WP_TCELL_ACTIVATION_SARSCOV2 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | NFKBIA | NF-kappa-B inhibitor alpha | [1] | -1.49[2] | -2.87[3] | -3.41[4] | -3.29[5] | -1.65[6] | -1.28[7] |
2 | RHEB | GTP-binding protein Rheb | [8] | -2.38[9] | -1.39[10] | -1.63[11] | -0.87[12] | -1.00[13] | -1.24[14] |
3 | JUN | Transcription factor AP-1 | [15] | -0.92[16] | -2.05[17] | -1.94[18] | -1.47[19] | -1.14[20] | -1.96[21] |
4 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [22] | 0.41[23] | -0.57[24] | -3.42[25] | -1.75[26] | 0.56[27] | -1.98[28] |
5 | FOS | Proto-oncogene c-Fos | [29] | -6.44[30] | -4.77[31] | -5.60[32] | -5.93[33] | -5.11[34] | -1.45[35] |
6 | AKT1 | RAC-alpha serine/threonine-protein kinase | [36] | -0.35[37] | -0.17[38] | -1.41[39] | 0.18[40] | -0.04[41] | -0.39[42] |
7 | HLA-DRA | HLA class II histocompatibility antigen, DR alpha chain | [43] | -13.70[44] | [45] | -14.46[46] | -5.52[47] | -7.69[48] | -0.72[49] |
8 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [50] | -1.36[51] | -1.28[52] | -0.86[53] | -0.31[54] | -0.05[55] | -1.34[56] |
9 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [57] | -0.38[58] | -0.29[59] | 0.42[60] | -0.61[61] | -0.37[62] | -1.85[63] |
10 | BCL2L1 | Bcl-2-like protein 1 | [64] | 1.71[65] | 1.51[66] | 2.30[67] | -0.38[68] | -0.24[69] | -0.96[70] |
11 | BAX | Apoptosis regulator BAX | [71] | -0.10[72] | -0.48[73] | -1.11[74] | -1.37[75] | -1.23[76] | -4.10[77] |
12 | CCND1 | G1/S-specific cyclin-D1 | [78] | 2.62[79] | 0.53[80] | 1.20[81] | 2.11[82] | 0.39[83] | 0.91[84] |
13 | IKBKG | NF-kappa-B essential modulator | [85] | -1.32[86] | -0.76[87] | -3.17[88] | -0.62[89] | -2.07[90] | -0.75[91] |
14 | GRB2 | Growth factor receptor-bound protein 2 | [92] | 0.76[93] | 1.01[94] | 0.97[95] | 0.79[96] | 0.46[97] | 0.15[98] |
15 | HLA-DRB1 | HLA class II histocompatibility antigen, DRB1-15 beta chain | [99] | -8.87[100] | [101] | [102] | -5.87[103] | -11.19[104] | -1.80[105] |
16 | RELA | Transcription factor p65 | [106] | -0.30[107] | -0.39[108] | -0.42[109] | 0.18[110] | -0.16[111] | -1.03[112] |
17 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [113] | -0.49[114] | 0.32[115] | 1.43[116] | 0.05[117] | 0.67[118] | 0.95[119] |
18 | CD4 | T-cell surface glycoprotein CD4 | [120] | -6.19[121] | -3.59[122] | -6.38[123] | -7.22[124] | -9.52[125] | -0.23[126] |
19 | IFNAR2 | Interferon alpha/beta receptor 2 | [127] | -1.64[128] | -1.57[129] | -1.05[130] | -1.16[131] | -1.41[132] | -0.92[133] |
20 | MYD88 | Myeloid differentiation primary response protein MyD88 | [134] | -0.62[135] | -0.15[136] | -0.88[137] | -0.80[138] | -0.75[139] | 0.65[140] |
21 | HRAS | GTPase HRas | [141] | -1.44[142] | -1.73[143] | -2.69[144] | -0.72[145] | -1.17[146] | -2.81[147] |
22 | MAPK1 | Mitogen-activated protein kinase 1 | [148] | 1.28[149] | 1.83[150] | 1.49[151] | 2.08[152] | 1.49[153] | 1.63[154] |
23 | MLST8 | Target of rapamycin complex subunit LST8 | [155] | -0.60[156] | 0.14[157] | 0.35[158] | -0.74[159] | -0.64[160] | -0.71[161] |
24 | IFNAR1 | Interferon alpha/beta receptor 1 | [162] | -0.37[163] | 0.51[164] | 0.06[165] | 1.22[166] | 0.97[167] | 2.29[168] |
25 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [169] | -0.90[170] | -0.37[171] | 0.56[172] | 2.30[173] | 1.56[174] | 2.85[175] |
26 | SOS1 | Son of sevenless homolog 1 | [176] | -0.53[177] | 1.41[178] | 0.76[179] | 1.08[180] | 0.07[181] | 0.39[182] |
27 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | -0.97[183] | 0.83[184] | 0.87[185] | -0.33[186] | 0.68[187] | 2.33[188] | |
28 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [189] | 0.24[190] | 0.33[191] | -0.04[192] | -0.01[193] | 0.65[194] | 0.30[195] |
29 | TP53 | Cellular tumor antigen p53 | [196] | 1.21[197] | 1.18[198] | 1.78[199] | 1.53[200] | 0.95[201] | -0.19[202] |
30 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | [203] | 0.71[204] | 1.48[205] | 1.45[206] | 0.98[207] | 1.66[208] | 1.84[209] |
31 | MAPK3 | Mitogen-activated protein kinase 3 | [210] | 1.42[211] | 1.88[212] | 1.75[213] | 0.66[214] | 0.43[215] | -1.19[216] |
32 | GSK3B | Glycogen synthase kinase-3 beta | [217] | 0.84[218] | 0.88[219] | 1.29[220] | 2.05[221] | 1.63[222] | 1.02[223] |
33 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [224] | 0.47[225] | 2.10[226] | 1.90[227] | 0.88[228] | 1.45[229] | 1.37[230] |
34 | PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform | -1.13[231] | -0.59[232] | -1.14[233] | -0.85[234] | -0.18[235] | -0.09[236] | |
35 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [237] | 1.90[238] | 3.50[239] | 2.05[240] | 1.67[241] | 1.82[242] | 2.36[243] |
36 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.06[244] | 3.09[245] | 2.26[246] | 3.05[247] | 2.30[248] | 0.19[249] | |
37 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [250] | 0.09[251] | 0.56[252] | 0.50[253] | 0.49[254] | 0.34[255] | 1.04[256] |
38 | MTOR | Serine/threonine-protein kinase mTOR | [257] | 2.10[258] | 3.53[259] | 2.93[260] | 2.92[261] | 2.75[262] | 3.30[263] |
39 | IRF2BPL | Interferon regulatory factor 2-binding protein-like | [264] | 0.38[265] | 0.34[266] | 0.65[267] | 1.47[268] | 1.61[269] | 0.71[270] |
40 | TSC2 | Tuberin | [271] | 1.38[272] | 1.32[273] | 1.85[274] | 1.43[275] | 1.71[276] | 1.93[277] |
41 | BCL10 | B-cell lymphoma/leukemia 10 | [278] | -0.34[279] | -0.43[280] | 0.40[281] | 0.77[282] | 0.57[283] | 0.39[284] |
42 | DEPTOR | DEP domain-containing mTOR-interacting protein | [285] | -3.75[286] | -2.15[287] | 1.73[288] | -4.02[289] | -1.62[290] | 0.71[291] |
43 | FOXO3 | Forkhead box protein O3 | [292] | 0.02[293] | 0.52[294] | 1.00[295] | 0.63[296] | 1.63[297] | 2.19[298] |
44 | FYN | Tyrosine-protein kinase Fyn | [299] | 0.51[300] | -7.68[301] | 0.73[302] | 1.70[303] | 2.99[304] | 0.82[305] |
45 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 2.43[306] | 2.68[307] | 1.94[308] | 2.27[309] | 1.31[310] | 2.12[311] | |
46 | RPTOR | Regulatory-associated protein of mTOR | [312] | 2.65[313] | 2.30[314] | 2.24[315] | 2.08[316] | 2.07[317] | 2.19[318] |
47 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.46[319] | 2.95[320] | -1.02[321] | 0.51[322] | 1.04[323] | 0.15[324] | |
48 | TSC1 | Hamartin | [325] | 1.46[326] | 2.53[327] | 2.52[328] | 2.29[329] | 2.26[330] | 2.61[331] |
49 | RICTOR | Rapamycin-insensitive companion of mTOR | [332] | 0.30[333] | 2.79[334] | 3.30[335] | 2.59[336] | 2.55[337] | 3.37[338] |
50 | IL18R1 | Interleukin-18 receptor 1 | [339] | -7.34[340] | -7.12[341] | -7.46[342] | -3.81[343] | 3.10[344] | 2.06[345] |
51 | IL23A | Interleukin-23 subunit alpha | [346] | -2.57[347] | -2.05[348] | -3.97[349] | -4.70[350] | -3.87[351] | -3.94[352] |
52 | STAT4 | Signal transducer and activator of transcription 4 | [353] | -5.27[354] | -3.79[355] | -3.43[356] | 1.87[357] | 0.43[358] | 0.88[359] |
53 | JAK2 | Tyrosine-protein kinase JAK2 | [360] | -0.20[361] | 0.20[362] | -0.40[363] | 1.00[364] | 1.35[365] | 2.56[366] |
54 | LCP2 | Lymphocyte cytosolic protein 2 | [367] | [368] | [369] | [370] | -3.48[371] | [372] | 1.00[373] |
55 | CCL28 | C-C motif chemokine 28 | [374] | -5.21[375] | -4.40[376] | -4.70[377] | -0.42[378] | -0.91[379] | -1.62[380] |
56 | IL12RB1 | Interleukin-12 receptor subunit beta-1 | [381] | -2.55[382] | -1.96[383] | -2.65[384] | -2.37[385] | -3.49[386] | -0.99[387] |
57 | LAT | Linker for activation of T-cells family member 1 | [388] | -1.88[389] | 0.07[390] | -1.69[391] | -1.13[392] | -0.80[393] | -0.57[394] |
58 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | [395] | -9.29[396] | [397] | -5.57[398] | [399] | [400] | -0.75[401] |
59 | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 | [402] | -2.38[403] | -4.49[404] | 1.95[405] | -5.74[406] | 2.42[407] | 0.58[408] |
60 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | [409] | 2.71[410] | 3.00[411] | 4.00[412] | 3.08[413] | 3.71[414] | 4.50[415] |
61 | CD86 | T-lymphocyte activation antigen CD86 | [416] | [417] | [418] | -4.89[419] | -3.86[420] | -6.13[421] | 1.20[422] |
62 | CD247 | T-cell surface glycoprotein CD3 zeta chain | [423] | -5.30[424] | -5.56[425] | -7.23[426] | -3.28[427] | -4.91[428] | -0.16[429] |
63 | CD3D | T-cell surface glycoprotein CD3 delta chain | [430] | 0.97[431] | -0.63[432] | -3.16[433] | -6.27[434] | -4.52[435] | -0.47[436] |
64 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [437] | 3.65[438] | 1.83[439] | 5.07[440] | 5.44[441] | 6.98[442] | -2.30[443] |
65 | LCK | Tyrosine-protein kinase Lck | [444] | 2.35[445] | 2.84[446] | -7.32[447] | -4.85[448] | -5.30[449] | 1.09[450] |
66 | CD3G | T-cell surface glycoprotein CD3 gamma chain | [451] | -4.02[452] | -2.86[453] | -4.08[454] | -4.38[455] | -4.03[456] | -0.49[457] |
67 | ZAP70 | Tyrosine-protein kinase ZAP-70 | [458] | 0.57[459] | 1.20[460] | -5.19[461] | -5.31[462] | -4.21[463] | 2.01[464] |
68 | IFNG | Interferon gamma | [465] | [466] | [467] | [468] | -0.46[469] | [470] | -2.44[471] |
69 | IL12A | Interleukin-12 subunit alpha | [472] | -1.84[473] | [474] | -0.09[475] | -1.31[476] | 0.24[477] | -3.32[478] |
70 | TNF | Tumor necrosis factor | [479] | 0.67[480] | -1.05[481] | -5.81[482] | -1.99[483] | -5.45[484] | -2.04[485] |
71 | IL23R | Interleukin-23 receptor | [486] | -2.49[487] | -0.90[488] | 0.83[489] | -2.70[490] | -3.19[491] | -1.66[492] |
72 | CARD11 | Caspase recruitment domain-containing protein 11 | [493] | 0.70[494] | -5.40[495] | -6.33[496] | 1.48[497] | 5.75[498] | 2.13[499] |
73 | CD28 | T-cell-specific surface glycoprotein CD28 | [500] | -4.43[501] | -3.15[502] | -3.28[503] | -2.11[504] | -2.41[505] | 0.97[506] |
74 | GRAP2 | GRB2-related adapter protein 2 | [507] | -6.28[508] | [509] | -2.41[510] | -1.74[511] | -0.95[512] | 0.69[513] |
75 | PRKCQ | Protein kinase C theta type | [514] | 0.47[515] | -2.68[516] | [517] | 2.36[518] | 3.62[519] | 1.94[520] |
76 | LTA | Lymphotoxin-alpha | [521] | -3.81[522] | [523] | -3.13[524] | -0.62[525] | -3.12[526] | -1.99[527] |
77 | CD80 | T-lymphocyte activation antigen CD80 | [528] | [529] | [530] | -5.44[531] | -0.92[532] | -2.23[533] | 2.48[534] |
78 | ICOS | Inducible T-cell costimulator | [535] | [536] | -3.39[537] | [538] | [539] | [540] | -0.70[541] |
79 | IL17A | Interleukin-17A | [542] | [543] | [544] | [545] | [546] | [547] | [548] |
80 | CCL19 | C-C motif chemokine 19 | [549] | [550] | -1.69[551] | [552] | [553] | [554] | 2.77[555] |
81 | RASGRP1 | RAS guanyl-releasing protein 1 | [556] | 0.80[557] | 1.91[558] | 2.39[559] | 4.38[560] | 5.22[561] | 6.66[562] |
82 | IL12RB2 | Interleukin-12 receptor subunit beta-2 | [563] | 2.44[564] | 3.45[565] | 5.31[566] | 5.63[567] | 3.46[568] | 7.82[569] |
83 | IL4 | Interleukin-4 | [570] | [571] | [572] | [573] | [574] | [575] | [576] |
84 | IFNB1 | Interferon beta | [577] | [578] | [579] | [580] | [581] | [582] | [583] |
85 | CTLA4 | Cytotoxic T-lymphocyte protein 4 | [584] | [585] | [586] | [587] | [588] | [589] | [590] |
86 | IL2 | Interleukin-2 | [591] | [592] | [593] | [594] | [595] | [596] | [597] |
87 | IL12B | Interleukin-12 subunit beta | [598] | [599] | [600] | [601] | [602] | [603] | [604] |