WP_TAMOXIFEN_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2E1 Cytochrome P450 2E1 [1] -9.00[2] -9.89[3] -5.06[4] -8.75[5] -8.94[6] -0.45[7]
2 CYP2C8 Cytochrome P450 2C8 [8] -11.00[9] -7.00[10] -3.22[11] -5.83[12] [13] 0.47[14]
3 CYP2C9 Cytochrome P450 2C9 [15] [16] -11.92[17] -3.43[18] -8.52[19] -9.46[20] 0.97[21]
4 SULT2A1 Bile salt sulfotransferase [22] 2.22[23] 2.41[24] 2.73[25] -4.93[26] -6.48[27] 0.24[28]
5 CYP3A4 Cytochrome P450 3A4 [29] -6.25[30] -7.11[31] -7.25[32] -8.84[33] -9.04[34] 0.68[35]
6 CYP2A6 Cytochrome P450 2A6 [36] -12.37[37] [38] -3.68[39] -5.59[40] -9.77[41] -1.66[42]
7 CYP3A5 Cytochrome P450 3A5 [43] -1.32[44] 0.17[45] -1.00[46] -1.41[47] -5.37[48] 1.05[49]
8 FMO3 Dimethylaniline monooxygenase [N-oxide-forming] 3 [50] [51] -10.78[52] -2.34[53] -1.09[54] -9.67[55] -1.15[56]
9 UGT2B7 UDP-glucuronosyltransferase 2B7 [57] 2.15[58] 1.56[59] -2.33[60] -4.64[61] -7.96[62] -0.57[63]
10 SULT1A1 Sulfotransferase 1A1 [64] 3.99[65] 3.89[66] 2.00[67] 4.08[68] 2.41[69] -2.20[70]
11 CYP1A2 Cytochrome P450 1A2 [71] -5.43[72] -4.87[73] -3.94[74] -2.40[75] -4.57[76] -1.70[77]
12 UGT2B15 UDP-glucuronosyltransferase 2B15 [78] -6.19[79] -5.37[80] -3.08[81] -4.51[82] -6.80[83] -1.03[84]
13 UGT1A4 UDP-glucuronosyltransferase 1-4 [85] -8.25[86] [87] -7.02[88] -3.94[89] [90] 0.09[91]
14 CYP1A1 Cytochrome P450 1A1 [92] 1.03[93] -1.30[94] 3.95[95] 2.20[96] -0.10[97] -5.84[98]
15 CYP2D6 Cytochrome P450 2D6 [99] -2.41[100] -0.67[101] -1.62[102] -1.90[103] -4.16[104] 1.17[105]
16 CYP2C19 Cytochrome P450 2C19 [106] [107] [108] -0.58[109] -6.21[110] -7.77[111] 1.53[112]
17 SULT1E1 Estrogen sulfotransferase [113] 2.63[114] 4.56[115] 6.62[116] -0.51[117] 6.45[118] 1.04[119]
18 CYP1B1 Cytochrome P450 1B1 [120] -1.56[121] -1.73[122] 3.96[123] 9.19[124] 10.05[125] 0.97[126]
19 FMO1 Dimethylaniline monooxygenase [N-oxide-forming] 1 [127] 0.34[128] 1.10[129] 9.46[130] 3.59[131] [132] 1.36[133]
20 UGT1A8 UDP-glucuronosyltransferase 1-8 [134] [135] [136] [137] [138] [139] [140]
21 UGT1A10 UDP-glucuronosyltransferase 1-10 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte CYP2E1
Mean 1.39e+03
Standard deviation 1.9e+03
Values 90 4.1e+03 2.7e+03 0 4.6
[2]
HepG2 CYP2E1
Mean 0.133
Standard deviation 0.1
Values 0.06 0.21
[3]
HepG2.C3A CYP2E1
Mean 0.107
Standard deviation 0.15
Values 0 0.21
[4]
HuH.7 CYP2E1
Mean 0.975
Standard deviation 0.29
Values 0.99 1.3 0.67
[5]
SNU475 CYP2E1
Mean 0.0289
Standard deviation 0.005
Values 0.025 0.032
[6]
THLE CYP2E1
Mean 0.0955
Standard deviation 0.082
Values 0.15 0.037
[7]
liver CYP2E1
Mean 1.49e+03
Standard deviation 8.2e+02
Values 6.9e+02 1e+03 2.6e+03 1.7e+03
[8]
ref_hepatocyte CYP2C8
Mean 328
Standard deviation 4.4e+02
Values 19 9.1e+02 7.1e+02 0 1.2
[9]
HepG2 CYP2C8
Mean 0.00788
Standard deviation 0.0051
Values 0.0043 0.011
[10]
HepG2.C3A CYP2C8
Mean 0.186
Standard deviation 0.071
Values 0.24 0.14
[11]
HuH.7 CYP2C8
Mean 0.822
Standard deviation 1
Values 0.3 2 0.16
[12]
SNU475 CYP2C8
Mean 0.0515
Standard deviation 0.02
Values 0.066 0.037
[13]
THLE CYP2C8
Mean 0
Standard deviation 0
Values 0 0
[14]
liver CYP2C8
Mean 666
Standard deviation 3.9e+02
Values 2e+02 6.2e+02 6.8e+02 1.2e+03
[15]
ref_hepatocyte CYP2C9
Mean 285
Standard deviation 4.1e+02
Values 21 9.2e+02 4.7e+02 0.064 20
[16]
HepG2 CYP2C9
Mean 0
Standard deviation 0
Values 0 0
[17]
HepG2.C3A CYP2C9
Mean 0.00536
Standard deviation 0.0076
Values 0.011 0
[18]
HuH.7 CYP2C9
Mean 0.616
Standard deviation 0.63
Values 0.25 1.3 0.25
[19]
SNU475 CYP2C9
Mean 0.00696
Standard deviation 0.0098
Values 0 0.014
[20]
THLE CYP2C9
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[21]
liver CYP2C9
Mean 822
Standard deviation 5.3e+02
Values 2.9e+02 6.1e+02 8.6e+02 1.5e+03
[22]
ref_hepatocyte SULT2A1
Mean 281
Standard deviation 2.8e+02
Values 7.2 3e+02 6.4e+02 4.5e+02 5.2
[23]
HepG2 SULT2A1
Mean 64.4
Standard deviation 29
Values 85 44
[24]
HepG2.C3A SULT2A1
Mean 109
Standard deviation 37
Values 83 1.4e+02
[25]
HuH.7 SULT2A1
Mean 43.5
Standard deviation 18
Values 38 64 29
[26]
SNU475 SULT2A1
Mean 0.0827
Standard deviation 0.012
Values 0.091 0.074
[27]
THLE SULT2A1
Mean 0.106
Standard deviation 0.0079
Values 0.1 0.11
[28]
liver SULT2A1
Mean 489
Standard deviation 2.7e+02
Values 2.3e+02 2.9e+02 8.1e+02 6.3e+02
[29]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 11 9.6e+02 3.2e+02 0.24 11
[30]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.24 0.097
[31]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.2 0.068
[32]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.047 0.064 0.0082
[33]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[34]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[35]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 49 6.4e+02 4.3e+02 1.3e+03
[36]
ref_hepatocyte CYP2A6
Mean 231
Standard deviation 3e+02
Values 38 5.5e+02 5.6e+02 0 4.6
[37]
HepG2 CYP2A6
Mean 0.00214
Standard deviation 0.003
Values 0.0043 0
[38]
HepG2.C3A CYP2A6
Mean 0
Standard deviation 0
Values 0 0
[39]
HuH.7 CYP2A6
Mean 0.421
Standard deviation 0.53
Values 0.12 1 0.11
[40]
SNU475 CYP2A6
Mean 0.0428
Standard deviation 0.025
Values 0.025 0.06
[41]
THLE CYP2A6
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[42]
liver CYP2A6
Mean 107
Standard deviation 1e+02
Values 13 1.8e+02 29 2.1e+02
[43]
ref_hepatocyte CYP3A5
Mean 139
Standard deviation 1.6e+02
Values 35 3.9e+02 2e+02 22 55
[44]
HepG2 CYP3A5
Mean 2.75
Standard deviation 2.1
Values 4.2 1.3
[45]
HepG2.C3A CYP3A5
Mean 11.4
Standard deviation 3.8
Values 8.7 14
[46]
HuH.7 CYP3A5
Mean 1.63
Standard deviation 1.6
Values 0.83 3.5 0.58
[47]
SNU475 CYP3A5
Mean 0.471
Standard deviation 0.12
Values 0.39 0.56
[48]
THLE CYP3A5
Mean 0.113
Standard deviation 0.032
Values 0.14 0.09
[49]
liver CYP3A5
Mean 424
Standard deviation 3.2e+02
Values 2.8e+02 2.7e+02 9e+02 2.5e+02
[50]
ref_hepatocyte FMO3
Mean 129
Standard deviation 2.2e+02
Values 4.9 5.1e+02 1.2e+02 0 3.5
[51]
HepG2 FMO3
Mean 0
Standard deviation 0
Values 0 0
[52]
HepG2.C3A FMO3
Mean 0.00536
Standard deviation 0.0076
Values 0.011 0
[53]
HuH.7 FMO3
Mean 0.593
Standard deviation 0.31
Values 0.47 0.95 0.36
[54]
SNU475 FMO3
Mean 0.542
Standard deviation 0.086
Values 0.48 0.6
[55]
THLE FMO3
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[56]
liver FMO3
Mean 85.3
Standard deviation 26
Values 80 64 1.2e+02 75
[57]
ref_hepatocyte UGT2B7
Mean 122
Standard deviation 1.9e+02
Values 5.3 4.3e+02 1.6e+02 3.3 8.1
[58]
HepG2 UGT2B7
Mean 26.6
Standard deviation 9
Values 20 33
[59]
HepG2.C3A UGT2B7
Mean 26.2
Standard deviation 13
Values 35 17
[60]
HuH.7 UGT2B7
Mean 0.568
Standard deviation 0.44
Values 0.34 1.1 0.3
[61]
SNU475 UGT2B7
Mean 0.0439
Standard deviation 0.0096
Values 0.051 0.037
[62]
THLE UGT2B7
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[63]
liver UGT2B7
Mean 121
Standard deviation 61
Values 61 77 1.7e+02 1.7e+02
[64]
ref_hepatocyte SULT1A1
Mean 97.6
Standard deviation 1.2e+02
Values 6 3e+02 1.2e+02 27 33
[65]
HepG2 SULT1A1
Mean 76.1
Standard deviation 9
Values 70 82
[66]
HepG2.C3A SULT1A1
Mean 105
Standard deviation 7.6
Values 1e+02 1.1e+02
[67]
HuH.7 SULT1A1
Mean 9.1
Standard deviation 2.4
Values 12 6.8 8.9
[68]
SNU475 SULT1A1
Mean 14.8
Standard deviation 8.6
Values 8.8 21
[69]
THLE SULT1A1
Mean 17.4
Standard deviation 0.098
Values 17 17
[70]
liver SULT1A1
Mean 31.2
Standard deviation 17
Values 17 16 44 47
[71]
ref_hepatocyte CYP1A2
Mean 78.9
Standard deviation 1.3e+02
Values 0.97 3e+02 71 0.4 18
[72]
HepG2 CYP1A2
Mean 0.0901
Standard deviation 0.055
Values 0.13 0.052
[73]
HepG2.C3A CYP1A2
Mean 0.197
Standard deviation 0.066
Values 0.15 0.24
[74]
HuH.7 CYP1A2
Mean 0.12
Standard deviation 0.026
Values 0.15 0.1 0.11
[75]
SNU475 CYP1A2
Mean 0.134
Standard deviation 0.091
Values 0.2 0.07
[76]
THLE CYP1A2
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[77]
liver CYP1A2
Mean 35.7
Standard deviation 24
Values 19 12 55 58
[78]
ref_hepatocyte UGT2B15
Mean 72.3
Standard deviation 99
Values 3.3 2.3e+02 1.2e+02 0.2 13
[79]
HepG2 UGT2B15
Mean 0.0487
Standard deviation 0.004
Values 0.051 0.046
[80]
HepG2.C3A UGT2B15
Mean 0.127
Standard deviation 0.013
Values 0.12 0.14
[81]
HuH.7 UGT2B15
Mean 0.2
Standard deviation 0.22
Values 0.084 0.45 0.066
[82]
SNU475 UGT2B15
Mean 0.0285
Standard deviation 0.019
Values 0.015 0.042
[83]
THLE UGT2B15
Mean 0.0219
Standard deviation 0.014
Values 0.012 0.032
[84]
liver UGT2B15
Mean 52
Standard deviation 21
Values 21 56 66 64
[85]
ref_hepatocyte UGT1A4
Mean 53.1
Standard deviation 73
Values 2.5 1.6e+02 99 0 4.2
[86]
HepG2 UGT1A4
Mean 0.00858
Standard deviation 0.012
Values 0.017 0
[87]
HepG2.C3A UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 UGT1A4
Mean 0.00954
Standard deviation 0.0096
Values 0.0094 0.019 0
[89]
SNU475 UGT1A4
Mean 0.031
Standard deviation 0.015
Values 0.02 0.042
[90]
THLE UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[91]
liver UGT1A4
Mean 83.1
Standard deviation 65
Values 32 95 36 1.7e+02
[92]
ref_hepatocyte CYP1A1
Mean 43.8
Standard deviation 36
Values 0.06 82 17 77 43
[93]
HepG2 CYP1A1
Mean 4.39
Standard deviation 2.6
Values 2.6 6.2
[94]
HepG2.C3A CYP1A1
Mean 1.3
Standard deviation 0.1
Values 1.2 1.4
[95]
HuH.7 CYP1A1
Mean 15.8
Standard deviation 1.4
Values 17 17 14
[96]
SNU475 CYP1A1
Mean 1.8
Standard deviation 1.8
Values 3.1 0.49
[97]
THLE CYP1A1
Mean 1.38
Standard deviation 0.04
Values 1.4 1.4
[98]
liver CYP1A1
Mean 1.12
Standard deviation 0.58
Values 1.8 0.47 1.2 0.92
[99]
ref_hepatocyte CYP2D6
Mean 41.3
Standard deviation 55
Values 3.7 87 1.1e+02 0.24 0.47
[100]
HepG2 CYP2D6
Mean 0.382
Standard deviation 0.03
Values 0.4 0.36
[101]
HepG2.C3A CYP2D6
Mean 1.89
Standard deviation 1
Values 1.2 2.6
[102]
HuH.7 CYP2D6
Mean 0.314
Standard deviation 0.087
Values 0.31 0.4 0.23
[103]
SNU475 CYP2D6
Mean 0.0992
Standard deviation 0.004
Values 0.096 0.1
[104]
THLE CYP2D6
Mean 0.0775
Standard deviation 0.049
Values 0.11 0.043
[105]
liver CYP2D6
Mean 137
Standard deviation 1.2e+02
Values 57 53 3.1e+02 1.3e+02
[106]
ref_hepatocyte CYP2C19
Mean 19.2
Standard deviation 30
Values 0 72 18 0 5.9
[107]
HepG2 CYP2C19
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A CYP2C19
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 CYP2C19
Mean 0.3
Standard deviation 0.27
Values 0.2 0.6 0.098
[110]
SNU475 CYP2C19
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[111]
THLE CYP2C19
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[112]
liver CYP2C19
Mean 81.4
Standard deviation 39
Values 38 92 65 1.3e+02
[113]
ref_hepatocyte SULT1E1
Mean 2.69
Standard deviation 3.5
Values 0.15 8.5 3.3 0.8 0.67
[114]
HepG2 SULT1E1
Mean 0.821
Standard deviation 0.16
Values 0.93 0.71
[115]
HepG2.C3A SULT1E1
Mean 4.62
Standard deviation 1.2
Values 5.5 3.8
[116]
HuH.7 SULT1E1
Mean 6.19
Standard deviation 1.8
Values 6.3 7.9 4.4
[117]
SNU475 SULT1E1
Mean 0.0169
Standard deviation 0.0024
Values 0.015 0.019
[118]
THLE SULT1E1
Mean 7.92
Standard deviation 1.1
Values 7.1 8.7
[119]
liver SULT1E1
Mean 8.11
Standard deviation 8.7
Values 4.8 2.4 21 4.2
[120]
ref_hepatocyte CYP1B1
Mean 2.62
Standard deviation 3.2
Values 0.92 1.4 2.7 0.024 8
[121]
HepG2 CYP1B1
Mean 0.0437
Standard deviation 0.019
Values 0.03 0.057
[122]
HepG2.C3A CYP1B1
Mean 0.0575
Standard deviation 0.04
Values 0.086 0.029
[123]
HuH.7 CYP1B1
Mean 0.95
Standard deviation 0.082
Values 0.95 1 0.87
[124]
SNU475 CYP1B1
Mean 13.6
Standard deviation 3.1
Values 11 16
[125]
THLE CYP1B1
Mean 93
Standard deviation 14
Values 1e+02 83
[126]
liver CYP1B1
Mean 7.5
Standard deviation 1.4
Values 6.2 7.4 6.9 9.5
[127]
ref_hepatocyte FMO1
Mean 0.0687
Standard deviation 0.12
Values 0 0 0.069 0 0.27
[128]
HepG2 FMO1
Mean 0.00429
Standard deviation 0.0061
Values 0.0086 0
[129]
HepG2.C3A FMO1
Mean 0.0107
Standard deviation 0.015
Values 0.021 0
[130]
HuH.7 FMO1
Mean 1.13
Standard deviation 1.7
Values 0.094 3.1 0.16
[131]
SNU475 FMO1
Mean 0.00739
Standard deviation 0.0039
Values 0.01 0.0046
[132]
THLE FMO1
Mean 0
Standard deviation 0
Values 0 0
[133]
liver FMO1
Mean 0.26
Standard deviation 0.27
Values 0.13 0.043 0.66 0.21
[134]
ref_hepatocyte UGT1A8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 UGT1A8
Mean 0.0407
Standard deviation 0.027
Values 0.019 0.071 0.033
[138]
SNU475 UGT1A8
Mean 0.152
Standard deviation 0.028
Values 0.13 0.17
[139]
THLE UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[140]
liver UGT1A8
Mean 0.0104
Standard deviation 0.014
Values 0.013 0.029 0 0
[141]
ref_hepatocyte UGT1A10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 UGT1A10
Mean 0.00788
Standard deviation 0.0051
Values 0.0043 0.011
[143]
HepG2.C3A UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 UGT1A10
Mean 0.115
Standard deviation 0.078
Values 0.075 0.21 0.066
[145]
SNU475 UGT1A10
Mean 0.012
Standard deviation 0.0027
Values 0.01 0.014
[146]
THLE UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[147]
liver UGT1A10
Mean 0.0104
Standard deviation 0.014
Values 0.013 0.029 0 0