WP_TCELL_RECEPTOR_TCR_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CDC42 | Cell division control protein 42 homolog | [1] | -0.80[2] | -0.17[3] | -1.09[4] | -1.06[5] | -1.65[6] | -2.01[7] |
2 | NFKBIA | NF-kappa-B inhibitor alpha | [8] | -1.03[9] | -2.90[10] | -3.20[11] | -4.05[12] | -2.04[13] | -1.07[14] |
3 | VIM | Vimentin | [15] | -8.32[16] | -8.84[17] | -3.11[18] | 2.07[19] | 1.62[20] | -1.17[21] |
4 | JUN | Transcription factor AP-1 | [22] | -0.46[23] | -2.09[24] | -1.74[25] | -2.23[26] | -1.53[27] | -1.74[28] |
5 | FOS | Proto-oncogene c-Fos | [29] | -5.98[30] | -4.81[31] | -5.39[32] | -6.70[33] | -5.50[34] | -1.23[35] |
6 | AKT1 | RAC-alpha serine/threonine-protein kinase | [36] | 0.11[37] | -0.21[38] | -1.21[39] | -0.58[40] | -0.43[41] | -0.18[42] |
7 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [43] | -0.90[44] | -1.31[45] | -0.65[46] | -1.07[47] | -0.43[48] | -1.12[49] |
8 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [50] | 0.08[51] | -0.32[52] | 0.62[53] | -1.37[54] | -0.76[55] | -1.63[56] |
9 | DBNL | Drebrin-like protein | [57] | -0.42[58] | -1.09[59] | -1.33[60] | -0.50[61] | -0.56[62] | -0.61[63] |
10 | IKBKG | NF-kappa-B essential modulator | [64] | -0.86[65] | -0.80[66] | -2.97[67] | -1.38[68] | -2.46[69] | -0.53[70] |
11 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [71] | 0.47[72] | 0.82[73] | 0.85[74] | 0.36[75] | 1.12[76] | 1.33[77] |
12 | GRB2 | Growth factor receptor-bound protein 2 | [78] | 1.22[79] | 0.98[80] | 1.18[81] | 0.03[82] | 0.07[83] | 0.37[84] |
13 | CRK | Adapter molecule crk | [85] | -0.18[86] | -0.32[87] | -0.18[88] | -0.77[89] | -0.24[90] | 0.91[91] |
14 | SHC1 | SHC-transforming protein 1 | [92] | 1.19[93] | 1.33[94] | 1.48[95] | 2.12[96] | 1.74[97] | 0.85[98] |
15 | RELA | Transcription factor p65 | [99] | 0.16[100] | -0.43[101] | -0.21[102] | -0.58[103] | -0.55[104] | -0.81[105] |
16 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [106] | -0.04[107] | 0.29[108] | 1.63[109] | -0.71[110] | 0.28[111] | 1.17[112] |
17 | CD4 | T-cell surface glycoprotein CD4 | [113] | -5.73[114] | -3.63[115] | -6.18[116] | -7.98[117] | -9.90[118] | -0.01[119] |
18 | HRAS | GTPase HRas | [120] | -0.98[121] | -1.77[122] | -2.48[123] | -1.48[124] | -1.56[125] | -2.59[126] |
19 | NCK1 | Cytoplasmic protein NCK1 | [127] | -1.57[128] | -1.55[129] | -1.36[130] | -1.09[131] | -0.85[132] | -0.40[133] |
20 | FAS | Tumor necrosis factor receptor superfamily member 6 | [134] | -1.57[135] | -0.88[136] | -8.81[137] | -2.27[138] | -1.62[139] | -1.65[140] |
21 | MAPK1 | Mitogen-activated protein kinase 1 | [141] | 1.74[142] | 1.79[143] | 1.70[144] | 1.32[145] | 1.10[146] | 1.84[147] |
22 | MAPK14 | Mitogen-activated protein kinase 14 | [148] | 1.50[149] | 1.49[150] | 1.14[151] | 1.15[152] | 0.76[153] | 1.35[154] |
23 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [155] | -0.07[156] | 0.91[157] | 0.86[158] | -0.04[159] | 0.27[160] | 0.32[161] |
24 | IL15RA | Interleukin-15 receptor subunit alpha | [162] | -5.86[163] | -8.64[164] | -8.52[165] | -1.99[166] | -1.91[167] | -1.30[168] |
25 | CRKL | Crk-like protein | [169] | 1.73[170] | 1.74[171] | 2.43[172] | 0.60[173] | 0.93[174] | 1.52[175] |
26 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [176] | 0.67[177] | 1.63[178] | 1.94[179] | 0.25[180] | 0.16[181] | 1.09[182] |
27 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [183] | -0.44[184] | -0.41[185] | 0.76[186] | 1.54[187] | 1.17[188] | 3.07[189] |
28 | MAPK8 | Mitogen-activated protein kinase 8 | [190] | -1.42[191] | -0.09[192] | -1.14[193] | -1.43[194] | -1.44[195] | -0.44[196] |
29 | SOS1 | Son of sevenless homolog 1 | [197] | -0.07[198] | 1.37[199] | 0.96[200] | 0.32[201] | -0.32[202] | 0.61[203] |
30 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [204] | 0.70[205] | 0.29[206] | 0.16[207] | -0.78[208] | 0.26[209] | 0.52[210] |
31 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [211] | 1.90[212] | 2.04[213] | 2.73[214] | 0.18[215] | 0.87[216] | -0.22[217] |
32 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | [218] | -0.55[219] | -0.03[220] | 0.06[221] | -0.73[222] | -0.63[223] | -1.06[224] |
33 | MAPK9 | Mitogen-activated protein kinase 9 | [225] | 1.25[226] | 1.40[227] | 1.54[228] | 1.19[229] | 0.77[230] | 0.58[231] |
34 | SKAP1 | Src kinase-associated phosphoprotein 1 | [232] | -9.96[233] | -7.41[234] | -8.25[235] | -4.40[236] | -6.24[237] | -1.01[238] |
35 | MAPK3 | Mitogen-activated protein kinase 3 | [239] | 1.88[240] | 1.84[241] | 1.96[242] | -0.10[243] | 0.05[244] | -0.97[245] |
36 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [246] | 0.93[247] | 2.07[248] | 2.11[249] | 0.12[250] | 1.06[251] | 1.58[252] |
37 | PRKCD | Protein kinase C delta type | [253] | 1.13[254] | 1.29[255] | 0.85[256] | -1.03[257] | 0.25[258] | -1.00[259] |
38 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [260] | 2.36[261] | 3.47[262] | 2.26[263] | 0.91[264] | 1.43[265] | 2.57[266] |
39 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.52[267] | 3.05[268] | 2.46[269] | 2.29[270] | 1.92[271] | 0.41[272] | |
40 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [273] | 0.55[274] | 0.52[275] | 0.71[276] | -0.27[277] | -0.05[278] | 1.25[279] |
41 | IL1B | Interleukin-1 beta | [280] | -8.67[281] | -8.62[282] | -4.22[283] | -4.12[284] | 1.60[285] | -5.13[286] |
42 | BCL10 | B-cell lymphoma/leukemia 10 | [287] | 0.12[288] | -0.46[289] | 0.60[290] | 0.01[291] | 0.18[292] | 0.60[293] |
43 | SH2B3 | SH2B adapter protein 3 | [294] | 1.15[295] | 0.65[296] | 0.95[297] | 1.03[298] | 1.98[299] | 1.47[300] |
44 | PAK1 | Serine/threonine-protein kinase PAK 1 | [301] | 0.02[302] | -0.83[303] | 1.66[304] | -2.38[305] | 1.52[306] | 0.34[307] |
45 | TGFB1 | Transforming growth factor beta-1 | [308] | 3.50[309] | 2.38[310] | -0.29[311] | 3.31[312] | 2.67[313] | -1.16[314] |
46 | FYN | Tyrosine-protein kinase Fyn | [315] | 0.97[316] | -7.71[317] | 0.93[318] | 0.94[319] | 2.60[320] | 1.04[321] |
47 | CBLB | E3 ubiquitin-protein ligase CBL-B | [322] | -0.62[323] | 0.54[324] | 1.05[325] | 0.25[326] | 1.24[327] | 1.44[328] |
48 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 2.88[329] | 2.64[330] | 2.14[331] | 1.51[332] | 0.92[333] | 2.33[334] | |
49 | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | [335] | -0.37[336] | 0.00[337] | -1.09[338] | 1.55[339] | 0.66[340] | 0.95[341] |
50 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [342] | 1.75[343] | 2.82[344] | 3.39[345] | 2.01[346] | 2.08[347] | 2.41[348] |
51 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [349] | 1.77[350] | 1.70[351] | 0.96[352] | -0.42[353] | 1.03[354] | 0.56[355] |
52 | PTK2B | Protein-tyrosine kinase 2-beta | [356] | -0.78[357] | 0.49[358] | 1.54[359] | -2.31[360] | 0.45[361] | 1.84[362] |
53 | GAB2 | GRB2-associated-binding protein 2 | [363] | 1.59[364] | 1.30[365] | 1.62[366] | 0.39[367] | 0.61[368] | 0.61[369] |
54 | IL6 | Interleukin-6 | [370] | -8.41[371] | [372] | -4.81[373] | -1.38[374] | 1.26[375] | [376] |
55 | CD83 | CD83 antigen | [377] | -0.14[378] | -2.56[379] | -2.95[380] | -1.14[381] | 0.29[382] | -2.25[383] |
56 | TRAF6 | TNF receptor-associated factor 6 | [384] | 1.12[385] | 0.92[386] | 1.57[387] | 1.13[388] | 0.72[389] | 2.98[390] |
57 | WAS | Wiskott-Aldrich syndrome protein | [391] | -5.69[392] | -5.22[393] | -1.71[394] | -4.04[395] | -4.95[396] | -0.34[397] |
58 | LCP2 | Lymphocyte cytosolic protein 2 | [398] | [399] | [400] | [401] | -4.24[402] | [403] | 1.22[404] |
59 | LAT | Linker for activation of T-cells family member 1 | [405] | -1.42[406] | 0.03[407] | -1.48[408] | -1.89[409] | -1.19[410] | -0.35[411] |
60 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | [412] | -8.84[413] | [414] | -5.36[415] | [416] | [417] | -0.54[418] |
61 | VAV3 | Guanine nucleotide exchange factor VAV3 | [419] | 1.84[420] | 0.04[421] | 2.29[422] | 3.16[423] | -2.69[424] | 1.42[425] |
62 | CBL | E3 ubiquitin-protein ligase CBL | [426] | 4.48[427] | 3.34[428] | 3.64[429] | 4.61[430] | 4.22[431] | 3.83[432] |
63 | REL | Proto-oncogene c-Rel | [433] | -0.49[434] | 1.19[435] | 1.21[436] | -0.38[437] | -0.10[438] | 2.41[439] |
64 | IRF4 | Interferon regulatory factor 4 | [440] | -4.80[441] | -4.55[442] | -5.09[443] | -4.83[444] | -5.82[445] | 0.68[446] |
65 | VAV1 | Proto-oncogene vav | [447] | -8.47[448] | -3.72[449] | -5.36[450] | -6.61[451] | -7.75[452] | 1.25[453] |
66 | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 | [454] | -1.92[455] | -4.52[456] | 2.16[457] | -6.50[458] | 2.03[459] | 0.79[460] |
67 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | [461] | 3.17[462] | 2.97[463] | 4.20[464] | 2.32[465] | 3.32[466] | 4.72[467] |
68 | CD247 | T-cell surface glycoprotein CD3 zeta chain | [468] | -4.84[469] | -5.60[470] | -7.02[471] | -4.04[472] | -5.30[473] | 0.05[474] |
69 | TNFRSF9 | Tumor necrosis factor receptor superfamily member 9 | [475] | 0.39[476] | -0.90[477] | -1.36[478] | 4.03[479] | 3.57[480] | -1.64[481] |
70 | CD3D | T-cell surface glycoprotein CD3 delta chain | [482] | 1.43[483] | -0.67[484] | -2.96[485] | -7.03[486] | -4.91[487] | -0.26[488] |
71 | NFATC2 | Nuclear factor of activated T-cells, cytoplasmic 2 | [489] | 2.61[490] | 3.79[491] | 3.28[492] | -0.35[493] | 0.74[494] | 3.35[495] |
72 | LCK | Tyrosine-protein kinase Lck | [496] | 2.80[497] | 2.80[498] | -7.12[499] | -5.61[500] | -5.68[501] | 1.30[502] |
73 | CD8A | T-cell surface glycoprotein CD8 alpha chain | [503] | -0.60[504] | -4.44[505] | 0.77[506] | -5.21[507] | -3.72[508] | 0.91[509] |
74 | PSTPIP1 | Proline-serine-threonine phosphatase-interacting protein 1 | [510] | 0.26[511] | 1.90[512] | [513] | -4.82[514] | -0.04[515] | 0.75[516] |
75 | CD3G | T-cell surface glycoprotein CD3 gamma chain | [517] | -3.56[518] | -2.89[519] | -3.87[520] | -5.14[521] | -4.42[522] | -0.27[523] |
76 | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 | [524] | -2.37[525] | -0.74[526] | -1.29[527] | -0.68[528] | -1.95[529] | 1.40[530] |
77 | ZAP70 | Tyrosine-protein kinase ZAP-70 | [531] | 1.03[532] | 1.16[533] | -4.98[534] | -6.07[535] | -4.60[536] | 2.23[537] |
78 | ITK | Tyrosine-protein kinase ITK/TSK | [538] | -6.87[539] | -3.97[540] | [541] | -0.69[542] | -5.30[543] | 2.26[544] |
79 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | [545] | -4.16[546] | [547] | 2.74[548] | 0.78[549] | 1.03[550] | 1.28[551] |
80 | CARD11 | Caspase recruitment domain-containing protein 11 | [552] | 1.16[553] | -5.44[554] | -6.13[555] | 0.72[556] | 5.36[557] | 2.34[558] |
81 | CD28 | T-cell-specific surface glycoprotein CD28 | [559] | -3.97[560] | -3.19[561] | -3.08[562] | -2.87[563] | -2.80[564] | 1.19[565] |
82 | CCR5 | C-C chemokine receptor type 5 | [566] | -6.09[567] | [568] | 2.12[569] | -6.56[570] | [571] | 0.63[572] |
83 | GRAP2 | GRB2-related adapter protein 2 | [573] | -5.82[574] | [575] | -2.21[576] | -2.51[577] | -1.34[578] | 0.91[579] |
84 | PRKCQ | Protein kinase C theta type | [580] | 0.93[581] | -2.71[582] | [583] | 1.60[584] | 3.23[585] | 2.16[586] |
85 | IL1A | Interleukin-1 alpha | [587] | -0.40[588] | -0.88[589] | -1.98[590] | -1.17[591] | 5.71[592] | -1.51[593] |
86 | ICOS | Inducible T-cell costimulator | [594] | [595] | -3.43[596] | [597] | [598] | [599] | -0.49[600] |
87 | IL17A | Interleukin-17A | [601] | [602] | [603] | [604] | [605] | [606] | [607] |
88 | OPRM1 | Mu-type opioid receptor | [608] | [609] | -2.45[610] | [611] | [612] | -3.58[613] | -2.41[614] |
89 | IL9 | Interleukin-9 | [615] | [616] | [617] | [618] | [619] | [620] | [621] |
90 | FYB1 | FYN-binding protein 1 | [622] | [623] | [624] | [625] | [626] | [627] | [628] |
91 | MIR6837 | [629] | [630] | [631] | [632] | [633] | [634] | [635] |