WP_SPHINGOLIPID_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CERS2 | Ceramide synthase 2 | [1] | -0.78[2] | -1.26[3] | -0.36[4] | -1.03[5] | -1.34[6] | -0.48[7] |
2 | SERINC1 | Serine incorporator 1 | [8] | -0.49[9] | -0.26[10] | -0.86[11] | -0.51[12] | -0.02[13] | 0.29[14] |
3 | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | [15] | -0.02[16] | -0.46[17] | 0.69[18] | 1.35[19] | -0.75[20] | -1.02[21] |
4 | ASAH1 | Acid ceramidase | [22] | 0.10[23] | -0.23[24] | -0.03[25] | -0.94[26] | -0.74[27] | -0.49[28] |
5 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 0.27[29] | 0.20[30] | -0.49[31] | 0.56[32] | 0.97[33] | -0.17[34] | |
6 | CERS4 | Ceramide synthase 4 | [35] | -0.84[36] | -0.18[37] | -0.52[38] | -3.56[39] | -3.31[40] | -0.30[41] |
7 | SPTLC1 | Serine palmitoyltransferase 1 | [42] | 0.17[43] | 0.68[44] | -0.07[45] | 0.16[46] | 1.10[47] | -0.90[48] |
8 | SPHK1 | Sphingosine kinase 1 | [49] | 1.57[50] | 2.10[51] | -0.44[52] | -2.38[53] | 0.18[54] | -5.07[55] |
9 | GBA | Glucosylceramidase | [56] | 0.10[57] | -1.58[58] | 0.15[59] | 0.66[60] | 1.11[61] | -0.98[62] |
10 | KDSR | 3-ketodihydrosphingosine reductase | [63] | -0.57[64] | -0.42[65] | -1.05[66] | -0.39[67] | 0.85[68] | 1.48[69] |
11 | CERS5 | Ceramide synthase 5 | [70] | 0.58[71] | -0.17[72] | -0.62[73] | 0.12[74] | 0.39[75] | -1.14[76] |
12 | GBA2 | Non-lysosomal glucosylceramidase | [77] | 0.93[78] | 1.65[79] | 1.22[80] | -0.29[81] | 0.53[82] | 1.57[83] |
13 | UGCG | Ceramide glucosyltransferase | [84] | -2.46[85] | -1.54[86] | -0.93[87] | -0.48[88] | 1.25[89] | -0.63[90] |
14 | SPTLC3 | Serine palmitoyltransferase 3 | [91] | -0.47[92] | 0.48[93] | 1.82[94] | -3.68[95] | -1.18[96] | 0.69[97] |
15 | SGPL1 | Sphingosine-1-phosphate lyase 1 | [98] | 2.03[99] | 1.30[100] | 0.48[101] | 1.43[102] | 1.16[103] | 2.18[104] |
16 | CERK | Ceramide kinase | [105] | 2.12[106] | 2.56[107] | 1.89[108] | 1.29[109] | 1.61[110] | 1.10[111] |
17 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | [112] | -0.57[113] | 0.25[114] | -0.84[115] | 0.86[116] | 1.09[117] | 1.02[118] |
18 | CERS6 | Ceramide synthase 6 | [119] | 0.53[120] | 0.32[121] | 2.14[122] | 1.03[123] | 0.81[124] | 1.29[125] |
19 | SPHK2 | Sphingosine kinase 2 | [126] | -0.16[127] | -0.14[128] | -0.48[129] | -0.01[130] | -0.30[131] | 0.34[132] |
20 | SGMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | [133] | -2.04[134] | -1.84[135] | -5.96[136] | 0.72[137] | 2.27[138] | 1.75[139] |
21 | SPTLC2 | Serine palmitoyltransferase 2 | [140] | 2.60[141] | 2.27[142] | 1.31[143] | 2.58[144] | 2.55[145] | 2.77[146] |
22 | GAL3ST1 | Galactosylceramide sulfotransferase | [147] | 0.84[148] | 1.69[149] | 0.56[150] | -0.19[151] | -3.90[152] | -2.11[153] |
23 | UGT8 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | [154] | -1.56[155] | -0.08[156] | 1.88[157] | 0.91[158] | 1.33[159] | 2.94[160] |
24 | B4GALT6 | Beta-1,4-galactosyltransferase 6 | [161] | 0.43[162] | 1.30[163] | 1.80[164] | 3.56[165] | 2.89[166] | 0.83[167] |
25 | ASAH2 | Neutral ceramidase | [168] | 1.05[169] | 2.43[170] | -0.61[171] | -1.39[172] | -0.72[173] | 0.33[174] |
26 | ACER1 | Alkaline ceramidase 1 | [175] | [176] | [177] | [178] | [179] | [180] | [181] |
27 | CERT1 | [182] | [183] | [184] | [185] | [186] | [187] | [188] | |
28 | SGPP2 | Sphingosine-1-phosphate phosphatase 2 | [189] | [190] | [191] | [192] | [193] | [194] | [195] |
29 | PLPP1 | Phospholipid phosphatase 1 | [196] | [197] | [198] | [199] | [200] | [201] | [202] |
30 | CERS3 | Ceramide synthase 3 | [203] | [204] | [205] | [206] | [207] | [208] | [209] |