WP_THYROID_STIMULATING_HORMONE_TSH_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | MYL12B | Myosin regulatory light chain 12B | [8] | -1.17[9] | -1.12[10] | -1.05[11] | -0.92[12] | -1.36[13] | -1.36[14] |
3 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 1.27[15] | 1.23[16] | 0.99[17] | 1.44[18] | 0.95[19] | -0.31[20] | |
4 | RAP1B | Ras-related protein Rap-1b | [21] | -1.47[22] | -0.92[23] | -1.04[24] | 0.07[25] | 0.10[26] | -0.86[27] |
5 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | [28] | 0.93[29] | 0.52[30] | 1.53[31] | -0.22[32] | -0.29[33] | -0.64[34] |
6 | JUN | Transcription factor AP-1 | [35] | 0.35[36] | -1.26[37] | -0.89[38] | -1.11[39] | -0.27[40] | -0.78[41] |
7 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | [42] | 1.85[43] | 1.80[44] | 1.42[45] | 1.88[46] | 1.94[47] | -0.20[48] |
8 | FOS | Proto-oncogene c-Fos | [49] | -5.18[50] | -3.98[51] | -4.55[52] | -5.58[53] | -4.24[54] | -0.27[55] |
9 | AKT1 | RAC-alpha serine/threonine-protein kinase | [56] | 0.92[57] | 0.62[58] | -0.36[59] | 0.54[60] | 0.84[61] | 0.79[62] |
10 | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | [63] | 0.90[64] | -0.23[65] | 0.04[66] | 0.42[67] | 1.76[68] | 0.84[69] |
11 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [70] | -0.38[71] | -0.15[72] | -1.15[73] | -1.23[74] | -1.10[75] | -0.41[76] |
12 | STAT3 | Signal transducer and activator of transcription 3 | [77] | 1.39[78] | -0.18[79] | 0.66[80] | 0.83[81] | 0.38[82] | 3.44[83] |
13 | MYC | Myc proto-oncogene protein | [84] | 1.27[85] | 0.86[86] | -1.07[87] | -2.20[88] | 0.45[89] | -0.97[90] |
14 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [91] | -0.09[92] | -0.49[93] | 0.19[94] | 0.05[95] | 0.83[96] | -0.16[97] |
15 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [98] | 0.76[99] | -0.22[100] | 0.98[101] | 3.12[102] | 1.13[103] | 1.98[104] |
16 | CDK4 | Cyclin-dependent kinase 4 | [105] | 2.17[106] | 2.68[107] | 2.41[108] | 0.77[109] | 1.70[110] | 0.20[111] |
17 | RAP1A | Ras-related protein Rap-1A | [112] | -0.21[113] | -0.34[114] | 0.59[115] | 0.38[116] | 0.41[117] | -0.26[118] |
18 | GNAI3 | Guanine nucleotide-binding protein G(k) subunit alpha | [119] | 0.96[120] | 1.44[121] | 1.64[122] | 1.70[123] | 1.60[124] | 1.26[125] |
19 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [126] | 0.77[127] | 1.11[128] | 2.48[129] | 0.41[130] | 1.54[131] | 2.13[132] |
20 | JAK1 | Tyrosine-protein kinase JAK1 | [133] | 1.35[134] | 0.77[135] | 1.05[136] | 1.22[137] | 2.14[138] | 2.56[139] |
21 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [140] | 0.75[141] | 1.13[142] | 1.42[143] | -0.52[144] | 0.22[145] | 0.12[146] |
22 | EGR1 | Early growth response protein 1 | [147] | -0.97[148] | -0.55[149] | -2.57[150] | -1.74[151] | 0.20[152] | 2.18[153] |
23 | CDK2 | Cyclin-dependent kinase 2 | [154] | 0.42[155] | 0.52[156] | 1.00[157] | 0.57[158] | 1.44[159] | -1.16[160] |
24 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | [161] | 0.96[162] | 1.06[163] | 1.63[164] | 1.78[165] | 0.89[166] | 1.57[167] |
25 | HRAS | GTPase HRas | [168] | -0.17[169] | -0.94[170] | -1.64[171] | -0.36[172] | -0.30[173] | -1.63[174] |
26 | MAPK1 | Mitogen-activated protein kinase 1 | [175] | 2.55[176] | 2.62[177] | 2.54[178] | 2.44[179] | 2.36[180] | 2.81[181] |
27 | MAPK14 | Mitogen-activated protein kinase 14 | [182] | 2.31[183] | 2.31[184] | 1.99[185] | 2.27[186] | 2.02[187] | 2.31[188] |
28 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [189] | 0.37[190] | 0.42[191] | 1.61[192] | 2.66[193] | 2.43[194] | 4.03[195] |
29 | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 | [196] | -0.81[197] | -1.82[198] | 0.42[199] | 1.81[200] | 1.45[201] | 1.86[202] |
30 | RBL2 | Retinoblastoma-like protein 2 | [203] | 1.67[204] | 2.45[205] | 2.61[206] | 1.82[207] | 1.80[208] | 3.17[209] |
31 | RAP1GAP | Rap1 GTPase-activating protein 1 | [210] | 2.04[211] | 2.66[212] | 0.35[213] | -0.62[214] | -3.82[215] | 0.95[216] |
32 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [217] | 2.71[218] | 2.87[219] | 3.58[220] | 1.30[221] | 2.13[222] | 0.74[223] |
33 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [224] | [225] | [226] | [227] | [228] | [229] | [230] |
34 | GNA12 | Guanine nucleotide-binding protein subunit alpha-12 | [231] | 2.82[232] | 2.67[233] | 2.09[234] | 2.32[235] | 2.69[236] | 1.12[237] |
35 | SCRIB | Protein scribble homolog | [238] | 3.01[239] | 2.28[240] | 2.80[241] | 2.57[242] | 2.14[243] | 1.49[244] |
36 | MAPK3 | Mitogen-activated protein kinase 3 | [245] | 2.69[246] | 2.67[247] | 2.80[248] | 1.01[249] | 1.31[250] | -0.01[251] |
37 | SRC | Proto-oncogene tyrosine-protein kinase Src | [252] | 3.86[253] | 3.78[254] | 2.88[255] | 2.99[256] | 2.44[257] | 0.18[258] |
38 | CCND3 | G1/S-specific cyclin-D3 | [259] | 1.79[260] | 0.66[261] | -0.87[262] | 4.26[263] | 3.70[264] | 1.69[265] |
39 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [266] | 3.17[267] | 4.29[268] | 3.10[269] | 2.03[270] | 2.70[271] | 3.53[272] |
40 | CCNE1 | G1/S-specific cyclin-E1 | [273] | 2.07[274] | 2.12[275] | 0.40[276] | 0.19[277] | 1.06[278] | -3.60[279] |
41 | MTOR | Serine/threonine-protein kinase mTOR | [280] | 3.37[281] | 4.32[282] | 3.98[283] | 3.27[284] | 3.63[285] | 4.48[286] |
42 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [287] | [288] | [289] | [290] | [291] | [292] | [293] |
43 | RB1 | Retinoblastoma-associated protein | [294] | 2.06[295] | 2.49[296] | 3.15[297] | 2.87[298] | 3.47[299] | 2.51[300] |
44 | GNAO1 | Guanine nucleotide-binding protein G(o) subunit alpha | [301] | -5.59[302] | -7.24[303] | -6.30[304] | -1.99[305] | -5.59[306] | 1.51[307] |
45 | E2F1 | Transcription factor E2F1 | [308] | 2.78[309] | 2.57[310] | 2.80[311] | 2.46[312] | 3.17[313] | -2.58[314] |
46 | PLD1 | Phospholipase D1 | [315] | 3.26[316] | 3.90[317] | 4.49[318] | 1.64[319] | 2.50[320] | 3.09[321] |
47 | TTF1 | Transcription termination factor 1 | [322] | 0.58[323] | 0.99[324] | 1.69[325] | 1.47[326] | 2.02[327] | 0.72[328] |
48 | GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | [329] | 0.91[330] | 1.62[331] | 2.23[332] | 2.18[333] | 2.67[334] | 2.47[335] |
49 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.46[336] | 2.03[337] | 2.31[338] | 1.72[339] | 2.20[340] | 2.94[341] | |
50 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [342] | 2.56[343] | 3.65[344] | 4.24[345] | 3.13[346] | 3.35[347] | 3.37[348] |
51 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [349] | 1.13[350] | -2.15[351] | 2.80[352] | 1.60[353] | -2.16[354] | -0.59[355] |
52 | TTF2 | Transcription termination factor 2 | [356] | 2.80[357] | 2.98[358] | 2.53[359] | 2.77[360] | 2.72[361] | 1.59[362] |
53 | BRAF | Serine/threonine-protein kinase B-raf | [363] | 1.08[364] | 0.75[365] | 2.88[366] | 1.33[367] | 1.30[368] | 2.88[369] |
54 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | [370] | 3.63[371] | 5.19[372] | 4.71[373] | 1.37[374] | 2.13[375] | 3.52[376] |
55 | RALGDS | Ral guanine nucleotide dissociation stimulator | [377] | 3.89[378] | 3.47[379] | 2.36[380] | 3.37[381] | 3.21[382] | 2.30[383] |
56 | PAX8 | Paired box protein Pax-8 | [384] | 1.32[385] | 2.62[386] | 0.12[387] | -1.78[388] | -2.45[389] | -0.35[390] |
57 | JAK2 | Tyrosine-protein kinase JAK2 | [391] | 1.06[392] | 0.99[393] | 0.65[394] | 1.35[395] | 2.22[396] | 3.74[397] |
58 | IGF1R | Insulin-like growth factor 1 receptor | [398] | 5.58[399] | 4.82[400] | 3.59[401] | 5.06[402] | 4.88[403] | 3.12[404] |
59 | GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | -5.44[405] | -6.39[406] | [407] | 3.71[408] | 3.46[409] | 3.81[410] | |
60 | KCNIP3 | Calsenilin | [411] | -5.40[412] | -5.54[413] | -4.57[414] | 0.98[415] | 3.51[416] | 1.12[417] |
61 | PDE4D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | [418] | 4.28[419] | 7.36[420] | 7.56[421] | 5.17[422] | 6.67[423] | 5.76[424] |
62 | ADCY3 | Adenylate cyclase type 3 | [425] | 2.30[426] | 0.99[427] | 4.41[428] | 5.33[429] | 7.13[430] | 4.55[431] |
63 | ADCY2 | Adenylate cyclase type 2 | [432] | -4.54[433] | -2.68[434] | -3.84[435] | -2.14[436] | -2.99[437] | -3.09[438] |
64 | CGA | Glycoprotein hormones alpha chain | [439] | [440] | [441] | -1.48[442] | -2.92[443] | -3.96[444] | -3.07[445] |
65 | TSHR | Thyrotropin receptor | [446] | [447] | 0.51[448] | -1.91[449] | -0.15[450] | -2.73[451] | 7.79[452] |
66 | TSHB | Thyrotropin subunit beta | [453] | [454] | [455] | [456] | [457] | [458] | [459] |
67 | MIR937 | [460] | [461] | [462] | [463] | [464] | [465] | [466] | |
68 | MIR197 | [467] | [468] | [469] | [470] | [471] | [472] | [473] |