WP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKT1 RAC-alpha serine/threonine-protein kinase [1] -0.44[2] -0.84[3] -1.80[4] -0.67[5] -0.46[6] -0.78[7]
2 NRAS GTPase NRas [8] 0.11[9] 0.38[10] 0.91[11] 0.38[12] 0.13[13] -0.78[14]
3 PTGES2 Prostaglandin E synthase 2 [15] -0.08[16] -0.13[17] -0.75[18] -1.10[19] -1.05[20] -1.05[21]
4 HRAS GTPase HRas [22] -1.53[23] -2.40[24] -3.07[25] -1.56[26] -1.60[27] -3.19[28]
5 MAPK1 Mitogen-activated protein kinase 1 [29] 1.18[30] 1.16[31] 1.11[32] 1.23[33] 1.06[34] 1.24[35]
6 AKT2 RAC-beta serine/threonine-protein kinase [36] 0.43[37] 0.55[38] 0.80[39] 0.24[40] 0.22[41] 0.60[42]
7 MMP1 Interstitial collagenase [43] -5.69[44] -9.62[45] [46] -2.36[47] -2.64[48] -12.66[49]
8 PLA1A Phospholipase A1 member A [50] -7.03[51] -10.22[52] -4.96[53] -4.58[54] [55] 0.23[56]
9 KRAS GTPase KRas [57] -1.04[58] -1.22[59] 0.50[60] 0.19[61] 0.03[62] 0.14[63]
10 EGFR Epidermal growth factor receptor [64] -1.22[65] -1.75[66] 1.25[67] -0.18[68] 0.62[69] 2.12[70]
11 MAPK3 Mitogen-activated protein kinase 3 [71] 1.33[72] 1.21[73] 1.37[74] -0.19[75] 0.01[76] -1.57[77]
12 SRC Proto-oncogene tyrosine-protein kinase Src [78] 2.50[79] 2.32[80] 1.44[81] 1.78[82] 1.14[83] -1.38[84]
13 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0.69[85] 1.03[86] 1.32[87] 0.44[88] 0.77[89] 0.62[90]
14 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.90[91] 0.57[92] 0.88[93] 0.51[94] 0.90[95] 1.38[96]
15 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1.36[97] 2.29[98] -1.40[99] -0.33[100] 0.61[101] -0.23[102]
16 ESR1 Estrogen receptor [103] -7.83[104] [105] -6.35[106] -4.78[107] -6.86[108] 1.87[109]
17 CYP19A1 Aromatase [110] 1.41[111] 2.26[112] -4.07[113] -2.27[114] -4.54[115] -6.87[116]
18 BRAF Serine/threonine-protein kinase B-raf [117] -0.28[118] -0.71[119] 1.45[120] 0.13[121] 0.00[122] 1.32[123]
19 AKT3 RAC-gamma serine/threonine-protein kinase [124] -2.37[125] -5.09[126] -4.28[127] 5.23[128] 4.36[129] 3.08[130]
20 PTGER1 Prostaglandin E2 receptor EP1 subtype [131] -0.52[132] -2.43[133] -4.29[134] -5.37[135] -0.85[136] -2.43[137]
21 PTGER2 Prostaglandin E2 receptor EP2 subtype [138] [139] [140] 0.36[141] 4.18[142] 3.17[143] 0.86[144]
22 PTGER4 Prostaglandin E2 receptor EP4 subtype [145] -4.56[146] -6.31[147] 2.58[148] 0.28[149] -0.29[150] 2.44[151]
23 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [152] [153] [154] 0.73[155] -3.98[156] 3.57[157]
24 PTGS2 Prostaglandin G/H synthase 2 [158] [159] -3.31[160] -2.93[161] 2.25[162] 8.25[163] 2.30[164]
25 PTGER3 Prostaglandin E2 receptor EP3 subtype [165] -2.43[166] [167] [168] 5.29[169] 2.51[170] 4.11[171]
[1]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[2]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[3]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[4]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[5]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[6]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[7]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[8]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 9.3 4.6 3.3 32 23
[9]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 57 42
[10]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 72 47
[11]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 71 70 86
[12]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 46 59
[13]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[14]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 16 21 14 18
[15]
ref_hepatocyte PTGES2
Mean 13.3
Standard deviation 2.7
Values 11 13 18 12 13
[16]
HepG2 PTGES2
Mean 40
Standard deviation 6.9
Values 35 45
[17]
HepG2.C3A PTGES2
Mean 38.5
Standard deviation 2.5
Values 37 40
[18]
HuH.7 PTGES2
Mean 22.1
Standard deviation 9.4
Values 29 11 26
[19]
SNU475 PTGES2
Mean 17.5
Standard deviation 0.86
Values 18 17
[20]
THLE PTGES2
Mean 17.8
Standard deviation 4.4
Values 15 21
[21]
liver PTGES2
Mean 13.2
Standard deviation 3.7
Values 10 9.8 16 17
[22]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 11 8.8 7.4 4 27
[23]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 12 14
[24]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 7.9 6
[25]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 5.6 2.4 3.6
[26]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[27]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[28]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 1.4 1.1 4.1 3.8
[29]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[30]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[31]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[32]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[33]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[34]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[35]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[36]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 11 14 13 7.2 8.4
[37]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 43 48
[38]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 43 55
[39]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 55 41 59
[40]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 31 39
[41]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[42]
liver AKT2
Mean 33
Standard deviation 9.4
Values 45 36 24 27
[43]
ref_hepatocyte MMP1
Mean 10.4
Standard deviation 23
Values 52 0.12 0.078 0 0.4
[44]
HepG2 MMP1
Mean 0.642
Standard deviation 0.089
Values 0.58 0.7
[45]
HepG2.C3A MMP1
Mean 0.0419
Standard deviation 0.032
Values 0.064 0.019
[46]
HuH.7 MMP1
Mean 0
Standard deviation 0
Values 0 0 0
[47]
SNU475 MMP1
Mean 5.69
Standard deviation 7.7
Values 11 0.27
[48]
THLE MMP1
Mean 4.66
Standard deviation 3.3
Values 2.4 7
[49]
liver MMP1
Mean 0.00331
Standard deviation 0.0066
Values 0.013 0 0 0
[50]
ref_hepatocyte PLA1A
Mean 9.14
Standard deviation 11
Values 0.33 24 17 0.45 4
[51]
HepG2 PLA1A
Mean 0.223
Standard deviation 0.19
Values 0.09 0.36
[52]
HepG2.C3A PLA1A
Mean 0.0243
Standard deviation 0.034
Values 0 0.049
[53]
HuH.7 PLA1A
Mean 0.817
Standard deviation 0.71
Values 0.51 1.6 0.32
[54]
SNU475 PLA1A
Mean 1.07
Standard deviation 0.68
Values 0.59 1.5
[55]
THLE PLA1A
Mean 0
Standard deviation 0
Values 0 0
[56]
liver PLA1A
Mean 22
Standard deviation 8.6
Values 19 11 29 28
[57]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 5.4 2.7 1.7 18 17
[58]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 16 12
[59]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 14 11
[60]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 36 30 40
[61]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 25 33
[62]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[63]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 14 16 33 19
[64]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 11 3.5 3.5 0.94 8.5
[65]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 8.2 6.9
[66]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 4.7 5.7
[67]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 15 63 32
[68]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 14 13
[69]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[70]
liver EGFR
Mean 49.4
Standard deviation 14
Values 42 69 39 47
[71]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 3.6 3.3 6 5.1 2.8
[72]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 29 37
[73]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 22 39
[74]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 32 25 34
[75]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 8.5 12
[76]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[77]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 0.82 0.81 5 4.8
[78]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 2.2 1.2 0.77 9.6 4.7
[79]
HepG2 SRC
Mean 66
Standard deviation 21
Values 51 81
[80]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 45 71
[81]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 26 29 28
[82]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 33 38
[83]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[84]
liver SRC
Mean 2.9
Standard deviation 1
Values 3.2 2.5 4.1 1.7
[85]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 2.6 2.1 1.8 5.2 4.2
[86]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 18 15
[87]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 19 23
[88]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 20 23 24
[89]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 10 14
[90]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[91]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 11 15 6.4 7.9
[92]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 0.94 1.2 2.3 2.6
[93]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 4.3 2.1
[94]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 9.6 8
[95]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 7 12 10
[96]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 6.8 8.1
[97]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[98]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 13 15 6.1 6
[99]
ref_hepatocyte PIK3CD
Mean 1.86
Standard deviation 1.7
Values 3.3 0.66 0.38 4.1 0.94
[100]
HepG2 PIK3CD
Mean 15.2
Standard deviation 3.8
Values 13 18
[101]
HepG2.C3A PIK3CD
Mean 28.8
Standard deviation 2.6
Values 27 31
[102]
HuH.7 PIK3CD
Mean 1.97
Standard deviation 0.32
Values 1.6 2.3 2
[103]
SNU475 PIK3CD
Mean 4.15
Standard deviation 0.57
Values 3.7 4.6
[104]
THLE PIK3CD
Mean 7.91
Standard deviation 1.1
Values 7.1 8.7
[105]
liver PIK3CD
Mean 3.25
Standard deviation 1.3
Values 5.1 3 2.4 2.6
[106]
ref_hepatocyte ESR1
Mean 1.54
Standard deviation 2.3
Values 0 5.3 2.2 0 0.17
[107]
HepG2 ESR1
Mean 0.0215
Standard deviation 0.018
Values 0.0086 0.034
[108]
HepG2.C3A ESR1
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 ESR1
Mean 0.0525
Standard deviation 0.047
Values 0.019 0.032 0.11
[110]
SNU475 ESR1
Mean 0.157
Standard deviation 0.14
Values 0.25 0.06
[111]
THLE ESR1
Mean 0.0367
Standard deviation 0.0067
Values 0.041 0.032
[112]
liver ESR1
Mean 11.5
Standard deviation 7
Values 22 11 7.2 6.1
[113]
ref_hepatocyte CYP19A1
Mean 1.13
Standard deviation 2.3
Values 0.28 0 0 5.3 0.08
[114]
HepG2 CYP19A1
Mean 9.51
Standard deviation 0.87
Values 10 8.9
[115]
HepG2.C3A CYP19A1
Mean 17.1
Standard deviation 5.6
Values 13 21
[116]
HuH.7 CYP19A1
Mean 0.188
Standard deviation 0.27
Values 0.047 0.5 0.016
[117]
SNU475 CYP19A1
Mean 0.66
Standard deviation 0.58
Values 1.1 0.25
[118]
THLE CYP19A1
Mean 0.135
Standard deviation 0.018
Values 0.15 0.12
[119]
liver CYP19A1
Mean 0.0199
Standard deviation 0.04
Values 0.079 0 0 0
[120]
ref_hepatocyte BRAF
Mean 1.07
Standard deviation 0.72
Values 2.3 0.67 0.67 0.56 1.2
[121]
HepG2 BRAF
Mean 2.8
Standard deviation 0.62
Values 3.2 2.4
[122]
HepG2.C3A BRAF
Mean 2.07
Standard deviation 0.66
Values 2.5 1.6
[123]
HuH.7 BRAF
Mean 8.12
Standard deviation 5.8
Values 3.4 15 6.4
[124]
SNU475 BRAF
Mean 3.28
Standard deviation 0.16
Values 3.4 3.2
[125]
THLE BRAF
Mean 2.97
Standard deviation 0.38
Values 2.7 3.2
[126]
liver BRAF
Mean 5.48
Standard deviation 2.9
Values 7.9 8 3.1 2.9
[127]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0.83 0.41 0.16 0 0.53
[128]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.13 0.34
[129]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.043 0.029
[130]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.028 0.09 0.049
[131]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 34 48
[132]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[133]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 9.4 12 2.8 2.3
[134]
ref_hepatocyte PTGER1
Mean 0.18
Standard deviation 0.16
Values 0.22 0.057 0.21 0 0.41
[135]
HepG2 PTGER1
Mean 0.4
Standard deviation 0.31
Values 0.18 0.62
[136]
HepG2.C3A PTGER1
Mean 0.106
Standard deviation 0.029
Values 0.086 0.13
[137]
HuH.7 PTGER1
Mean 0.0258
Standard deviation 0.026
Values 0.056 0.013 0.0082
[138]
SNU475 PTGER1
Mean 0.0122
Standard deviation 0.0042
Values 0.015 0.0093
[139]
THLE PTGER1
Mean 0.279
Standard deviation 0.042
Values 0.25 0.31
[140]
liver PTGER1
Mean 0.0686
Standard deviation 0.072
Values 0.12 0.014 0.14 0
[141]
ref_hepatocyte PTGER2
Mean 0.135
Standard deviation 0.19
Values 0 0.39 0.28 0 0
[142]
HepG2 PTGER2
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A PTGER2
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 PTGER2
Mean 0.484
Standard deviation 0.19
Values 0.38 0.7 0.37
[145]
SNU475 PTGER2
Mean 6.87
Standard deviation 0.93
Values 6.2 7.5
[146]
THLE PTGER2
Mean 3.39
Standard deviation 1.4
Values 4.3 2.4
[147]
liver PTGER2
Mean 0.503
Standard deviation 0.15
Values 0.66 0.56 0.31 0.49
[148]
ref_hepatocyte PTGER4
Mean 0.122
Standard deviation 0.13
Values 0.17 0.33 0.078 0 0.034
[149]
HepG2 PTGER4
Mean 0.0165
Standard deviation 0.0071
Values 0.021 0.011
[150]
HepG2.C3A PTGER4
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[151]
HuH.7 PTGER4
Mean 2.04
Standard deviation 0.27
Values 1.8 2.3 2
[152]
SNU475 PTGER4
Mean 0.416
Standard deviation 0.071
Values 0.47 0.37
[153]
THLE PTGER4
Mean 0.278
Standard deviation 0.009
Values 0.28 0.27
[154]
liver PTGER4
Mean 1.36
Standard deviation 0.5
Values 1.9 1.7 0.99 0.87
[155]
ref_hepatocyte PIK3CG
Mean 0.0637
Standard deviation 0.13
Values 0 0.29 0.026 0 0
[156]
HepG2 PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 PIK3CG
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 PIK3CG
Mean 0.296
Standard deviation 0.1
Values 0.37 0.22
[160]
THLE PIK3CG
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[161]
liver PIK3CG
Mean 1.55
Standard deviation 0.43
Values 1.6 1.9 0.94 1.7
[162]
ref_hepatocyte PTGS2
Mean 0.032
Standard deviation 0.045
Values 0 0.065 0.095 0 0
[163]
HepG2 PTGS2
Mean 0
Standard deviation 0
Values 0 0
[164]
HepG2.C3A PTGS2
Mean 0.0102
Standard deviation 0.00071
Values 0.011 0.0097
[165]
HuH.7 PTGS2
Mean 0.0117
Standard deviation 0.013
Values 0.0094 0.026 0
[166]
SNU475 PTGS2
Mean 0.428
Standard deviation 0.51
Values 0.79 0.07
[167]
THLE PTGS2
Mean 27
Standard deviation 7.8
Values 33 22
[168]
liver PTGS2
Mean 0.325
Standard deviation 0.24
Values 0.26 0.67 0.24 0.13
[169]
ref_hepatocyte PTGER3
Mean 0.00488
Standard deviation 0.011
Values 0 0.024 0 0 0
[170]
HepG2 PTGER3
Mean 0.00287
Standard deviation 0.0041
Values 0 0.0057
[171]
HepG2.C3A PTGER3
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 PTGER3
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 PTGER3
Mean 0.536
Standard deviation 0.48
Values 0.88 0.19
[174]
THLE PTGER3
Mean 0.0775
Standard deviation 0.049
Values 0.11 0.043
[175]
liver PTGER3
Mean 0.173
Standard deviation 0.08
Values 0.079 0.27 0.19 0.15