WP_RETINOBLASTOMA_GENE_IN_CANCER | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HMGB1 | High mobility group protein B1 | [1] | -1.37[2] | -0.81[3] | -1.29[4] | -0.58[5] | -1.49[6] | -0.38[7] |
2 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [8] | -0.23[9] | -1.80[10] | -4.72[11] | -3.03[12] | -0.86[13] | -1.66[14] |
3 | HMGB2 | High mobility group protein B2 | [15] | -1.42[16] | -0.43[17] | 0.14[18] | -2.68[19] | -1.36[20] | -3.15[21] |
4 | PCNA | Proliferating cell nuclear antigen | [22] | -0.18[23] | -0.38[24] | -2.01[25] | -1.26[26] | -1.36[27] | -2.90[28] |
5 | MYC | Myc proto-oncogene protein | [29] | -0.64[30] | -1.16[31] | -3.41[32] | -3.83[33] | -1.85[34] | -1.83[35] |
6 | TYMS | Thymidylate synthase | [36] | -2.34[37] | -2.11[38] | -2.50[39] | -2.35[40] | -2.68[41] | -5.76[42] |
7 | STMN1 | Stathmin | [43] | -0.08[44] | 0.55[45] | 0.54[46] | -0.16[47] | 0.02[48] | -2.38[49] |
8 | RBBP7 | Histone-binding protein RBBP7 | [50] | -1.20[51] | -1.20[52] | -1.74[53] | -0.39[54] | -0.04[55] | -0.49[56] |
9 | RPA2 | Replication protein A 32 kDa subunit | [57] | -2.52[58] | -2.63[59] | -2.30[60] | -1.79[61] | -2.09[62] | -2.23[63] |
10 | CCND1 | G1/S-specific cyclin-D1 | [64] | 1.99[65] | -0.70[66] | -0.10[67] | 0.84[68] | -1.03[69] | 1.22[70] |
11 | HDAC1 | Histone deacetylase 1 | [71] | -0.56[72] | -0.73[73] | -0.27[74] | -0.40[75] | -1.00[76] | -0.29[77] |
12 | CDK4 | Cyclin-dependent kinase 4 | [78] | 0.27[79] | 0.67[80] | 0.07[81] | -0.86[82] | -0.60[83] | -0.67[84] |
13 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [85] | -1.13[86] | -0.91[87] | 0.14[88] | -1.23[89] | -0.75[90] | 1.27[91] |
14 | TFDP1 | Transcription factor Dp-1 | [92] | -0.40[93] | -1.25[94] | -1.41[95] | -0.44[96] | -0.25[97] | -0.97[98] |
15 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [99] | -1.15[100] | -0.89[101] | -0.92[102] | -2.15[103] | -2.07[104] | -0.74[105] |
16 | MCM7 | DNA replication licensing factor MCM7 | [106] | 0.85[107] | 0.46[108] | 1.46[109] | 0.24[110] | 0.41[111] | -0.63[112] |
17 | MCM3 | DNA replication licensing factor MCM3 | [113] | 1.24[114] | 0.90[115] | 0.79[116] | -0.06[117] | 0.64[118] | -0.52[119] |
18 | CDK2 | Cyclin-dependent kinase 2 | [120] | -1.48[121] | -1.50[122] | -1.35[123] | -1.06[124] | -0.86[125] | -2.02[126] |
19 | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | [127] | 0.51[128] | 0.47[129] | -0.27[130] | 1.07[131] | 0.72[132] | -0.67[133] |
20 | RFC4 | Replication factor C subunit 4 | [134] | -2.04[135] | -1.59[136] | -1.24[137] | -2.01[138] | -1.06[139] | -2.58[140] |
21 | MSH6 | DNA mismatch repair protein Msh6 | [141] | -0.75[142] | -0.45[143] | -0.47[144] | -0.14[145] | -0.11[146] | 0.46[147] |
22 | SMC3 | Structural maintenance of chromosomes protein 3 | [148] | -2.23[149] | 0.24[150] | 0.47[151] | -0.63[152] | -0.59[153] | 0.23[154] |
23 | MCM4 | DNA replication licensing factor MCM4 | [155] | 1.00[156] | 0.70[157] | 1.19[158] | 0.96[159] | 1.21[160] | -0.81[161] |
24 | RRM1 | Ribonucleoside-diphosphate reductase large subunit | [162] | 0.41[163] | -0.24[164] | 0.23[165] | 1.01[166] | 0.73[167] | 0.26[168] |
25 | PRMT2 | Protein arginine N-methyltransferase 2 | [169] | -0.26[170] | -0.14[171] | -1.77[172] | -0.23[173] | -1.96[174] | 0.29[175] |
26 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [176] | 0.25[177] | -0.20[178] | -0.15[179] | 0.81[180] | 0.44[181] | 0.17[182] |
27 | RPA3 | Replication protein A 14 kDa subunit | [183] | -1.43[184] | -0.81[185] | -0.32[186] | -1.95[187] | -2.05[188] | -0.52[189] |
28 | CCNB1 | G2/mitotic-specific cyclin-B1 | [190] | 0.78[191] | 0.83[192] | 0.79[193] | 0.56[194] | 1.16[195] | -2.17[196] |
29 | ZNF655 | Zinc finger protein 655 | [197] | -1.26[198] | -0.51[199] | -1.15[200] | -0.91[201] | -1.56[202] | 1.05[203] |
30 | FAF1 | FAS-associated factor 1 | [204] | -1.02[205] | -1.34[206] | -0.71[207] | -0.69[208] | -1.00[209] | 0.09[210] |
31 | DCK | Deoxycytidine kinase | [211] | -1.48[212] | -1.15[213] | -2.19[214] | -1.00[215] | -0.89[216] | -1.72[217] |
32 | RBBP4 | Histone-binding protein RBBP4 | [218] | 0.88[219] | 0.81[220] | 0.40[221] | 0.64[222] | 0.64[223] | 1.67[224] |
33 | DHFR | Dihydrofolate reductase | [225] | 0.48[226] | 1.01[227] | 1.12[228] | 0.21[229] | 0.69[230] | 0.29[231] |
34 | SMARCA2 | Probable global transcription activator SNF2L2 | [232] | -1.08[233] | -1.04[234] | -0.87[235] | -1.13[236] | -0.68[237] | 1.57[238] |
35 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [239] | 1.04[240] | 2.28[241] | -0.71[242] | -0.53[243] | -0.04[244] | 2.33[245] |
36 | TOP2A | DNA topoisomerase 2-alpha | [246] | 1.46[247] | 2.34[248] | 2.79[249] | 2.39[250] | 2.77[251] | -0.21[252] |
37 | CDK1 | Cyclin-dependent kinase 1 | [253] | 0.19[254] | 2.07[255] | 0.57[256] | 1.22[257] | 1.66[258] | -2.30[259] |
38 | RFC5 | Replication factor C subunit 5 | [260] | -0.94[261] | -0.66[262] | -0.69[263] | -0.78[264] | -0.63[265] | -0.71[266] |
39 | MAPK13 | Mitogen-activated protein kinase 13 | [267] | 1.28[268] | 1.50[269] | -1.41[270] | -2.93[271] | -1.79[272] | -1.55[273] |
40 | TP53 | Cellular tumor antigen p53 | [274] | 0.57[275] | -0.05[276] | 0.48[277] | 0.25[278] | -0.47[279] | 0.13[280] |
41 | WEE1 | Wee1-like protein kinase | [281] | -0.76[282] | -0.53[283] | -0.02[284] | -0.32[285] | -1.18[286] | -0.37[287] |
42 | CCDC6 | Coiled-coil domain-containing protein 6 | [288] | 0.14[289] | 0.64[290] | -0.46[291] | 0.34[292] | 0.32[293] | 1.16[294] |
43 | SMC1A | Structural maintenance of chromosomes protein 1A | [295] | 1.03[296] | 0.72[297] | 1.50[298] | 1.97[299] | 2.43[300] | 2.61[301] |
44 | MCM6 | DNA replication licensing factor MCM6 | [302] | 0.13[303] | -0.34[304] | 1.46[305] | 1.38[306] | 1.79[307] | -1.12[308] |
45 | ANLN | Anillin | [309] | 0.00[310] | 1.41[311] | 1.36[312] | 2.36[313] | 2.40[314] | -1.57[315] |
46 | RBP1 | Retinol-binding protein 1 | [316] | 1.08[317] | -3.82[318] | -2.77[319] | -2.22[320] | -6.42[321] | 1.02[322] |
47 | CDK6 | Cyclin-dependent kinase 6 | [323] | 0.98[324] | 1.50[325] | -0.33[326] | -0.13[327] | 0.29[328] | 2.24[329] |
48 | ABL1 | Tyrosine-protein kinase ABL1 | [330] | 1.16[331] | 0.38[332] | 0.94[333] | 1.03[334] | 1.33[335] | 1.11[336] |
49 | SIN3A | Paired amphipathic helix protein Sin3a | [337] | 0.31[338] | 0.22[339] | 1.19[340] | 0.95[341] | 0.31[342] | 1.45[343] |
50 | SAP30 | Histone deacetylase complex subunit SAP30 | [344] | -1.59[345] | -1.19[346] | -0.81[347] | -2.02[348] | -0.75[349] | -2.28[350] |
51 | CDC25B | M-phase inducer phosphatase 2 | [351] | 0.80[352] | 0.80[353] | -0.05[354] | 1.68[355] | 1.45[356] | 0.51[357] |
52 | CCND3 | G1/S-specific cyclin-D3 | [358] | -0.11[359] | -1.36[360] | -3.21[361] | 2.62[362] | 1.41[363] | 0.83[364] |
53 | SKP2 | S-phase kinase-associated protein 2 | [365] | 0.25[366] | 0.52[367] | 1.43[368] | 0.22[369] | -0.08[370] | 1.25[371] |
54 | CCNE1 | G1/S-specific cyclin-E1 | [372] | 0.17[373] | 0.10[374] | -1.94[375] | -1.45[376] | -1.23[377] | -4.46[378] |
55 | PRKDC | DNA-dependent protein kinase catalytic subunit | [379] | 3.15[380] | 2.43[381] | 4.09[382] | 3.85[383] | 3.55[384] | 4.41[385] |
56 | CCNA2 | Cyclin-A2 | [386] | 1.14[387] | 1.97[388] | 1.08[389] | 0.96[390] | 1.96[391] | -1.06[392] |
57 | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | [393] | 1.90[394] | 1.24[395] | 1.89[396] | 2.06[397] | 2.33[398] | 1.25[399] |
58 | RFC3 | Replication factor C subunit 3 | [400] | 0.11[401] | 0.79[402] | 0.71[403] | 0.21[404] | 0.42[405] | -0.70[406] |
59 | HLTF | Helicase-like transcription factor | [407] | -0.66[408] | 0.68[409] | 1.82[410] | 1.33[411] | 1.23[412] | 1.77[413] |
60 | RB1 | Retinoblastoma-associated protein | [414] | 0.15[415] | 0.47[416] | 0.81[417] | 1.23[418] | 1.17[419] | 1.65[420] |
61 | CDC45 | Cell division control protein 45 homolog | [421] | 0.14[422] | -0.10[423] | 0.34[424] | 0.22[425] | 0.17[426] | -2.74[427] |
62 | E2F1 | Transcription factor E2F1 | [428] | 0.88[429] | 0.55[430] | 0.46[431] | 0.82[432] | 0.88[433] | -3.45[434] |
63 | CHEK1 | Serine/threonine-protein kinase Chk1 | [435] | 0.47[436] | 0.65[437] | -0.01[438] | 1.11[439] | 0.95[440] | -1.86[441] |
64 | PRIM1 | DNA primase small subunit | [442] | -0.40[443] | 0.75[444] | 0.85[445] | 0.12[446] | 0.32[447] | -0.74[448] |
65 | RABIF | Guanine nucleotide exchange factor MSS4 | [449] | -0.55[450] | -0.90[451] | -2.30[452] | 0.15[453] | -0.90[454] | 0.64[455] |
66 | E2F3 | Transcription factor E2F3 | [456] | 0.65[457] | 0.30[458] | -0.67[459] | 1.58[460] | 0.65[461] | 0.00[462] |
67 | SUV39H1 | Histone-lysine N-methyltransferase SUV39H1 | [463] | -0.76[464] | -1.05[465] | 0.26[466] | -0.28[467] | -0.69[468] | 0.29[469] |
68 | CDC25A | M-phase inducer phosphatase 1 | [470] | 0.36[471] | 0.81[472] | 0.94[473] | -0.70[474] | 0.37[475] | -2.49[476] |
69 | SMC2 | Structural maintenance of chromosomes protein 2 | [477] | -0.33[478] | 1.44[479] | 1.08[480] | 1.61[481] | 2.13[482] | 1.24[483] |
70 | CCNB2 | G2/mitotic-specific cyclin-B2 | [484] | 1.03[485] | 1.60[486] | 1.76[487] | 1.48[488] | 2.08[489] | -1.43[490] |
71 | TFDP2 | Transcription factor Dp-2 | [491] | 0.84[492] | 1.35[493] | 1.14[494] | 1.34[495] | 1.19[496] | 2.52[497] |
72 | ORC1 | Origin recognition complex subunit 1 | [498] | 0.48[499] | 0.33[500] | 1.61[501] | 0.23[502] | 0.42[503] | -1.93[504] |
73 | POLD3 | DNA polymerase delta subunit 3 | [505] | 0.11[506] | -0.20[507] | 0.54[508] | 1.07[509] | 1.17[510] | 1.15[511] |
74 | POLE | DNA polymerase epsilon catalytic subunit A | [512] | 1.98[513] | 2.42[514] | 2.25[515] | 1.69[516] | 2.32[517] | 3.11[518] |
75 | KIF4A | Chromosome-associated kinesin KIF4A | [519] | 1.39[520] | 1.55[521] | 1.75[522] | 2.44[523] | 2.02[524] | -1.39[525] |
76 | POLE2 | DNA polymerase epsilon subunit 2 | [526] | -0.36[527] | 0.25[528] | 1.02[529] | 0.11[530] | 0.27[531] | -0.99[532] |
77 | CDT1 | DNA replication factor Cdt1 | [533] | 2.18[534] | 2.28[535] | 3.53[536] | 1.49[537] | 1.70[538] | -1.66[539] |
78 | FANCG | Fanconi anemia group G protein | [540] | 0.90[541] | 1.53[542] | 2.09[543] | 0.67[544] | 1.17[545] | 0.05[546] |
79 | CDC7 | Cell division cycle 7-related protein kinase | [547] | -0.57[548] | 0.21[549] | 0.80[550] | 1.37[551] | 1.71[552] | -0.62[553] |
80 | TTK | Dual specificity protein kinase TTK | [554] | -0.21[555] | 2.10[556] | 1.88[557] | 1.92[558] | 2.09[559] | -0.95[560] |
81 | POLA1 | DNA polymerase alpha catalytic subunit | [561] | 0.94[562] | 0.87[563] | 1.20[564] | 1.94[565] | 1.53[566] | 1.84[567] |
82 | CCNE2 | G1/S-specific cyclin-E2 | [568] | -0.64[569] | -0.43[570] | -1.12[571] | 2.00[572] | 1.51[573] | -0.18[574] |
83 | PLK4 | Serine/threonine-protein kinase PLK4 | [575] | 0.77[576] | 2.21[577] | 1.06[578] | 1.53[579] | 2.02[580] | -0.97[581] |
84 | NPAT | Protein NPAT | [582] | 0.56[583] | 1.65[584] | 1.24[585] | 2.55[586] | 2.16[587] | 3.66[588] |
85 | BARD1 | BRCA1-associated RING domain protein 1 | [589] | 0.25[590] | 1.05[591] | 0.85[592] | 1.65[593] | 1.35[594] | 2.04[595] |
86 | E2F2 | Transcription factor E2F2 | [596] | 3.18[597] | 3.89[598] | 3.18[599] | 3.01[600] | 2.95[601] | 1.59[602] |
87 | H2AZ1 | [603] | [604] | [605] | [606] | [607] | [608] | [609] | |
88 | MIR3917 | [610] | [611] | [612] | [613] | [614] | [615] | [616] |