WP_RAS_AND_BRADYKININ_PATHWAYS_IN_COVID19 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SERPING1 | Plasma protease C1 inhibitor | [1] | -5.18[2] | -14.18[3] | -4.74[4] | -6.94[5] | -4.20[6] | -0.72[7] |
2 | AGT | Angiotensinogen | [8] | 0.13[9] | 0.99[10] | 0.52[11] | -2.78[12] | -10.46[13] | 1.37[14] |
3 | KNG1 | Kininogen-1 | [15] | -5.65[16] | -6.28[17] | 0.48[18] | -9.05[19] | -10.84[20] | -0.57[21] |
4 | CYP3A4 | Cytochrome P450 3A4 | [22] | -9.78[23] | -10.01[24] | -10.60[25] | -12.68[26] | -13.75[27] | 0.25[28] |
5 | RHOA | Transforming protein RhoA | [29] | 1.02[30] | 0.42[31] | 1.77[32] | 2.61[33] | 0.45[34] | -1.80[35] |
6 | F12 | Coagulation factor XII | [36] | -5.28[37] | -2.87[38] | -1.51[39] | -9.81[40] | -7.76[41] | -0.89[42] |
7 | SERPINE1 | Plasminogen activator inhibitor 1 | [43] | 3.09[44] | 3.21[45] | -2.40[46] | 0.03[47] | 4.09[48] | -4.36[49] |
8 | KLKB1 | Plasma kallikrein | [50] | -6.70[51] | -3.90[52] | -3.79[53] | -8.35[54] | -9.59[55] | -0.16[56] |
9 | CPN1 | Carboxypeptidase N catalytic chain | [57] | -2.93[58] | 0.33[59] | 1.14[60] | -8.73[61] | -10.00[62] | -0.25[63] |
10 | MAPK1 | Mitogen-activated protein kinase 1 | [64] | 3.67[65] | 3.71[66] | 4.66[67] | 5.68[68] | 2.72[69] | 1.30[70] |
11 | ROCK1 | Rho-associated protein kinase 1 | [71] | 1.01[72] | 2.43[73] | 4.33[74] | 5.20[75] | 1.93[76] | 1.10[77] |
12 | AGTR1 | Type-1 angiotensin II receptor | [78] | -5.39[79] | -3.66[80] | 2.97[81] | 2.56[82] | -4.45[83] | 0.95[84] |
13 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [85] | 2.63[86] | 2.21[87] | 3.12[88] | 3.59[89] | 1.88[90] | -0.03[91] |
14 | IL1B | Interleukin-1 beta | [92] | -6.74[93] | -6.70[94] | -1.26[95] | 0.24[96] | 3.22[97] | -5.68[98] |
15 | ACE | Angiotensin-converting enzyme | [99] | -2.80[100] | -5.39[101] | -1.76[102] | 1.83[103] | -1.63[104] | 1.70[105] |
16 | ACE2 | Angiotensin-converting enzyme 2 | [106] | 1.65[107] | 2.89[108] | 3.04[109] | -3.18[110] | -5.20[111] | -0.56[112] |
17 | CYP24A1 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | [113] | 10.10[114] | 5.14[115] | 0.61[116] | 7.94[117] | -1.48[118] | -7.58[119] |
18 | VDR | Vitamin D3 receptor | [120] | 1.80[121] | 2.12[122] | 3.88[123] | 6.17[124] | 4.89[125] | 0.00[126] |
19 | REN | Renin | [127] | -0.98[128] | [129] | [130] | 1.97[131] | [132] | -2.33[133] |
20 | NOS3 | Nitric oxide synthase, endothelial | [134] | 6.73[135] | 3.73[136] | 4.32[137] | 3.89[138] | 2.61[139] | 2.29[140] |
21 | NPR1 | Atrial natriuretic peptide receptor 1 | [141] | -0.80[142] | -1.84[143] | 2.28[144] | 2.61[145] | 5.53[146] | 4.81[147] |
22 | TNF | Tumor necrosis factor | [148] | 3.06[149] | 0.83[150] | -2.65[151] | 1.61[152] | -4.22[153] | -2.37[154] |
23 | NOS1 | Nitric oxide synthase, brain | [155] | 0.41[156] | 2.27[157] | 1.82[158] | 3.16[159] | 0.45[160] | 0.21[161] |
24 | IL1A | Interleukin-1 alpha | [162] | 1.54[163] | 1.03[164] | 0.98[165] | 3.19[166] | 7.33[167] | -2.06[168] |
25 | PRKG1 | cGMP-dependent protein kinase 1 | [169] | 1.80[170] | [171] | 4.20[172] | 7.01[173] | 6.31[174] | 6.03[175] |
26 | BDKRB2 | B2 bradykinin receptor | [176] | 4.36[177] | -0.89[178] | 1.21[179] | 12.48[180] | 7.88[181] | 2.65[182] |
27 | AGTR2 | Type-2 angiotensin II receptor | [183] | [184] | [185] | [186] | [187] | [188] | [189] |
28 | BDKRB1 | B1 bradykinin receptor | [190] | [191] | [192] | [193] | [194] | [195] | [196] |
29 | KLK1 | Kallikrein-1 | [197] | [198] | [199] | [200] | [201] | [202] | [203] |