WP_SEROTONIN_RECEPTOR_2_AND_ELKSRFGATA4_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [1] -1.29[2] -1.58[3] -1.53[4] -1.06[5] -0.57[6] -1.41[7]
2 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [8] -0.31[9] -0.59[10] -0.25[11] -1.36[12] -0.89[13] -1.92[14]
3 RAF1 RAF proto-oncogene serine/threonine-protein kinase [15] -0.43[16] 0.02[17] 0.76[18] -0.70[19] 0.15[20] 0.88[21]
4 NRAS GTPase NRas [22] 0.27[23] 0.74[24] 0.62[25] 0.48[26] 0.04[27] -0.47[28]
5 MAPKAPK2 MAP kinase-activated protein kinase 2 [29] 0.09[30] -0.82[31] -0.94[32] 0.88[33] 0.07[34] -1.16[35]
6 HRAS GTPase HRas [36] -1.37[37] -2.03[38] -3.36[39] -1.47[40] -1.70[41] -2.88[42]
7 MAPK1 Mitogen-activated protein kinase 1 [43] 1.35[44] 1.53[45] 0.82[46] 1.33[47] 0.97[48] 1.56[49]
8 KRAS GTPase KRas [50] -0.88[51] -0.85[52] 0.21[53] 0.28[54] -0.07[55] 0.46[56]
9 ELK1 ETS domain-containing protein Elk-1 [57] -0.68[58] -2.77[59] -0.88[60] -0.25[61] 0.33[62] -0.39[63]
10 SRF Serum response factor [64] 1.10[65] 0.71[66] -0.56[67] 1.02[68] 0.09[69] -1.00[70]
11 MAPK3 Mitogen-activated protein kinase 3 [71] 1.49[72] 1.58[73] 1.08[74] -0.10[75] -0.09[76] -1.26[77]
12 GATA4 Transcription factor GATA-4 [78] 0.42[79] 0.41[80] 1.30[81] -1.74[82] 1.19[83] 0.37[84]
13 ELK4 ETS domain-containing protein Elk-4 [85] 0.54[86] 1.61[87] 0.81[88] 1.08[89] 1.45[90] 2.77[91]
14 GNAQ Guanine nucleotide-binding protein G(q) subunit alpha [92] -0.29[93] 0.53[94] 0.51[95] 1.07[96] 1.27[97] 1.22[98]
15 ITPR1 Inositol 1,4,5-trisphosphate receptor type 1 [99] 2.77[100] 2.70[101] 3.32[102] 2.33[103] 3.19[104] 4.43[105]
16 HTR2B 5-hydroxytryptamine receptor 2B [106] -2.68[107] -2.25[108] -3.20[109] 2.82[110] -2.63[111] 3.53[112]
17 HTR2A 5-hydroxytryptamine receptor 2A [113] [114] -1.33[115] [116] -2.90[117] -0.46[118] 4.52[119]
18 RASGRF1 Ras-specific guanine nucleotide-releasing factor 1 [120] 3.86[121] 4.76[122] -3.04[123] 2.20[124] -0.72[125] [126]
19 RASGRP1 RAS guanyl-releasing protein 1 [127] 0.87[128] 1.61[129] 1.72[130] 3.62[131] 4.70[132] 6.59[133]
20 HTR2C 5-hydroxytryptamine receptor 2C [134] [135] [136] [137] [138] [139] [140]
[1]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 32 27 15 27 39
[2]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 30 35
[3]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[4]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 40 27 33
[5]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 39 32
[6]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[7]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 12 11 28 18
[8]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 28 26 42 22 20
[9]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 48 79
[10]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 36 55
[11]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 69 82 87
[12]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[13]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[14]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 11 11 17 9.8
[15]
ref_hepatocyte RAF1
Mean 15.5
Standard deviation 5.7
Values 20 17 20 6 14
[16]
HepG2 RAF1
Mean 32.7
Standard deviation 5.2
Values 36 29
[17]
HepG2.C3A RAF1
Mean 38.6
Standard deviation 2.8
Values 37 41
[18]
HuH.7 RAF1
Mean 89
Standard deviation 4.2
Values 89 93 85
[19]
SNU475 RAF1
Mean 25
Standard deviation 4.6
Values 28 22
[20]
THLE RAF1
Mean 50.9
Standard deviation 5.2
Values 47 55
[21]
liver RAF1
Mean 47
Standard deviation 3.6
Values 46 42 51 49
[22]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 9.3 4.6 3.3 32 23
[23]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 57 42
[24]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 72 47
[25]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 71 70 86
[26]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 46 59
[27]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[28]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 16 21 14 18
[29]
ref_hepatocyte MAPKAPK2
Mean 13.1
Standard deviation 7.6
Values 24 8.7 17 5.2 10
[30]
HepG2 MAPKAPK2
Mean 39.7
Standard deviation 1.4
Values 39 41
[31]
HepG2.C3A MAPKAPK2
Mean 18.1
Standard deviation 4.5
Values 15 21
[32]
HuH.7 MAPKAPK2
Mean 23.2
Standard deviation 2.9
Values 25 20 25
[33]
SNU475 MAPKAPK2
Mean 63.2
Standard deviation 4
Values 60 66
[34]
THLE MAPKAPK2
Mean 40.9
Standard deviation 0.33
Values 41 41
[35]
liver MAPKAPK2
Mean 9.67
Standard deviation 2.5
Values 11 11 10 6
[36]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 11 8.8 7.4 4 27
[37]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 12 14
[38]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 7.9 6
[39]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 5.6 2.4 3.6
[40]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[41]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[42]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 1.4 1.1 4.1 3.8
[43]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[44]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[45]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[46]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[47]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[48]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[49]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[50]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 5.4 2.7 1.7 18 17
[51]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 16 12
[52]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 14 11
[53]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 36 30 40
[54]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 25 33
[55]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[56]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 14 16 33 19
[57]
ref_hepatocyte ELK1
Mean 6.81
Standard deviation 3.9
Values 7.5 4.4 8.5 1.7 12
[58]
HepG2 ELK1
Mean 12.1
Standard deviation 1.5
Values 11 13
[59]
HepG2.C3A ELK1
Mean 2.45
Standard deviation 0.82
Values 1.9 3
[60]
HuH.7 ELK1
Mean 12.6
Standard deviation 1.8
Values 13 11 14
[61]
SNU475 ELK1
Mean 15.1
Standard deviation 0.2
Values 15 15
[62]
THLE ELK1
Mean 25.4
Standard deviation 3.5
Values 23 28
[63]
liver ELK1
Mean 8.61
Standard deviation 2.4
Values 7.1 6 10 11
[64]
ref_hepatocyte SRF
Mean 6.43
Standard deviation 4.1
Values 12 1.5 6.2 9.2 3.7
[65]
HepG2 SRF
Mean 39.1
Standard deviation 3.7
Values 36 42
[66]
HepG2.C3A SRF
Mean 25.8
Standard deviation 4.2
Values 23 29
[67]
HuH.7 SRF
Mean 14.9
Standard deviation 1.6
Values 16 13 16
[68]
SNU475 SRF
Mean 34.4
Standard deviation 3.7
Values 32 37
[69]
THLE SRF
Mean 20.4
Standard deviation 3.8
Values 18 23
[70]
liver SRF
Mean 5.31
Standard deviation 3.4
Values 9.8 5.8 3.8 1.8
[71]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 3.6 3.3 6 5.1 2.8
[72]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 29 37
[73]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 22 39
[74]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 32 25 34
[75]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 8.5 12
[76]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[77]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 0.82 0.81 5 4.8
[78]
ref_hepatocyte GATA4
Mean 3.97
Standard deviation 2.3
Values 2.3 4.3 6 6.3 1
[79]
HepG2 GATA4
Mean 15.1
Standard deviation 1.5
Values 16 14
[80]
HepG2.C3A GATA4
Mean 12.9
Standard deviation 0.72
Values 12 13
[81]
HuH.7 GATA4
Mean 33.3
Standard deviation 6.5
Values 29 41 30
[82]
SNU475 GATA4
Mean 3.13
Standard deviation 0.12
Values 3 3.2
[83]
THLE GATA4
Mean 26.9
Standard deviation 1.1
Values 26 28
[84]
liver GATA4
Mean 8.47
Standard deviation 2.5
Values 6.2 6.8 12 9.2
[85]
ref_hepatocyte ELK4
Mean 2.56
Standard deviation 1.2
Values 3.5 1.4 1.5 4 2.4
[86]
HepG2 ELK4
Mean 10.6
Standard deviation 2.7
Values 12 8.7
[87]
HepG2.C3A ELK4
Mean 19.2
Standard deviation 4.5
Values 16 22
[88]
HuH.7 ELK4
Mean 15.3
Standard deviation 4.1
Values 11 20 15
[89]
SNU475 ELK4
Mean 14.3
Standard deviation 2.9
Values 12 16
[90]
THLE ELK4
Mean 20.8
Standard deviation 3.7
Values 23 18
[91]
liver ELK4
Mean 28.8
Standard deviation 12
Values 40 37 21 17
[92]
ref_hepatocyte GNAQ
Mean 1.88
Standard deviation 1
Values 3.6 1.1 1.1 1.6 2
[93]
HepG2 GNAQ
Mean 4.36
Standard deviation 1.2
Values 5.2 3.5
[94]
HepG2.C3A GNAQ
Mean 6.67
Standard deviation 0.93
Values 7.3 6
[95]
HuH.7 GNAQ
Mean 9.12
Standard deviation 3.7
Values 4.8 11 11
[96]
SNU475 GNAQ
Mean 10.4
Standard deviation 1.4
Values 9.4 11
[97]
THLE GNAQ
Mean 13.5
Standard deviation 3.4
Values 11 16
[98]
liver GNAQ
Mean 7.23
Standard deviation 3.8
Values 9.6 11 5.1 3
[99]
ref_hepatocyte ITPR1
Mean 0.398
Standard deviation 0.44
Values 0.1 0.25 0.2 1.2 0.25
[100]
HepG2 ITPR1
Mean 7.73
Standard deviation 1.3
Values 6.8 8.7
[101]
HepG2.C3A ITPR1
Mean 6.36
Standard deviation 0.83
Values 5.8 7
[102]
HuH.7 ITPR1
Mean 13.6
Standard deviation 3.5
Values 9.6 16 15
[103]
SNU475 ITPR1
Mean 5.27
Standard deviation 3.4
Values 7.7 2.8
[104]
THLE ITPR1
Mean 10.8
Standard deviation 2.1
Values 12 9.3
[105]
liver ITPR1
Mean 14.2
Standard deviation 12
Values 29 20 4.3 3.8
[106]
ref_hepatocyte HTR2B
Mean 0.127
Standard deviation 0.15
Values 0 0.36 0.069 0 0.21
[107]
HepG2 HTR2B
Mean 0.0565
Standard deviation 0.023
Values 0.073 0.04
[108]
HepG2.C3A HTR2B
Mean 0.0657
Standard deviation 0.017
Values 0.054 0.078
[109]
HuH.7 HTR2B
Mean 0.0472
Standard deviation 0.021
Values 0.066 0.051 0.025
[110]
SNU475 HTR2B
Mean 2.36
Standard deviation 0.57
Values 2 2.8
[111]
THLE HTR2B
Mean 0.0612
Standard deviation 0.011
Values 0.053 0.069
[112]
liver HTR2B
Mean 2.43
Standard deviation 1.7
Values 2.1 4.9 1.1 1.6
[113]
ref_hepatocyte HTR2A
Mean 0.0215
Standard deviation 0.022
Values 0 0.033 0.052 0 0.023
[114]
HepG2 HTR2A
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A HTR2A
Mean 0.0209
Standard deviation 0.016
Values 0.032 0.0097
[116]
HuH.7 HTR2A
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 HTR2A
Mean 0.0076
Standard deviation 0.011
Values 0.015 0
[118]
THLE HTR2A
Mean 0.0464
Standard deviation 0.043
Values 0.077 0.016
[119]
liver HTR2A
Mean 0.814
Standard deviation 0.77
Values 1.6 1.3 0.21 0.1
[120]
ref_hepatocyte RASGRF1
Mean 0.0103
Standard deviation 0.023
Values 0.052 0 0 0 0
[121]
HepG2 RASGRF1
Mean 0.426
Standard deviation 0.18
Values 0.3 0.56
[122]
HepG2.C3A RASGRF1
Mean 0.687
Standard deviation 0.032
Values 0.66 0.71
[123]
HuH.7 RASGRF1
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[124]
SNU475 RASGRF1
Mean 0.125
Standard deviation 0.11
Values 0.2 0.046
[125]
THLE RASGRF1
Mean 0.0186
Standard deviation 0.026
Values 0 0.037
[126]
liver RASGRF1
Mean 0
Standard deviation 0
Values 0 0 0 0
[127]
ref_hepatocyte RASGRP1
Mean 0.00813
Standard deviation 0.018
Values 0 0.041 0 0 0
[128]
HepG2 RASGRP1
Mean 0.0422
Standard deviation 0.0051
Values 0.039 0.046
[129]
HepG2.C3A RASGRP1
Mean 0.0608
Standard deviation 0.01
Values 0.054 0.068
[130]
HuH.7 RASGRP1
Mean 0.0912
Standard deviation 0.044
Values 0.075 0.14 0.057
[131]
SNU475 RASGRP1
Mean 0.264
Standard deviation 0.23
Values 0.43 0.1
[132]
THLE RASGRP1
Mean 0.628
Standard deviation 0.099
Values 0.7 0.56
[133]
liver RASGRP1
Mean 1.29
Standard deviation 0.68
Values 1.9 1.9 0.61 0.8
[134]
ref_hepatocyte HTR2C
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 HTR2C
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A HTR2C
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 HTR2C
Mean 0.00586
Standard deviation 0.0051
Values 0.0094 0 0.0082
[138]
SNU475 HTR2C
Mean 0.507
Standard deviation 0.064
Values 0.46 0.55
[139]
THLE HTR2C
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[140]
liver HTR2C
Mean 0.00331
Standard deviation 0.0066
Values 0.013 0 0 0