WP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CTNNB1 Catenin beta-1 [1] -0.41[2] -0.12[3] -0.01[4] -0.62[5] -0.49[6] -1.69[7]
2 CSNK1A1 Casein kinase I isoform alpha [8] -1.69[9] -0.91[10] -1.92[11] -0.54[12] -0.55[13] -2.10[14]
3 LRP1 Prolow-density lipoprotein receptor-related protein 1 [15] 1.80[16] 0.89[17] 1.09[18] 0.98[19] 0.85[20] 2.35[21]
4 AXIN1 Axin-1 [22] -0.68[23] 0.44[24] -1.91[25] -10.07[26] -1.32[27] -3.45[28]
5 GSK3B Glycogen synthase kinase-3 beta [29] -0.77[30] -0.33[31] -0.54[32] 0.44[33] 0.17[34] -1.63[35]
6 DVL2 Segment polarity protein dishevelled homolog DVL-2 [36] 0.08[37] 0.64[38] 0.84[39] 0.85[40] 0.39[41] -2.78[42]
7 TNKS Tankyrase-1 [43] 0.70[44] 1.82[45] 2.01[46] 0.24[47] 1.16[48] 0.41[49]
8 SFRP4 Secreted frizzled-related protein 4 [50] -4.21[51] -4.15[52] [53] -2.32[54] -6.09[55] -7.41[56]
9 MBOAT1 Lysophospholipid acyltransferase 1 [57] -8.32[58] -8.63[59] -2.18[60] -1.21[61] -1.73[62] -0.31[63]
10 APC Adenomatous polyposis coli protein [64] -1.46[65] 1.01[66] 0.06[67] 0.85[68] 1.38[69] 0.94[70]
11 FZD8 Frizzled-8 [71] -5.16[72] -9.70[73] -3.11[74] -4.34[75] -3.23[76] -2.99[77]
12 DKK3 Dickkopf-related protein 3 [78] -2.87[79] [80] -0.15[81] 2.76[82] 3.18[83] -1.46[84]
13 FZD7 Frizzled-7 [85] 0.17[86] -3.07[87] 2.16[88] 3.19[89] 0.49[90] -2.77[91]
14 FZD1 Frizzled-1 [92] -0.48[93] -1.64[94] 1.25[95] 1.04[96] 2.06[97] -0.01[98]
15 TCF4 Transcription factor 4 [99] -4.27[100] -2.53[101] 3.05[102] 3.96[103] 3.31[104] 2.52[105]
16 LEF1 Lymphoid enhancer-binding factor 1 [106] 0.62[107] -5.51[108] 1.63[109] -0.29[110] -2.10[111] -1.71[112]
17 MIR4683 [113] [114] [115] [116] [117] [118] [119]
18 WNT1 Proto-oncogene Wnt-1 [120] [121] [122] [123] [124] [125] [126]
[1]
ref_hepatocyte CTNNB1
Mean 37.2
Standard deviation 16
Values 22 31 23 57 53
[2]
HepG2 CTNNB1
Mean 252
Standard deviation 27
Values 2.7e+02 2.3e+02
[3]
HepG2.C3A CTNNB1
Mean 158
Standard deviation 34
Values 1.8e+02 1.3e+02
[4]
HuH.7 CTNNB1
Mean 282
Standard deviation 64
Values 3.1e+02 2.1e+02 3.3e+02
[5]
SNU475 CTNNB1
Mean 115
Standard deviation 10
Values 1.1e+02 1.2e+02
[6]
THLE CTNNB1
Mean 151
Standard deviation 19
Values 1.4e+02 1.6e+02
[7]
liver CTNNB1
Mean 114
Standard deviation 15
Values 1.1e+02 1.3e+02 98 1.2e+02
[8]
ref_hepatocyte CSNK1A1
Mean 20.7
Standard deviation 9.8
Values 35 14 10 20 24
[9]
HepG2 CSNK1A1
Mean 57.9
Standard deviation 0.1
Values 58 58
[10]
HepG2.C3A CSNK1A1
Mean 51.1
Standard deviation 2
Values 53 50
[11]
HuH.7 CSNK1A1
Mean 41.8
Standard deviation 2.9
Values 41 39 45
[12]
SNU475 CSNK1A1
Mean 67.7
Standard deviation 7.6
Values 62 73
[13]
THLE CSNK1A1
Mean 81.2
Standard deviation 5.1
Values 78 85
[14]
liver CSNK1A1
Mean 47.5
Standard deviation 6.3
Values 47 56 41 47
[15]
ref_hepatocyte LRP1
Mean 12.6
Standard deviation 14
Values 1.8 29 26 4.1 2.3
[16]
HepG2 LRP1
Mean 396
Standard deviation 1.6e+02
Values 2.8e+02 5.1e+02
[17]
HepG2.C3A LRP1
Mean 108
Standard deviation 18
Values 95 1.2e+02
[18]
HuH.7 LRP1
Mean 204
Standard deviation 59
Values 1.4e+02 2.4e+02 2.4e+02
[19]
SNU475 LRP1
Mean 118
Standard deviation 49
Values 83 1.5e+02
[20]
THLE LRP1
Mean 130
Standard deviation 35
Values 1.1e+02 1.6e+02
[21]
liver LRP1
Mean 635
Standard deviation 3.6e+02
Values 1e+03 8.3e+02 3.4e+02 3.3e+02
[22]
ref_hepatocyte AXIN1
Mean 4.86
Standard deviation 2.8
Values 7.6 1.6 2.2 6.8 6.1
[23]
HepG2 AXIN1
Mean 27.3
Standard deviation 5.7
Values 23 31
[24]
HepG2.C3A AXIN1
Mean 30.4
Standard deviation 14
Values 21 40
[25]
HuH.7 AXIN1
Mean 9.87
Standard deviation 0.66
Values 10 10 9.1
[26]
SNU475 AXIN1
Mean 0.0215
Standard deviation 0.0089
Values 0.015 0.028
[27]
THLE AXIN1
Mean 11.1
Standard deviation 0.85
Values 11 12
[28]
liver AXIN1
Mean 4.4
Standard deviation 1.7
Values 6.6 4.8 3.3 2.9
[29]
ref_hepatocyte GSK3B
Mean 4.16
Standard deviation 1.7
Values 4.9 2.1 2.7 5.2 5.9
[30]
HepG2 GSK3B
Mean 22.1
Standard deviation 6
Values 26 18
[31]
HepG2.C3A GSK3B
Mean 15.3
Standard deviation 2.3
Values 17 14
[32]
HuH.7 GSK3B
Mean 21.8
Standard deviation 5.6
Values 15 26 24
[33]
SNU475 GSK3B
Mean 26.9
Standard deviation 2.6
Values 25 29
[34]
THLE GSK3B
Mean 26.7
Standard deviation 2.9
Values 25 29
[35]
liver GSK3B
Mean 13.2
Standard deviation 3.2
Values 16 15 14 8.6
[36]
ref_hepatocyte DVL2
Mean 2.34
Standard deviation 0.94
Values 2.7 2.4 2.5 3.3 0.77
[37]
HepG2 DVL2
Mean 22.4
Standard deviation 2.6
Values 21 24
[38]
HepG2.C3A DVL2
Mean 16.8
Standard deviation 0.55
Values 16 17
[39]
HuH.7 DVL2
Mean 31.8
Standard deviation 1.9
Values 32 34 30
[40]
SNU475 DVL2
Mean 20
Standard deviation 2.6
Values 18 22
[41]
THLE DVL2
Mean 17.6
Standard deviation 1.2
Values 17 18
[42]
liver DVL2
Mean 3.34
Standard deviation 0.75
Values 4.3 3.2 3.5 2.5
[43]
ref_hepatocyte TNKS
Mean 1.48
Standard deviation 0.41
Values 1.4 1.6 0.85 2 1.6
[44]
HepG2 TNKS
Mean 21.7
Standard deviation 1.5
Values 23 21
[45]
HepG2.C3A TNKS
Mean 24.2
Standard deviation 6
Values 20 28
[46]
HuH.7 TNKS
Mean 45.6
Standard deviation 18
Values 29 65 44
[47]
SNU475 TNKS
Mean 8.29
Standard deviation 0.84
Values 7.7 8.9
[48]
THLE TNKS
Mean 19
Standard deviation 1.5
Values 20 18
[49]
liver TNKS
Mean 19.4
Standard deviation 8.9
Values 25 29 13 11
[50]
ref_hepatocyte SFRP4
Mean 1.46
Standard deviation 3
Values 0 0.024 0.052 6.8 0.39
[51]
HepG2 SFRP4
Mean 0.711
Standard deviation 0.025
Values 0.73 0.69
[52]
HepG2.C3A SFRP4
Mean 0.379
Standard deviation 0.23
Values 0.21 0.54
[53]
HuH.7 SFRP4
Mean 0
Standard deviation 0
Values 0 0 0
[54]
SNU475 SFRP4
Mean 1.39
Standard deviation 0.77
Values 0.85 1.9
[55]
THLE SFRP4
Mean 0.122
Standard deviation 0.053
Values 0.16 0.085
[56]
liver SFRP4
Mean 0.0846
Standard deviation 0.038
Values 0.04 0.1 0.071 0.13
[57]
ref_hepatocyte MBOAT1
Mean 1.34
Standard deviation 0.87
Values 2 1.8 0.92 0 2
[58]
HepG2 MBOAT1
Mean 0.0379
Standard deviation 0.011
Values 0.03 0.046
[59]
HepG2.C3A MBOAT1
Mean 0.0156
Standard deviation 0.0083
Values 0.021 0.0097
[60]
HuH.7 MBOAT1
Mean 2.25
Standard deviation 0.49
Values 2.6 1.7 2.4
[61]
SNU475 MBOAT1
Mean 2.74
Standard deviation 0.37
Values 2.5 3
[62]
THLE MBOAT1
Mean 2.31
Standard deviation 0.24
Values 2.1 2.5
[63]
liver MBOAT1
Mean 10.7
Standard deviation 7.6
Values 5.3 3.3 19 15
[64]
ref_hepatocyte APC
Mean 1.09
Standard deviation 0.39
Values 1 0.97 0.53 1.4 1.5
[65]
HepG2 APC
Mean 3.57
Standard deviation 1.5
Values 4.6 2.5
[66]
HepG2.C3A APC
Mean 10.1
Standard deviation 2.6
Values 12 8.3
[67]
HuH.7 APC
Mean 8.67
Standard deviation 2.6
Values 5.7 11 9.7
[68]
SNU475 APC
Mean 9.33
Standard deviation 3.4
Values 12 6.9
[69]
THLE APC
Mean 16.3
Standard deviation 4.6
Values 20 13
[70]
liver APC
Mean 20.6
Standard deviation 6.3
Values 22 28 20 12
[71]
ref_hepatocyte FZD8
Mean 0.963
Standard deviation 1
Values 2.3 1.5 0.92 0 0.036
[72]
HepG2 FZD8
Mean 0.243
Standard deviation 0.2
Values 0.1 0.38
[73]
HepG2.C3A FZD8
Mean 0.00536
Standard deviation 0.0076
Values 0.011 0
[74]
HuH.7 FZD8
Mean 0.853
Standard deviation 0.068
Values 0.82 0.93 0.81
[75]
SNU475 FZD8
Mean 0.227
Standard deviation 0.034
Values 0.2 0.25
[76]
THLE FZD8
Mean 0.588
Standard deviation 0.15
Values 0.48 0.7
[77]
liver FZD8
Mean 1.19
Standard deviation 0.79
Values 2.3 1.3 0.54 0.64
[78]
ref_hepatocyte DKK3
Mean 0.724
Standard deviation 1.2
Values 0.22 0.43 0.16 0 2.8
[79]
HepG2 DKK3
Mean 0.893
Standard deviation 0.072
Values 0.94 0.84
[80]
HepG2.C3A DKK3
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 DKK3
Mean 4.98
Standard deviation 0.43
Values 4.7 5.5 4.8
[82]
SNU475 DKK3
Mean 23.4
Standard deviation 11
Values 15 31
[83]
THLE DKK3
Mean 37.6
Standard deviation 5.4
Values 34 41
[84]
liver DKK3
Mean 2.59
Standard deviation 1
Values 3.4 1.7 3.5 1.7
[85]
ref_hepatocyte FZD7
Mean 0.384
Standard deviation 0.68
Values 1.6 0.27 0.069 0 0
[86]
HepG2 FZD7
Mean 3.9
Standard deviation 2.2
Values 2.3 5.5
[87]
HepG2.C3A FZD7
Mean 0.211
Standard deviation 0.065
Values 0.26 0.17
[88]
HuH.7 FZD7
Mean 13.1
Standard deviation 4.3
Values 15 8.1 16
[89]
SNU475 FZD7
Mean 16.6
Standard deviation 5.6
Values 13 21
[90]
THLE FZD7
Mean 3.09
Standard deviation 0.13
Values 3.2 3
[91]
liver FZD7
Mean 0.554
Standard deviation 0.38
Values 1.1 0.47 0.38 0.26
[92]
ref_hepatocyte FZD1
Mean 0.275
Standard deviation 0.23
Values 0.2 0.11 0.2 0.67 0.19
[93]
HepG2 FZD1
Mean 1.78
Standard deviation 0.25
Values 1.6 2
[94]
HepG2.C3A FZD1
Mean 0.407
Standard deviation 0.27
Values 0.6 0.21
[95]
HuH.7 FZD1
Mean 5
Standard deviation 1.3
Values 6.1 3.6 5.2
[96]
SNU475 FZD1
Mean 2.69
Standard deviation 0.5
Values 3.1 2.3
[97]
THLE FZD1
Mean 6.59
Standard deviation 1.5
Values 5.5 7.7
[98]
liver FZD1
Mean 2.7
Standard deviation 1.5
Values 4.9 2.3 2.2 1.5
[99]
ref_hepatocyte TCF4
Mean 0.191
Standard deviation 0.17
Values 0.41 0.3 0.16 0 0.085
[100]
HepG2 TCF4
Mean 0.0894
Standard deviation 0.086
Values 0.15 0.029
[101]
HepG2.C3A TCF4
Mean 0.153
Standard deviation 0.0038
Values 0.15 0.16
[102]
HuH.7 TCF4
Mean 12.1
Standard deviation 4
Values 7.8 16 13
[103]
SNU475 TCF4
Mean 14.1
Standard deviation 2.2
Values 13 16
[104]
THLE TCF4
Mean 10.9
Standard deviation 0.72
Values 10 11
[105]
liver TCF4
Mean 10.8
Standard deviation 2.4
Values 9.7 14 9.7 9.6
[106]
ref_hepatocyte LEF1
Mean 0.0478
Standard deviation 0.085
Values 0.2 0 0.043 0 0
[107]
HepG2 LEF1
Mean 0.663
Standard deviation 0.44
Values 0.35 0.97
[108]
HepG2.C3A LEF1
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[109]
HuH.7 LEF1
Mean 1.13
Standard deviation 0.42
Values 0.77 1.6 1
[110]
SNU475 LEF1
Mean 0.186
Standard deviation 0.2
Values 0.33 0.042
[111]
THLE LEF1
Mean 0.0639
Standard deviation 0.015
Values 0.053 0.074
[112]
liver LEF1
Mean 0.144
Standard deviation 0.047
Values 0.13 0.13 0.21 0.1
[113]
ref_hepatocyte MIR4683
Missing
[114]
HepG2 MIR4683
Missing
[115]
HepG2.C3A MIR4683
Missing
[116]
HuH.7 MIR4683
Missing
[117]
SNU475 MIR4683
Missing
[118]
THLE MIR4683
Missing
[119]
liver MIR4683
Missing
[120]
ref_hepatocyte WNT1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 WNT1
Mean 0.043
Standard deviation 0.036
Values 0.017 0.069
[122]
HepG2.C3A WNT1
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 WNT1
Mean 0.37
Standard deviation 0.12
Values 0.47 0.23 0.41
[124]
SNU475 WNT1
Mean 0.00464
Standard deviation 0.0066
Values 0 0.0093
[125]
THLE WNT1
Mean 0
Standard deviation 0
Values 0 0
[126]
liver WNT1
Mean 0.0351
Standard deviation 0.032
Values 0.04 0 0.024 0.077