WP_RANKLRANK_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SQSTM1 | Sequestosome-1 | [1] | -1.25[2] | -2.15[3] | -1.60[4] | -0.96[5] | -0.89[6] | -1.18[7] |
2 | CDC42 | Cell division control protein 42 homolog | [8] | -0.32[9] | 0.55[10] | -0.46[11] | -0.33[12] | -0.89[13] | -1.47[14] |
3 | NFKBIA | NF-kappa-B inhibitor alpha | [15] | -0.55[16] | -2.19[17] | -2.57[18] | -3.31[19] | -1.27[20] | -0.53[21] |
4 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [22] | 0.11[23] | -0.06[24] | 0.64[25] | 0.22[26] | 0.37[27] | -0.35[28] |
5 | JUN | Transcription factor AP-1 | [29] | 0.01[30] | -1.37[31] | -1.11[32] | -1.50[33] | -0.77[34] | -1.20[35] |
6 | FOS | Proto-oncogene c-Fos | [36] | -5.51[37] | -4.09[38] | -4.76[39] | -5.96[40] | -4.73[41] | -0.69[42] |
7 | AKT1 | RAC-alpha serine/threonine-protein kinase | [43] | 0.58[44] | 0.51[45] | -0.58[46] | 0.16[47] | 0.34[48] | 0.37[49] |
8 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [50] | -0.43[51] | -0.60[52] | -0.02[53] | -0.34[54] | 0.33[55] | -0.58[56] |
9 | IKBKG | NF-kappa-B essential modulator | [57] | -0.39[58] | -0.08[59] | -2.33[60] | -0.64[61] | -1.69[62] | 0.01[63] |
10 | PAPSS2 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | [64] | -5.14[65] | -6.91[66] | 0.33[67] | 0.07[68] | 0.66[69] | 2.12[70] |
11 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [71] | 0.43[72] | -0.33[73] | 0.77[74] | 2.74[75] | 0.63[76] | 1.56[77] |
12 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | [78] | -0.27[79] | 0.19[80] | 0.64[81] | -1.17[82] | -0.16[83] | -2.41[84] |
13 | RELA | Transcription factor p65 | [85] | 0.64[86] | 0.29[87] | 0.42[88] | 0.15[89] | 0.22[90] | -0.27[91] |
14 | ICAM1 | Intercellular adhesion molecule 1 | [92] | 2.40[93] | 1.93[94] | 2.34[95] | 0.40[96] | 2.73[97] | 0.20[98] |
15 | MAPK1 | Mitogen-activated protein kinase 1 | [99] | 2.21[100] | 2.51[101] | 2.33[102] | 2.06[103] | 1.87[104] | 2.39[105] |
16 | AKT2 | RAC-beta serine/threonine-protein kinase | [106] | 1.46[107] | 1.90[108] | 2.02[109] | 1.06[110] | 1.02[111] | 1.74[112] |
17 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [113] | 0.87[114] | 1.19[115] | 1.45[116] | 1.91[117] | 1.53[118] | 0.85[119] |
18 | PTK2 | Focal adhesion kinase 1 | [120] | 1.24[121] | 1.88[122] | 2.26[123] | 2.15[124] | 1.52[125] | 1.37[126] |
19 | MAPK14 | Mitogen-activated protein kinase 14 | [127] | 1.98[128] | 2.20[129] | 1.78[130] | 1.89[131] | 1.52[132] | 1.89[133] |
20 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [134] | 0.40[135] | 1.63[136] | 1.50[137] | 0.70[138] | 1.04[139] | 0.86[140] |
21 | FHL2 | Four and a half LIM domains protein 2 | [141] | 1.03[142] | 0.45[143] | -6.30[144] | 0.91[145] | 1.09[146] | -1.42[147] |
22 | TRAF1 | TNF receptor-associated factor 1 | [148] | -3.92[149] | -3.89[150] | -3.05[151] | -3.33[152] | -2.61[153] | -2.28[154] |
23 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [155] | 0.03[156] | 0.31[157] | 1.39[158] | 2.27[159] | 1.94[160] | 3.61[161] |
24 | MAPK8 | Mitogen-activated protein kinase 8 | [162] | -0.94[163] | 0.63[164] | -0.51[165] | -0.70[166] | -0.68[167] | 0.10[168] |
25 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [169] | 1.17[170] | 1.01[171] | 0.79[172] | -0.04[173] | 1.03[174] | 1.06[175] |
26 | LYN | Tyrosine-protein kinase Lyn | [176] | -0.36[177] | -0.38[178] | 0.15[179] | 1.26[180] | 0.18[181] | 0.63[182] |
27 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [183] | 2.38[184] | 2.76[185] | 3.36[186] | 0.91[187] | 1.63[188] | 0.32[189] |
28 | TRAF2 | TNF receptor-associated factor 2 | [190] | 0.73[191] | 0.95[192] | 0.68[193] | 0.33[194] | 0.50[195] | -0.19[196] |
29 | MAPK9 | Mitogen-activated protein kinase 9 | [197] | 1.73[198] | 2.11[199] | 2.17[200] | 1.92[201] | 1.54[202] | 1.12[203] |
30 | MAPK3 | Mitogen-activated protein kinase 3 | [204] | 2.35[205] | 2.56[206] | 2.59[207] | 0.63[208] | 0.81[209] | -0.43[210] |
31 | RELB | Transcription factor RelB | [211] | 0.22[212] | -0.05[213] | 0.20[214] | -0.81[215] | 0.58[216] | -1.90[217] |
32 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [218] | 1.41[219] | 2.78[220] | 2.74[221] | 0.86[222] | 1.83[223] | 2.13[224] |
33 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [225] | 1.46[226] | 1.77[227] | 2.34[228] | 0.49[229] | 1.20[230] | -0.15[231] |
34 | SRC | Proto-oncogene tyrosine-protein kinase Src | [232] | 3.53[233] | 3.67[234] | 2.66[235] | 2.61[236] | 1.94[237] | -0.24[238] |
35 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [239] | 1.15[240] | 1.95[241] | 2.03[242] | 0.22[243] | 0.72[244] | 0.83[245] |
36 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.99[246] | 3.77[247] | 3.10[248] | 3.03[249] | 2.68[250] | 0.95[251] | |
37 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [252] | 1.02[253] | 1.24[254] | 1.34[255] | 0.47[256] | 0.72[257] | 1.79[258] |
38 | MTOR | Serine/threonine-protein kinase mTOR | [259] | 3.04[260] | 4.21[261] | 3.77[262] | 2.89[263] | 3.13[264] | 4.06[265] |
39 | ACP5 | Tartrate-resistant acid phosphatase type 5 | [266] | -0.44[267] | 0.81[268] | -1.05[269] | -3.66[270] | -7.30[271] | 1.26[272] |
40 | MITF | Microphthalmia-associated transcription factor | [273] | -3.83[274] | -4.59[275] | -6.47[276] | 1.48[277] | -0.10[278] | -0.15[279] |
41 | TNFSF11 | Tumor necrosis factor ligand superfamily member 11 | [280] | [281] | [282] | [283] | -10.33[284] | -4.68[285] | -3.15[286] |
42 | SPI1 | Transcription factor PU.1 | [287] | -8.65[288] | [289] | -9.60[290] | -9.44[291] | -10.10[292] | 0.04[293] |
43 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [294] | 0.79[295] | -2.26[296] | 2.59[297] | 1.22[298] | -2.66[299] | -1.01[300] |
44 | GAB2 | GRB2-associated-binding protein 2 | [301] | 2.07[302] | 2.01[303] | 2.25[304] | 1.13[305] | 1.38[306] | 1.16[307] |
45 | TRAF3 | TNF receptor-associated factor 3 | [308] | 3.39[309] | 2.97[310] | 2.57[311] | 3.04[312] | 3.61[313] | 2.54[314] |
46 | VCAM1 | Vascular cell adhesion protein 1 | [315] | -6.52[316] | [317] | -3.13[318] | 0.73[319] | 4.28[320] | 4.14[321] |
47 | TRAF6 | TNF receptor-associated factor 6 | [322] | 1.59[323] | 1.64[324] | 2.20[325] | 1.87[326] | 1.48[327] | 3.52[328] |
48 | TNFRSF11 | Tumor necrosis factor receptor superfamily member 11A | [329] | 2.55[330] | 1.48[331] | -0.37[332] | -0.42[333] | 1.07[334] | -0.63[335] |
49 | CBL | E3 ubiquitin-protein ligase CBL | [336] | 4.95[337] | 4.05[338] | 4.27[339] | 5.34[340] | 4.99[341] | 4.37[342] |
50 | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 | [343] | -1.45[344] | -3.81[345] | 2.79[346] | -5.77[347] | 2.80[348] | 1.34[349] |
51 | TNFRSF11 | Tumor necrosis factor receptor superfamily member 11B | [350] | -2.91[351] | -3.30[352] | 3.02[353] | 2.25[354] | 2.79[355] | 3.39[356] |
52 | TRAF5 | TNF receptor-associated factor 5 | [357] | 1.20[358] | 1.56[359] | 1.94[360] | 5.71[361] | 3.64[362] | 2.49[363] |
53 | SYK | Tyrosine-protein kinase SYK | [364] | -7.66[365] | -1.63[366] | -4.65[367] | 0.31[368] | -3.05[369] | 3.97[370] |
54 | CTSK | Cathepsin K | [371] | 1.48[372] | 3.63[373] | 3.17[374] | 3.29[375] | 3.31[376] | 3.73[377] |
55 | CALCR | Calcitonin receptor | [378] | [379] | [380] | [381] | [382] | [383] | [384] |