WP_PYRIMIDINE_METABOLISM_AND_RELATED_DISEASES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CPS1 Carbamoyl-phosphate synthase [ammonia], mitochondrial [1] -2.27[2] -2.27[3] -2.47[4] -10.20[5] -3.65[6] 1.24[7]
2 DPYS Dihydropyrimidinase [8] [9] [10] -14.30[11] -11.42[12] [13] -0.57[14]
3 TYMP Thymidine phosphorylase [15] -2.93[16] -2.47[17] -5.39[18] -7.37[19] -5.00[20] -3.48[21]
4 UPB1 Beta-ureidopropionase [22] -6.77[23] -4.54[24] -2.81[25] -6.86[26] -12.15[27] -1.28[28]
5 OTC Ornithine carbamoyltransferase, mitochondrial [29] -8.49[30] -7.73[31] -2.41[32] -11.35[33] -10.19[34] -2.00[35]
6 DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial [36] -1.42[37] -1.48[38] -0.84[39] -2.04[40] -2.25[41] -0.93[42]
7 TYMS Thymidylate synthase [43] 0.40[44] 0.67[45] 0.55[46] 0.28[47] 0.21[48] -7.24[49]
8 GLS2 Glutaminase liver isoform, mitochondrial [50] -0.82[51] -0.37[52] -4.66[53] -5.51[54] -5.12[55] -0.83[56]
9 NT5C 5'(3')-deoxyribonucleotidase, cytosolic type [57] 0.28[58] 1.13[59] 0.10[60] 0.12[61] -0.01[62] -3.26[63]
10 RRM2 Ribonucleoside-diphosphate reductase subunit M2 [64] 3.25[65] 3.24[66] 2.78[67] 3.69[68] 3.61[69] -2.15[70]
11 RRM1 Ribonucleoside-diphosphate reductase large subunit [71] 3.15[72] 2.54[73] 3.28[74] 3.63[75] 3.62[76] -1.22[77]
12 DPYD Dihydropyrimidine dehydrogenase [NADP(+)] [78] -3.30[79] -2.47[80] 3.21[81] 2.32[82] 1.52[83] 2.08[84]
13 UMPS Uridine 5'-monophosphate synthase [85] 3.21[86] 3.32[87] 2.86[88] 2.11[89] 2.61[90] 0.32[91]
14 RRM2B Ribonucleoside-diphosphate reductase subunit M2 B [92] 2.91[93] 2.93[94] 1.80[95] 2.59[96] 2.26[97] -0.86[98]
15 TK2 Thymidine kinase 2, mitochondrial [99] 1.73[100] 2.03[101] 0.87[102] 1.90[103] 2.66[104] 0.80[105]
16 CAD CAD protein [106] 5.00[107] 4.75[108] 5.25[109] 4.73[110] 4.71[111] 0.93[112]
17 NT5C3A Cytosolic 5'-nucleotidase 3A [113] [114] [115] [116] [117] [118] [119]
[1]
ref_hepatocyte CPS1
Mean 128
Standard deviation 1.9e+02
Values 1.6 4.2e+02 2e+02 7.7 8.2
[2]
HepG2 CPS1
Mean 18.3
Standard deviation 4.2
Values 21 15
[3]
HepG2.C3A CPS1
Mean 18
Standard deviation 4.7
Values 21 15
[4]
HuH.7 CPS1
Mean 14.7
Standard deviation 2.6
Values 12 17 15
[5]
SNU475 CPS1
Mean 0.0667
Standard deviation 0.042
Values 0.096 0.037
[6]
THLE CPS1
Mean 7.64
Standard deviation 0.35
Values 7.4 7.9
[7]
liver CPS1
Mean 1.06e+03
Standard deviation 4.4e+02
Values 1e+03 1.7e+03 7.5e+02 7.9e+02
[8]
ref_hepatocyte DPYS
Mean 68
Standard deviation 1e+02
Values 1.4 2.4e+02 96 0 3.8
[9]
HepG2 DPYS
Mean 0
Standard deviation 0
Values 0 0
[10]
HepG2.C3A DPYS
Mean 0
Standard deviation 0
Values 0 0
[11]
HuH.7 DPYS
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[12]
SNU475 DPYS
Mean 0.0152
Standard deviation 0.022
Values 0.03 0
[13]
THLE DPYS
Mean 0
Standard deviation 0
Values 0 0
[14]
liver DPYS
Mean 161
Standard deviation 36
Values 1.6e+02 2.1e+02 1.6e+02 1.2e+02
[15]
ref_hepatocyte TYMP
Mean 63.3
Standard deviation 55
Values 70 38 56 1.8 1.5e+02
[16]
HepG2 TYMP
Mean 5.73
Standard deviation 3.7
Values 3.1 8.4
[17]
HepG2.C3A TYMP
Mean 7.77
Standard deviation 1.5
Values 6.7 8.9
[18]
HuH.7 TYMP
Mean 0.958
Standard deviation 0.51
Values 1 1.4 0.41
[19]
SNU475 TYMP
Mean 0.235
Standard deviation 0.14
Values 0.14 0.33
[20]
THLE TYMP
Mean 1.49
Standard deviation 0.28
Values 1.3 1.7
[21]
liver TYMP
Mean 19.9
Standard deviation 5.7
Values 28 19 17 15
[22]
ref_hepatocyte UPB1
Mean 34.1
Standard deviation 46
Values 8 1.1e+02 52 0.23 4
[23]
HepG2 UPB1
Mean 0.216
Standard deviation 0.0023
Values 0.21 0.22
[24]
HepG2.C3A UPB1
Mean 1
Standard deviation 0.041
Values 1 0.97
[25]
HuH.7 UPB1
Mean 3.08
Standard deviation 0.98
Values 4 2 3.2
[26]
SNU475 UPB1
Mean 0.181
Standard deviation 0.11
Values 0.1 0.26
[27]
THLE UPB1
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[28]
liver UPB1
Mean 49.6
Standard deviation 25
Values 26 30 75 67
[29]
ref_hepatocyte OTC
Mean 32.4
Standard deviation 50
Values 2.1 1.2e+02 41 1.7 0.78
[30]
HepG2 OTC
Mean 0.0623
Standard deviation 0.015
Values 0.073 0.052
[31]
HepG2.C3A OTC
Mean 0.104
Standard deviation 0.065
Values 0.15 0.058
[32]
HuH.7 OTC
Mean 3.85
Standard deviation 0.39
Values 3.7 3.6 4.3
[33]
SNU475 OTC
Mean 0.0076
Standard deviation 0.011
Values 0.015 0
[34]
THLE OTC
Mean 0.0207
Standard deviation 0.029
Values 0.041 0
[35]
liver OTC
Mean 28.5
Standard deviation 16
Values 19 19 52 24
[36]
ref_hepatocyte DHODH
Mean 27.3
Standard deviation 31
Values 5.7 55 67 3.2 5.2
[37]
HepG2 DHODH
Mean 7.06
Standard deviation 1
Values 6.4 7.8
[38]
HepG2.C3A DHODH
Mean 6.66
Standard deviation 0.088
Values 6.7 6.6
[39]
HuH.7 DHODH
Mean 9.66
Standard deviation 4.2
Values 12 4.8 12
[40]
SNU475 DHODH
Mean 4.06
Standard deviation 0.45
Values 4.4 3.7
[41]
THLE DHODH
Mean 4.31
Standard deviation 0.19
Values 4.2 4.4
[42]
liver DHODH
Mean 50.3
Standard deviation 12
Values 53 38 46 65
[43]
ref_hepatocyte TYMS
Mean 24.8
Standard deviation 32
Values 2.5 0.91 3.3 69 49
[44]
HepG2 TYMS
Mean 22.7
Standard deviation 7.9
Values 28 17
[45]
HepG2.C3A TYMS
Mean 26.9
Standard deviation 18
Values 40 14
[46]
HuH.7 TYMS
Mean 23
Standard deviation 12
Values 32 9.1 28
[47]
SNU475 TYMS
Mean 18.5
Standard deviation 1.2
Values 19 18
[48]
THLE TYMS
Mean 21.5
Standard deviation 4.9
Values 18 25
[49]
liver TYMS
Mean 0.58
Standard deviation 0.68
Values 0 0.4 0.35 1.6
[50]
ref_hepatocyte GLS2
Mean 17.1
Standard deviation 20
Values 2.5 43 36 1.3 3.2
[51]
HepG2 GLS2
Mean 6.74
Standard deviation 0.93
Values 7.4 6.1
[52]
HepG2.C3A GLS2
Mean 9.03
Standard deviation 1.6
Values 10 7.9
[53]
HuH.7 GLS2
Mean 0.429
Standard deviation 0.081
Values 0.37 0.52 0.4
[54]
SNU475 GLS2
Mean 0.231
Standard deviation 0.061
Values 0.19 0.27
[55]
THLE GLS2
Mean 0.37
Standard deviation 0.071
Values 0.42 0.32
[56]
liver GLS2
Mean 33.9
Standard deviation 12
Values 20 35 31 50
[57]
ref_hepatocyte NT5C
Mean 14.1
Standard deviation 2
Values 16 14 12 12 16
[58]
HepG2 NT5C
Mean 11.9
Standard deviation 0.64
Values 11 12
[59]
HepG2.C3A NT5C
Mean 21
Standard deviation 3.6
Values 19 24
[60]
HuH.7 NT5C
Mean 9.58
Standard deviation 3.9
Values 14 6.7 8.1
[61]
SNU475 NT5C
Mean 9.37
Standard deviation 2.2
Values 7.8 11
[62]
THLE NT5C
Mean 10.5
Standard deviation 0.81
Values 9.9 11
[63]
liver NT5C
Mean 5.18
Standard deviation 4
Values 1.5 1.9 8.2 9.2
[64]
ref_hepatocyte RRM2
Mean 11.3
Standard deviation 12
Values 0.89 2.6 4.7 21 27
[65]
HepG2 RRM2
Mean 74.3
Standard deviation 40
Values 1e+02 46
[66]
HepG2.C3A RRM2
Mean 72.7
Standard deviation 62
Values 1.2e+02 29
[67]
HuH.7 RRM2
Mean 49
Standard deviation 32
Values 68 12 67
[68]
SNU475 RRM2
Mean 89.3
Standard deviation 5.3
Values 93 86
[69]
THLE RRM2
Mean 103
Standard deviation 25
Values 85 1.2e+02
[70]
liver RRM2
Mean 8.94
Standard deviation 9.7
Values 0.81 9.4 3.1 22
[71]
ref_hepatocyte RRM1
Mean 8.31
Standard deviation 6.1
Values 3.3 4.7 5 11 18
[72]
HepG2 RRM1
Mean 51
Standard deviation 21
Values 66 37
[73]
HepG2.C3A RRM1
Mean 32.9
Standard deviation 21
Values 47 18
[74]
HuH.7 RRM1
Mean 51
Standard deviation 15
Values 61 34 59
[75]
SNU475 RRM1
Mean 63.2
Standard deviation 3.6
Values 66 61
[76]
THLE RRM1
Mean 76.5
Standard deviation 23
Values 60 93
[77]
liver RRM1
Mean 12.6
Standard deviation 3.4
Values 10 15 9.3 16
[78]
ref_hepatocyte DPYD
Mean 5.41
Standard deviation 7.8
Values 0.79 19 5.5 0.66 1.2
[79]
HepG2 DPYD
Mean 0.381
Standard deviation 0.23
Values 0.54 0.22
[80]
HepG2.C3A DPYD
Mean 0.663
Standard deviation 0.13
Values 0.57 0.76
[81]
HuH.7 DPYD
Mean 31.7
Standard deviation 5.8
Values 28 38 29
[82]
SNU475 DPYD
Mean 16.6
Standard deviation 0.43
Values 16 17
[83]
THLE DPYD
Mean 11.6
Standard deviation 1
Values 11 12
[84]
liver DPYD
Mean 80.3
Standard deviation 30
Values 1.1e+02 93 69 45
[85]
ref_hepatocyte UMPS
Mean 5.13
Standard deviation 2
Values 4.2 3.3 3.6 7.5 7.1
[86]
HepG2 UMPS
Mean 32.8
Standard deviation 4.8
Values 36 29
[87]
HepG2.C3A UMPS
Mean 35
Standard deviation 4.5
Values 38 32
[88]
HuH.7 UMPS
Mean 23.6
Standard deviation 3.4
Values 25 20 26
[89]
SNU475 UMPS
Mean 13.6
Standard deviation 0.94
Values 14 13
[90]
THLE UMPS
Mean 23.4
Standard deviation 4.7
Values 20 27
[91]
liver UMPS
Mean 22.6
Standard deviation 3.3
Values 20 22 20 27
[92]
ref_hepatocyte RRM2B
Mean 5.12
Standard deviation 4.1
Values 2.8 2.6 1.6 7.3 11
[93]
HepG2 RRM2B
Mean 26.7
Standard deviation 1.8
Values 28 25
[94]
HepG2.C3A RRM2B
Mean 26.7
Standard deviation 5.2
Values 30 23
[95]
HuH.7 RRM2B
Mean 11.3
Standard deviation 1.7
Values 9.5 13 12
[96]
SNU475 RRM2B
Mean 18.9
Standard deviation 5.1
Values 15 23
[97]
THLE RRM2B
Mean 18.4
Standard deviation 0.84
Values 19 18
[98]
liver RRM2B
Mean 9.96
Standard deviation 2.3
Values 8.6 12 7.4 12
[99]
ref_hepatocyte TK2
Mean 4.07
Standard deviation 2.8
Values 2.1 7.7 6.5 1.9 2.1
[100]
HepG2 TK2
Mean 9.37
Standard deviation 2.7
Values 11 7.4
[101]
HepG2.C3A TK2
Mean 11.3
Standard deviation 0.3
Values 11 11
[102]
HuH.7 TK2
Mean 4.72
Standard deviation 0.87
Values 5.2 5.2 3.7
[103]
SNU475 TK2
Mean 9.29
Standard deviation 3.2
Values 7 12
[104]
THLE TK2
Mean 19.2
Standard deviation 0.11
Values 19 19
[105]
liver TK2
Mean 25
Standard deviation 6.3
Values 18 22 32 28
[106]
ref_hepatocyte CAD
Mean 2.02
Standard deviation 0.66
Values 2.1 1.4 2.5 1.3 2.8
[107]
HepG2 CAD
Mean 44.5
Standard deviation 9.8
Values 38 51
[108]
HepG2.C3A CAD
Mean 37.1
Standard deviation 4.2
Values 34 40
[109]
HuH.7 CAD
Mean 48.6
Standard deviation 25
Values 51 22 72
[110]
SNU475 CAD
Mean 32.8
Standard deviation 3.1
Values 35 31
[111]
THLE CAD
Mean 39.6
Standard deviation 2.9
Values 38 42
[112]
liver CAD
Mean 13.5
Standard deviation 4.8
Values 18 17 8.5 10
[113]
ref_hepatocyte NT5C3A
Missing
[114]
HepG2 NT5C3A
Missing
[115]
HepG2.C3A NT5C3A
Missing
[116]
HuH.7 NT5C3A
Missing
[117]
SNU475 NT5C3A
Missing
[118]
THLE NT5C3A
Missing
[119]
liver NT5C3A
Missing