WP_SPHINGOLIPID_METABOLISM_OVERVIEW | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CERS2 | Ceramide synthase 2 | [1] | -0.69[2] | -1.14[3] | -0.12[4] | -0.66[5] | -1.24[6] | -0.54[7] |
2 | ASAH1 | Acid ceramidase | [8] | 0.20[9] | -0.11[10] | 0.21[11] | -0.56[12] | -0.64[13] | -0.54[14] |
3 | CERS4 | Ceramide synthase 4 | [15] | -0.75[16] | -0.06[17] | -0.28[18] | -3.18[19] | -3.20[20] | -0.36[21] |
4 | SMPD1 | Sphingomyelin phosphodiesterase | [22] | -2.02[23] | -2.80[24] | -2.93[25] | -1.27[26] | -0.76[27] | 0.35[28] |
5 | DEGS1 | Sphingolipid delta(4)-desaturase DES1 | [29] | -0.59[30] | -1.25[31] | -1.07[32] | 1.45[33] | 0.88[34] | -0.60[35] |
6 | SPTLC1 | Serine palmitoyltransferase 1 | [36] | 0.26[37] | 0.79[38] | 0.17[39] | 0.54[40] | 1.20[41] | -0.96[42] |
7 | SPHK1 | Sphingosine kinase 1 | [43] | 1.67[44] | 2.22[45] | -0.21[46] | -2.01[47] | 0.28[48] | -5.13[49] |
8 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | [50] | -0.79[51] | -0.79[52] | -1.81[53] | -0.30[54] | -0.08[55] | 0.58[56] |
9 | KDSR | 3-ketodihydrosphingosine reductase | [57] | -0.48[58] | -0.30[59] | -0.82[60] | -0.01[61] | 0.95[62] | 1.43[63] |
10 | UGCG | Ceramide glucosyltransferase | [64] | -2.36[65] | -1.42[66] | -0.69[67] | -0.11[68] | 1.35[69] | -0.68[70] |
11 | SGPL1 | Sphingosine-1-phosphate lyase 1 | [71] | 2.12[72] | 1.42[73] | 0.72[74] | 1.81[75] | 1.26[76] | 2.13[77] |
12 | CERK | Ceramide kinase | [78] | 2.21[79] | 2.68[80] | 2.13[81] | 1.66[82] | 1.71[83] | 1.04[84] |
13 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | [85] | -0.47[86] | 0.37[87] | -0.60[88] | 1.23[89] | 1.19[90] | 0.96[91] |
14 | CERS6 | Ceramide synthase 6 | [92] | 0.63[93] | 0.44[94] | 2.38[95] | 1.41[96] | 0.91[97] | 1.24[98] |
15 | SPHK2 | Sphingosine kinase 2 | [99] | -0.07[100] | -0.02[101] | -0.25[102] | 0.36[103] | -0.20[104] | 0.28[105] |
16 | SGMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | [106] | -1.94[107] | -1.72[108] | -5.72[109] | 1.10[110] | 2.37[111] | 1.69[112] |
17 | SPTLC2 | Serine palmitoyltransferase 2 | [113] | 2.69[114] | 2.39[115] | 1.54[116] | 2.96[117] | 2.65[118] | 2.71[119] |
18 | UGT8 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | [120] | -1.47[121] | 0.03[122] | 2.12[123] | 1.29[124] | 1.44[125] | 2.88[126] |
19 | CERS1 | Ceramide synthase 1 | [127] | 1.46[128] | 0.30[129] | 2.06[130] | -1.15[131] | -1.24[132] | [133] |
20 | DEGS2 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 | [134] | 4.87[135] | -1.20[136] | 0.74[137] | 1.35[138] | -1.13[139] | 2.89[140] |
21 | CERS3 | Ceramide synthase 3 | [141] | [142] | [143] | [144] | [145] | [146] | [147] |
22 | PLPP3 | Phospholipid phosphatase 3 | [148] | [149] | [150] | [151] | [152] | [153] | [154] |
23 | GDF1 | Embryonic growth/differentiation factor 1 | [155] | [156] | [157] | [158] | [159] | [160] | [161] |
24 | SGPP2 | Sphingosine-1-phosphate phosphatase 2 | [162] | [163] | [164] | [165] | [166] | [167] | [168] |