WP_STEROL_REGULATORY_ELEMENTBINDING_PROTEINS_SREBP_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RBP4 | Retinol-binding protein 4 | [1] | -3.71[2] | -3.33[3] | -2.91[4] | -10.59[5] | -9.95[6] | -0.58[7] |
2 | DBI | Acyl-CoA-binding protein | [8] | -3.22[9] | -2.11[10] | -2.97[11] | -3.15[12] | -3.28[13] | -2.86[14] |
3 | SCD | Acyl-CoA desaturase | [15] | 1.23[16] | 2.25[17] | 2.72[18] | -0.64[19] | -1.42[20] | 1.04[21] |
4 | FDPS | Farnesyl pyrophosphate synthase | [22] | -1.11[23] | -0.30[24] | -0.31[25] | -0.60[26] | -0.59[27] | -1.05[28] |
5 | HMGCS1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | [29] | -1.95[30] | 0.48[31] | 1.57[32] | -1.94[33] | -2.06[34] | 0.30[35] |
6 | FDFT1 | Squalene synthase | [36] | 0.10[37] | 1.24[38] | 0.49[39] | -1.42[40] | -0.24[41] | -0.41[42] |
7 | MDH1 | Malate dehydrogenase, cytoplasmic | [43] | 1.22[44] | 1.02[45] | 0.15[46] | 1.83[47] | 1.59[48] | -0.04[49] |
8 | INSIG1 | Insulin-induced gene 1 protein | [50] | -9.02[51] | -9.61[52] | -0.15[53] | -1.77[54] | -2.53[55] | 1.67[56] |
9 | SEC13 | Protein SEC13 homolog | [57] | 0.91[58] | 0.47[59] | 0.36[60] | 0.62[61] | 0.90[62] | -1.02[63] |
10 | CYP51A1 | Lanosterol 14-alpha demethylase | [64] | -0.85[65] | 0.74[66] | 0.37[67] | -0.08[68] | -0.30[69] | 1.35[70] |
11 | IDI1 | Isopentenyl-diphosphate Delta-isomerase 1 | [71] | -0.99[72] | 1.69[73] | -0.03[74] | 0.78[75] | -0.30[76] | 0.86[77] |
12 | SCARB1 | Scavenger receptor class B member 1 | [78] | 2.82[79] | 1.63[80] | 1.02[81] | 1.42[82] | 0.37[83] | 1.15[84] |
13 | KPNB1 | Importin subunit beta-1 | [85] | 2.78[86] | 2.12[87] | 2.11[88] | 3.54[89] | 3.28[90] | -0.01[91] |
14 | AKT1 | RAC-alpha serine/threonine-protein kinase | [92] | 1.94[93] | 0.90[94] | -0.48[95] | 2.29[96] | 2.45[97] | 0.30[98] |
15 | SQLE | Squalene monooxygenase | [99] | -0.01[100] | 1.76[101] | 1.19[102] | 0.20[103] | -0.25[104] | 0.23[105] |
16 | SEC23A | Protein transport protein Sec23A | [106] | 3.79[107] | 1.77[108] | 2.52[109] | 3.26[110] | 2.65[111] | 1.60[112] |
17 | ACLY | ATP-citrate synthase | [113] | 3.04[114] | 1.89[115] | 2.51[116] | 3.40[117] | 3.30[118] | 0.19[119] |
18 | SREBF1 | Sterol regulatory element-binding protein 1 | [120] | 1.09[121] | 0.56[122] | 0.80[123] | 0.81[124] | 1.12[125] | 1.04[126] |
19 | SAR1A | GTP-binding protein SAR1a | [127] | 1.72[128] | 1.42[129] | 0.44[130] | 2.49[131] | 2.81[132] | 1.26[133] |
20 | AMFR | E3 ubiquitin-protein ligase AMFR | [134] | 2.30[135] | 0.91[136] | -0.20[137] | 1.84[138] | 2.42[139] | 2.15[140] |
21 | MVD | Diphosphomevalonate decarboxylase | [141] | 0.61[142] | 2.28[143] | 1.17[144] | -0.06[145] | 0.10[146] | 0.11[147] |
22 | INSIG2 | Insulin-induced gene 2 protein | [148] | 1.99[149] | 2.20[150] | 0.03[151] | 0.03[152] | 0.79[153] | -0.53[154] |
23 | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | [155] | 0.44[156] | 0.16[157] | -0.02[158] | 2.00[159] | 1.84[160] | -1.11[161] |
24 | SEC31A | Protein transport protein Sec31A | [162] | 3.65[163] | 2.82[164] | 2.60[165] | 3.37[166] | 3.45[167] | 2.21[168] |
25 | FASN | Fatty acid synthase | [169] | 4.26[170] | 4.09[171] | 4.35[172] | 3.08[173] | 3.24[174] | 3.05[175] |
26 | LSS | Lanosterol synthase | [176] | 1.22[177] | 2.51[178] | 1.15[179] | 1.45[180] | 1.18[181] | 1.60[182] |
27 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [183] | 1.70[184] | 0.71[185] | 0.41[186] | 1.88[187] | 2.60[188] | -0.24[189] |
28 | SEC23B | Protein transport protein Sec23B | [190] | 3.29[191] | 2.47[192] | 1.11[193] | 3.02[194] | 2.72[195] | 1.15[196] |
29 | GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial | [197] | 2.77[198] | 3.44[199] | 1.88[200] | -0.97[201] | 3.30[202] | 3.21[203] |
30 | HMGCR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | [204] | 1.30[205] | 3.24[206] | 3.21[207] | 2.04[208] | 1.86[209] | 1.92[210] |
31 | YY1 | Transcriptional repressor protein YY1 | [211] | 1.88[212] | 1.08[213] | 0.67[214] | 3.04[215] | 2.72[216] | 0.56[217] |
32 | LDLR | Low-density lipoprotein receptor | [218] | 2.05[219] | 2.08[220] | 2.78[221] | 1.45[222] | 2.77[223] | 1.77[224] |
33 | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | [225] | -2.20[226] | -8.11[227] | -1.97[228] | 0.60[229] | 0.88[230] | 0.07[231] |
34 | NR1H2 | Oxysterols receptor LXR-beta | [232] | 1.18[233] | 0.25[234] | 0.31[235] | 2.10[236] | 2.58[237] | 0.56[238] |
35 | MBTPS1 | Membrane-bound transcription factor site-1 protease | [239] | 3.45[240] | 2.45[241] | 2.14[242] | 3.73[243] | 3.92[244] | 1.86[245] |
36 | SEC24C | Protein transport protein Sec24C | [246] | 3.37[247] | 2.96[248] | 1.96[249] | 3.98[250] | 3.59[251] | 1.85[252] |
37 | SAR1B | GTP-binding protein SAR1b | [253] | 1.60[254] | 2.01[255] | 1.55[256] | 2.35[257] | 2.90[258] | 3.40[259] |
38 | SREBF2 | Sterol regulatory element-binding protein 2 | [260] | 3.12[261] | 3.16[262] | 4.04[263] | 2.01[264] | 2.43[265] | 2.02[266] |
39 | SEC24D | Protein transport protein Sec24D | [267] | 2.19[268] | 2.21[269] | 1.88[270] | 3.33[271] | 3.15[272] | 2.37[273] |
40 | GSK3A | Glycogen synthase kinase-3 alpha | [274] | 2.48[275] | 1.41[276] | 1.20[277] | 2.42[278] | 3.32[279] | -1.29[280] |
41 | MED15 | Mediator of RNA polymerase II transcription subunit 15 | [281] | 3.00[282] | 1.38[283] | 0.89[284] | 3.61[285] | 3.54[286] | 0.07[287] |
42 | FGF21 | Fibroblast growth factor 21 | [288] | -6.85[289] | -9.66[290] | -6.35[291] | -6.91[292] | -7.25[293] | -1.67[294] |
43 | SCAP | Sterol regulatory element-binding protein cleavage-activating protein | 3.17[295] | 2.58[296] | 2.89[297] | 2.51[298] | 3.38[299] | 2.37[300] | |
44 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | [301] | 1.78[302] | 2.25[303] | 3.46[304] | 3.81[305] | 4.21[306] | 2.60[307] |
45 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | [308] | 2.75[309] | 3.12[310] | 2.93[311] | 3.37[312] | 2.47[313] | 1.95[314] |
46 | RNF139 | E3 ubiquitin-protein ligase RNF139 | [315] | 1.98[316] | 1.50[317] | 0.92[318] | 2.67[319] | 2.26[320] | 0.79[321] |
47 | LPIN1 | Phosphatidate phosphatase LPIN1 | [322] | 0.28[323] | 1.29[324] | -0.08[325] | 2.87[326] | 2.06[327] | 1.99[328] |
48 | SEC24A | Protein transport protein Sec24A | [329] | 3.06[330] | 2.76[331] | 3.08[332] | 3.93[333] | 3.31[334] | 2.95[335] |
49 | SEC24B | Protein transport protein Sec24B | [336] | 2.04[337] | 1.56[338] | 1.35[339] | 2.80[340] | 3.50[341] | 2.63[342] |
50 | CDK8 | Cyclin-dependent kinase 8 | [343] | 1.01[344] | 0.75[345] | -0.48[346] | 1.84[347] | 1.58[348] | -1.21[349] |
51 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | [350] | 2.57[351] | 2.29[352] | 1.14[353] | 2.28[354] | 2.52[355] | 0.54[356] |
52 | ATF6 | Cyclic AMP-dependent transcription factor ATF-6 alpha | [357] | 3.60[358] | 2.83[359] | 2.12[360] | 4.80[361] | 5.03[362] | 3.24[363] |
53 | NFYA | Nuclear transcription factor Y subunit alpha | [364] | 3.41[365] | 2.82[366] | 2.39[367] | 3.78[368] | 3.37[369] | 1.01[370] |
54 | PPARG | Peroxisome proliferator-activated receptor gamma | [371] | 1.77[372] | 2.58[373] | 2.79[374] | 3.19[375] | 3.29[376] | 0.16[377] |
55 | SP1 | Transcription factor Sp1 | [378] | 3.68[379] | 3.11[380] | 3.87[381] | 5.02[382] | 4.83[383] | 2.70[384] |
56 | MTOR | Serine/threonine-protein kinase mTOR | [385] | 4.39[386] | 4.60[387] | 3.86[388] | 5.03[389] | 5.24[390] | 3.99[391] |
57 | ACSS1 | Acetyl-coenzyme A synthetase 2-like, mitochondrial | [392] | 4.57[393] | 2.35[394] | -7.06[395] | -0.76[396] | -0.01[397] | 2.64[398] |
58 | ACACA | Acetyl-CoA carboxylase 1 | [399] | 4.31[400] | 3.84[401] | 4.46[402] | 4.93[403] | 4.25[404] | 3.90[405] |
59 | MBTPS2 | Membrane-bound transcription factor site-2 protease | [406] | 2.81[407] | 2.35[408] | 2.84[409] | 4.44[410] | 4.47[411] | 2.10[412] |
60 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1.48[413] | 2.31[414] | 2.19[415] | 3.47[416] | 3.81[417] | 2.46[418] | |
61 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | [419] | 2.36[420] | 2.65[421] | 1.90[422] | 3.91[423] | 4.28[424] | 1.88[425] |
62 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [426] | 3.58[427] | 3.93[428] | 4.11[429] | 4.89[430] | 4.96[431] | 2.88[432] |
63 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | [433] | 4.89[434] | 4.53[435] | 4.26[436] | 5.39[437] | 3.56[438] | 2.39[439] |
64 | SEC31B | Protein transport protein Sec31B | [440] | 2.21[441] | 4.53[442] | 3.72[443] | 2.85[444] | 5.91[445] | 4.50[446] |
65 | LPL | Lipoprotein lipase | [447] | [448] | [449] | -6.66[450] | 2.91[451] | -0.59[452] | 0.31[453] |
66 | PPARGC1 | Peroxisome proliferator-activated receptor gamma coactivator 1-beta | 4.23[454] | -0.51[455] | 4.96[456] | 5.01[457] | 5.51[458] | 5.48[459] | |
67 | CAMP | Cathelicidin antimicrobial peptide | [460] | -4.04[461] | [462] | -5.35[463] | [464] | 0.03[465] | 0.69[466] |
68 | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | [467] | 0.12[468] | [469] | -1.32[470] | 1.33[471] | [472] | 3.67[473] |
69 | INS | Insulin | [474] | [475] | [476] | [477] | [478] | [479] | [480] |
70 | MIR33B | [481] | [482] | [483] | [484] | [485] | [486] | [487] | |
71 | MIR6764 | [488] | [489] | [490] | [491] | [492] | [493] | [494] | |
72 | MIR6886 | [495] | [496] | [497] | [498] | [499] | [500] | [501] | |
73 | MIR33A | [502] | [503] | [504] | [505] | [506] | [507] | [508] |