WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SERPINE1 | Plasminogen activator inhibitor 1 | [1] | -0.08[2] | 0.59[3] | -5.38[4] | -4.45[5] | 1.33[6] | -4.30[7] |
2 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | [8] | -1.32[9] | -1.28[10] | -2.08[11] | -0.91[12] | -2.21[13] | -1.80[14] |
3 | JUN | Transcription factor AP-1 | [15] | -1.70[16] | -2.80[17] | -1.76[18] | -2.35[19] | -2.67[20] | -2.23[21] |
4 | FOS | Proto-oncogene c-Fos | [22] | -7.22[23] | -5.52[24] | -5.41[25] | -6.82[26] | -6.64[27] | -1.73[28] |
5 | CTNNB1 | Catenin beta-1 | [29] | 0.41[30] | 0.35[31] | 2.01[32] | 0.11[33] | -0.55[34] | 0.68[35] |
6 | STAT3 | Signal transducer and activator of transcription 3 | [36] | -0.66[37] | -1.71[38] | -0.21[39] | -0.41[40] | -2.02[41] | 1.98[42] |
7 | SPP1 | Osteopontin | [43] | 1.97[44] | 1.18[45] | -6.55[46] | 1.25[47] | -7.71[48] | -1.51[49] |
8 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [50] | -1.28[51] | -1.76[52] | 0.12[53] | 1.88[54] | -1.27[55] | 0.52[56] |
9 | TGIF1 | Homeobox protein TGIF1 | [57] | -1.51[58] | -1.71[59] | -0.11[60] | -1.04[61] | -2.29[62] | -2.28[63] |
10 | JAK1 | Tyrosine-protein kinase JAK1 | [64] | -0.70[65] | -0.77[66] | 0.18[67] | -0.02[68] | -0.27[69] | 1.10[70] |
11 | HRAS | GTPase HRas | [71] | -2.22[72] | -2.48[73] | -2.50[74] | -1.60[75] | -2.70[76] | -3.09[77] |
12 | TGFBR2 | TGF-beta receptor type-2 | [78] | 1.61[79] | 1.52[80] | 1.94[81] | 0.41[82] | 1.24[83] | 1.08[84] |
13 | THBS1 | Thrombospondin-1 | [85] | 1.29[86] | -3.09[87] | -2.32[88] | 2.19[89] | 0.99[90] | 0.69[91] |
14 | TFE3 | Transcription factor E3 | [92] | -0.55[93] | -0.76[94] | 0.51[95] | 0.78[96] | -1.14[97] | -0.52[98] |
15 | BAMBI | BMP and activin membrane-bound inhibitor homolog | [99] | 0.01[100] | -0.59[101] | 0.85[102] | 0.36[103] | -1.24[104] | -2.08[105] |
16 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [106] | -0.54[107] | -0.42[108] | 0.14[109] | -0.90[110] | -0.87[111] | 0.02[112] |
17 | SMAD3 | Mothers against decapentaplegic homolog 3 | [113] | 0.72[114] | 0.56[115] | 1.56[116] | 1.15[117] | 1.14[118] | -0.21[119] |
18 | SMAD1 | Mothers against decapentaplegic homolog 1 | [120] | -2.26[121] | -1.56[122] | -0.50[123] | -1.38[124] | -1.71[125] | 0.20[126] |
19 | LTBP3 | Latent-transforming growth factor beta-binding protein 3 | [127] | 0.77[128] | 0.63[129] | 0.74[130] | 1.04[131] | 1.25[132] | -0.15[133] |
20 | TGFBR1 | TGF-beta receptor type-1 | [134] | -0.88[135] | -0.21[136] | 0.06[137] | -0.31[138] | -0.09[139] | 0.91[140] |
21 | MAPK9 | Mitogen-activated protein kinase 9 | [141] | 0.02[142] | 0.69[143] | 1.52[144] | 1.06[145] | -0.37[146] | 0.08[147] |
22 | MAPK3 | Mitogen-activated protein kinase 3 | [148] | 0.64[149] | 1.13[150] | 1.94[151] | -0.23[152] | -1.09[153] | -1.47[154] |
23 | SMAD7 | Mothers against decapentaplegic homolog 7 | [155] | 0.65[156] | -0.79[157] | -1.04[158] | -0.06[159] | -1.25[160] | -0.43[161] |
24 | FST | Follistatin | [162] | -1.25[163] | 0.85[164] | -2.08[165] | -5.40[166] | -5.01[167] | -0.38[168] |
25 | SKI | Ski oncogene | [169] | 1.26[170] | 1.40[171] | 1.65[172] | 1.52[173] | 0.97[174] | 0.60[175] |
26 | SMAD4 | Mothers against decapentaplegic homolog 4 | [176] | 0.18[177] | 1.26[178] | 1.99[179] | 1.26[180] | 0.74[181] | 2.36[182] |
27 | SMAD5 | Mothers against decapentaplegic homolog 5 | [183] | 0.62[184] | 1.76[185] | 2.31[186] | 2.00[187] | 1.15[188] | 2.53[189] |
28 | SMAD2 | Mothers against decapentaplegic homolog 2 | [190] | 0.81[191] | 1.51[192] | 1.78[193] | 1.73[194] | 1.04[195] | 2.14[196] |
29 | EP300 | Histone acetyltransferase p300 | [197] | 1.51[198] | 1.55[199] | 3.21[200] | 1.92[201] | 1.09[202] | 2.33[203] |
30 | TGFB1 | Transforming growth factor beta-1 | [204] | 2.26[205] | 1.67[206] | -0.31[207] | 3.19[208] | 1.53[209] | -1.66[210] |
31 | SKIL | Ski-like protein | [211] | 0.45[212] | 0.94[213] | 3.16[214] | 1.99[215] | 1.12[216] | 2.73[217] |
32 | ZFYVE9 | Zinc finger FYVE domain-containing protein 9 | [218] | 0.43[219] | 1.12[220] | 1.83[221] | 0.95[222] | 0.52[223] | 1.78[224] |
33 | TGFBR3 | Transforming growth factor beta receptor type 3 | [225] | 1.08[226] | 3.57[227] | 2.91[228] | 1.21[229] | -1.35[230] | 2.55[231] |
34 | CREBBP | CREB-binding protein | [232] | 1.69[233] | 1.35[234] | 2.73[235] | 2.11[236] | 1.23[237] | 2.81[238] |
35 | LTBP1 | Latent-transforming growth factor beta-binding protein 1 | [239] | -1.96[240] | -7.57[241] | -0.77[242] | 1.61[243] | 0.94[244] | 1.96[245] |
36 | BMP4 | Bone morphogenetic protein 4 | [246] | 3.28[247] | 2.95[248] | 0.65[249] | 1.35[250] | -1.67[251] | -1.61[252] |
37 | LIF | Leukemia inhibitory factor | [253] | 1.07[254] | 1.35[255] | 2.95[256] | 0.97[257] | 1.10[258] | -5.61[259] |
38 | ENG | Endoglin | [260] | -2.10[261] | 0.14[262] | -5.10[263] | 2.40[264] | -2.34[265] | 3.48[266] |
39 | SMAD6 | Mothers against decapentaplegic homolog 6 | [267] | 0.20[268] | -1.09[269] | 0.09[270] | 0.80[271] | -1.63[272] | 0.43[273] |
40 | INHBA | Inhibin beta A chain | [274] | -8.70[275] | -7.97[276] | -6.75[277] | 2.27[278] | -2.22[279] | 0.18[280] |
41 | ADAMTSL | ADAMTS-like protein 2 | [281] | 2.73[282] | -0.25[283] | -2.72[284] | -3.74[285] | -4.69[286] | 2.65[287] |
42 | LEFTY1 | Left-right determination factor 1 | [288] | -1.75[289] | -2.78[290] | -0.78[291] | -5.21[292] | -6.05[293] | -1.36[294] |
43 | ZEB2 | Zinc finger E-box-binding homeobox 2 | [295] | -1.83[296] | -5.73[297] | -4.45[298] | 4.16[299] | 4.17[300] | 5.09[301] |
44 | SMAD9 | Mothers against decapentaplegic homolog 9 | [302] | 2.77[303] | 2.91[304] | 2.94[305] | 1.55[306] | 2.17[307] | 2.45[308] |
45 | ITGB6 | Integrin beta-6 | [309] | [310] | [311] | [312] | -1.75[313] | -5.44[314] | -3.19[315] |
46 | ADAMTS1 | A disintegrin and metalloproteinase with thrombospondin motifs 10 | -0.57[316] | -5.49[317] | 2.33[318] | 2.08[319] | -0.29[320] | 2.30[321] | |
47 | IFNG | Interferon gamma | [322] | [323] | [324] | [325] | -1.34[326] | [327] | -2.72[328] |
48 | RUNX3 | Runt-related transcription factor 3 | [329] | -0.45[330] | -0.98[331] | 2.77[332] | 2.92[333] | -3.16[334] | 0.94[335] |
49 | TNF | Tumor necrosis factor | [336] | -0.11[337] | -1.80[338] | -5.63[339] | -2.87[340] | -6.98[341] | -2.32[342] |
50 | FOXH1 | Forkhead box protein H1 | [343] | -4.15[344] | 2.07[345] | -3.96[346] | -3.70[347] | -4.65[348] | -3.65[349] |
51 | FBN1 | Fibrillin-1 | [350] | 1.85[351] | 0.36[352] | 3.67[353] | 5.69[354] | 7.77[355] | 6.97[356] |
52 | LEFTY2 | Left-right determination factor 2 | [357] | -0.95[358] | -0.70[359] | 3.06[360] | -0.46[361] | -5.92[362] | -2.45[363] |
53 | LEF1 | Lymphoid enhancer-binding factor 1 | [364] | 1.44[365] | -5.04[366] | 3.65[367] | 0.43[368] | -2.16[369] | 0.66[370] |
54 | ZNF423 | Zinc finger protein 423 | [371] | 0.39[372] | -4.67[373] | 0.79[374] | 0.79[375] | -4.26[376] | 3.05[377] |
55 | RUNX2 | Runt-related transcription factor 2 | [378] | -2.06[379] | -1.97[380] | 3.86[381] | 6.47[382] | 7.54[383] | 3.20[384] |
56 | EGF | Pro-epidermal growth factor | [385] | 0.76[386] | 2.99[387] | 7.37[388] | 8.38[389] | 4.91[390] | 1.15[391] |
57 | LINC02478 | [392] | [393] | [394] | [395] | [396] | [397] | [398] | |
58 | MIR6869 | [399] | [400] | [401] | [402] | [403] | [404] | [405] | |
59 | WNT1 | Proto-oncogene Wnt-1 | [406] | [407] | [408] | [409] | [410] | [411] | [412] |
60 | MIR302A | [413] | [414] | [415] | [416] | [417] | [418] | [419] | |
61 | NOG | Noggin | [420] | [421] | [422] | [423] | [424] | [425] | [426] |
62 | MIR1281 | [427] | [428] | [429] | [430] | [431] | [432] | [433] |