WP_REGULATORY_CIRCUITS_OF_THE_STAT3_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | STAT3 | Signal transducer and activator of transcription 3 | [1] | -0.09[2] | -1.81[3] | -1.13[4] | -0.45[5] | -1.36[6] | 0.90[7] |
2 | IFNGR1 | Interferon gamma receptor 1 | [8] | 0.14[9] | -1.20[10] | -2.71[11] | -1.07[12] | -1.50[13] | -1.82[14] |
3 | TRIM28 | Transcription intermediary factor 1-beta | [15] | 0.82[16] | 0.38[17] | 1.34[18] | 0.32[19] | -0.13[20] | -2.17[21] |
4 | STMN1 | Stathmin | [22] | 0.35[23] | 0.94[24] | 1.10[25] | 0.19[26] | 0.57[27] | -4.05[28] |
5 | MAPK6 | Mitogen-activated protein kinase 6 | [29] | -0.61[30] | 0.64[31] | 0.72[32] | -0.06[33] | -1.04[34] | -1.57[35] |
6 | MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | [36] | -0.65[37] | -1.12[38] | -0.95[39] | -0.62[40] | -0.61[41] | -1.68[42] |
7 | IL6ST | Interleukin-6 receptor subunit beta | [43] | -0.38[44] | 0.65[45] | 0.12[46] | 1.03[47] | 2.02[48] | 2.28[49] |
8 | AKT1S1 | Proline-rich AKT1 substrate 1 | [50] | -1.11[51] | -1.47[52] | -1.18[53] | -1.45[54] | -1.01[55] | -2.69[56] |
9 | IFNGR2 | Interferon gamma receptor 2 | [57] | -0.68[58] | -0.33[59] | -2.41[60] | -2.06[61] | -0.96[62] | -2.09[63] |
10 | JAK1 | Tyrosine-protein kinase JAK1 | [64] | -0.13[65] | -0.86[66] | -0.73[67] | -0.07[68] | 0.39[69] | 0.03[70] |
11 | IFNAR2 | Interferon alpha/beta receptor 2 | [71] | -1.85[72] | -2.41[73] | -1.79[74] | -2.09[75] | -2.28[76] | -2.28[77] |
12 | GHR | Growth hormone receptor | [78] | -8.39[79] | -9.71[80] | -3.88[81] | -8.78[82] | -3.07[83] | 0.14[84] |
13 | SOCS3 | Suppressor of cytokine signaling 3 | [85] | -4.78[86] | -5.41[87] | -3.75[88] | -1.50[89] | -2.75[90] | -1.37[91] |
14 | SETD7 | Histone-lysine N-methyltransferase SETD7 | [92] | -2.85[93] | -7.08[94] | 0.10[95] | 0.56[96] | 0.58[97] | 0.75[98] |
15 | MAPK1 | Mitogen-activated protein kinase 1 | [99] | 1.07[100] | 0.99[101] | 0.76[102] | 1.15[103] | 0.62[104] | 0.27[105] |
16 | IL6R | Interleukin-6 receptor subunit alpha | [106] | -0.86[107] | -0.75[108] | -1.63[109] | -1.57[110] | -5.85[111] | 0.15[112] |
17 | MLST8 | Target of rapamycin complex subunit LST8 | [113] | -0.82[114] | -0.70[115] | -0.39[116] | -1.67[117] | -1.51[118] | -2.07[119] |
18 | MAPK14 | Mitogen-activated protein kinase 14 | [120] | 0.83[121] | 0.69[122] | 0.20[123] | 0.99[124] | 0.28[125] | -0.22[126] |
19 | IL10RB | Interleukin-10 receptor subunit beta | [127] | -1.18[128] | -1.58[129] | -2.66[130] | -0.91[131] | -0.97[132] | -1.48[133] |
20 | IL15RA | Interleukin-15 receptor subunit alpha | [134] | -6.54[135] | -9.44[136] | -9.45[137] | -2.16[138] | -2.39[139] | -2.87[140] |
21 | IFNAR1 | Interferon alpha/beta receptor 1 | [141] | -0.58[142] | -0.32[143] | -0.68[144] | 0.29[145] | 0.10[146] | 0.93[147] |
22 | MAPK8 | Mitogen-activated protein kinase 8 | [148] | -2.09[149] | -0.89[150] | -2.08[151] | -1.60[152] | -1.93[153] | -2.01[154] |
23 | AGTR1 | Type-1 angiotensin II receptor | [155] | -7.99[156] | -6.37[157] | -0.92[158] | -1.97[159] | -6.55[160] | -0.07[161] |
24 | OSMR | Oncostatin-M-specific receptor subunit beta | [162] | 1.37[163] | 0.87[164] | -0.58[165] | 1.02[166] | 1.99[167] | 0.00[168] |
25 | EGFR | Epidermal growth factor receptor | [169] | -1.34[170] | -1.93[171] | 0.90[172] | -0.26[173] | 0.17[174] | 1.15[175] |
26 | MAPK13 | Mitogen-activated protein kinase 13 | [176] | 1.70[177] | 1.89[178] | -0.85[179] | -2.58[180] | -1.25[181] | -3.22[182] |
27 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | [183] | 0.49[184] | 0.64[185] | 0.71[186] | 0.05[187] | 0.79[188] | 0.49[189] |
28 | MAPK9 | Mitogen-activated protein kinase 9 | [190] | 0.58[191] | 0.60[192] | 0.60[193] | 1.02[194] | 0.29[195] | -0.99[196] |
29 | MAPK3 | Mitogen-activated protein kinase 3 | [197] | 1.21[198] | 1.04[199] | 1.02[200] | -0.27[201] | -0.44[202] | -2.54[203] |
30 | SRC | Proto-oncogene tyrosine-protein kinase Src | [204] | 2.38[205] | 2.15[206] | 1.09[207] | 1.70[208] | 0.70[209] | -2.35[210] |
31 | MTOR | Serine/threonine-protein kinase mTOR | [211] | 1.89[212] | 2.69[213] | 2.20[214] | 1.99[215] | 1.88[216] | 1.95[217] |
32 | DEPTOR | DEP domain-containing mTOR-interacting protein | [218] | -3.97[219] | -2.99[220] | 1.00[221] | -4.95[222] | -2.49[223] | -0.65[224] |
33 | IL11RA | Interleukin-11 receptor subunit alpha | [225] | -2.62[226] | -0.55[227] | -2.00[228] | -2.24[229] | -2.53[230] | -0.35[231] |
34 | RPTOR | Regulatory-associated protein of mTOR | [232] | 2.44[233] | 1.46[234] | 1.51[235] | 1.15[236] | 1.20[237] | 0.83[238] |
35 | CREBBP | CREB-binding protein | [239] | 2.26[240] | 1.26[241] | 1.81[242] | 2.06[243] | 1.88[244] | 1.73[245] |
36 | RICTOR | Rapamycin-insensitive companion of mTOR | [246] | 0.08[247] | 1.95[248] | 2.57[249] | 1.66[250] | 1.68[251] | 2.01[252] |
37 | CNTFR | Ciliary neurotrophic factor receptor subunit alpha | [253] | -7.29[254] | [255] | -3.33[256] | -4.16[257] | -6.99[258] | -2.73[259] |
38 | PIAS3 | E3 SUMO-protein ligase PIAS3 | [260] | 0.66[261] | -0.37[262] | 0.87[263] | 2.02[264] | 1.54[265] | -0.74[266] |
39 | IL22RA1 | Interleukin-22 receptor subunit alpha-1 | [267] | 0.21[268] | 2.50[269] | -2.42[270] | -1.85[271] | -2.34[272] | -1.07[273] |
40 | F2R | Proteinase-activated receptor 1 | [274] | 2.20[275] | 0.47[276] | 0.96[277] | 3.15[278] | 2.38[279] | 1.23[280] |
41 | MAPK7 | Mitogen-activated protein kinase 7 | [281] | 0.79[282] | -0.12[283] | -0.18[284] | 1.11[285] | 1.02[286] | -1.17[287] |
42 | IL2RG | Cytokine receptor common subunit gamma | [288] | -2.29[289] | -4.39[290] | -3.81[291] | -4.29[292] | [293] | -1.61[294] |
43 | PTPRC | Receptor-type tyrosine-protein phosphatase C | [295] | [296] | [297] | [298] | -0.32[299] | -9.43[300] | 1.64[301] |
44 | JAK2 | Tyrosine-protein kinase JAK2 | [302] | -0.42[303] | -0.64[304] | -1.14[305] | 0.07[306] | 0.48[307] | 1.20[308] |
45 | MAPK12 | Mitogen-activated protein kinase 12 | [309] | 2.18[310] | 1.63[311] | 2.68[312] | 0.79[313] | 1.86[314] | -2.41[315] |
46 | LIFR | Leukemia inhibitory factor receptor | [316] | 0.28[317] | 2.76[318] | 3.27[319] | 3.37[320] | 2.68[321] | 5.02[322] |
47 | F2RL2 | Proteinase-activated receptor 3 | [323] | -6.08[324] | -5.33[325] | -3.45[326] | 3.02[327] | -2.24[328] | -0.68[329] |
48 | IL27RA | Interleukin-27 receptor subunit alpha | [330] | 1.22[331] | 1.44[332] | 1.65[333] | -1.02[334] | 0.30[335] | -1.06[336] |
49 | IL10RA | Interleukin-10 receptor subunit alpha | [337] | -6.28[338] | [339] | [340] | -5.34[341] | -6.65[342] | 1.14[343] |
50 | CSF3R | Granulocyte colony-stimulating factor receptor | [344] | 0.31[345] | 2.43[346] | 2.05[347] | -6.46[348] | -8.58[349] | 0.96[350] |
51 | DUSP2 | Dual specificity protein phosphatase 2 | [351] | -3.41[352] | [353] | -8.40[354] | -0.97[355] | -1.11[356] | -1.45[357] |
52 | PDGFRA | Platelet-derived growth factor receptor alpha | [358] | -4.26[359] | -5.46[360] | 2.12[361] | -0.17[362] | 4.32[363] | 3.82[364] |
53 | PDGFRB | Platelet-derived growth factor receptor beta | [365] | 0.66[366] | 0.84[367] | -1.67[368] | 1.16[369] | 1.53[370] | 1.91[371] |
54 | PTPRD | Receptor-type tyrosine-protein phosphatase delta | [372] | -5.56[373] | -8.29[374] | [375] | -7.61[376] | -1.46[377] | 2.55[378] |
55 | IL20RB | Interleukin-20 receptor subunit beta | [379] | -2.81[380] | -4.16[381] | -1.39[382] | -1.67[383] | 1.53[384] | -2.84[385] |
56 | CSF2RA | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha | [386] | [387] | [388] | [389] | [390] | -7.96[391] | |
57 | IL2RB | Interleukin-2 receptor subunit beta | [392] | -5.41[393] | -6.18[394] | -7.21[395] | -3.51[396] | -6.12[397] | 0.04[398] |
58 | MAPK11 | Mitogen-activated protein kinase 11 | [399] | -0.82[400] | -1.13[401] | -2.08[402] | -0.34[403] | 1.47[404] | -1.34[405] |
59 | IL7R | Interleukin-7 receptor subunit alpha | [406] | -4.88[407] | -5.68[408] | -5.84[409] | 4.55[410] | 4.27[411] | 0.71[412] |
60 | PRKCB | Protein kinase C beta type | [413] | -7.46[414] | -6.47[415] | [416] | 1.79[417] | -3.70[418] | 2.03[419] |
61 | IL3RA | Interleukin-3 receptor subunit alpha | [420] | [421] | [422] | [423] | [424] | [425] | [426] |
62 | MPL | Thrombopoietin receptor | [427] | -2.91[428] | -2.21[429] | -2.72[430] | -3.07[431] | -3.58[432] | -1.24[433] |
63 | JAK3 | Tyrosine-protein kinase JAK3 | [434] | 1.60[435] | 3.66[436] | -2.41[437] | -1.33[438] | -0.78[439] | 1.60[440] |
64 | MAPK4 | Mitogen-activated protein kinase 4 | [441] | -7.56[442] | -5.74[443] | 1.39[444] | -7.10[445] | -4.44[446] | 1.51[447] |
65 | CSF2RB | Cytokine receptor common subunit beta | [448] | [449] | [450] | [451] | -6.84[452] | -4.72[453] | 1.36[454] |
66 | F2RL3 | Proteinase-activated receptor 4 | [455] | -4.05[456] | -3.13[457] | -4.03[458] | -4.12[459] | -0.51[460] | -1.86[461] |
67 | CTF1 | Cardiotrophin-1 | [462] | 1.05[463] | 0.55[464] | -2.08[465] | -4.54[466] | 0.32[467] | -3.87[468] |
68 | IL2RA | Interleukin-2 receptor subunit alpha | [469] | [470] | -6.45[471] | [472] | -5.30[473] | -7.39[474] | -0.97[475] |
69 | IL21R | Interleukin-21 receptor | [476] | -1.13[477] | 0.34[478] | -4.31[479] | -3.16[480] | -0.95[481] | -0.16[482] |
70 | MAPK15 | Mitogen-activated protein kinase 15 | [483] | -0.92[484] | 0.09[485] | -2.26[486] | -3.06[487] | 0.20[488] | -1.76[489] |
71 | IL9R | Interleukin-9 receptor | [490] | [491] | [492] | [493] | [494] | [495] | [496] |
72 | IL5RA | Interleukin-5 receptor subunit alpha | [497] | [498] | [499] | [500] | -1.28[501] | -1.38[502] | 0.83[503] |
73 | IL12RB2 | Interleukin-12 receptor subunit beta-2 | [504] | 2.22[505] | 2.61[506] | 4.58[507] | 4.70[508] | 2.59[509] | 6.46[510] |
74 | MAPK10 | Mitogen-activated protein kinase 10 | [511] | -2.13[512] | [513] | [514] | 8.21[515] | 3.76[516] | 5.75[517] |
75 | PTPRT | Receptor-type tyrosine-protein phosphatase T | [518] | 4.15[519] | [520] | [521] | [522] | -1.30[523] | 8.75[524] |
76 | IL20RA | Interleukin-20 receptor subunit alpha | [525] | [526] | [527] | [528] | [529] | [530] | [531] |
77 | AGTR2 | Type-2 angiotensin II receptor | [532] | [533] | [534] | [535] | [536] | [537] | [538] |
78 | IFNLR1 | Interferon lambda receptor 1 | [539] | [540] | [541] | [542] | [543] | [544] | [545] |
79 | MIR3917 | [546] | [547] | [548] | [549] | [550] | [551] | [552] |