WP_THYROID_HORMONES_PRODUCTION_AND_PERIPHERAL_DOWNSTREAM_SIGNALING_ | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | RHEB | GTP-binding protein Rheb | [8] | -1.12[9] | -0.75[10] | -0.87[11] | -0.24[12] | -0.07[13] | -0.62[14] |
3 | CTNNB1 | Catenin beta-1 | [15] | 2.44[16] | 1.73[17] | 2.58[18] | 1.62[19] | 1.90[20] | 1.58[21] |
4 | DIO1 | Type I iodothyronine deiodinase | [22] | -1.43[23] | -1.23[24] | -2.33[25] | -9.23[26] | -8.50[27] | 0.87[28] |
5 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [29] | -0.10[30] | -0.64[31] | -0.10[32] | 0.32[33] | 0.88[34] | -0.72[35] |
6 | MGLL | Monoglyceride lipase | [36] | -8.76[37] | -7.53[38] | 0.50[39] | -2.40[40] | -2.23[41] | 1.71[42] |
7 | GRB2 | Growth factor receptor-bound protein 2 | [43] | 2.02[44] | 1.65[45] | 1.73[46] | 1.42[47] | 1.39[48] | 0.77[49] |
8 | CREB3 | Cyclic AMP-responsive element-binding protein 3 | [50] | 0.20[51] | -0.12[52] | -0.66[53] | -0.30[54] | 0.24[55] | -0.64[56] |
9 | BAD | Bcl2-associated agonist of cell death | [57] | -0.84[58] | -0.92[59] | -1.91[60] | -0.20[61] | 0.25[62] | -0.95[63] |
10 | AKT1S1 | Proline-rich AKT1 substrate 1 | [64] | 0.36[65] | 0.00[66] | 0.31[67] | 0.11[68] | 0.79[69] | -0.72[70] |
11 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [71] | 0.66[72] | 0.28[73] | 0.24[74] | 0.40[75] | 1.04[76] | -0.31[77] |
12 | ITGAV | Integrin alpha-V | [78] | 2.37[79] | 1.96[80] | 1.27[81] | 3.15[82] | 3.08[83] | 0.91[84] |
13 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [85] | 0.76[86] | 0.96[87] | 2.19[88] | 0.68[89] | 1.60[90] | 1.57[91] |
14 | KDM1A | Lysine-specific histone demethylase 1A | [92] | 1.90[93] | 2.29[94] | 1.76[95] | 1.74[96] | 1.32[97] | -0.35[98] |
15 | RXRA | Retinoic acid receptor RXR-alpha | [99] | 0.77[100] | 0.37[101] | 1.17[102] | 0.88[103] | 0.60[104] | 2.62[105] |
16 | PNPLA2 | Patatin-like phospholipase domain-containing protein 2 | [106] | 1.41[107] | 1.29[108] | 0.31[109] | 1.18[110] | 1.10[111] | 0.44[112] |
17 | HRAS | GTPase HRas | [113] | -0.18[114] | -1.09[115] | -1.93[116] | -0.08[117] | -0.25[118] | -2.19[119] |
18 | MAPK1 | Mitogen-activated protein kinase 1 | [120] | 2.53[121] | 2.47[122] | 2.25[123] | 2.71[124] | 2.42[125] | 2.25[126] |
19 | MLST8 | Target of rapamycin complex subunit LST8 | [127] | 0.65[128] | 0.78[129] | 1.10[130] | -0.11[131] | 0.29[132] | -0.09[133] |
20 | KLB | Beta-klotho | [134] | 1.42[135] | 1.05[136] | 2.46[137] | -5.10[138] | -5.69[139] | 2.02[140] |
21 | MAPK14 | Mitogen-activated protein kinase 14 | [141] | 2.30[142] | 2.16[143] | 1.70[144] | 2.55[145] | 2.08[146] | 1.75[147] |
22 | SLC16A2 | Monocarboxylate transporter 8 | [148] | -2.21[149] | -8.03[150] | -9.81[151] | 0.35[152] | -1.16[153] | 1.65[154] |
23 | FGF21 | Fibroblast growth factor 21 | [155] | -7.89[156] | -10.09[157] | -6.52[158] | -8.39[159] | -8.81[160] | -1.74[161] |
24 | MAPKAPK | MAP kinase-activated protein kinase 3 | [162] | 1.84[163] | 1.58[164] | 0.63[165] | -0.61[166] | 1.16[167] | 0.24[168] |
25 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [169] | 1.46[170] | 2.31[171] | 2.49[172] | 1.65[173] | 1.47[174] | 1.49[175] |
26 | SOS1 | Son of sevenless homolog 1 | [176] | 0.73[177] | 2.05[178] | 1.51[179] | 1.71[180] | 1.00[181] | 1.01[182] |
27 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [183] | 2.93[184] | 4.15[185] | 1.34[186] | 1.38[187] | 2.30[188] | 2.64[189] |
28 | MAP4K5 | Mitogen-activated protein kinase kinase kinase kinase 5 | [190] | 0.89[191] | 1.32[192] | 0.14[193] | 2.51[194] | 1.75[195] | 0.64[196] |
29 | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 | [197] | 1.74[198] | 2.99[199] | 1.40[200] | 0.87[201] | 1.06[202] | 4.34[203] |
30 | AQP7 | Aquaporin-7 | [204] | -3.47[205] | -2.56[206] | -3.24[207] | -7.81[208] | -10.14[209] | -0.45[210] |
31 | NHSL1 | NHS-like protein 1 | [211] | 2.06[212] | 2.00[213] | 1.70[214] | -0.85[215] | -0.04[216] | 2.72[217] |
32 | TP53 | Cellular tumor antigen p53 | [218] | 2.46[219] | 1.82[220] | 2.54[221] | 2.16[222] | 1.87[223] | 0.43[224] |
33 | SIRT6 | NAD-dependent protein deacetylase sirtuin-6 | [225] | 0.13[226] | -0.37[227] | 0.31[228] | -0.30[229] | 0.26[230] | -1.18[231] |
34 | TBC1D4 | TBC1 domain family member 4 | [232] | 2.19[233] | 2.66[234] | 2.17[235] | 2.29[236] | 0.18[237] | 1.30[238] |
35 | GSK3B | Glycogen synthase kinase-3 beta | [239] | 2.09[240] | 1.52[241] | 2.05[242] | 2.68[243] | 2.56[244] | 1.63[245] |
36 | KDM3B | Lysine-specific demethylase 3B | [246] | 2.96[247] | 2.64[248] | 2.66[249] | 3.25[250] | 2.89[251] | 2.12[252] |
37 | DUOXA2 | Dual oxidase maturation factor 2 | [253] | -4.08[254] | -8.91[255] | -7.59[256] | [257] | -10.62[258] | -10.21[259] |
38 | SRC | Proto-oncogene tyrosine-protein kinase Src | [260] | 3.85[261] | 3.63[262] | 2.59[263] | 3.26[264] | 2.49[265] | -0.38[266] |
39 | PPARG | Peroxisome proliferator-activated receptor gamma | [267] | 0.74[268] | 2.15[269] | 2.62[270] | 1.71[271] | 1.73[272] | 0.09[273] |
40 | MTOR | Serine/threonine-protein kinase mTOR | [274] | 3.36[275] | 4.17[276] | 3.69[277] | 3.55[278] | 3.68[279] | 3.92[280] |
41 | TSC2 | Tuberin | [281] | 2.64[282] | 1.96[283] | 2.61[284] | 2.07[285] | 2.64[286] | 2.55[287] |
42 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [288] | [289] | [290] | [291] | [292] | [293] | [294] |
43 | SECISBP2L | Selenocysteine insertion sequence-binding protein 2-like | [295] | 1.23[296] | 2.23[297] | 2.96[298] | 3.13[299] | 2.99[300] | 2.29[301] |
44 | CASP9 | Caspase-9 | [302] | 0.98[303] | 1.74[304] | 0.81[305] | 1.11[306] | 0.48[307] | -0.07[308] |
45 | TTF1 | Transcription termination factor 1 | [309] | 0.56[310] | 0.84[311] | 1.40[312] | 1.74[313] | 2.07[314] | 0.16[315] |
46 | THRB | Thyroid hormone receptor beta | [316] | 1.39[317] | 2.01[318] | 3.48[319] | 0.37[320] | 0.08[321] | 2.97[322] |
47 | RPTOR | Regulatory-associated protein of mTOR | [323] | 3.91[324] | 2.94[325] | 3.00[326] | 2.71[327] | 3.00[328] | 2.81[329] |
48 | PLIN1 | Perilipin-1 | [330] | -3.04[331] | -2.86[332] | -3.83[333] | -3.38[334] | -4.01[335] | 2.48[336] |
49 | SLC16A10 | Monocarboxylate transporter 10 | [337] | -0.05[338] | -6.66[339] | 0.91[340] | -5.08[341] | -3.94[342] | 1.01[343] |
50 | PPARGC1 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | -0.26[344] | 2.42[345] | -8.40[346] | 1.63[347] | -1.62[348] | 3.91[349] | |
51 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.45[350] | 1.88[351] | 2.02[352] | 1.99[353] | 2.25[354] | 2.39[355] | |
52 | TSC1 | Hamartin | [356] | 2.71[357] | 3.17[358] | 3.28[359] | 2.92[360] | 3.19[361] | 3.23[362] |
53 | FOXO1 | Forkhead box protein O1 | [363] | 2.52[364] | 1.98[365] | 2.07[366] | 2.04[367] | 4.11[368] | 3.56[369] |
54 | THRA | Thyroid hormone receptor alpha | [370] | 1.93[371] | 0.61[372] | 1.91[373] | 3.69[374] | 2.79[375] | 1.02[376] |
55 | TTF2 | Transcription termination factor 2 | [377] | 2.79[378] | 2.83[379] | 2.24[380] | 3.05[381] | 2.78[382] | 1.03[383] |
56 | ZNF516 | Zinc finger protein 516 | [384] | 3.39[385] | 3.23[386] | 3.19[387] | 2.99[388] | 3.19[389] | 3.19[390] |
57 | IYD | Iodotyrosine deiodinase 1 | [391] | -2.50[392] | -2.46[393] | -1.69[394] | -4.48[395] | -4.23[396] | 2.14[397] |
58 | SHH | Sonic hedgehog protein | [398] | 1.21[399] | 0.85[400] | 0.89[401] | -6.31[402] | -6.40[403] | 0.60[404] |
59 | FRS2 | Fibroblast growth factor receptor substrate 2 | [405] | 2.11[406] | 3.00[407] | 3.46[408] | 3.77[409] | 3.45[410] | 3.81[411] |
60 | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 | [412] | 2.52[413] | 2.81[414] | 2.08[415] | 3.19[416] | 1.83[417] | 2.35[418] |
61 | ITGB3 | Integrin beta-3 | [419] | -0.81[420] | -3.72[421] | -0.24[422] | 3.72[423] | 3.44[424] | 1.80[425] |
62 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | [426] | 3.61[427] | 5.04[428] | 4.42[429] | 1.64[430] | 2.19[431] | 2.96[432] |
63 | POMC | Pro-opiomelanocortin | [433] | [434] | -7.74[435] | [436] | [437] | -6.20[438] | -1.72[439] |
64 | PAX8 | Paired box protein Pax-8 | [440] | 1.31[441] | 2.47[442] | -0.17[443] | -1.51[444] | -2.40[445] | -0.91[446] |
65 | FGFR1 | Fibroblast growth factor receptor 1 | [447] | 5.40[448] | 3.51[449] | 5.12[450] | 5.92[451] | 5.24[452] | 2.13[453] |
66 | NOTCH1 | Neurogenic locus notch homolog protein 1 | [454] | 2.73[455] | 1.37[456] | 2.66[457] | 3.45[458] | 3.86[459] | 5.11[460] |
67 | AKT3 | RAC-gamma serine/threonine-protein kinase | [461] | -1.02[462] | -3.78[463] | -3.13[464] | 6.71[465] | 5.71[466] | 4.08[467] |
68 | NPPB | Natriuretic peptides B | [468] | 1.65[469] | -0.54[470] | -1.58[471] | -0.67[472] | 2.04[473] | [474] |
69 | DIO3 | Thyroxine 5-deiodinase | [475] | [476] | [477] | -3.07[478] | -4.35[479] | -6.20[480] | -2.23[481] |
70 | SLC5A5 | Sodium/iodide cotransporter | [482] | -1.29[483] | -0.66[484] | -0.16[485] | -0.77[486] | -1.35[487] | -1.28[488] |
71 | WNT4 | Protein Wnt-4 | [489] | -2.86[490] | -2.21[491] | -3.36[492] | -0.50[493] | -1.77[494] | 0.68[495] |
72 | DUOX2 | Dual oxidase 2 | [496] | 1.47[497] | -3.70[498] | -1.97[499] | -2.89[500] | -3.26[501] | -1.31[502] |
73 | RPS6KA6 | Ribosomal protein S6 kinase alpha-6 | [503] | [504] | [505] | [506] | [507] | [508] | [509] |
74 | NPR1 | Atrial natriuretic peptide receptor 1 | [510] | -1.94[511] | -3.08[512] | -0.12[513] | -0.36[514] | 5.23[515] | 5.76[516] |
75 | ADCY3 | Adenylate cyclase type 3 | [517] | 2.28[518] | 0.84[519] | 4.12[520] | 5.60[521] | 7.19[522] | 3.99[523] |
76 | MAFA | Transcription factor MafA | [524] | 1.24[525] | -0.61[526] | 0.07[527] | -2.57[528] | -0.50[529] | [530] |
77 | PRKCQ | Protein kinase C theta type | [531] | 1.73[532] | -2.04[533] | [534] | 2.99[535] | 4.55[536] | 2.56[537] |
78 | SLC26A4 | Pendrin | [538] | 0.86[539] | 2.12[540] | 1.89[541] | 1.96[542] | 2.90[543] | 3.84[544] |
79 | NPPA | Natriuretic peptides A | [545] | 0.27[546] | 5.09[547] | 1.01[548] | 1.15[549] | 0.06[550] | -0.14[551] |
80 | TSHR | Thyrotropin receptor | [552] | [553] | 0.36[554] | -2.20[555] | 0.12[556] | -2.67[557] | 7.23[558] |
81 | DIO2 | Type II iodothyronine deiodinase | [559] | -0.25[560] | [561] | -0.75[562] | 6.38[563] | 6.52[564] | 2.63[565] |
82 | PRDM16 | PR domain zinc finger protein 16 | [566] | 3.95[567] | 0.72[568] | 8.20[569] | 1.24[570] | 0.73[571] | 3.86[572] |
83 | PRKG2 | cGMP-dependent protein kinase 2 | [573] | 3.73[574] | [575] | [576] | 7.65[577] | 2.00[578] | 2.51[579] |
84 | TG | Thyroglobulin | [580] | 2.43[581] | -0.84[582] | 5.86[583] | 5.45[584] | 5.61[585] | 6.65[586] |
85 | ADRB3 | Beta-3 adrenergic receptor | [587] | [588] | [589] | [590] | [591] | [592] | [593] |
86 | MC4R | Melanocortin receptor 4 | [594] | [595] | [596] | [597] | [598] | [599] | [600] |
87 | TSHB | Thyrotropin subunit beta | [601] | [602] | [603] | [604] | [605] | [606] | [607] |
88 | UCP1 | Mitochondrial brown fat uncoupling protein 1 | [608] | [609] | [610] | [611] | [612] | [613] | [614] |
89 | AGRP | Agouti-related protein | [615] | [616] | [617] | [618] | [619] | [620] | [621] |
90 | NPY | Pro-neuropeptide Y | [622] | [623] | [624] | [625] | [626] | [627] | [628] |
91 | TPO | Thyroid peroxidase | [629] | [630] | [631] | [632] | [633] | [634] | [635] |
92 | TRH | Pro-thyrotropin-releasing hormone | [636] | [637] | [638] | [639] | [640] | [641] | [642] |
93 | SLCO1C1 | Solute carrier organic anion transporter family member 1C1 | [643] | [644] | [645] | [646] | [647] | [648] | [649] |
94 | ACTL6B | Actin-like protein 6B | [650] | [651] | [652] | [653] | [654] | [655] | [656] |
95 | ADCY8 | Adenylate cyclase type 8 | [657] | [658] | [659] | [660] | [661] | [662] | [663] |