor 3 | [425] | 3.38[426] | 3.04[427] | 2.91[428] | 3.41[429] | 4.14[430] | 1.96[431] |
63 | TLR3 | Toll-like receptor 3 | [432] | -3.35[433] | -3.57[434] | -3.64[435] | 0.22[436] | 1.61[437] | 1.09[438] |
64 | IRF5 | Interferon regulatory factor 5 | [439] | 0.79[440] | 0.82[441] | -0.10[442] | 0.94[443] | -1.01[444] | 1.01[445] |
65 | TRAF6 | TNF receptor-associated factor 6 | [446] | 1.58[447] | 1.72[448] | 2.54[449] | 2.24[450] | 2.01[451] | 2.94[452] |
66 | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | [453] | 2.21[454] | 2.33[455] | 1.47[456] | 3.14[457] | 3.01[458] | -0.20[459] |
67 | MAPK12 | Mitogen-activated protein kinase 12 | [460] | 3.31[461] | 3.22[462] | 4.58[463] | 2.07[464] | 3.63[465] | -0.87[466] |
68 | TLR4 | Toll-like receptor 4 | [467] | 0.76[468] | -4.14[469] | -4.78[470] | -4.52[471] | 6.22[472] | 4.50[473] |
69 | TLR1 | Toll-like receptor 1 | [474] | -2.88[475] | [476] | -6.03[477] | 0.19[478] | 1.68[479] | 2.10[480] |
70 | TICAM2 | TIR domain-containing adapter molecule 2 | [481] | -7.38[482] | [483] | -6.31[484] | -0.91[485] | -0.26[486] | -1.94[487] |
71 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [488] | 2.21[489] | 2.47[490] | 3.57[491] | 3.75[492] | 3.08[493] | 2.71[494] |
72 | CXCL11 | C-X-C motif chemokine 11 | [495] | -7.79[496] | -4.93[497] | -4.52[498] | -1.96[499] | -4.45[500] | -2.81[501] |
73 | CD86 | T-lymphocyte activation antigen CD86 | [502] | [503] | [504] | -3.72[505] | -3.51[506] | -5.22[507] | 1.38[508] |
74 | AKT3 | RAC-gamma serine/threonine-protein kinase | [509] | -1.35[510] | -3.66[511] | -2.72[512] | 6.42[513] | 5.69[514] | 3.64[515] |
75 | MAPK11 | Mitogen-activated protein kinase 11 | [516] | 0.32[517] | 0.46[518] | -0.17[519] | 0.94[520] | 3.25[521] | 0.20[522] |
76 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [523] | -6.68[524] | [525] | -1.54[526] | -3.34[527] | -2.68[528] | 2.37[529] |
77 | CXCL9 | C-X-C motif chemokine 9 | [530] | -7.19[531] | [532] | -3.30[533] | -1.39[534] | [535] | 0.42[536] |
78 | TLR6 | Toll-like receptor 6 | [537] | 1.27[538] | 1.63[539] | 1.12[540] | 2.89[541] | 3.28[542] | 2.78[543] |
79 | IL12A | Interleukin-12 subunit alpha | [544] | -0.92[545] | [546] | 1.08[547] | -0.96[548] | 1.15[549] | -3.14[550] |
80 | TNF | Tumor necrosis factor | [551] | 1.59[552] | -0.30[553] | -4.64[554] | -1.64[555] | -4.55[556] | -1.86[557] |
81 | TLR5 | Toll-like receptor 5 | [558] | -2.79[559] | -4.60[560] | 1.13[561] | -1.41[562] | -0.95[563] | 2.95[564] |
82 | TLR7 | Toll-like receptor 7 | [565] | -0.34[566] | 0.70[567] | 1.25[568] | 0.00[569] | -0.12[570] | 1.31[571] |
83 | TLR8 | Toll-like receptor 8 | [572] | [573] | [574] | [575] | [576] | -5.13[577] | 3.70[578] |
84 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [579] | [580] | [581] | 1.92[582] | -2.65[583] | 4.13[584] | |
85 | CD80 | T-lymphocyte activation antigen CD80 | [585] | [586] | [587] | -4.27[588] | -0.57[589] | -1.32[590] | 2.66[591] |
86 | MAPK10 | Mitogen-activated protein kinase 10 | [592] | -0.99[593] | [594] | [595] | 9.49[596] | 5.54[597] | 7.28[598] |
87 | CXCL8 | Interleukin-8 | [599] | [600] | [601] | [602] | [603] | [604] | [605] |
88 | IFNA8 | Interferon alpha-8 | [606] | [607] | [608] | [609] | [610] | [611] | [612] |
89 | IFNA14 | Interferon alpha-14 | [613] | [614] | [615] | [616] | [617] | [618] | [619] |
90 | IFNA4 | Interferon alpha-4 | [620] | [621] | [622] | [623] | [624] | [625] | [626] |
91 | MIR718 | [627] | [628] | [629] | [630] | [631] | [632] | [633] | |
92 | IFNA2 | Interferon alpha-2 | [634] | [635] | [636] | [637] | [638] | [639] | [640] |
93 | IFNB1 | Interferon beta | [641] | [642] | [643] | [644] | [645] | [646] | [647] |
94 | IFNA6 | Interferon alpha-6 | [648] | [649] | [650] | [651] | [652] | [653] | [654] |
95 | IFNA21 | Interferon alpha-21 | [655] | [656] | [657] | [658] | [659] | [660] | [661] |
96 | IFNA17 | Interferon alpha-17 | [662] | [663] | [664] | [665] | [666] | [667] | [668] |
97 | IFNA10 | Interferon alpha-10 | [669] | [670] | [671] | [672] | [673] | [674] | [675] |
98 | IFNA5 | Interferon alpha-5 | [676] | [677] | [678] | [679] | [680] | [681] | [682] |
99 | IFNA13 | [683] | [684] | [685] | [686] | [687] | [688] | [689] | |
100 | IFNA1 | Interferon alpha-1/13 | [690] | [691] | [692] | [693] | [694] | [695] | [696] |
101 | IL12B | Interleukin-12 subunit beta | [697] | [698] | [699] | [700] | [701] | [702] | [703] |
102 | TLR9 | Toll-like receptor 9 | [704] | [705] | [706] | [707] | [708] | [709] | [710] |
103 | IFNA7 | Interferon alpha-7 | [711] | [712] | [713] | [714] | [715] | [716] | [717] |
104 | IFNA16 | Interferon alpha-16 | [718] | [719] | [720] | [721] | [722] | [723] | [724] |