WP_TCA_CYCLE_AND_DEFICIENCY_OF_PYRUVATE_DEHYDROGENASE_COMPLEX_PDHC Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PCK1 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] [1] -8.37[2] -4.37[3] -12.47[4] [5] -15.70[6] 0.57[7]
2 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic [8] 0.16[9] 0.66[10] 1.32[11] -0.63[12] -1.50[13] -0.98[14]
3 MDH1 Malate dehydrogenase, cytoplasmic [15] 0.04[16] 0.40[17] -0.58[18] 0.42[19] 0.17[20] -1.07[21]
4 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial -0.56[22] -1.04[23] -1.57[24] -0.91[25] -0.22[26] -0.42[27]
5 SUCLG2 Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial [28] -1.41[29] -1.15[30] -1.91[31] -1.93[32] -1.14[33] -0.58[34]
6 FH Fumarate hydratase, mitochondrial [35] -0.90[36] -0.92[37] -1.12[38] 0.10[39] -0.28[40] -0.35[41]
7 PC Pyruvate carboxylase, mitochondrial [42] -0.59[43] -0.64[44] 0.14[45] -0.64[46] -2.99[47] 1.65[48]
8 DLD Dihydrolipoyl dehydrogenase, mitochondrial [49] -0.46[50] 0.00[51] -0.58[52] 0.66[53] 0.24[54] -0.40[55]
9 ACO1 Cytoplasmic aconitate hydratase [56] -0.92[57] -1.09[58] -1.30[59] -0.67[60] 1.32[61] 0.62[62]
10 ACLY ATP-citrate synthase [63] 1.86[64] 1.27[65] 1.78[66] 1.99[67] 1.87[68] -0.84[69]
11 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial -0.11[70] -0.37[71] 0.24[72] 0.39[73] 0.05[74] -0.34[75]
12 DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 1.13[76] 1.39[77] -0.09[78] 1.23[79] 1.47[80] -1.05[81]
13 CS Citrate synthase, mitochondrial [82] 3.01[83] 2.53[84] 1.57[85] 2.15[86] 2.33[87] -0.18[88]
14 OGDH 2-oxoglutarate dehydrogenase, mitochondrial [89] 1.42[90] 0.55[91] 1.04[92] 1.97[93] 2.03[94] 0.80[95]
15 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [96] 0.23[97] 0.51[98] -0.89[99] 1.17[100] 1.66[101] 0.26[102]
16 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial 1.49[103] 1.06[104] 1.11[105] 1.93[106] 1.58[107] -0.14[108]
[1]
ref_hepatocyte PCK1
Mean 142
Standard deviation 1.9e+02
Values 5.3 2.4e+02 4.4e+02 30 0.041
[2]
HepG2 PCK1
Mean 0.593
Standard deviation 0.35
Values 0.34 0.84
[3]
HepG2.C3A PCK1
Mean 10.1
Standard deviation 5.7
Values 6 14
[4]
HuH.7 PCK1
Mean 0.0471
Standard deviation 0.082
Values 0 0.14 0
[5]
SNU475 PCK1
Mean 0
Standard deviation 0
Values 0 0
[6]
THLE PCK1
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[7]
liver PCK1
Mean 420
Standard deviation 94
Values 3.2e+02 4.8e+02 3.7e+02 5.2e+02
[8]
ref_hepatocyte IDH1
Mean 120
Standard deviation 80
Values 23 1.8e+02 1.2e+02 2.1e+02 57
[9]
HepG2 IDH1
Mean 186
Standard deviation 83
Values 2.4e+02 1.3e+02
[10]
HepG2.C3A IDH1
Mean 278
Standard deviation 72
Values 3.3e+02 2.3e+02
[11]
HuH.7 IDH1
Mean 559
Standard deviation 1.1e+02
Values 6.5e+02 4.4e+02 5.8e+02
[12]
SNU475 IDH1
Mean 74.8
Standard deviation 19
Values 61 88
[13]
THLE IDH1
Mean 42.2
Standard deviation 1.1
Values 43 41
[14]
liver IDH1
Mean 121
Standard deviation 35
Values 74 1.2e+02 1.4e+02 1.5e+02
[15]
ref_hepatocyte MDH1
Mean 74.5
Standard deviation 43
Values 9.2 1.1e+02 1e+02 99 52
[16]
HepG2 MDH1
Mean 106
Standard deviation 36
Values 1.3e+02 80
[17]
HepG2.C3A MDH1
Mean 144
Standard deviation 49
Values 1.8e+02 1.1e+02
[18]
HuH.7 MDH1
Mean 93.1
Standard deviation 25
Values 1.2e+02 67 96
[19]
SNU475 MDH1
Mean 95.9
Standard deviation 44
Values 65 1.3e+02
[20]
THLE MDH1
Mean 83.2
Standard deviation 9.4
Values 77 90
[21]
liver MDH1
Mean 70.6
Standard deviation 50
Values 22 34 1.2e+02 1.1e+02
[22]
ref_hepatocyte SDHA
Mean 64.8
Standard deviation 32
Values 36 1.1e+02 93 47 43
[23]
HepG2 SDHA
Mean 60.8
Standard deviation 7
Values 66 56
[24]
HepG2.C3A SDHA
Mean 46
Standard deviation 2.9
Values 44 48
[25]
HuH.7 SDHA
Mean 40.8
Standard deviation 11
Values 47 28 48
[26]
SNU475 SDHA
Mean 33.3
Standard deviation 7.3
Values 28 38
[27]
THLE SDHA
Mean 55.2
Standard deviation 3.8
Values 53 58
[28]
liver SDHA
Mean 96.7
Standard deviation 39
Values 61 78 97 1.5e+02
[29]
ref_hepatocyte SUCLG2
Mean 52.6
Standard deviation 48
Values 14 1.3e+02 71 15 33
[30]
HepG2 SUCLG2
Mean 27.4
Standard deviation 5.7
Values 31 23
[31]
HepG2.C3A SUCLG2
Mean 34.7
Standard deviation 8.9
Values 41 28
[32]
HuH.7 SUCLG2
Mean 26.2
Standard deviation 0.91
Values 26 26 27
[33]
SNU475 SUCLG2
Mean 13.3
Standard deviation 5.2
Values 9.7 17
[34]
THLE SUCLG2
Mean 23.8
Standard deviation 4.1
Values 21 27
[35]
liver SUCLG2
Mean 69.9
Standard deviation 18
Values 48 63 77 91
[36]
ref_hepatocyte FH
Mean 43.1
Standard deviation 38
Values 8.7 78 91 17 21
[37]
HepG2 FH
Mean 32
Standard deviation 8
Values 38 26
[38]
HepG2.C3A FH
Mean 33.4
Standard deviation 7.2
Values 39 28
[39]
HuH.7 FH
Mean 37.1
Standard deviation 6.3
Values 43 31 38
[40]
SNU475 FH
Mean 44.6
Standard deviation 4.8
Values 41 48
[41]
THLE FH
Mean 35.3
Standard deviation 6.3
Values 31 40
[42]
liver FH
Mean 67.3
Standard deviation 23
Values 42 55 82 90
[43]
ref_hepatocyte PC
Mean 39.5
Standard deviation 46
Values 3.9 93 87 8 5.6
[44]
HepG2 PC
Mean 36.2
Standard deviation 7.4
Values 31 41
[45]
HepG2.C3A PC
Mean 37.2
Standard deviation 8
Values 32 43
[46]
HuH.7 PC
Mean 81.4
Standard deviation 7.4
Values 77 77 90
[47]
SNU475 PC
Mean 24.3
Standard deviation 13
Values 15 33
[48]
THLE PC
Mean 4.93
Standard deviation 0.64
Values 4.5 5.4
[49]
liver PC
Mean 248
Standard deviation 63
Values 2.4e+02 2.7e+02 1.7e+02 3.2e+02
[50]
ref_hepatocyte DLD
Mean 31.7
Standard deviation 25
Values 13 19 16 39 73
[51]
HepG2 DLD
Mean 31.9
Standard deviation 11
Values 39 24
[52]
HepG2.C3A DLD
Mean 46.4
Standard deviation 13
Values 56 37
[53]
HuH.7 DLD
Mean 39.8
Standard deviation 5.6
Values 43 33 44
[54]
SNU475 DLD
Mean 48.2
Standard deviation 1.7
Values 47 49
[55]
THLE DLD
Mean 37.3
Standard deviation 2.8
Values 35 39
[56]
liver DLD
Mean 47.9
Standard deviation 25
Values 20 37 56 79
[57]
ref_hepatocyte ACO1
Mean 31.6
Standard deviation 14
Values 12 46 42 23 36
[58]
HepG2 ACO1
Mean 23.1
Standard deviation 6.4
Values 28 19
[59]
HepG2.C3A ACO1
Mean 21.8
Standard deviation 0.47
Values 22 22
[60]
HuH.7 ACO1
Mean 24.1
Standard deviation 2.5
Values 24 22 27
[61]
SNU475 ACO1
Mean 19.1
Standard deviation 1.3
Values 18 20
[62]
THLE ACO1
Mean 78.6
Standard deviation 31
Values 57 1e+02
[63]
liver ACO1
Mean 97.1
Standard deviation 28
Values 69 1.1e+02 81 1.3e+02
[64]
ref_hepatocyte ACLY
Mean 28.9
Standard deviation 24
Values 33 4.3 9.2 64 33
[65]
HepG2 ACLY
Mean 145
Standard deviation 3.8
Values 1.4e+02 1.5e+02
[66]
HepG2.C3A ACLY
Mean 102
Standard deviation 23
Values 86 1.2e+02
[67]
HuH.7 ACLY
Mean 185
Standard deviation 35
Values 1.8e+02 1.5e+02 2.2e+02
[68]
SNU475 ACLY
Mean 111
Standard deviation 0.23
Values 1.1e+02 1.1e+02
[69]
THLE ACLY
Mean 105
Standard deviation 22
Values 89 1.2e+02
[70]
liver ACLY
Mean 32.1
Standard deviation 9.8
Values 46 32 25 26
[71]
ref_hepatocyte PDHA1
Mean 24.9
Standard deviation 8.4
Values 16 20 25 25 38
[72]
HepG2 PDHA1
Mean 32
Standard deviation 3.7
Values 35 29
[73]
HepG2.C3A PDHA1
Mean 28.2
Standard deviation 0.42
Values 28 28
[74]
HuH.7 PDHA1
Mean 55
Standard deviation 18
Values 67 34 64
[75]
SNU475 PDHA1
Mean 31.4
Standard deviation 0.34
Values 31 32
[76]
THLE PDHA1
Mean 25.6
Standard deviation 3
Values 24 28
[77]
liver PDHA1
Mean 39.1
Standard deviation 23
Values 17 22 54 63
[78]
ref_hepatocyte DLST
Mean 19.4
Standard deviation 4.5
Values 24 19 22 12 20
[79]
HepG2 DLST
Mean 58.7
Standard deviation 1.6
Values 58 60
[80]
HepG2.C3A DLST
Mean 74.5
Standard deviation 3.3
Values 72 77
[81]
HuH.7 DLST
Mean 34.1
Standard deviation 5.6
Values 39 28 36
[82]
SNU475 DLST
Mean 43.8
Standard deviation 3.5
Values 41 46
[83]
THLE DLST
Mean 53.2
Standard deviation 2.1
Values 52 55
[84]
liver DLST
Mean 18.7
Standard deviation 14
Values 28 33 6.4 6.7
[85]
ref_hepatocyte CS
Mean 15.3
Standard deviation 5.2
Values 19 12 13 23 9.8
[86]
HepG2 CS
Mean 170
Standard deviation 16
Values 1.8e+02 1.6e+02
[87]
HepG2.C3A CS
Mean 129
Standard deviation 6.5
Values 1.2e+02 1.3e+02
[88]
HuH.7 CS
Mean 85.2
Standard deviation 12
Values 86 73 96
[89]
SNU475 CS
Mean 65.5
Standard deviation 9.6
Values 59 72
[90]
THLE CS
Mean 76.6
Standard deviation 19
Values 63 90
[91]
liver CS
Mean 26.9
Standard deviation 9.6
Values 20 18 31 38
[92]
ref_hepatocyte OGDH
Mean 9.59
Standard deviation 2.6
Values 12 7.8 11 6.1 11
[93]
HepG2 OGDH
Mean 35.5
Standard deviation 0.48
Values 36 35
[94]
HepG2.C3A OGDH
Mean 20.6
Standard deviation 2.9
Values 19 23
[95]
HuH.7 OGDH
Mean 37
Standard deviation 11
Values 38 26 47
[96]
SNU475 OGDH
Mean 36.2
Standard deviation 8.1
Values 31 42
[97]
THLE OGDH
Mean 38.9
Standard deviation 6
Values 35 43
[98]
liver OGDH
Mean 33.2
Standard deviation 11
Values 45 41 21 26
[99]
ref_hepatocyte IDH3A
Mean 8.88
Standard deviation 1.1
Values 8.8 8.3 10 7.4 9.8
[100]
HepG2 IDH3A
Mean 14.4
Standard deviation 2.4
Values 16 13
[101]
HepG2.C3A IDH3A
Mean 18.5
Standard deviation 3.9
Values 21 16
[102]
HuH.7 IDH3A
Mean 8.96
Standard deviation 1.7
Values 9.9 7 10
[103]
SNU475 IDH3A
Mean 19.2
Standard deviation 3.3
Values 22 17
[104]
THLE IDH3A
Mean 28
Standard deviation 4
Values 25 31
[105]
liver IDH3A
Mean 21.2
Standard deviation 6.2
Values 13 19 25 27
[106]
ref_hepatocyte DLAT
Mean 7.51
Standard deviation 3.3
Values 9.3 5.2 4.2 6.6 12
[107]
HepG2 DLAT
Mean 29.3
Standard deviation 8.9
Values 36 23
[108]
HepG2.C3A DLAT
Mean 22.9
Standard deviation 4.1
Values 26 20
[109]
HuH.7 DLAT
Mean 30.4
Standard deviation 4
Values 30 26 35
[110]
SNU475 DLAT
Mean 27.6
Standard deviation 0.023
Values 28 28
[111]
THLE DLAT
Mean 22.4
Standard deviation 2.8
Values 20 24
[112]
liver DLAT
Mean 13.6
Standard deviation 1.8
Values 12 13 13 16