WP_TARGET_OF_RAPAMYCIN_TOR_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CDC42 | Cell division control protein 42 homolog | [1] | -0.55[2] | -0.31[3] | -1.10[4] | -0.21[5] | -0.94[6] | -1.79[7] |
2 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | [8] | 0.16[9] | -0.72[10] | -2.07[11] | 0.06[12] | -0.36[13] | -1.08[14] |
3 | RHEB | GTP-binding protein Rheb | [15] | -1.67[16] | -1.58[17] | -1.43[18] | -0.78[19] | -0.67[20] | -0.80[21] |
4 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [22] | -0.12[23] | -0.93[24] | 0.00[25] | 0.34[26] | 0.32[27] | -0.67[28] |
5 | IDI1 | Isopentenyl-diphosphate Delta-isomerase 1 | [29] | -2.57[30] | 0.43[31] | -0.76[32] | -1.24[33] | -2.46[34] | 0.61[35] |
6 | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 | [36] | -0.71[37] | -1.52[38] | -0.69[39] | -2.98[40] | -1.43[41] | -1.30[42] |
7 | AKT1 | RAC-alpha serine/threonine-protein kinase | [43] | 0.36[44] | -0.36[45] | -1.21[46] | 0.27[47] | 0.29[48] | 0.05[49] |
8 | DDIT4 | DNA damage-inducible transcript 4 protein | [50] | 1.13[51] | 1.32[52] | 0.06[53] | -1.77[54] | 1.20[55] | -0.45[56] |
9 | RRAGA | Ras-related GTP-binding protein A | [57] | 0.59[58] | -0.65[59] | -1.70[60] | -0.71[61] | -0.11[62] | -0.54[63] |
10 | MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | [64] | 0.27[65] | -0.47[66] | -0.02[67] | 0.40[68] | 0.59[69] | 0.11[70] |
11 | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | [71] | -1.14[72] | -1.09[73] | -0.75[74] | -0.02[75] | -0.31[76] | -1.35[77] |
12 | AKT1S1 | Proline-rich AKT1 substrate 1 | [78] | -0.19[79] | -0.82[80] | -0.25[81] | -0.43[82] | 0.19[83] | -0.90[84] |
13 | HMGCR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | [85] | -0.28[86] | 1.99[87] | 2.48[88] | 0.01[89] | -0.30[90] | 1.67[91] |
14 | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | [92] | -3.78[93] | -9.36[94] | -2.70[95] | -1.42[96] | -1.28[97] | -0.18[98] |
15 | MLST8 | Target of rapamycin complex subunit LST8 | [99] | 0.10[100] | -0.05[101] | 0.54[102] | -0.66[103] | -0.31[104] | -0.27[105] |
16 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | [106] | 0.19[107] | 0.99[108] | 2.73[109] | 1.78[110] | 2.05[111] | 2.35[112] |
17 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | [113] | 1.16[114] | 1.87[115] | 2.20[116] | 1.35[117] | 0.32[118] | 1.70[119] |
18 | RRAGC | Ras-related GTP-binding protein C | [120] | -0.28[121] | -1.60[122] | -0.98[123] | 0.69[124] | 0.38[125] | -0.67[126] |
19 | PRR5 | Proline-rich protein 5 | [127] | -0.31[128] | -0.74[129] | -1.43[130] | -1.97[131] | -4.76[132] | -0.49[133] |
20 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | [134] | 0.99[135] | 1.04[136] | 0.41[137] | 0.26[138] | 0.36[139] | 0.29[140] |
21 | ULK3 | Serine/threonine-protein kinase ULK3 | [141] | 0.49[142] | 0.48[143] | 0.02[144] | 0.51[145] | 0.90[146] | 1.95[147] |
22 | MTOR | Serine/threonine-protein kinase mTOR | [148] | 2.81[149] | 3.34[150] | 3.13[151] | 3.00[152] | 3.08[153] | 3.74[154] |
23 | TSC2 | Tuberin | [155] | 2.09[156] | 1.14[157] | 2.04[158] | 1.52[159] | 2.04[160] | 2.37[161] |
24 | ULK1 | Serine/threonine-protein kinase ULK1 | [162] | 1.59[163] | 1.38[164] | 2.81[165] | 2.30[166] | 1.64[167] | 2.19[168] |
25 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [169] | [170] | [171] | [172] | [173] | [174] | [175] |
26 | PRKCA | Protein kinase C alpha type | [176] | 3.11[177] | 2.67[178] | 3.25[179] | 2.47[180] | 2.83[181] | 2.21[182] |
27 | RPTOR | Regulatory-associated protein of mTOR | [183] | 3.36[184] | 2.12[185] | 2.44[186] | 2.17[187] | 2.40[188] | 2.63[189] |
28 | RRAGD | Ras-related GTP-binding protein D | [190] | -0.74[191] | -4.92[192] | 3.19[193] | 1.44[194] | -0.28[195] | 1.48[196] |
29 | TSC1 | Hamartin | [197] | 2.17[198] | 2.34[199] | 2.71[200] | 2.38[201] | 2.59[202] | 3.05[203] |
30 | RRAGB | Ras-related GTP-binding protein B | [204] | 0.00[205] | 0.08[206] | -9.16[207] | 0.77[208] | 0.59[209] | 0.88[210] |
31 | RICTOR | Rapamycin-insensitive companion of mTOR | [211] | 1.00[212] | 2.60[213] | 3.50[214] | 2.68[215] | 2.88[216] | 3.81[217] |
32 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | [218] | 3.31[219] | 3.27[220] | 3.53[221] | 3.36[222] | 1.40[223] | 2.15[224] |
33 | ULK2 | Serine/threonine-protein kinase ULK2 | [225] | -2.82[226] | -2.33[227] | 0.81[228] | 3.61[229] | 2.92[230] | 2.70[231] |
34 | PRR5L | Proline-rich protein 5-like | [232] | 1.75[233] | -3.76[234] | 0.56[235] | 7.25[236] | 4.47[237] | 3.97[238] |
35 | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | [239] | -1.46[240] | [241] | -2.05[242] | -0.70[243] | [244] | 3.42[245] |
36 | DDIT4L | DNA damage-inducible transcript 4-like protein | [246] | [247] | [248] | [249] | [250] | [251] | [252] |
37 | MIR6869 | [253] | [254] | [255] | [256] | [257] | [258] | [259] |