WP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SCD Acyl-CoA desaturase [1] -0.32[2] 0.13[3] 0.15[4] -1.73[5] -2.67[6] -0.62[7]
2 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic [8] -3.50[9] -1.64[10] -1.00[11] -3.03[12] -3.31[13] -1.36[14]
3 SREBF1 Sterol regulatory element-binding protein 1 [15] -0.47[16] -1.56[17] -1.77[18] -0.29[19] -0.13[20] -0.62[21]
4 FASN Fatty acid synthase [22] 2.71[23] 1.97[24] 1.78[25] 1.98[26] 1.99[27] 1.39[28]
5 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase [29] -0.26[30] 1.12[31] 0.64[32] 0.94[33] 0.61[34] 0.26[35]
6 NR1H3 Oxysterols receptor LXR-alpha [36] -1.36[37] -1.72[38] -1.54[39] -1.48[40] -2.85[41] -1.42[42]
7 LDLR Low-density lipoprotein receptor [43] 0.49[44] -0.04[45] 0.21[46] 0.35[47] 1.52[48] 0.11[49]
8 SREBF2 Sterol regulatory element-binding protein 2 [50] 1.57[51] 1.04[52] 1.47[53] 0.92[54] 1.18[55] 0.36[56]
9 MED15 Mediator of RNA polymerase II transcription subunit 15 [57] 1.44[58] -0.74[59] -1.68[60] 2.52[61] 2.29[62] -1.59[63]
10 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 [64] 0.22[65] 0.13[66] 0.89[67] 2.72[68] 2.96[69] 0.94[70]
11 SIRT6 NAD-dependent protein deacetylase sirtuin-6 [71] -0.39[72] -2.06[73] -2.09[74] 0.08[75] 0.56[76] -2.77[77]
12 ABCA1 ATP-binding cassette sub-family A member 1 [78] 1.97[79] 1.50[80] 0.52[81] 2.47[82] 3.01[83] 4.10[84]
13 PPARA Peroxisome proliferator-activated receptor alpha [85] 0.98[86] 0.58[87] 0.68[88] 1.29[89] 0.43[90] 3.03[91]
14 MTOR Serine/threonine-protein kinase mTOR [92] 2.84[93] 2.48[94] 1.29[95] 3.93[96] 3.99[97] 2.33[98]
15 PPARGC1A Peroxisome proliferator-activated receptor gamma coactivator 1-alpha -0.78[99] 0.73[100] -10.80[101] 2.01[102] -1.31[103] 2.32[104]
16 SIRT1 NAD-dependent protein deacetylase sirtuin-1 [105] 0.80[106] 0.53[107] -0.67[108] 2.81[109] 3.03[110] 0.22[111]
17 MIR33B [112] [113] [114] [115] [116] [117] [118]
18 MIR33A [119] [120] [121] [122] [123] [124] [125]
19 MIR6886 [126] [127] [128] [129] [130] [131] [132]
[1]
ref_hepatocyte SCD
Mean 184
Standard deviation 1.7e+02
Values 35 3.1e+02 1.3e+02 4.1e+02 33
[2]
HepG2 SCD
Mean 263
Standard deviation 44
Values 2.9e+02 2.3e+02
[3]
HepG2.C3A SCD
Mean 832
Standard deviation 2.9e+02
Values 6.3e+02 1e+03
[4]
HuH.7 SCD
Mean 1.37e+03
Standard deviation 3.6e+02
Values 1e+03 1.7e+03 1.4e+03
[5]
SNU475 SCD
Mean 42.8
Standard deviation 2.4
Values 41 45
[6]
THLE SCD
Mean 25.4
Standard deviation 2.3
Values 24 27
[7]
liver SCD
Mean 369
Standard deviation 2.8e+02
Values 1.4e+02 5.6e+02 1.1e+02 6.7e+02
[8]
ref_hepatocyte HMGCS1
Mean 128
Standard deviation 1e+02
Values 58 72 32 2.5e+02 2.3e+02
[9]
HepG2 HMGCS1
Mean 20.3
Standard deviation 12
Values 28 12
[10]
HepG2.C3A HMGCS1
Mean 170
Standard deviation 81
Values 1.1e+02 2.3e+02
[11]
HuH.7 HMGCS1
Mean 427
Standard deviation 1.7e+02
Values 3.3e+02 6.2e+02 3.3e+02
[12]
SNU475 HMGCS1
Mean 12.1
Standard deviation 4.1
Values 9.2 15
[13]
THLE HMGCS1
Mean 11.4
Standard deviation 0.78
Values 11 12
[14]
liver HMGCS1
Mean 154
Standard deviation 63
Values 2.2e+02 1.9e+02 79 1.3e+02
[15]
ref_hepatocyte SREBF1
Mean 27.4
Standard deviation 36
Values 6.5 85 42 1.8 1.2
[16]
HepG2 SREBF1
Mean 35.4
Standard deviation 8.8
Values 29 42
[17]
HepG2.C3A SREBF1
Mean 38.3
Standard deviation 21
Values 24 53
[18]
HuH.7 SREBF1
Mean 53.8
Standard deviation 3.4
Values 56 55 50
[19]
SNU475 SREBF1
Mean 17.3
Standard deviation 4.1
Values 14 20
[20]
THLE SREBF1
Mean 21.9
Standard deviation 0.74
Values 21 22
[21]
liver SREBF1
Mean 54.7
Standard deviation 14
Values 35 59 58 67
[22]
ref_hepatocyte FASN
Mean 16.9
Standard deviation 11
Values 11 22 17 31 3.5
[23]
HepG2 FASN
Mean 197
Standard deviation 11
Values 2e+02 1.9e+02
[24]
HepG2.C3A FASN
Mean 273
Standard deviation 1.4e+02
Values 1.7e+02 3.7e+02
[25]
HuH.7 FASN
Mean 387
Standard deviation 1.1e+02
Values 2.9e+02 3.8e+02 5e+02
[26]
SNU475 FASN
Mean 51.5
Standard deviation 12
Values 43 60
[27]
THLE FASN
Mean 59
Standard deviation 19
Values 46 72
[28]
liver FASN
Mean 136
Standard deviation 1e+02
Values 2.8e+02 1.2e+02 92 54
[29]
ref_hepatocyte HMGCR
Mean 14.8
Standard deviation 13
Values 9.1 9.8 5.9 37 12
[30]
HepG2 HMGCR
Mean 22.2
Standard deviation 14
Values 32 12
[31]
HepG2.C3A HMGCR
Mean 133
Standard deviation 31
Values 1.1e+02 1.5e+02
[32]
HuH.7 HMGCR
Mean 154
Standard deviation 61
Values 1.1e+02 2.2e+02 1.3e+02
[33]
SNU475 HMGCR
Mean 22
Standard deviation 2.5
Values 20 24
[34]
THLE HMGCR
Mean 19.8
Standard deviation 3.5
Values 17 22
[35]
liver HMGCR
Mean 54.5
Standard deviation 28
Values 81 71 20 46
[36]
ref_hepatocyte NR1H3
Mean 14.8
Standard deviation 10
Values 6.4 29 22 6.4 9.6
[37]
HepG2 NR1H3
Mean 10.3
Standard deviation 0.1
Values 10 10
[38]
HepG2.C3A NR1H3
Mean 18.6
Standard deviation 4.7
Values 15 22
[39]
HuH.7 NR1H3
Mean 33.8
Standard deviation 2.7
Values 35 36 31
[40]
SNU475 NR1H3
Mean 4.08
Standard deviation 1.1
Values 4.8 3.3
[41]
THLE NR1H3
Mean 1.8
Standard deviation 0.21
Values 1.7 1.9
[42]
liver NR1H3
Mean 16.9
Standard deviation 7.5
Values 9.7 12 25 21
[43]
ref_hepatocyte LDLR
Mean 13.7
Standard deviation 8.6
Values 27 4.3 16 7.7 14
[44]
HepG2 LDLR
Mean 34.6
Standard deviation 16
Values 23 46
[45]
HepG2.C3A LDLR
Mean 55.1
Standard deviation 38
Values 29 82
[46]
HuH.7 LDLR
Mean 106
Standard deviation 31
Values 78 1.4e+02 1e+02
[47]
SNU475 LDLR
Mean 13.5
Standard deviation 6.6
Values 8.9 18
[48]
THLE LDLR
Mean 34.7
Standard deviation 13
Values 25 44
[49]
liver LDLR
Mean 45.8
Standard deviation 27
Values 84 24 45 30
[50]
ref_hepatocyte SREBF2
Mean 9.95
Standard deviation 4.6
Values 17 11 9.9 5 6.7
[51]
HepG2 SREBF2
Mean 52.8
Standard deviation 5.8
Values 49 57
[52]
HepG2.C3A SREBF2
Mean 84.4
Standard deviation 47
Values 51 1.2e+02
[53]
HuH.7 SREBF2
Mean 184
Standard deviation 38
Values 1.4e+02 2.2e+02 1.9e+02
[54]
SNU475 SREBF2
Mean 14.5
Standard deviation 9
Values 8.1 21
[55]
THLE SREBF2
Mean 19.8
Standard deviation 7.5
Values 14 25
[56]
liver SREBF2
Mean 39.3
Standard deviation 16
Values 59 46 23 30
[57]
ref_hepatocyte MED15
Mean 8.77
Standard deviation 8.9
Values 25 3.8 4.2 4.2 7.1
[58]
HepG2 MED15
Mean 42.5
Standard deviation 5.6
Values 39 47
[59]
HepG2.C3A MED15
Mean 21.7
Standard deviation 7.4
Values 16 27
[60]
HuH.7 MED15
Mean 18.3
Standard deviation 1.4
Values 17 19 19
[61]
SNU475 MED15
Mean 38.7
Standard deviation 10
Values 32 46
[62]
THLE MED15
Mean 37.8
Standard deviation 0.025
Values 38 38
[63]
liver MED15
Mean 8.98
Standard deviation 3.7
Values 6.7 5.1 12 12
[64]
ref_hepatocyte PRKAA1
Mean 8.04
Standard deviation 3.4
Values 6.1 14 7.2 5.4 7.6
[65]
HepG2 PRKAA1
Mean 16.8
Standard deviation 2.1
Values 18 15
[66]
HepG2.C3A PRKAA1
Mean 36.3
Standard deviation 5.5
Values 40 32
[67]
HuH.7 PRKAA1
Mean 99.5
Standard deviation 14
Values 84 1e+02 1.1e+02
[68]
SNU475 PRKAA1
Mean 40.7
Standard deviation 4.8
Values 37 44
[69]
THLE PRKAA1
Mean 55.1
Standard deviation 6.9
Values 60 50
[70]
liver PRKAA1
Mean 47.6
Standard deviation 7.3
Values 47 58 40 45
[71]
ref_hepatocyte SIRT6
Mean 5.25
Standard deviation 1.6
Values 6.5 4.9 6 2.6 6.4
[72]
HepG2 SIRT6
Mean 7.17
Standard deviation 1.1
Values 6.4 8
[73]
HepG2.C3A SIRT6
Mean 5.21
Standard deviation 0.34
Values 5 5.5
[74]
HuH.7 SIRT6
Mean 8.24
Standard deviation 2.7
Values 11 5.8 7.7
[75]
SNU475 SIRT6
Mean 4.28
Standard deviation 0.79
Values 4.8 3.7
[76]
THLE SIRT6
Mean 6.83
Standard deviation 0.32
Values 7.1 6.6
[77]
liver SIRT6
Mean 2.37
Standard deviation 1.6
Values 1.1 0.86 4 3.5
[78]
ref_hepatocyte ABCA1
Mean 4.97
Standard deviation 4
Values 0.95 10 5.2 7.4 1.1
[79]
HepG2 ABCA1
Mean 34.8
Standard deviation 18
Values 48 22
[80]
HepG2.C3A ABCA1
Mean 58.2
Standard deviation 2.3
Values 60 57
[81]
HuH.7 ABCA1
Mean 47.7
Standard deviation 23
Values 26 73 44
[82]
SNU475 ABCA1
Mean 21.2
Standard deviation 3.5
Values 24 19
[83]
THLE ABCA1
Mean 35.1
Standard deviation 5.6
Values 39 31
[84]
liver ABCA1
Mean 262
Standard deviation 1.4e+02
Values 4.4e+02 2.8e+02 2.1e+02 1.2e+02
[85]
ref_hepatocyte PPARA
Mean 3.95
Standard deviation 2.1
Values 1.6 6.2 5.5 4.6 1.9
[86]
HepG2 PPARA
Mean 13.9
Standard deviation 0.43
Values 14 14
[87]
HepG2.C3A PPARA
Mean 24.4
Standard deviation 5.6
Values 20 28
[88]
HuH.7 PPARA
Mean 42.3
Standard deviation 18
Values 25 60 42
[89]
SNU475 PPARA
Mean 7.44
Standard deviation 1.6
Values 6.3 8.5
[90]
THLE PPARA
Mean 4.68
Standard deviation 0.38
Values 4.9 4.4
[91]
liver PPARA
Mean 99.6
Standard deviation 24
Values 79 1.3e+02 88 97
[92]
ref_hepatocyte MTOR
Mean 3.34
Standard deviation 0.62
Values 4.3 3.2 3.5 2.6 3.1
[93]
HepG2 MTOR
Mean 42.7
Standard deviation 6.3
Values 47 38
[94]
HepG2.C3A MTOR
Mean 76.8
Standard deviation 17
Values 65 89
[95]
HuH.7 MTOR
Mean 54.5
Standard deviation 17
Values 41 50 73
[96]
SNU475 MTOR
Mean 39.4
Standard deviation 0.66
Values 40 39
[97]
THLE MTOR
Mean 46.6
Standard deviation 4.9
Values 43 50
[98]
liver MTOR
Mean 51.8
Standard deviation 18
Values 62 72 34 39
[99]
ref_hepatocyte PPARGC1A
Mean 1.87
Standard deviation 1.7
Values 0.25 1.6 3.2 4 0.26
[100]
HepG2 PPARGC1A
Mean 1.94
Standard deviation 0.37
Values 2.2 1.7
[101]
HepG2.C3A PPARGC1A
Mean 12.8
Standard deviation 3.6
Values 10 15
[102]
HuH.7 PPARGC1A
Mean 0.00701
Standard deviation 0.0065
Values 0 0.013 0.0082
[103]
SNU475 PPARGC1A
Mean 5.83
Standard deviation 1.4
Values 4.9 6.8
[104]
THLE PPARGC1A
Mean 0.662
Standard deviation 0.1
Values 0.73 0.59
[105]
liver PPARGC1A
Mean 28.7
Standard deviation 18
Values 26 54 20 15
[106]
ref_hepatocyte SIRT1
Mean 1.83
Standard deviation 0.67
Values 1.2 2 1.4 2.9 1.6
[107]
HepG2 SIRT1
Mean 5.71
Standard deviation 1.4
Values 6.7 4.7
[108]
HepG2.C3A SIRT1
Mean 10.9
Standard deviation 1
Values 12 10
[109]
HuH.7 SIRT1
Mean 7.67
Standard deviation 1.5
Values 6.3 9.3 7.5
[110]
SNU475 SIRT1
Mean 9.92
Standard deviation 1.6
Values 11 8.8
[111]
THLE SIRT1
Mean 13.2
Standard deviation 0.39
Values 13 13
[112]
liver SIRT1
Mean 6.57
Standard deviation 1.6
Values 7.7 6.2 7.9 4.4
[113]
ref_hepatocyte MIR33B
Missing
[114]
HepG2 MIR33B
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A MIR33B
Mean 0.00972
Standard deviation 0.014
Values 0 0.019
[116]
HuH.7 MIR33B
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[117]
SNU475 MIR33B
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[118]
THLE MIR33B
Mean 0
Standard deviation 0
Values 0 0
[119]
liver MIR33B
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte MIR33A
Missing
[121]
HepG2 MIR33A
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A MIR33A
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[123]
HuH.7 MIR33A
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 MIR33A
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE MIR33A
Mean 0
Standard deviation 0
Values 0 0
[126]
liver MIR33A
Mean 0
Standard deviation 0
Values 0 0 0 0
[127]
ref_hepatocyte MIR6886
Missing
[128]
HepG2 MIR6886
Missing
[129]
HepG2.C3A MIR6886
Missing
[130]
HuH.7 MIR6886
Missing
[131]
SNU475 MIR6886
Missing
[132]
THLE MIR6886
Missing
[133]
liver MIR6886
Missing