WP_TNFALPHA_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | TXN | Thioredoxin | [1] | -2.48[2] | -2.65[3] | -2.95[4] | -1.96[5] | -2.45[6] | -2.63[7] |
2 | HSP90AA1 | Heat shock protein HSP 90-alpha | [8] | -0.21[9] | 0.53[10] | -0.06[11] | 0.60[12] | 0.24[13] | -0.62[14] |
3 | NFKBIA | NF-kappa-B inhibitor alpha | [15] | -0.62[16] | -2.64[17] | -2.84[18] | -3.01[19] | -1.17[20] | -0.50[21] |
4 | SKP1 | S-phase kinase-associated protein 1 | [22] | -0.54[23] | -0.38[24] | -1.07[25] | 0.01[26] | 0.18[27] | -0.06[28] |
5 | CDC37 | Hsp90 co-chaperone Cdc37 | [29] | -0.32[30] | -1.20[31] | -0.65[32] | -1.30[33] | -0.76[34] | -1.35[35] |
6 | GLUL | Glutamine synthetase | [36] | -0.51[37] | 0.49[38] | 0.96[39] | -2.37[40] | -1.19[41] | 2.16[42] |
7 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [43] | 0.99[44] | -0.16[45] | 0.11[46] | 0.15[47] | 1.42[48] | 0.10[49] |
8 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [50] | 0.04[51] | -0.51[52] | 0.37[53] | 0.52[54] | 0.46[55] | -0.33[56] |
9 | JUN | Transcription factor AP-1 | [57] | -0.05[58] | -1.82[59] | -1.38[60] | -1.19[61] | -0.67[62] | -1.17[63] |
10 | TRAP1 | Heat shock protein 75 kDa, mitochondrial | [64] | 0.56[65] | 0.53[66] | 0.71[67] | -1.06[68] | -0.86[69] | 0.57[70] |
11 | PYGL | Glycogen phosphorylase, liver form | [71] | -0.87[72] | -0.45[73] | 0.39[74] | -0.74[75] | -1.35[76] | 0.56[77] |
12 | AKT1 | RAC-alpha serine/threonine-protein kinase | [78] | 0.52[79] | 0.06[80] | -0.85[81] | 0.46[82] | 0.44[83] | 0.39[84] |
13 | CSNK2A1 | Casein kinase II subunit alpha | [85] | 0.55[86] | 0.20[87] | 0.31[88] | 0.15[89] | -0.26[90] | -1.10[91] |
14 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [92] | -0.78[93] | -0.71[94] | -1.64[95] | -1.32[96] | -1.50[97] | -0.80[98] |
15 | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | [99] | -0.03[100] | -0.72[101] | -0.25[102] | 0.88[103] | 1.01[104] | 0.71[105] |
16 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 0.71[106] | 0.58[107] | 0.12[108] | 1.25[109] | 1.32[110] | 0.53[111] | |
17 | BCL2L1 | Bcl-2-like protein 1 | [112] | 2.58[113] | 1.74[114] | 2.87[115] | -0.11[116] | 0.24[117] | -0.18[118] |
18 | BAX | Apoptosis regulator BAX | [119] | 0.77[120] | -0.26[121] | -0.54[122] | -1.09[123] | -0.75[124] | -3.32[125] |
19 | IKBKG | NF-kappa-B essential modulator | [126] | -0.45[127] | -0.53[128] | -2.60[129] | -0.34[130] | -1.60[131] | 0.03[132] |
20 | GRB2 | Growth factor receptor-bound protein 2 | [133] | 1.63[134] | 1.24[135] | 1.54[136] | 1.06[137] | 0.93[138] | 0.93[139] |
21 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | [140] | -0.33[141] | -0.26[142] | 0.37[143] | -0.87[144] | -0.06[145] | -2.38[146] |
22 | BAD | Bcl2-associated agonist of cell death | [147] | -1.23[148] | -1.33[149] | -2.10[150] | -0.56[151] | -0.20[152] | -0.79[153] |
23 | CFLAR | CASP8 and FADD-like apoptosis regulator | [154] | 0.05[155] | 0.57[156] | 0.30[157] | -0.03[158] | 0.08[159] | 2.20[160] |
24 | DIABLO | Diablo homolog, mitochondrial | [161] | 0.29[162] | 0.32[163] | 0.19[164] | 0.18[165] | -0.11[166] | -0.10[167] |
25 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | [168] | -2.68[169] | -1.88[170] | -4.10[171] | -2.61[172] | 1.11[173] | -1.44[174] |
26 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [175] | 0.37[176] | 0.55[177] | 2.00[178] | 0.33[179] | 1.14[180] | 1.73[181] |
27 | CYBA | Cytochrome b-245 light chain | [182] | 1.92[183] | 1.74[184] | 0.81[185] | 0.72[186] | 0.57[187] | -0.78[188] |
28 | NRAS | GTPase NRas | [189] | 1.07[190] | 1.27[191] | 1.86[192] | 1.51[193] | 1.03[194] | 0.38[195] |
29 | CUL1 | Cullin-1 | [196] | 0.05[197] | 0.50[198] | 0.23[199] | 1.09[200] | 0.70[201] | 1.38[202] |
30 | NFKBIB | NF-kappa-B inhibitor beta | [203] | -0.73[204] | -1.13[205] | -0.62[206] | -1.30[207] | -1.01[208] | -1.09[209] |
31 | CASP3 | Caspase-3 | [210] | 0.57[211] | 1.02[212] | -1.35[213] | -0.39[214] | 0.56[215] | -0.17[216] |
32 | BID | BH3-interacting domain death agonist | [217] | 0.17[218] | 0.04[219] | -0.16[220] | 0.22[221] | -0.36[222] | 0.81[223] |
33 | HRAS | GTPase HRas | [224] | -0.57[225] | -1.50[226] | -2.12[227] | -0.44[228] | -0.70[229] | -2.03[230] |
34 | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | [231] | 1.07[232] | 1.54[233] | -1.54[234] | -0.70[235] | 1.22[236] | -0.39[237] |
35 | MAPK1 | Mitogen-activated protein kinase 1 | [238] | 2.15[239] | 2.06[240] | 2.06[241] | 2.36[242] | 1.96[243] | 2.41[244] |
36 | CCL2 | C-C motif chemokine 2 | [245] | -12.96[246] | [247] | -12.43[248] | -3.61[249] | -1.49[250] | -3.06[251] |
37 | CASP7 | Caspase-7 | [252] | 0.13[253] | -0.46[254] | 0.15[255] | -0.39[256] | -0.23[257] | 0.15[258] |
38 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | [259] | 0.68[260] | 1.41[261] | 0.53[262] | 0.93[263] | 1.67[264] | 1.36[265] |
39 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [266] | 0.80[267] | 0.74[268] | 1.18[269] | 2.21[270] | 1.62[271] | 0.88[272] |
40 | FADD | FAS-associated death domain protein | [273] | 0.48[274] | -0.46[275] | 0.44[276] | 2.44[277] | 0.21[278] | -1.14[279] |
41 | KRAS | GTPase KRas | [280] | -0.08[281] | -0.33[282] | 1.45[283] | 1.31[284] | 0.93[285] | 1.31[286] |
42 | RFFL | E3 ubiquitin-protein ligase rififylin | [287] | -1.38[288] | -1.32[289] | -0.44[290] | -1.89[291] | -2.90[292] | -0.83[293] |
43 | CASP8 | Caspase-8 | [294] | 0.46[295] | 0.80[296] | 0.15[297] | 0.43[298] | -0.36[299] | -0.78[300] |
44 | RFK | Riboflavin kinase | [301] | 0.67[302] | 0.52[303] | 1.36[304] | 0.71[305] | 0.95[306] | 0.54[307] |
45 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [308] | 0.34[309] | 1.18[310] | 1.23[311] | 1.00[312] | 1.14[313] | 0.88[314] |
46 | TANK | TRAF family member-associated NF-kappa-B activator | [315] | -0.70[316] | 1.06[317] | 0.86[318] | 0.64[319] | -0.17[320] | 1.17[321] |
47 | PRKCZ | Protein kinase C zeta type | [322] | 0.91[323] | 1.06[324] | -0.76[325] | -1.79[326] | -4.03[327] | -1.01[328] |
48 | TRAF1 | TNF receptor-associated factor 1 | [329] | -3.99[330] | -4.34[331] | -3.32[332] | -3.03[333] | -2.51[334] | -2.26[335] |
49 | MAPK8 | Mitogen-activated protein kinase 8 | [336] | -1.01[337] | 0.18[338] | -0.78[339] | -0.39[340] | -0.58[341] | 0.12[342] |
50 | TBK1 | Serine/threonine-protein kinase TBK1 | [343] | -0.20[344] | 1.25[345] | 0.57[346] | 1.00[347] | 1.04[348] | 1.11[349] |
51 | SOS1 | Son of sevenless homolog 1 | [350] | 0.34[351] | 1.64[352] | 1.32[353] | 1.36[354] | 0.54[355] | 1.17[356] |
52 | TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | [357] | 0.49[358] | 2.21[359] | 2.48[360] | 0.86[361] | 2.01[362] | 1.46[363] |
53 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [364] | 1.11[365] | 0.56[366] | 0.52[367] | 0.26[368] | 1.13[369] | 1.09[370] |
54 | FBXW11 | F-box/WD repeat-containing protein 11 | [371] | 1.81[372] | 1.49[373] | 2.43[374] | 2.03[375] | 1.90[376] | 1.58[377] |
55 | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein | 0.18[378] | -0.21[379] | -1.20[380] | -0.47[381] | -0.67[382] | 0.05[383] | |
56 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [384] | 1.14[385] | 1.54[386] | 0.92[387] | 1.72[388] | 1.07[389] | 1.70[390] |
57 | TRAF2 | TNF receptor-associated factor 2 | [391] | 0.67[392] | 0.50[393] | 0.41[394] | 0.63[395] | 0.60[396] | -0.16[397] |
58 | PLK1 | Serine/threonine-protein kinase PLK1 | [398] | 2.93[399] | 2.44[400] | 2.48[401] | 1.76[402] | 2.75[403] | -2.00[404] |
59 | MAPK9 | Mitogen-activated protein kinase 9 | [405] | 1.66[406] | 1.66[407] | 1.90[408] | 2.22[409] | 1.64[410] | 1.14[411] |
60 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [412] | 0.72[413] | 0.66[414] | 0.52[415] | 1.59[416] | 1.07[417] | 2.12[418] |
61 | MAPK3 | Mitogen-activated protein kinase 3 | [419] | 2.29[420] | 2.11[421] | 2.32[422] | 0.93[423] | 0.91[424] | -0.41[425] |
62 | NFKBIE | NF-kappa-B inhibitor epsilon | [426] | 0.47[427] | 1.17[428] | -0.52[429] | -0.27[430] | 0.14[431] | -0.63[432] |
63 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [433] | 1.34[434] | 2.33[435] | 2.47[436] | 1.16[437] | 1.93[438] | 2.15[439] |
64 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [440] | 1.40[441] | 1.32[442] | 2.07[443] | 0.79[444] | 1.30[445] | -0.12[446] |
65 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [447] | 1.08[448] | 1.50[449] | 1.76[450] | 0.52[451] | 0.81[452] | 0.86[453] |
66 | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | [454] | -1.69[455] | -6.03[456] | -6.51[457] | -2.86[458] | -1.26[459] | 2.09[460] |
67 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [461] | 0.96[462] | 0.79[463] | 1.07[464] | 0.77[465] | 0.82[466] | 1.82[467] |
68 | NSMAF | Protein FAN | [468] | 1.25[469] | 0.93[470] | -1.33[471] | 2.56[472] | 1.74[473] | 0.81[474] |
69 | OTUD7B | OTU domain-containing protein 7B | [475] | 1.51[476] | 0.86[477] | 1.44[478] | 2.59[479] | 2.00[480] | 2.05[481] |
70 | SMPD2 | Sphingomyelin phosphodiesterase 2 | [482] | -0.52[483] | -0.41[484] | -0.84[485] | -1.26[486] | -0.19[487] | -0.97[488] |
71 | CASP9 | Caspase-9 | [489] | 0.59[490] | 1.32[491] | 0.62[492] | 0.76[493] | 0.03[494] | 0.10[495] |
72 | BTRC | F-box/WD repeat-containing protein 1A | [496] | 1.85[497] | 2.41[498] | 2.20[499] | 1.27[500] | 1.76[501] | 1.98[502] |
73 | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | [503] | 0.04[504] | 0.27[505] | -0.72[506] | 2.58[507] | 1.52[508] | 1.51[509] |
74 | MADD | MAP kinase-activating death domain protein | [510] | 2.99[511] | 2.63[512] | 3.23[513] | 2.60[514] | 2.25[515] | 3.20[516] |
75 | CREBBP | CREB-binding protein | [517] | 3.34[518] | 2.32[519] | 3.11[520] | 3.27[521] | 3.23[522] | 3.87[523] |
76 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [524] | 2.18[525] | 1.96[526] | 1.32[527] | 0.61[528] | 1.89[529] | 1.12[530] |
77 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [531] | 0.73[532] | -2.71[533] | 2.32[534] | 1.52[535] | -2.56[536] | -0.98[537] |
78 | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | [538] | 2.06[539] | 2.32[540] | 1.78[541] | 2.59[542] | 2.80[543] | 2.78[544] |
79 | APAF1 | Apoptotic protease-activating factor 1 | [545] | 2.09[546] | 2.29[547] | 2.72[548] | 3.14[549] | 2.19[550] | 2.12[551] |
80 | IL6 | Interleukin-6 | [552] | -8.01[553] | [554] | -4.45[555] | -0.34[556] | 2.13[557] | [558] |
81 | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | [559] | -3.86[560] | -7.02[561] | -0.95[562] | -1.36[563] | 3.00[564] | 3.69[565] |
82 | PTPRCAP | Protein tyrosine phosphatase receptor type C-associated protein | [566] | -3.49[567] | -2.04[568] | -1.68[569] | -0.56[570] | -2.91[571] | 0.74[572] |
83 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [573] | 3.09[574] | 2.57[575] | 2.48[576] | 2.83[577] | 1.67[578] | 3.43[579] |
84 | MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 | [580] | 2.87[581] | 2.19[582] | 1.63[583] | 2.36[584] | 2.61[585] | 0.71[586] |
85 | SELE | E-selectin | [587] | -5.19[588] | [589] | -4.74[590] | -4.02[591] | [592] | 3.33[593] |
86 | REL | Proto-oncogene c-Rel | [594] | -0.08[595] | 1.46[596] | 1.57[597] | 0.66[598] | 0.77[599] | 2.98[600] |
87 | KSR1 | Kinase suppressor of Ras 1 | [601] | 3.70[602] | 3.17[603] | 0.27[604] | 2.56[605] | 3.01[606] | 1.36[607] |
88 | NOXO1 | NADPH oxidase organizer 1 | [608] | -0.07[609] | 1.02[610] | -1.50[611] | -1.99[612] | -1.80[613] | -0.08[614] |
89 | RIPK3 | Receptor-interacting serine/threonine-protein kinase 3 | [615] | -6.21[616] | [617] | -4.94[618] | [619] | -4.91[620] | 1.19[621] |
90 | TNF | Tumor necrosis factor | [622] | 1.54[623] | -0.82[624] | -5.25[625] | -1.71[626] | -4.98[627] | -1.26[628] |
91 | KSR2 | Kinase suppressor of Ras 2 | [629] | 0.67[630] | -0.57[631] | [632] | -0.75[633] | [634] | 1.95[635] |
92 | NOX1 | NADPH oxidase 1 | [636] | 0.79[637] | -0.20[638] | 5.14[639] | 0.45[640] | 1.78[641] | 1.47[642] |
93 | MIR1181 | [643] | [644] | [645] | [646] | [647] | [648] | [649] | |
94 | MIR7846 | [650] | [651] | [652] | [653] | [654] | [655] | [656] |