WP_THERMOGENESIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ACTB | Actin, cytoplasmic 1 | [1] | -0.61[2] | -1.08[3] | -0.67[4] | -0.04[5] | -0.32[6] | -0.68[7] |
2 | RPS6 | 40S ribosomal protein S6 | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | ACTG1 | Actin, cytoplasmic 2 | [15] | 0.67[16] | -0.44[17] | -0.56[18] | -0.24[19] | 0.26[20] | -1.43[21] |
4 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | [22] | -1.25[23] | -3.50[24] | -3.09[25] | -4.00[26] | -0.73[27] | 2.77[28] |
5 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 1.20[29] | 1.46[30] | 0.89[31] | 1.80[32] | 1.14[33] | -0.83[34] | |
6 | CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3 | [35] | -4.40[36] | -2.27[37] | -0.99[38] | -8.93[39] | -7.53[40] | 0.38[41] |
7 | RHEB | GTP-binding protein Rheb | [42] | -1.17[43] | -0.37[44] | -0.67[45] | -0.15[46] | 0.06[47] | -0.58[48] |
8 | SLC25A20 | Mitochondrial carnitine/acylcarnitine carrier protein | [49] | -1.52[50] | -1.02[51] | -0.65[52] | -3.00[53] | -2.07[54] | 0.72[55] |
9 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [56] | -0.44[57] | 0.08[58] | -1.25[59] | -0.88[60] | -0.91[61] | -0.93[62] |
10 | ACSL5 | Long-chain-fatty-acid--CoA ligase 5 | [63] | 1.02[64] | 1.15[65] | -2.50[66] | -2.45[67] | -4.89[68] | 1.60[69] |
11 | SMARCE1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 0.53[70] | 0.58[71] | 0.59[72] | 0.89[73] | 0.38[74] | -0.58[75] | |
12 | MGLL | Monoglyceride lipase | [76] | -8.81[77] | -7.15[78] | 0.70[79] | -2.32[80] | -2.09[81] | 1.74[82] |
13 | GRB2 | Growth factor receptor-bound protein 2 | [83] | 1.97[84] | 2.03[85] | 1.93[86] | 1.50[87] | 1.52[88] | 0.80[89] |
14 | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | [90] | -0.64[91] | 0.11[92] | 0.01[93] | 0.61[94] | 0.42[95] | -1.14[96] |
15 | ACSL3 | Long-chain-fatty-acid--CoA ligase 3 | [97] | 0.88[98] | 3.24[99] | 2.20[100] | 1.16[101] | 0.76[102] | 1.23[103] |
16 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | [104] | [105] | [106] | [107] | [108] | [109] | [110] |
17 | CREB3 | Cyclic AMP-responsive element-binding protein 3 | [111] | 0.15[112] | 0.26[113] | -0.46[114] | -0.22[115] | 0.37[116] | -0.61[117] |
18 | SMARCD2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 1.56[118] | 2.23[119] | 1.21[120] | 0.47[121] | 1.03[122] | 0.24[123] | |
19 | AKT1S1 | Proline-rich AKT1 substrate 1 | [124] | 0.31[125] | 0.38[126] | 0.51[127] | 0.20[128] | 0.93[129] | -0.68[130] |
20 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [131] | 0.61[132] | 0.66[133] | 0.43[134] | 0.48[135] | 1.18[136] | -0.27[137] |
21 | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 1.16[138] | 1.57[139] | 1.33[140] | 0.96[141] | 0.29[142] | -0.78[143] | |
22 | KDM1A | Lysine-specific histone demethylase 1A | [144] | 1.85[145] | 2.67[146] | 1.95[147] | 1.83[148] | 1.46[149] | -0.32[150] |
23 | SMARCC1 | SWI/SNF complex subunit SMARCC1 | [151] | 1.92[152] | 2.14[153] | 3.41[154] | 1.56[155] | 1.67[156] | 0.32[157] |
24 | NRAS | GTPase NRas | [158] | 1.41[159] | 2.06[160] | 2.24[161] | 1.95[162] | 1.62[163] | 0.26[164] |
25 | ACTL6A | Actin-like protein 6A | [165] | 1.07[166] | 1.41[167] | 1.23[168] | 1.16[169] | 1.50[170] | -0.65[171] |
26 | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | [172] | -3.28[173] | -8.16[174] | -1.95[175] | -0.79[176] | -0.54[177] | 0.03[178] |
27 | PNPLA2 | Patatin-like phospholipase domain-containing protein 2 | [179] | 1.36[180] | 1.67[181] | 0.50[182] | 1.27[183] | 1.24[184] | 0.48[185] |
28 | CPT2 | Carnitine O-palmitoyltransferase 2, mitochondrial | [186] | -0.73[187] | 0.35[188] | 0.72[189] | -0.50[190] | -0.13[191] | 2.40[192] |
29 | HRAS | GTPase HRas | [193] | -0.23[194] | -0.72[195] | -1.73[196] | 0.00[197] | -0.11[198] | -2.15[199] |
30 | CPT1A | Carnitine O-palmitoyltransferase 1, liver isoform | [200] | 2.23[201] | 0.89[202] | 1.44[203] | 3.19[204] | 1.99[205] | 3.44[206] |
31 | MLST8 | Target of rapamycin complex subunit LST8 | [207] | 0.60[208] | 1.15[209] | 1.30[210] | -0.03[211] | 0.43[212] | -0.06[213] |
32 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | [214] | [215] | [216] | [217] | [218] | [219] | [220] |
33 | KLB | Beta-klotho | [221] | 1.37[222] | 1.43[223] | 2.65[224] | -5.02[225] | -5.55[226] | 2.06[227] |
34 | KRAS | GTPase KRas | [228] | 0.26[229] | 0.46[230] | 1.84[231] | 1.75[232] | 1.52[233] | 1.18[234] |
35 | MAPK14 | Mitogen-activated protein kinase 14 | [235] | 2.25[236] | 2.54[237] | 1.89[238] | 2.63[239] | 2.21[240] | 1.79[241] |
36 | ACSL4 | Long-chain-fatty-acid--CoA ligase 4 | [242] | 3.49[243] | 5.44[244] | 5.52[245] | 2.50[246] | 3.43[247] | 1.47[248] |
37 | FGF21 | Fibroblast growth factor 21 | [249] | -7.94[250] | -9.72[251] | -6.33[252] | -8.31[253] | -8.67[254] | -1.71[255] |
38 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | [256] | 0.69[257] | 2.19[258] | 3.48[259] | 2.41[260] | 2.79[261] | 2.57[262] |
39 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | [263] | 1.66[264] | 3.07[265] | 2.96[266] | 1.98[267] | 1.05[268] | 1.92[269] |
40 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [270] | 1.41[271] | 2.68[272] | 2.69[273] | 1.73[274] | 1.61[275] | 1.53[276] |
41 | SMARCA4 | Transcription activator BRG1 | [277] | 3.17[278] | 2.21[279] | 3.10[280] | 2.34[281] | 2.88[282] | 1.03[283] |
42 | SOS1 | Son of sevenless homolog 1 | [284] | 0.68[285] | 2.43[286] | 1.71[287] | 1.79[288] | 1.13[289] | 1.05[290] |
43 | SMARCA2 | Probable global transcription activator SNF2L2 | [291] | 0.76[292] | 1.21[293] | 1.38[294] | 0.86[295] | 1.81[296] | 1.91[297] |
44 | MAPK13 | Mitogen-activated protein kinase 13 | [298] | 3.12[299] | 3.74[300] | 0.84[301] | -0.94[302] | 0.69[303] | -1.21[304] |
45 | SMARCD1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 2.65[305] | 2.79[306] | 2.78[307] | 2.31[308] | 1.97[309] | -0.30[310] | |
46 | SIRT6 | NAD-dependent protein deacetylase sirtuin-6 | [311] | 0.08[312] | 0.01[313] | 0.51[314] | -0.22[315] | 0.39[316] | -1.15[317] |
47 | SMARCC2 | SWI/SNF complex subunit SMARCC2 | [318] | 2.01[319] | 2.17[320] | 2.43[321] | 3.06[322] | 3.11[323] | 1.97[324] |
48 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | [325] | 1.49[326] | 2.24[327] | 1.16[328] | 0.88[329] | 1.10[330] | 0.51[331] |
49 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [332] | [333] | [334] | [335] | [336] | [337] | [338] |
50 | CREB3L2 | Cyclic AMP-responsive element-binding protein 3-like protein 2 | [339] | 3.17[340] | 3.75[341] | 3.58[342] | 2.86[343] | 2.60[344] | 2.21[345] |
51 | KDM3B | Lysine-specific demethylase 3B | [346] | 2.91[347] | 3.02[348] | 2.85[349] | 3.34[350] | 3.02[351] | 2.15[352] |
52 | PPARG | Peroxisome proliferator-activated receptor gamma | [353] | 0.69[354] | 2.52[355] | 2.81[356] | 1.79[357] | 1.87[358] | 0.13[359] |
53 | MTOR | Serine/threonine-protein kinase mTOR | [360] | 3.31[361] | 4.54[362] | 3.89[363] | 3.63[364] | 3.82[365] | 3.96[366] |
54 | TSC2 | Tuberin | [367] | 2.59[368] | 2.34[369] | 2.80[370] | 2.15[371] | 2.78[372] | 2.59[373] |
55 | ARID1A | AT-rich interactive domain-containing protein 1A | [374] | 3.12[375] | 2.86[376] | 3.15[377] | 3.81[378] | 3.73[379] | 2.94[380] |
56 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [381] | [382] | [383] | [384] | [385] | [386] | [387] |
57 | SLC25A29 | Mitochondrial basic amino acids transporter | [388] | 1.00[389] | 1.59[390] | 0.32[391] | 2.22[392] | 1.42[393] | 0.47[394] |
58 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [395] | -0.06[396] | 0.94[397] | 2.00[398] | 3.18[399] | 2.15[400] | 2.22[401] |
59 | ADCY9 | Adenylate cyclase type 9 | [402] | 3.39[403] | 2.80[404] | 3.00[405] | 1.91[406] | 1.56[407] | 2.92[408] |
60 | KDM3A | Lysine-specific demethylase 3A | [409] | 3.69[410] | 4.38[411] | 3.99[412] | 3.06[413] | 2.85[414] | 1.83[415] |
61 | SOS2 | Son of sevenless homolog 2 | [416] | 0.75[417] | 2.10[418] | 1.10[419] | 2.64[420] | 2.61[421] | 2.35[422] |
62 | CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4 | [423] | 0.19[424] | 1.38[425] | 2.36[426] | 1.33[427] | 0.60[428] | -0.17[429] |
63 | RPTOR | Regulatory-associated protein of mTOR | [430] | 3.86[431] | 3.32[432] | 3.19[433] | 2.80[434] | 3.14[435] | 2.84[436] |
64 | PLIN1 | Perilipin-1 | [437] | -3.09[438] | -2.48[439] | -3.64[440] | -3.29[441] | -3.87[442] | 2.52[443] |
65 | PPARGC1 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | -0.31[444] | 2.80[445] | -8.20[446] | 1.71[447] | -1.48[448] | 3.94[449] | |
66 | ADCY6 | Adenylate cyclase type 6 | [450] | 2.83[451] | 3.51[452] | 3.25[453] | 3.46[454] | 4.23[455] | 3.14[456] |
67 | TSC1 | Hamartin | [457] | 2.67[458] | 3.55[459] | 3.47[460] | 3.01[461] | 3.32[462] | 3.26[463] |
68 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [464] | 2.50[465] | 3.88[466] | 4.14[467] | 3.49[468] | 3.54[469] | 2.85[470] |
69 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | [471] | [472] | [473] | [474] | [475] | [476] | [477] |
70 | ZNF516 | Zinc finger protein 516 | [478] | 3.34[479] | 3.60[480] | 3.38[481] | 3.07[482] | 3.33[483] | 3.23[484] |
71 | ARID1B | AT-rich interactive domain-containing protein 1B | [485] | 3.85[486] | 4.04[487] | 3.61[488] | 3.38[489] | 3.99[490] | 3.48[491] |
72 | DPF3 | Zinc finger protein DPF3 | [492] | -2.95[493] | -4.08[494] | [495] | -3.98[496] | -3.07[497] | 0.18[498] |
73 | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | [499] | -3.52[500] | -6.23[501] | -0.56[502] | -0.92[503] | 3.59[504] | 3.56[505] |
74 | FRS2 | Fibroblast growth factor receptor substrate 2 | [506] | 2.06[507] | 3.38[508] | 3.65[509] | 3.85[510] | 3.59[511] | 3.85[512] |
75 | CPT1B | Carnitine O-palmitoyltransferase 1, muscle isoform | [513] | -2.95[514] | -1.00[515] | -0.80[516] | -3.42[517] | -2.93[518] | -1.59[519] |
76 | FGFR1 | Fibroblast growth factor receptor 1 | [520] | 5.35[521] | 3.89[522] | 5.31[523] | 6.01[524] | 5.38[525] | 2.17[526] |
77 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | [527] | 3.81[528] | 4.48[529] | 4.28[530] | 3.99[531] | 2.14[532] | 2.36[533] |
78 | ADCY1 | Adenylate cyclase type 1 | [534] | -0.06[535] | -1.71[536] | -2.13[537] | -1.16[538] | -1.07[539] | 5.50[540] |
79 | MAPK12 | Mitogen-activated protein kinase 12 | [541] | 3.60[542] | 3.48[543] | 4.37[544] | 2.43[545] | 3.79[546] | -0.40[547] |
80 | ADCY7 | Adenylate cyclase type 7 | [548] | 4.29[549] | 4.13[550] | 2.86[551] | 4.26[552] | 3.84[553] | 3.43[554] |
81 | MAPK11 | Mitogen-activated protein kinase 11 | [555] | 0.60[556] | 0.72[557] | -0.39[558] | 1.30[559] | 3.41[560] | 0.67[561] |
82 | CREB5 | Cyclic AMP-responsive element-binding protein 5 | [562] | 1.71[563] | -1.57[564] | 1.88[565] | 2.41[566] | 3.06[567] | 1.00[568] |
83 | ADCY10 | Adenylate cyclase type 10 | [569] | -1.42[570] | -2.08[571] | 3.83[572] | -0.01[573] | -2.69[574] | 3.27[575] |
84 | SMARCD3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 2.25[576] | 0.80[577] | 2.63[578] | 4.21[579] | 4.50[580] | 1.87[581] | |
85 | BMP8B | Bone morphogenetic protein 8B | [582] | 0.87[583] | 1.45[584] | 2.75[585] | 0.69[586] | 0.46[587] | 0.46[588] |
86 | ACSL6 | Long-chain-fatty-acid--CoA ligase 6 | [589] | 0.71[590] | 3.30[591] | 0.46[592] | -0.32[593] | -0.78[594] | 3.53[595] |
87 | RPS6KA6 | Ribosomal protein S6 kinase alpha-6 | [596] | [597] | [598] | [599] | [600] | [601] | [602] |
88 | NPR1 | Atrial natriuretic peptide receptor 1 | [603] | -1.99[604] | -2.71[605] | 0.07[606] | -0.28[607] | 5.36[608] | 5.80[609] |
89 | BMP8A | Bone morphogenetic protein 8A | [610] | 0.47[611] | 1.93[612] | 3.10[613] | 0.79[614] | 2.77[615] | 3.60[616] |
90 | ADCY3 | Adenylate cyclase type 3 | [617] | 2.24[618] | 1.21[619] | 4.31[620] | 5.69[621] | 7.32[622] | 4.02[623] |
91 | CREB3L1 | Cyclic AMP-responsive element-binding protein 3-like protein 1 | [624] | 0.77[625] | -1.94[626] | 7.51[627] | 6.26[628] | 6.65[629] | 0.27[630] |
92 | ADCY2 | Adenylate cyclase type 2 | [631] | -4.61[632] | -2.45[633] | -3.93[634] | -1.78[635] | -2.80[636] | -3.61[637] |
93 | CPT1C | Carnitine O-palmitoyltransferase 1, brain isoform | [638] | 0.50[639] | -0.33[640] | -0.43[641] | 2.50[642] | 7.12[643] | 2.11[644] |
94 | LIPE | Hormone-sensitive lipase | [645] | -4.07[646] | [647] | 0.46[648] | 3.00[649] | 3.10[650] | 2.64[651] |
95 | DPF1 | Zinc finger protein neuro-d4 | [652] | 3.68[653] | 2.73[654] | 2.52[655] | 3.72[656] | 4.84[657] | -4.20[658] |
96 | ADCY5 | Adenylate cyclase type 5 | [659] | 0.93[660] | 2.15[661] | 2.95[662] | 1.60[663] | 2.83[664] | 6.88[665] |
97 | PRKG1 | cGMP-dependent protein kinase 1 | [666] | 0.62[667] | [668] | 1.99[669] | 4.13[670] | 6.14[671] | 7.02[672] |
98 | PRDM16 | PR domain zinc finger protein 16 | [673] | 3.90[674] | 1.10[675] | 8.40[676] | 1.32[677] | 0.87[678] | 3.90[679] |
99 | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | [680] | -0.96[681] | [682] | -1.30[683] | -0.07[684] | [685] | 3.63[686] |
100 | PRKG2 | cGMP-dependent protein kinase 2 | [687] | 3.68[688] | [689] | [690] | 7.74[691] | 2.14[692] | 2.55[693] |
101 | ADCY4 | Adenylate cyclase type 4 | [694] | 0.87[695] | 0.01[696] | 2.43[697] | [698] | [699] | 8.87[700] |
102 | ADRB3 | Beta-3 adrenergic receptor | [701] | [702] | [703] | [704] | [705] | [706] | [707] |
103 | UCP1 | Mitochondrial brown fat uncoupling protein 1 | [708] | [709] | [710] | [711] | [712] | [713] | [714] |
104 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [715] | [716] | [717] | [718] | [719] | [720] | [721] |
105 | GCG | Glucagon | [722] | [723] | [724] | [725] | [726] | [727] | [728] |
106 | CNR1 | Cannabinoid receptor 1 | [729] | [730] | [731] | [732] | [733] | [734] | [735] |
107 | ACTL6B | Actin-like protein 6B | [736] | [737] | [738] | [739] | [740] | [741] | [742] |
108 | ADCY8 | Adenylate cyclase type 8 | [743] | [744] | [745] | [746] | [747] | [748] | [749] |