WP_RAC1PAK1P38MMP2_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | FN1 | Fibronectin | [1] | 2.10[2] | 1.91[3] | 1.79[4] | 1.78[5] | 1.85[6] | 1.57[7] |
2 | ITGB1 | Integrin beta-1 | [8] | -1.16[9] | -0.80[10] | -0.68[11] | 0.32[12] | 0.27[13] | -0.56[14] |
3 | TNIP1 | TNFAIP3-interacting protein 1 | [15] | -3.02[16] | -3.14[17] | -3.27[18] | -3.43[19] | -1.89[20] | -2.93[21] |
4 | NFKBIA | NF-kappa-B inhibitor alpha | [22] | -2.44[23] | -3.90[24] | -4.30[25] | -4.66[26] | -2.91[27] | -1.86[28] |
5 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [29] | -1.78[30] | -1.78[31] | -1.08[32] | -1.12[33] | -1.27[34] | -1.69[35] |
6 | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 | [36] | -2.38[37] | -2.37[38] | -1.77[39] | -4.44[40] | -3.02[41] | -2.32[42] |
7 | AKT1 | RAC-alpha serine/threonine-protein kinase | [43] | -1.31[44] | -1.21[45] | -2.30[46] | -1.19[47] | -1.30[48] | -0.97[49] |
8 | CTNNB1 | Catenin beta-1 | [50] | 0.23[51] | 0.06[52] | 0.93[53] | -0.38[54] | -0.29[55] | 0.38[56] |
9 | STAT3 | Signal transducer and activator of transcription 3 | [57] | -0.84[58] | -2.01[59] | -1.28[60] | -0.90[61] | -1.76[62] | 1.68[63] |
10 | MYC | Myc proto-oncogene protein | [64] | -0.96[65] | -0.97[66] | -3.01[67] | -3.93[68] | -1.69[69] | -2.72[70] |
11 | BAX | Apoptosis regulator BAX | [71] | -1.06[72] | -1.52[73] | -2.00[74] | -2.74[75] | -2.49[76] | -4.68[77] |
12 | STMN1 | Stathmin | [78] | -0.40[79] | 0.74[80] | 0.95[81] | -0.25[82] | 0.17[83] | -3.27[84] |
13 | IKBKG | NF-kappa-B essential modulator | [85] | -2.28[86] | -1.80[87] | -4.06[88] | -1.99[89] | -3.34[90] | -1.33[91] |
14 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [92] | -0.94[93] | -0.18[94] | -0.24[95] | -0.25[96] | 0.25[97] | 0.54[98] |
15 | GRB2 | Growth factor receptor-bound protein 2 | [99] | -0.19[100] | -0.02[101] | 0.08[102] | -0.58[103] | -0.80[104] | -0.42[105] |
16 | CRK | Adapter molecule crk | [106] | -1.59[107] | -1.33[108] | -1.28[109] | -1.38[110] | -1.11[111] | 0.12[112] |
17 | BAD | Bcl2-associated agonist of cell death | [113] | -3.06[114] | -2.60[115] | -3.56[116] | -2.20[117] | -1.94[118] | -2.14[119] |
18 | RELA | Transcription factor p65 | [120] | -1.26[121] | -1.43[122] | -1.31[123] | -1.19[124] | -1.42[125] | -1.60[126] |
19 | TNIP2 | TNFAIP3-interacting protein 2 | [127] | -2.07[128] | -1.68[129] | -1.98[130] | -1.80[131] | -2.57[132] | -2.18[133] |
20 | NRAS | GTPase NRas | [134] | -0.76[135] | 0.00[136] | 0.40[137] | -0.14[138] | -0.70[139] | -0.97[140] |
21 | HRAS | GTPase HRas | [141] | -2.40[142] | -2.77[143] | -3.58[144] | -2.09[145] | -2.44[146] | -3.38[147] |
22 | YAP1 | Transcriptional coactivator YAP1 | [148] | 0.58[149] | 0.37[150] | -0.02[151] | 1.15[152] | 0.42[153] | -0.37[154] |
23 | NCK1 | Cytoplasmic protein NCK1 | [155] | -2.98[156] | -2.55[157] | -2.45[158] | -1.70[159] | -1.73[160] | -1.19[161] |
24 | MAPK1 | Mitogen-activated protein kinase 1 | [162] | 0.32[163] | 0.79[164] | 0.60[165] | 0.71[166] | 0.22[167] | 1.05[168] |
25 | CASP7 | Caspase-7 | [169] | -1.70[170] | -1.73[171] | -1.30[172] | -2.03[173] | -1.97[174] | -1.21[175] |
26 | PXN | Paxillin | [176] | -0.39[177] | -0.34[178] | -0.32[179] | 0.98[180] | 0.80[181] | -1.07[182] |
27 | KRAS | GTPase KRas | [183] | -1.90[184] | -1.59[185] | -0.01[186] | -0.34[187] | -0.81[188] | -0.05[189] |
28 | PTK2 | Focal adhesion kinase 1 | [190] | -0.65[191] | 0.17[192] | 0.53[193] | 0.81[194] | -0.13[195] | 0.04[196] |
29 | MAPK14 | Mitogen-activated protein kinase 14 | [197] | 0.09[198] | 0.49[199] | 0.05[200] | 0.55[201] | -0.12[202] | 0.56[203] |
30 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [204] | -1.86[205] | -1.41[206] | -0.33[207] | 0.93[208] | 0.30[209] | 2.28[210] |
31 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [211] | 0.19[212] | 0.97[213] | 0.91[214] | -0.46[215] | 0.24[216] | -3.04[217] |
32 | MAPK8 | Mitogen-activated protein kinase 8 | [218] | -2.83[219] | -1.09[220] | -2.23[221] | -2.04[222] | -2.32[223] | -1.23[224] |
33 | GRB14 | Growth factor receptor-bound protein 14 | [225] | -5.20[226] | -2.47[227] | 0.98[228] | -4.62[229] | -5.96[230] | 0.80[231] |
34 | SOS1 | Son of sevenless homolog 1 | [232] | -1.49[233] | 0.37[234] | -0.13[235] | -0.29[236] | -1.20[237] | -0.18[238] |
35 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [239] | 0.98[240] | 0.14[241] | 1.29[242] | 0.12[243] | -0.41[244] | -0.57[245] |
36 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [246] | -0.72[247] | -0.71[248] | -0.93[249] | -1.38[250] | -0.61[251] | -0.27[252] |
37 | EGFR | Epidermal growth factor receptor | [253] | -2.09[254] | -2.13[255] | 0.74[256] | -0.70[257] | -0.22[258] | 1.93[259] |
38 | MAPK13 | Mitogen-activated protein kinase 13 | [260] | 0.95[261] | 1.69[262] | -1.01[263] | -3.02[264] | -1.64[265] | -2.44[266] |
39 | TP53 | Cellular tumor antigen p53 | [267] | 0.25[268] | 0.14[269] | 0.89[270] | 0.15[271] | -0.32[272] | -0.76[273] |
40 | RAD51 | DNA repair protein RAD51 homolog 1 | [274] | -1.64[275] | -1.49[276] | -1.41[277] | -1.32[278] | -1.49[279] | -4.67[280] |
41 | MAPK9 | Mitogen-activated protein kinase 9 | [281] | -0.16[282] | 0.40[283] | 0.44[284] | 0.58[285] | -0.10[286] | -0.21[287] |
42 | MAPK3 | Mitogen-activated protein kinase 3 | [288] | 0.46[289] | 0.84[290] | 0.86[291] | -0.71[292] | -0.83[293] | -1.76[294] |
43 | STAT5B | Signal transducer and activator of transcription 5B | [295] | -0.03[296] | -0.07[297] | 0.61[298] | 0.41[299] | -0.58[300] | 0.90[301] |
44 | MSH2 | DNA mismatch repair protein Msh2 | [302] | -0.57[303] | 1.05[304] | 0.48[305] | 1.00[306] | 0.22[307] | -1.41[308] |
45 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [309] | -0.49[310] | 1.07[311] | 1.01[312] | -0.49[313] | 0.19[314] | 0.79[315] |
46 | SRC | Proto-oncogene tyrosine-protein kinase Src | [316] | 1.64[317] | 1.95[318] | 0.94[319] | 1.26[320] | 0.30[321] | -1.57[322] |
47 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [323] | -0.87[324] | -0.48[325] | -0.39[326] | -0.88[327] | -0.92[328] | 0.46[329] |
48 | RASA1 | Ras GTPase-activating protein 1 | [330] | -1.01[331] | 0.24[332] | 0.32[333] | 0.78[334] | -0.30[335] | 0.49[336] |
49 | CASP9 | Caspase-9 | [337] | -1.23[338] | 0.06[339] | -0.84[340] | -0.89[341] | -1.71[342] | -1.26[343] |
50 | STAT5A | Signal transducer and activator of transcription 5A | [344] | -3.34[345] | -1.83[346] | -2.78[347] | -1.98[348] | -1.36[349] | -0.49[350] |
51 | PAK1 | Serine/threonine-protein kinase PAK 1 | [351] | -1.40[352] | -1.83[353] | 0.57[354] | -2.99[355] | 0.65[356] | -0.45[357] |
52 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.77[358] | 0.20[359] | 0.37[360] | -0.01[361] | 0.06[362] | 1.19[363] | |
53 | GRB7 | Growth factor receptor-bound protein 7 | [364] | 1.02[365] | 1.67[366] | -1.17[367] | -3.79[368] | -3.19[369] | -1.04[370] |
54 | FOXO1 | Forkhead box protein O1 | [371] | 0.30[372] | 0.30[373] | 0.43[374] | 0.04[375] | 1.92[376] | 2.37[377] |
55 | MAPK12 | Mitogen-activated protein kinase 12 | [378] | 1.43[379] | 1.43[380] | 2.52[381] | 0.35[382] | 1.46[383] | -1.63[384] |
56 | NOS2 | Nitric oxide synthase, inducible | [385] | -1.37[386] | [387] | -7.29[388] | -5.99[389] | -7.02[390] | -8.03[391] |
57 | DOK2 | Docking protein 2 | [392] | -6.24[393] | -6.52[394] | -7.36[395] | -8.61[396] | -9.78[397] | 0.91[398] |
58 | MAPK11 | Mitogen-activated protein kinase 11 | [399] | -1.56[400] | -1.33[401] | -2.24[402] | -0.78[403] | 1.08[404] | -0.56[405] |
59 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | [406] | 2.63[407] | -0.93[408] | -6.80[409] | -2.30[410] | -0.39[411] | 3.19[412] |
60 | TEK | Angiopoietin-1 receptor | [413] | -5.93[414] | -7.12[415] | -6.10[416] | 3.18[417] | 0.65[418] | 4.71[419] |
61 | MMP2 | 72 kDa type IV collagenase | [420] | 2.05[421] | -4.61[422] | -3.34[423] | 6.30[424] | 5.72[425] | 3.21[426] |
62 | ANGPTL1 | Angiopoietin-related protein 1 | [427] | 0.80[428] | 1.76[429] | -3.09[430] | -0.32[431] | 0.98[432] | 4.70[433] |
63 | ANGPT2 | Angiopoietin-2 | [434] | -3.12[435] | -1.54[436] | -0.99[437] | -1.65[438] | -1.76[439] | 4.27[440] |
64 | NOS1 | Nitric oxide synthase, brain | [441] | -2.94[442] | -0.64[443] | -2.23[444] | -1.81[445] | -2.05[446] | -0.03[447] |
65 | TNIP3 | TNFAIP3-interacting protein 3 | [448] | -3.81[449] | -3.24[450] | -3.67[451] | 1.30[452] | 1.81[453] | -0.25[454] |
66 | ANGPT1 | Angiopoietin-1 | [455] | -1.10[456] | [457] | 6.15[458] | 9.28[459] | 4.69[460] | 5.96[461] |
67 | ANGPT4 | Angiopoietin-4 | [462] | [463] | [464] | [465] | [466] | [467] | [468] |
68 | MIR3917 | [469] | [470] | [471] | [472] | [473] | [474] | [475] | |
69 | RS1 | Retinoschisin | [476] | [477] | [478] | [479] | [480] | [481] | [482] |