WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CERS2 Ceramide synthase 2 [1] -0.71[2] -1.14[3] -0.11[4] -0.67[5] -1.25[6] -0.52[7]
2 ASAH1 Acid ceramidase [8] 0.18[9] -0.11[10] 0.22[11] -0.57[12] -0.66[13] -0.53[14]
3 CERS4 Ceramide synthase 4 [15] -0.76[16] -0.06[17] -0.28[18] -3.19[19] -3.22[20] -0.34[21]
4 SMPD1 Sphingomyelin phosphodiesterase [22] -2.04[23] -2.80[24] -2.92[25] -1.28[26] -0.77[27] 0.37[28]
5 DEGS1 Sphingolipid delta(4)-desaturase DES1 [29] -0.61[30] -1.25[31] -1.06[32] 1.44[33] 0.87[34] -0.58[35]
6 SPTLC1 Serine palmitoyltransferase 1 [36] 0.24[37] 0.79[38] 0.18[39] 0.53[40] 1.19[41] -0.94[42]
7 SPHK1 Sphingosine kinase 1 [43] 1.65[44] 2.22[45] -0.20[46] -2.02[47] 0.27[48] -5.11[49]
8 SGPP1 Sphingosine-1-phosphate phosphatase 1 [50] -0.81[51] -0.79[52] -1.80[53] -0.32[54] -0.09[55] 0.60[56]
9 KDSR 3-ketodihydrosphingosine reductase [57] -0.49[58] -0.30[59] -0.81[60] -0.03[61] 0.94[62] 1.44[63]
10 CERS5 Ceramide synthase 5 [64] 0.65[65] -0.05[66] -0.37[67] 0.48[68] 0.48[69] -1.18[70]
11 UGCG Ceramide glucosyltransferase [71] -2.38[72] -1.42[73] -0.69[74] -0.12[75] 1.34[76] -0.67[77]
12 SGPL1 Sphingosine-1-phosphate lyase 1 [78] 2.11[79] 1.42[80] 0.73[81] 1.80[82] 1.25[83] 2.14[84]
13 CERK Ceramide kinase [85] 2.19[86] 2.68[87] 2.14[88] 1.65[89] 1.70[90] 1.06[91]
14 SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 [92] -0.49[93] 0.37[94] -0.59[95] 1.22[96] 1.18[97] 0.98[98]
15 CERS6 Ceramide synthase 6 [99] 0.61[100] 0.44[101] 2.38[102] 1.40[103] 0.90[104] 1.25[105]
16 SPHK2 Sphingosine kinase 2 [106] -0.09[107] -0.02[108] -0.24[109] 0.35[110] -0.21[111] 0.30[112]
17 SGMS2 Phosphatidylcholine:ceramide cholinephosphotransferase 2 [113] -1.96[114] -1.72[115] -5.71[116] 1.09[117] 2.36[118] 1.71[119]
18 SPTLC2 Serine palmitoyltransferase 2 [120] 2.67[121] 2.39[122] 1.55[123] 2.95[124] 2.64[125] 2.73[126]
19 UGT8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [127] -1.49[128] 0.03[129] 2.13[130] 1.28[131] 1.42[132] 2.90[133]
20 CERS1 Ceramide synthase 1 [134] 1.45[135] 0.30[136] 2.07[137] -1.16[138] -1.25[139] [140]
21 DEGS2 Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [141] 4.85[142] -1.20[143] 0.75[144] 1.33[145] -1.14[146] 2.91[147]
22 GDF1 Embryonic growth/differentiation factor 1 [148] [149] [150] [151] [152] [153] [154]
23 PLPP1 Phospholipid phosphatase 1 [155] [156] [157] [158] [159] [160] [161]
24 PLPP3 Phospholipid phosphatase 3 [162] [163] [164] [165] [166] [167] [168]
25 CERS3 Ceramide synthase 3 [169] [170] [171] [172] [173] [174] [175]
26 PLPP2 Phospholipid phosphatase 2 [176] [177] [178] [179] [180] [181] [182]
27 SGPP2 Sphingosine-1-phosphate phosphatase 2 [183] [184] [185] [186] [187] [188] [189]
[1]
ref_hepatocyte CERS2
Mean 112
Standard deviation 71
Values 53 1.8e+02 2e+02 70 60
[2]
HepG2 CERS2
Mean 145
Standard deviation 9.9
Values 1.5e+02 1.4e+02
[3]
HepG2.C3A CERS2
Mean 103
Standard deviation 32
Values 81 1.3e+02
[4]
HuH.7 CERS2
Mean 194
Standard deviation 72
Values 1.6e+02 2.8e+02 1.5e+02
[5]
SNU475 CERS2
Mean 114
Standard deviation 11
Values 1.1e+02 1.2e+02
[6]
THLE CERS2
Mean 84.7
Standard deviation 14
Values 74 95
[7]
liver CERS2
Mean 121
Standard deviation 29
Values 1.1e+02 86 1.6e+02 1.3e+02
[8]
ref_hepatocyte ASAH1
Mean 31.4
Standard deviation 46
Values 6.3 14 15 1.1e+02 8.7
[9]
HepG2 ASAH1
Mean 74.5
Standard deviation 21
Values 90 59
[10]
HepG2.C3A ASAH1
Mean 59.1
Standard deviation 6.5
Values 64 55
[11]
HuH.7 ASAH1
Mean 67.7
Standard deviation 7
Values 62 76 65
[12]
SNU475 ASAH1
Mean 34.1
Standard deviation 3.7
Values 32 37
[13]
THLE ASAH1
Mean 35.6
Standard deviation 4.9
Values 39 32
[14]
liver ASAH1
Mean 33.4
Standard deviation 7.8
Values 24 30 39 41
[15]
ref_hepatocyte CERS4
Mean 16.6
Standard deviation 15
Values 6.6 33 32 9 2.4
[16]
HepG2 CERS4
Mean 20.5
Standard deviation 3
Values 23 18
[17]
HepG2.C3A CERS4
Mean 32.3
Standard deviation 9.4
Values 26 39
[18]
HuH.7 CERS4
Mean 25.4
Standard deviation 2.5
Values 26 28 23
[19]
SNU475 CERS4
Mean 2.93
Standard deviation 0.81
Values 2.4 3.5
[20]
THLE CERS4
Mean 3.19
Standard deviation 0.32
Values 3.4 3
[21]
liver CERS4
Mean 20
Standard deviation 11
Values 14 9.6 34 22
[22]
ref_hepatocyte SMPD1
Mean 15.8
Standard deviation 15
Values 9.3 29 34 1.7 5.5
[23]
HepG2 SMPD1
Mean 8.08
Standard deviation 2.4
Values 9.8 6.4
[24]
HepG2.C3A SMPD1
Mean 4.63
Standard deviation 0.31
Values 4.8 4.4
[25]
HuH.7 SMPD1
Mean 3.9
Standard deviation 0.17
Values 4.1 3.8 3.8
[26]
SNU475 SMPD1
Mean 10.5
Standard deviation 2.8
Values 8.6 12
[27]
THLE SMPD1
Mean 16.6
Standard deviation 1.6
Values 15 18
[28]
liver SMPD1
Mean 31.4
Standard deviation 20
Values 11 17 48 49
[29]
ref_hepatocyte DEGS1
Mean 15.3
Standard deviation 7.6
Values 14 13 11 11 29
[30]
HepG2 DEGS1
Mean 21.1
Standard deviation 0.78
Values 22 21
[31]
HepG2.C3A DEGS1
Mean 13.1
Standard deviation 0.69
Values 14 13
[32]
HuH.7 DEGS1
Mean 13.6
Standard deviation 0.88
Values 15 13 13
[33]
SNU475 DEGS1
Mean 67.4
Standard deviation 6.7
Values 63 72
[34]
THLE DEGS1
Mean 50.1
Standard deviation 5.8
Values 46 54
[35]
liver DEGS1
Mean 15.7
Standard deviation 8.4
Values 7.2 10 21 24
[36]
ref_hepatocyte SPTLC1
Mean 13.7
Standard deviation 9.5
Values 10 7.7 5.2 29 16
[37]
HepG2 SPTLC1
Mean 33.9
Standard deviation 2.4
Values 36 32
[38]
HepG2.C3A SPTLC1
Mean 48.2
Standard deviation 6.8
Values 53 43
[39]
HuH.7 SPTLC1
Mean 28.8
Standard deviation 0.78
Values 28 30 28
[40]
SNU475 SPTLC1
Mean 31.8
Standard deviation 5.1
Values 28 35
[41]
THLE SPTLC1
Mean 55.7
Standard deviation 4
Values 53 59
[42]
liver SPTLC1
Mean 10.9
Standard deviation 1.2
Values 9.6 10 12 12
[43]
ref_hepatocyte SPHK1
Mean 11.5
Standard deviation 14
Values 19 0.27 1.4 32 4.8
[44]
HepG2 SPHK1
Mean 75.9
Standard deviation 8.5
Values 70 82
[45]
HepG2.C3A SPHK1
Mean 109
Standard deviation 8.6
Values 1e+02 1.2e+02
[46]
HuH.7 SPHK1
Mean 18.7
Standard deviation 5.5
Values 24 13 19
[47]
SNU475 SPHK1
Mean 4.6
Standard deviation 3.4
Values 7 2.2
[48]
THLE SPHK1
Mean 24.9
Standard deviation 0.21
Values 25 25
[49]
liver SPHK1
Mean 0.512
Standard deviation 0.41
Values 0.46 0.3 1.1 0.18
[50]
ref_hepatocyte SGPP1
Mean 7.99
Standard deviation 3
Values 5.3 9.9 5.3 7.2 12
[51]
HepG2 SGPP1
Mean 9.55
Standard deviation 2.3
Values 7.9 11
[52]
HepG2.C3A SGPP1
Mean 9.38
Standard deviation 2.5
Values 7.6 11
[53]
HuH.7 SGPP1
Mean 4.25
Standard deviation 1.5
Values 3.5 6 3.2
[54]
SNU475 SGPP1
Mean 10.4
Standard deviation 1.7
Values 9.2 12
[55]
THLE SGPP1
Mean 13.4
Standard deviation 2.4
Values 12 15
[56]
liver SGPP1
Mean 18.6
Standard deviation 3.6
Values 23 18 19 14
[57]
ref_hepatocyte KDSR
Mean 7.84
Standard deviation 4.1
Values 6.7 10 14 2.7 6.3
[58]
HepG2 KDSR
Mean 11.7
Standard deviation 1.3
Values 11 13
[59]
HepG2.C3A KDSR
Mean 13
Standard deviation 4.2
Values 10 16
[60]
HuH.7 KDSR
Mean 8.32
Standard deviation 1.2
Values 7 8.9 9.1
[61]
SNU475 KDSR
Mean 12.4
Standard deviation 1.4
Values 11 13
[62]
THLE KDSR
Mean 26.9
Standard deviation 5
Values 23 30
[63]
liver KDSR
Mean 32.7
Standard deviation 10
Values 19 33 38 42
[64]
ref_hepatocyte CERS5
Mean 5.89
Standard deviation 2.7
Values 4.7 3.2 4.1 9.3 8.2
[65]
HepG2 CERS5
Mean 19.4
Standard deviation 4.7
Values 16 23
[66]
HepG2.C3A CERS5
Mean 11.6
Standard deviation 2.1
Values 10 13
[67]
HuH.7 CERS5
Mean 8.47
Standard deviation 1.1
Values 9.4 7.2 8.8
[68]
SNU475 CERS5
Mean 13.3
Standard deviation 1.2
Values 12 14
[69]
THLE CERS5
Mean 14.7
Standard deviation 0.49
Values 14 15
[70]
liver CERS5
Mean 4
Standard deviation 1.8
Values 2.3 2.9 4.3 6.4
[71]
ref_hepatocyte UGCG
Mean 5.29
Standard deviation 6.5
Values 8.1 0.45 1.1 1.4 16
[72]
HepG2 UGCG
Mean 2.13
Standard deviation 0.084
Values 2.2 2.1
[73]
HepG2.C3A UGCG
Mean 4.02
Standard deviation 0.11
Values 4.1 3.9
[74]
HuH.7 UGCG
Mean 6.11
Standard deviation 4.1
Values 3.4 11 4.1
[75]
SNU475 UGCG
Mean 7.88
Standard deviation 1.3
Values 6.9 8.8
[76]
THLE UGCG
Mean 24
Standard deviation 0.98
Values 25 23
[77]
liver UGCG
Mean 5.11
Standard deviation 1.5
Values 5.2 7.1 4.2 4
[78]
ref_hepatocyte SGPL1
Mean 5.24
Standard deviation 1.1
Values 3.5 6.5 5.2 5.1 6
[79]
HepG2 SGPL1
Mean 47.3
Standard deviation 3.3
Values 50 45
[80]
HepG2.C3A SGPL1
Mean 28.5
Standard deviation 0.64
Values 29 28
[81]
HuH.7 SGPL1
Mean 16.1
Standard deviation 4.5
Values 16 11 20
[82]
SNU475 SGPL1
Mean 29.4
Standard deviation 7.1
Values 24 34
[83]
THLE SGPL1
Mean 22.3
Standard deviation 1.4
Values 21 23
[84]
liver SGPL1
Mean 35.6
Standard deviation 3
Values 38 38 32 34
[85]
ref_hepatocyte CERK
Mean 4.91
Standard deviation 2.4
Values 6.8 1.8 3.4 7.6 4.9
[86]
HepG2 CERK
Mean 47.1
Standard deviation 9.7
Values 40 54
[87]
HepG2.C3A CERK
Mean 63.9
Standard deviation 2.2
Values 62 65
[88]
HuH.7 CERK
Mean 40.2
Standard deviation 1.8
Values 41 38 42
[89]
SNU475 CERK
Mean 24.9
Standard deviation 2.6
Values 23 27
[90]
THLE CERK
Mean 28.5
Standard deviation 9.3
Values 22 35
[91]
liver CERK
Mean 15.7
Standard deviation 4
Values 21 16 15 11
[92]
ref_hepatocyte SGMS1
Mean 4.43
Standard deviation 2
Values 4.1 3.9 2.2 4.2 7.7
[93]
HepG2 SGMS1
Mean 6.6
Standard deviation 2.6
Values 8.4 4.8
[94]
HepG2.C3A SGMS1
Mean 11.6
Standard deviation 2.4
Values 10 13
[95]
HuH.7 SGMS1
Mean 5.45
Standard deviation 1.4
Values 4.6 7.1 4.7
[96]
SNU475 SGMS1
Mean 16.7
Standard deviation 3.8
Values 14 19
[97]
THLE SGMS1
Mean 17.9
Standard deviation 2
Values 16 19
[98]
liver SGMS1
Mean 13.4
Standard deviation 1.8
Values 13 14 15 11
[99]
ref_hepatocyte CERS6
Mean 4.39
Standard deviation 3.9
Values 2.5 2.2 3 11 2.8
[100]
HepG2 CERS6
Mean 14
Standard deviation 4
Values 17 11
[101]
HepG2.C3A CERS6
Mean 12.1
Standard deviation 1.2
Values 13 11
[102]
HuH.7 CERS6
Mean 42.6
Standard deviation 12
Values 29 51 48
[103]
SNU475 CERS6
Mean 18.7
Standard deviation 5.2
Values 15 22
[104]
THLE CERS6
Mean 14.7
Standard deviation 0.18
Values 15 15
[105]
liver CERS6
Mean 16.1
Standard deviation 6.9
Values 21 23 8.3 12
[106]
ref_hepatocyte SPHK2
Mean 3.26
Standard deviation 2
Values 2.2 6.4 4 1.5 2.2
[107]
HepG2 SPHK2
Mean 6.43
Standard deviation 0.066
Values 6.5 6.4
[108]
HepG2.C3A SPHK2
Mean 6.53
Standard deviation 0.22
Values 6.7 6.4
[109]
HuH.7 SPHK2
Mean 5.14
Standard deviation 0.89
Values 5.5 4.1 5.8
[110]
SNU475 SPHK2
Mean 6.71
Standard deviation 0.21
Values 6.6 6.9
[111]
THLE SPHK2
Mean 5.03
Standard deviation 1.4
Values 4 6
[112]
liver SPHK2
Mean 6.15
Standard deviation 2.7
Values 4.9 3 8.7 8
[113]
ref_hepatocyte SGMS2
Mean 2.9
Standard deviation 2.1
Values 4.8 1.7 1.9 0.63 5.5
[114]
HepG2 SGMS2
Mean 1.56
Standard deviation 0.49
Values 1.9 1.2
[115]
HepG2.C3A SGMS2
Mean 1.79
Standard deviation 0.25
Values 2 1.6
[116]
HuH.7 SGMS2
Mean 0.103
Standard deviation 0.058
Values 0.037 0.15 0.12
[117]
SNU475 SGMS2
Mean 9.95
Standard deviation 0.77
Values 9.4 10
[118]
THLE SGMS2
Mean 26.6
Standard deviation 0.49
Values 26 27
[119]
liver SGMS2
Mean 14.5
Standard deviation 4.2
Values 16 20 11 12
[120]
ref_hepatocyte SPTLC2
Mean 1.58
Standard deviation 0.68
Values 1.4 0.98 1 2.6 2
[121]
HepG2 SPTLC2
Mean 21.1
Standard deviation 1.1
Values 22 20
[122]
HepG2.C3A SPTLC2
Mean 16.8
Standard deviation 1.3
Values 16 18
[123]
HuH.7 SPTLC2
Mean 8.59
Standard deviation 1.7
Values 6.7 10 8.9
[124]
SNU475 SPTLC2
Mean 19.7
Standard deviation 6.3
Values 15 24
[125]
THLE SPTLC2
Mean 17.6
Standard deviation 5.3
Values 14 21
[126]
liver SPTLC2
Mean 16
Standard deviation 6.3
Values 18 24 8.8 14
[127]
ref_hepatocyte UGT8
Mean 0.512
Standard deviation 0.37
Values 0.86 0.85 0.59 0.21 0.052
[128]
HepG2 UGT8
Mean 0.383
Standard deviation 0.047
Values 0.42 0.35
[129]
HepG2.C3A UGT8
Mean 1.06
Standard deviation 0.19
Values 0.93 1.2
[130]
HuH.7 UGT8
Mean 4.15
Standard deviation 1.5
Values 2.8 5.7 4
[131]
SNU475 UGT8
Mean 2
Standard deviation 0.068
Values 2.1 2
[132]
THLE UGT8
Mean 2.45
Standard deviation 0.14
Values 2.6 2.4
[133]
liver UGT8
Mean 5.84
Standard deviation 5
Values 9.2 11 1.6 1.5
[134]
ref_hepatocyte CERS1
Mean 0.438
Standard deviation 0.8
Values 0.27 0 0.069 1.8 0
[135]
HepG2 CERS1
Mean 2.5
Standard deviation 0.7
Values 2 3
[136]
HepG2.C3A CERS1
Mean 1.09
Standard deviation 0.42
Values 0.79 1.4
[137]
HuH.7 CERS1
Mean 3.42
Standard deviation 0.65
Values 4 3.5 2.7
[138]
SNU475 CERS1
Mean 0.316
Standard deviation 0.04
Values 0.34 0.29
[139]
THLE CERS1
Mean 0.329
Standard deviation 0.045
Values 0.36 0.3
[140]
liver CERS1
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte DEGS2
Mean 0.0171
Standard deviation 0.038
Values 0 0 0 0 0.085
[142]
HepG2 DEGS2
Mean 1.04
Standard deviation 1
Values 0.3 1.8
[143]
HepG2.C3A DEGS2
Mean 0.0151
Standard deviation 0.0062
Values 0.011 0.019
[144]
HuH.7 DEGS2
Mean 0.0534
Standard deviation 0.032
Values 0.037 0.09 0.033
[145]
SNU475 DEGS2
Mean 0.0696
Standard deviation 0.02
Values 0.056 0.083
[146]
THLE DEGS2
Mean 0.0139
Standard deviation 0.0029
Values 0.012 0.016
[147]
liver DEGS2
Mean 0.197
Standard deviation 0.15
Values 0.42 0.14 0.094 0.13
[148]
ref_hepatocyte GDF1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 GDF1
Missing
[150]
HepG2.C3A GDF1
Missing
[151]
HuH.7 GDF1
Missing
[152]
SNU475 GDF1
Missing
[153]
THLE GDF1
Missing
[154]
liver GDF1
Missing
[155]
ref_hepatocyte PLPP1
Missing
[156]
HepG2 PLPP1
Missing
[157]
HepG2.C3A PLPP1
Missing
[158]
HuH.7 PLPP1
Missing
[159]
SNU475 PLPP1
Missing
[160]
THLE PLPP1
Missing
[161]
liver PLPP1
Missing
[162]
ref_hepatocyte PLPP3
Missing
[163]
HepG2 PLPP3
Missing
[164]
HepG2.C3A PLPP3
Missing
[165]
HuH.7 PLPP3
Missing
[166]
SNU475 PLPP3
Missing
[167]
THLE PLPP3
Missing
[168]
liver PLPP3
Missing
[169]
ref_hepatocyte CERS3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 CERS3
Mean 0.00716
Standard deviation 0.002
Values 0.0086 0.0057
[171]
HepG2.C3A CERS3
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 CERS3
Mean 0.0509
Standard deviation 0.029
Values 0.028 0.083 0.041
[173]
SNU475 CERS3
Mean 0.00253
Standard deviation 0.0036
Values 0.0051 0
[174]
THLE CERS3
Mean 0.0263
Standard deviation 0.03
Values 0.047 0.0053
[175]
liver CERS3
Mean 0.0104
Standard deviation 0.014
Values 0.013 0.029 0 0
[176]
ref_hepatocyte PLPP2
Missing
[177]
HepG2 PLPP2
Missing
[178]
HepG2.C3A PLPP2
Missing
[179]
HuH.7 PLPP2
Missing
[180]
SNU475 PLPP2
Missing
[181]
THLE PLPP2
Missing
[182]
liver PLPP2
Missing
[183]
ref_hepatocyte SGPP2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[184]
HepG2 SGPP2
Mean 0.0222
Standard deviation 0.001
Values 0.021 0.023
[185]
HepG2.C3A SGPP2
Mean 0.0458
Standard deviation 0.004
Values 0.043 0.049
[186]
HuH.7 SGPP2
Mean 0.0568
Standard deviation 0.037
Values 0.094 0.019 0.057
[187]
SNU475 SGPP2
Mean 0.83
Standard deviation 0.33
Values 0.59 1.1
[188]
THLE SGPP2
Mean 0.218
Standard deviation 0.075
Values 0.17 0.27
[189]
liver SGPP2
Mean 0.0995
Standard deviation 0.11
Values 0.04 0.1 0.26 0