WP_SPHINGOLIPID_METABOLISM_IN_SENESCENCE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CERS2 | Ceramide synthase 2 | [1] | -1.11[2] | -1.52[3] | -0.49[4] | -0.80[5] | -1.71[6] | -0.41[7] |
2 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [8] | 0.51[9] | -0.97[10] | -3.60[11] | -1.93[12] | 0.31[13] | -1.84[14] |
3 | ASAH1 | Acid ceramidase | [15] | -0.22[16] | -0.48[17] | -0.16[18] | -0.70[19] | -1.12[20] | -0.42[21] |
4 | CDK4 | Cyclin-dependent kinase 4 | [22] | 1.00[23] | 1.49[24] | 1.19[25] | 0.24[26] | 0.57[27] | -0.84[28] |
5 | CERS4 | Ceramide synthase 4 | [29] | -1.17[30] | -0.44[31] | -0.66[32] | -3.32[33] | -3.68[34] | -0.23[35] |
6 | DEGS1 | Sphingolipid delta(4)-desaturase DES1 | [36] | -1.01[37] | -1.63[38] | -1.44[39] | 1.31[40] | 0.41[41] | -0.47[42] |
7 | GLB1 | Beta-galactosidase | [43] | 0.33[44] | -0.14[45] | 0.97[46] | -0.46[47] | 0.02[48] | 0.12[49] |
8 | SPTLC1 | Serine palmitoyltransferase 1 | [50] | -0.16[51] | 0.42[52] | -0.20[53] | 0.40[54] | 0.73[55] | -0.83[56] |
9 | CDK2 | Cyclin-dependent kinase 2 | [57] | -0.74[58] | -0.67[59] | -0.23[60] | 0.03[61] | 0.31[62] | -2.19[63] |
10 | SPHK1 | Sphingosine kinase 1 | [64] | 1.25[65] | 1.84[66] | -0.58[67] | -2.15[68] | -0.19[69] | -5.00[70] |
11 | MAPK1 | Mitogen-activated protein kinase 1 | [71] | 1.38[72] | 1.42[73] | 1.32[74] | 1.90[75] | 1.24[76] | 1.77[77] |
12 | GBA | Glucosylceramidase | [78] | -0.23[79] | -1.84[80] | 0.02[81] | 0.89[82] | 0.73[83] | -0.91[84] |
13 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | [85] | -1.21[86] | -1.17[87] | -2.18[88] | -0.44[89] | -0.55[90] | 0.71[91] |
14 | KDSR | 3-ketodihydrosphingosine reductase | [92] | -0.90[93] | -0.67[94] | -1.19[95] | -0.16[96] | 0.48[97] | 1.55[98] |
15 | UGCG | Ceramide glucosyltransferase | [99] | -2.78[100] | -1.79[101] | -1.07[102] | -0.25[103] | 0.88[104] | -0.56[105] |
16 | RPP38 | Ribonuclease P protein subunit p38 | [106] | -0.94[107] | -0.61[108] | -1.06[109] | 0.26[110] | -0.70[111] | -0.70[112] |
17 | MTOR | Serine/threonine-protein kinase mTOR | [113] | 2.21[114] | 3.12[115] | 2.76[116] | 2.74[117] | 2.50[118] | 3.45[119] |
18 | RB1 | Retinoblastoma-associated protein | [120] | 0.89[121] | 1.29[122] | 1.92[123] | 2.33[124] | 2.34[125] | 1.47[126] |
19 | SGMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | [127] | -2.36[128] | -2.09[129] | -6.09[130] | 0.96[131] | 1.90[132] | 1.82[133] |
20 | S1PR1 | Sphingosine 1-phosphate receptor 1 | [134] | -8.72[135] | [136] | -3.69[137] | -2.49[138] | -1.16[139] | 1.02[140] |
21 | E2F1 | Transcription factor E2F1 | [141] | 1.62[142] | 1.38[143] | 1.57[144] | 1.92[145] | 2.04[146] | -3.62[147] |
22 | PRKCA | Protein kinase C alpha type | [148] | 2.51[149] | 2.45[150] | 2.88[151] | 2.20[152] | 2.25[153] | 1.92[154] |
23 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | [155] | 2.46[156] | 3.99[157] | 3.48[158] | 0.83[159] | 1.01[160] | 2.49[161] |
24 | S1PR2 | Sphingosine 1-phosphate receptor 2 | [162] | 0.47[163] | 0.00[164] | 2.51[165] | 1.54[166] | 0.51[167] | 2.79[168] |
25 | SMPD3 | Sphingomyelin phosphodiesterase 3 | [169] | -0.21[170] | 0.17[171] | -0.50[172] | 0.39[173] | -0.86[174] | 2.92[175] |
26 | PRKCB | Protein kinase C beta type | [176] | -7.14[177] | -6.04[178] | [179] | 2.54[180] | -3.08[181] | 3.53[182] |
27 | TERT | Telomerase reverse transcriptase | [183] | 3.16[184] | 2.82[185] | 3.83[186] | 2.24[187] | -4.12[188] | -3.90[189] |
28 | S1PR5 | Sphingosine 1-phosphate receptor 5 | [190] | -1.09[191] | 0.27[192] | 3.08[193] | 4.13[194] | 2.04[195] | 0.19[196] |