WP_S1P_RECEPTOR_SIGNAL_TRANSDUCTION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKT1 RAC-alpha serine/threonine-protein kinase [1] -0.47[2] -0.97[3] -1.90[4] -0.70[5] -0.70[6] -0.49[7]
2 GNAI2 Guanine nucleotide-binding protein G(i) subunit alpha-2 [8] -0.48[9] -1.82[10] -1.50[11] -0.82[12] 0.23[13] -0.44[14]
3 ASAH1 Acid ceramidase [15] -0.44[16] -0.88[17] -0.48[18] -1.40[19] -1.53[20] -0.66[21]
4 MAPK6 Mitogen-activated protein kinase 6 [22] -0.51[23] 0.67[24] 0.97[25] -0.01[26] -0.83[27] -0.31[28]
5 GNAI3 Guanine nucleotide-binding protein G(k) subunit alpha [29] -0.42[30] -0.15[31] 0.10[32] 0.46[33] 0.06[34] -0.01[35]
6 SPHK1 Sphingosine kinase 1 [36] 1.03[37] 1.45[38] -0.89[39] -2.85[40] -0.60[41] -5.25[42]
7 MAPK1 Mitogen-activated protein kinase 1 [43] 1.16[44] 1.03[45] 1.00[46] 1.20[47] 0.83[48] 1.53[49]
8 AKT2 RAC-beta serine/threonine-protein kinase [50] 0.41[51] 0.41[52] 0.69[53] 0.21[54] -0.02[55] 0.89[56]
9 GNAI1 Guanine nucleotide-binding protein G(i) subunit alpha-1 [57] -2.20[58] -3.41[59] -1.12[60] 0.57[61] -0.09[62] 0.59[63]
10 MAPK3 Mitogen-activated protein kinase 3 [64] 1.30[65] 1.07[66] 1.26[67] -0.22[68] -0.23[69] -1.28[70]
11 SPHK2 Sphingosine kinase 2 [71] -0.71[72] -0.80[73] -0.93[74] -0.48[75] -1.09[76] 0.17[77]
12 SMPD2 Sphingomyelin phosphodiesterase 2 [78] -1.50[79] -1.44[80] -1.90[81] -2.42[82] -1.33[83] -1.85[84]
13 S1PR1 Sphingosine 1-phosphate receptor 1 [85] -8.94[86] [87] -4.00[88] -3.20[89] -1.58[90] 0.78[91]
14 RACGAP1 Rac GTPase-activating protein 1 [92] 1.55[93] 1.74[94] 2.14[95] 2.53[96] 3.05[97] -0.95[98]
15 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [99] 1.46[100] 0.67[101] 1.28[102] 2.06[103] 1.68[104] 0.48[105]
16 MAPK7 Mitogen-activated protein kinase 7 [106] 0.89[107] -0.09[108] 0.06[109] 1.16[110] 1.23[111] 0.09[112]
17 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [113] 2.24[114] 3.60[115] 3.17[116] 0.13[117] 0.60[118] 2.25[119]
18 MAPK12 Mitogen-activated protein kinase 12 [120] 2.27[121] 1.66[122] 2.92[123] 0.84[124] 2.06[125] -1.15[126]
19 PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1.24[127] -0.81[128] 2.14[129] 2.29[130] -0.32[131] 2.60[132]
20 S1PR2 Sphingosine 1-phosphate receptor 2 [133] 0.25[134] -0.39[135] 2.20[136] 0.84[137] 0.09[138] 2.55[139]
21 PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [140] -2.17[141] -7.23[142] -8.92[143] -2.58[144] -3.32[145] 1.99[146]
22 AKT3 RAC-gamma serine/threonine-protein kinase [147] -2.39[148] -5.22[149] -4.38[150] 5.19[151] 4.12[152] 3.37[153]
23 S1PR3 Sphingosine 1-phosphate receptor 3 [154] -2.45[155] -3.80[156] -2.20[157] 3.84[158] 4.84[159] 2.12[160]
24 MAPK4 Mitogen-activated protein kinase 4 [161] -7.46[162] -5.71[163] 1.63[164] -7.06[165] -4.24[166] 2.76[167]
25 S1PR5 Sphingosine 1-phosphate receptor 5 [168] -1.30[169] -0.13[170] 2.76[171] 3.43[172] 1.63[173] -0.06[174]
26 MIR197 [175] [176] [177] [178] [179] [180] [181]
[1]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[2]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[3]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[4]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[5]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[6]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[7]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[8]
ref_hepatocyte GNAI2
Mean 32.9
Standard deviation 13
Values 41 42 40 10 31
[9]
HepG2 GNAI2
Mean 76.1
Standard deviation 11
Values 84 68
[10]
HepG2.C3A GNAI2
Mean 32.5
Standard deviation 8.6
Values 39 26
[11]
HuH.7 GNAI2
Mean 34.9
Standard deviation 7.6
Values 37 26 41
[12]
SNU475 GNAI2
Mean 53.7
Standard deviation 11
Values 46 62
[13]
THLE GNAI2
Mean 126
Standard deviation 19
Values 1.1e+02 1.4e+02
[14]
liver GNAI2
Mean 40.9
Standard deviation 20
Values 21 27 61 54
[15]
ref_hepatocyte ASAH1
Mean 31.4
Standard deviation 46
Values 6.3 14 15 1.1e+02 8.7
[16]
HepG2 ASAH1
Mean 74.5
Standard deviation 21
Values 90 59
[17]
HepG2.C3A ASAH1
Mean 59.1
Standard deviation 6.5
Values 64 55
[18]
HuH.7 ASAH1
Mean 67.7
Standard deviation 7
Values 62 76 65
[19]
SNU475 ASAH1
Mean 34.1
Standard deviation 3.7
Values 32 37
[20]
THLE ASAH1
Mean 35.6
Standard deviation 4.9
Values 39 32
[21]
liver ASAH1
Mean 33.4
Standard deviation 7.8
Values 24 30 39 41
[22]
ref_hepatocyte MAPK6
Mean 22.6
Standard deviation 18
Values 22 5.8 6.2 46 33
[23]
HepG2 MAPK6
Mean 51.2
Standard deviation 13
Values 60 42
[24]
HepG2.C3A MAPK6
Mean 125
Standard deviation 9.4
Values 1.3e+02 1.2e+02
[25]
HuH.7 MAPK6
Mean 133
Standard deviation 43
Values 97 1.8e+02 1.2e+02
[26]
SNU475 MAPK6
Mean 64.4
Standard deviation 2.5
Values 63 66
[27]
THLE MAPK6
Mean 41.6
Standard deviation 0.58
Values 41 42
[28]
liver MAPK6
Mean 30.6
Standard deviation 10
Values 35 42 19 26
[29]
ref_hepatocyte GNAI3
Mean 15.6
Standard deviation 11
Values 11 10 6.9 15 35
[30]
HepG2 GNAI3
Mean 37.5
Standard deviation 8.9
Values 44 31
[31]
HepG2.C3A GNAI3
Mean 48.7
Standard deviation 8.6
Values 55 43
[32]
HuH.7 GNAI3
Mean 50
Standard deviation 3.6
Values 49 47 54
[33]
SNU475 GNAI3
Mean 61.5
Standard deviation 5.4
Values 58 65
[34]
THLE GNAI3
Mean 53.3
Standard deviation 7.7
Values 48 59
[35]
liver GNAI3
Mean 26
Standard deviation 3.5
Values 23 25 26 31
[36]
ref_hepatocyte SPHK1
Mean 11.5
Standard deviation 14
Values 19 0.27 1.4 32 4.8
[37]
HepG2 SPHK1
Mean 75.9
Standard deviation 8.5
Values 70 82
[38]
HepG2.C3A SPHK1
Mean 109
Standard deviation 8.6
Values 1e+02 1.2e+02
[39]
HuH.7 SPHK1
Mean 18.7
Standard deviation 5.5
Values 24 13 19
[40]
SNU475 SPHK1
Mean 4.6
Standard deviation 3.4
Values 7 2.2
[41]
THLE SPHK1
Mean 24.9
Standard deviation 0.21
Values 25 25
[42]
liver SPHK1
Mean 0.512
Standard deviation 0.41
Values 0.46 0.3 1.1 0.18
[43]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[44]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[45]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[46]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[47]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[48]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[49]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[50]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 11 14 13 7.2 8.4
[51]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 43 48
[52]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 43 55
[53]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 55 41 59
[54]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 31 39
[55]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[56]
liver AKT2
Mean 33
Standard deviation 9.4
Values 45 36 24 27
[57]
ref_hepatocyte GNAI1
Mean 6.48
Standard deviation 1.5
Values 6.3 6 4.7 6.5 8.9
[58]
HepG2 GNAI1
Mean 4.56
Standard deviation 1
Values 3.9 5.3
[59]
HepG2.C3A GNAI1
Mean 2.12
Standard deviation 0.54
Values 2.5 1.7
[60]
HuH.7 GNAI1
Mean 8.95
Standard deviation 1.2
Values 10 7.6 9.3
[61]
SNU475 GNAI1
Mean 27.6
Standard deviation 3.4
Values 25 30
[62]
THLE GNAI1
Mean 20
Standard deviation 0.41
Values 20 20
[63]
liver GNAI1
Mean 16.4
Standard deviation 11
Values 9 8.4 32 17
[64]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 3.6 3.3 6 5.1 2.8
[65]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 29 37
[66]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 22 39
[67]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 32 25 34
[68]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 8.5 12
[69]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[70]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 0.82 0.81 5 4.8
[71]
ref_hepatocyte SPHK2
Mean 3.26
Standard deviation 2
Values 2.2 6.4 4 1.5 2.2
[72]
HepG2 SPHK2
Mean 6.43
Standard deviation 0.066
Values 6.5 6.4
[73]
HepG2.C3A SPHK2
Mean 6.53
Standard deviation 0.22
Values 6.7 6.4
[74]
HuH.7 SPHK2
Mean 5.14
Standard deviation 0.89
Values 5.5 4.1 5.8
[75]
SNU475 SPHK2
Mean 6.71
Standard deviation 0.21
Values 6.6 6.9
[76]
THLE SPHK2
Mean 5.03
Standard deviation 1.4
Values 4 6
[77]
liver SPHK2
Mean 6.15
Standard deviation 2.7
Values 4.9 3 8.7 8
[78]
ref_hepatocyte SMPD2
Mean 2.83
Standard deviation 2.4
Values 6.8 1.8 3.1 0.63 1.8
[79]
HepG2 SMPD2
Mean 3.24
Standard deviation 0.12
Values 3.1 3.3
[80]
HepG2.C3A SMPD2
Mean 3.63
Standard deviation 0.1
Values 3.7 3.6
[81]
HuH.7 SMPD2
Mean 2.28
Standard deviation 0.65
Values 2.9 1.6 2.3
[82]
SNU475 SMPD2
Mean 1.52
Standard deviation 0.34
Values 1.8 1.3
[83]
THLE SMPD2
Mean 3.71
Standard deviation 0.59
Values 3.3 4.1
[84]
liver SMPD2
Mean 1.32
Standard deviation 0.52
Values 1 0.78 2 1.5
[85]
ref_hepatocyte S1PR1
Mean 2.72
Standard deviation 2
Values 3.8 3.5 4.9 0 1.4
[86]
HepG2 S1PR1
Mean 0.0179
Standard deviation 0.017
Values 0.03 0.0057
[87]
HepG2.C3A S1PR1
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 S1PR1
Mean 0.51
Standard deviation 0.036
Values 0.49 0.55 0.49
[89]
SNU475 S1PR1
Mean 0.855
Standard deviation 0.22
Values 1 0.7
[90]
THLE S1PR1
Mean 2.99
Standard deviation 0.015
Values 3 3
[91]
liver S1PR1
Mean 7.88
Standard deviation 2.5
Values 6.7 5 10 9.8
[92]
ref_hepatocyte RACGAP1
Mean 2.28
Standard deviation 2.7
Values 0.57 0.37 0.7 2.9 6.8
[93]
HepG2 RACGAP1
Mean 21.5
Standard deviation 3.8
Values 24 19
[94]
HepG2.C3A RACGAP1
Mean 26.5
Standard deviation 15
Values 37 16
[95]
HuH.7 RACGAP1
Mean 30.1
Standard deviation 12
Values 38 16 36
[96]
SNU475 RACGAP1
Mean 37.8
Standard deviation 3.8
Values 41 35
[97]
THLE RACGAP1
Mean 62
Standard deviation 13
Values 53 71
[98]
liver RACGAP1
Mean 1.97
Standard deviation 1.1
Values 1.1 3.4 1.3 2.1
[99]
ref_hepatocyte PLCB3
Mean 1.72
Standard deviation 1
Values 1.6 0.87 0.84 3.3 2
[100]
HepG2 PLCB3
Mean 15.2
Standard deviation 2.5
Values 17 13
[101]
HepG2.C3A PLCB3
Mean 9.48
Standard deviation 0.28
Values 9.7 9.3
[102]
HuH.7 PLCB3
Mean 12.5
Standard deviation 4.9
Values 16 6.9 15
[103]
SNU475 PLCB3
Mean 20.7
Standard deviation 4.4
Values 18 24
[104]
THLE PLCB3
Mean 18.1
Standard deviation 1.4
Values 17 19
[105]
liver PLCB3
Mean 4.04
Standard deviation 2.9
Values 7.5 5.4 1.7 1.5
[106]
ref_hepatocyte MAPK7
Mean 1.09
Standard deviation 0.71
Values 2.2 0.89 1 1.1 0.26
[107]
HepG2 MAPK7
Mean 6.54
Standard deviation 1.5
Values 7.6 5.4
[108]
HepG2.C3A MAPK7
Mean 3.58
Standard deviation 0.65
Values 3.1 4
[109]
HuH.7 MAPK7
Mean 3.43
Standard deviation 0.61
Values 3.6 2.8 4
[110]
SNU475 MAPK7
Mean 7.01
Standard deviation 0.043
Values 7 7
[111]
THLE MAPK7
Mean 8.39
Standard deviation 0.71
Values 7.9 8.9
[112]
liver MAPK7
Mean 1.96
Standard deviation 0.9
Values 1.6 0.9 2.9 2.4
[113]
ref_hepatocyte PLCB1
Mean 0.993
Standard deviation 1.3
Values 0.37 0.52 0.15 3.2 0.71
[114]
HepG2 PLCB1
Mean 15.2
Standard deviation 2.6
Values 17 13
[115]
HepG2.C3A PLCB1
Mean 41.8
Standard deviation 4.5
Values 39 45
[116]
HuH.7 PLCB1
Mean 26.9
Standard deviation 8.9
Values 19 36 26
[117]
SNU475 PLCB1
Mean 3.13
Standard deviation 0.39
Values 2.9 3.4
[118]
THLE PLCB1
Mean 4.93
Standard deviation 0.69
Values 5.4 4.4
[119]
liver PLCB1
Mean 7.93
Standard deviation 2.5
Values 6 11 8.6 6
[120]
ref_hepatocyte MAPK12
Mean 0.743
Standard deviation 0.94
Values 0.21 0.28 0.41 2.4 0.4
[121]
HepG2 MAPK12
Mean 11.6
Standard deviation 3.6
Values 9 14
[122]
HepG2.C3A MAPK12
Mean 8.16
Standard deviation 0.15
Values 8.3 8.1
[123]
HuH.7 MAPK12
Mean 16.9
Standard deviation 6.7
Values 23 9.7 18
[124]
SNU475 MAPK12
Mean 3.82
Standard deviation 1.9
Values 2.5 5.2
[125]
THLE MAPK12
Mean 10.2
Standard deviation 1.3
Values 9.2 11
[126]
liver MAPK12
Mean 0.564
Standard deviation 0.13
Values 0.69 0.43 0.47 0.67
[127]
ref_hepatocyte PIK3C2B
Mean 0.648
Standard deviation 0.13
Values 0.48 0.83 0.67 0.56 0.7
[128]
HepG2 PIK3C2B
Mean 4.95
Standard deviation 0.73
Values 5.5 4.4
[129]
HepG2.C3A PIK3C2B
Mean 1.29
Standard deviation 0.27
Values 1.5 1.1
[130]
HuH.7 PIK3C2B
Mean 8.58
Standard deviation 2.8
Values 9 5.6 11
[131]
SNU475 PIK3C2B
Mean 9.14
Standard deviation 1.7
Values 7.9 10
[132]
THLE PIK3C2B
Mean 1.7
Standard deviation 0.09
Values 1.6 1.8
[133]
liver PIK3C2B
Mean 6.59
Standard deviation 3.3
Values 11 7.4 5.1 3
[134]
ref_hepatocyte S1PR2
Mean 0.495
Standard deviation 0.34
Values 0.58 0.43 1 0.13 0.31
[135]
HepG2 S1PR2
Mean 1.9
Standard deviation 0.97
Values 1.2 2.6
[136]
HepG2.C3A S1PR2
Mean 1.31
Standard deviation 0.29
Values 1.1 1.5
[137]
HuH.7 S1PR2
Mean 6.83
Standard deviation 0.43
Values 6.4 7 7.2
[138]
SNU475 S1PR2
Mean 2.54
Standard deviation 0.063
Values 2.5 2.6
[139]
THLE S1PR2
Mean 1.73
Standard deviation 0.11
Values 1.7 1.8
[140]
liver S1PR2
Mean 4.88
Standard deviation 2.7
Values 3.3 2.2 8.2 5.8
[141]
ref_hepatocyte PLCB2
Mean 0.44
Standard deviation 0.47
Values 0.42 1.2 0.57 0 0.049
[142]
HepG2 PLCB2
Mean 0.316
Standard deviation 0.31
Values 0.099 0.53
[143]
HepG2.C3A PLCB2
Mean 0.0102
Standard deviation 0.00071
Values 0.011 0.0097
[144]
HuH.7 PLCB2
Mean 0.00273
Standard deviation 0.0047
Values 0 0 0.0082
[145]
SNU475 PLCB2
Mean 0.211
Standard deviation 0.062
Values 0.17 0.26
[146]
THLE PLCB2
Mean 0.145
Standard deviation 0.029
Values 0.12 0.16
[147]
liver PLCB2
Mean 2.94
Standard deviation 1.6
Values 4.9 3.5 1.8 1.5
[148]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0.83 0.41 0.16 0 0.53
[149]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.13 0.34
[150]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.043 0.029
[151]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.028 0.09 0.049
[152]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 34 48
[153]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[154]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 9.4 12 2.8 2.3
[155]
ref_hepatocyte S1PR3
Mean 0.365
Standard deviation 0.38
Values 0.78 0.11 0.77 0 0.17
[156]
HepG2 S1PR3
Mean 0.215
Standard deviation 0.02
Values 0.2 0.23
[157]
HepG2.C3A S1PR3
Mean 0.0915
Standard deviation 0.0081
Values 0.086 0.097
[158]
HuH.7 S1PR3
Mean 0.239
Standard deviation 0.08
Values 0.16 0.24 0.32
[159]
SNU475 S1PR3
Mean 15.1
Standard deviation 0.43
Values 15 15
[160]
THLE S1PR3
Mean 34.4
Standard deviation 3.4
Values 37 32
[161]
liver S1PR3
Mean 2.68
Standard deviation 0.32
Values 3 2.4 2.4 2.9
[162]
ref_hepatocyte MAPK4
Mean 0.234
Standard deviation 0.43
Values 0 0.024 1 0 0.15
[163]
HepG2 MAPK4
Mean 0.00429
Standard deviation 0.0061
Values 0.0086 0
[164]
HepG2.C3A MAPK4
Mean 0.0156
Standard deviation 0.0083
Values 0.021 0.0097
[165]
HuH.7 MAPK4
Mean 2.18
Standard deviation 0.55
Values 1.8 1.9 2.8
[166]
SNU475 MAPK4
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[167]
THLE MAPK4
Mean 0.0408
Standard deviation 0.043
Values 0.071 0.011
[168]
liver MAPK4
Mean 2.68
Standard deviation 1
Values 4 3.1 1.7 2
[169]
ref_hepatocyte S1PR5
Mean 0.0773
Standard deviation 0.11
Values 0 0.24 0 0 0.14
[170]
HepG2 S1PR5
Mean 0.101
Standard deviation 0.1
Values 0.03 0.17
[171]
HepG2.C3A S1PR5
Mean 0.246
Standard deviation 0.12
Values 0.16 0.33
[172]
HuH.7 S1PR5
Mean 1.58
Standard deviation 0.11
Values 1.7 1.5 1.5
[173]
SNU475 S1PR5
Mean 2.4
Standard deviation 0.14
Values 2.3 2.5
[174]
THLE S1PR5
Mean 0.782
Standard deviation 0.015
Values 0.79 0.77
[175]
liver S1PR5
Mean 0.125
Standard deviation 0.045
Values 0.079 0.1 0.14 0.18
[176]
ref_hepatocyte MIR197
Missing
[177]
HepG2 MIR197
Missing
[178]
HepG2.C3A MIR197
Missing
[179]
HuH.7 MIR197
Missing
[180]
SNU475 MIR197
Missing
[181]
THLE MIR197
Missing
[182]
liver MIR197
Missing