WP_PYRIMIDINE_METABOLISM |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
NME2 |
Nucleoside diphosphate kinase B |
[1] |
-3.38[2] |
-3.58[3] |
-3.14[4] |
-3.88[5] |
-4.03[6] |
-6.13[7] |
2 |
DPYS |
Dihydropyrimidinase |
[8] |
[9] |
[10] |
-15.29[11] |
-12.11[12] |
[13] |
1.36[14] |
3 |
POLR2L |
DNA-directed RNA polymerases I, II, and III subunit RPABC5 |
[15] |
-1.81[16] |
-1.95[17] |
-2.14[18] |
-1.30[19] |
-1.47[20] |
-0.72[21] |
4 |
TYMP |
Thymidine phosphorylase |
[22] |
-3.94[23] |
-3.47[24] |
-6.38[25] |
-8.05[26] |
-5.67[27] |
-1.56[28] |
5 |
CMPK1 |
UMP-CMP kinase |
[29] |
-0.58[30] |
-0.15[31] |
0.46[32] |
-0.23[33] |
-0.16[34] |
0.81[35] |
6 |
NME1 |
Nucleoside diphosphate kinase A |
[36] |
-0.46[37] |
-1.03[38] |
-1.42[39] |
-1.65[40] |
-1.78[41] |
-2.00[42] |
7 |
NME4 |
Nucleoside diphosphate kinase, mitochondrial |
[43] |
0.05[44] |
-0.12[45] |
0.81[46] |
-0.86[47] |
-1.20[48] |
-0.97[49] |
8 |
NME1-NME2 |
[50] |
-7.91[51] |
-7.49[52] |
-7.29[53] |
-8.58[54] |
-8.02[55] |
-7.78[56] |
9 |
POLR2J |
DNA-directed RNA polymerase II subunit RPB11-a |
[57] |
-2.50[58] |
-2.35[59] |
-2.02[60] |
-2.53[61] |
-2.31[62] |
-2.47[63] |
10 |
POLR1D |
DNA-directed RNA polymerases I and III subunit RPAC2 |
[64] |
0.20[65] |
0.74[66] |
0.48[67] |
-0.89[68] |
-1.10[69] |
-1.97[70] |
11 |
UPB1 |
Beta-ureidopropionase |
[71] |
-7.78[72] |
-5.53[73] |
-3.81[74] |
-7.54[75] |
-12.82[76] |
0.65[77] |
12 |
POLD2 |
DNA polymerase delta subunit 2 |
[78] |
0.07[79] |
0.11[80] |
0.66[81] |
0.03[82] |
0.29[83] |
0.49[84] |
13 |
POLD4 |
DNA polymerase delta subunit 4 |
[85] |
-1.46[86] |
-1.94[87] |
0.18[88] |
2.34[89] |
-1.36[90] |
0.14[91] |
14 |
DTYMK |
Thymidylate kinase |
[92] |
-0.32[93] |
0.36[94] |
-0.53[95] |
-0.71[96] |
-0.47[97] |
-2.31[98] |
15 |
POLE3 |
DNA polymerase epsilon subunit 3 |
[99] |
-0.12[100] |
-0.39[101] |
-0.06[102] |
-0.16[103] |
0.77[104] |
-0.96[105] |
16 |
POLR2E |
DNA-directed RNA polymerases I, II, and III subunit RPABC1 |
[106] |
1.27[107] |
1.10[108] |
1.23[109] |
0.33[110] |
1.08[111] |
1.09[112] |
17 |
CDA |
Cytidine deaminase |
[113] |
-1.46[114] |
-3.22[115] |
-6.02[116] |
-4.06[117] |
-5.54[118] |
-1.62[119] |
18 |
POLR2H |
DNA-directed RNA polymerases I, II, and III subunit RPABC3 |
[120] |
-0.91[121] |
-0.41[122] |
-0.40[123] |
-1.78[124] |
-1.20[125] |
-1.34[126] |
19 |
DHODH |
Dihydroorotate dehydrogenase (quinone), mitochondrial |
[127] |
-2.43[128] |
-2.47[129] |
-1.84[130] |
-2.73[131] |
-2.92[132] |
0.99[133] |
20 |
POLE4 |
DNA polymerase epsilon subunit 4 |
[134] |
-0.38[135] |
0.23[136] |
-3.19[137] |
-0.73[138] |
-1.31[139] |
-1.19[140] |
21 |
TYMS |
Thymidylate synthase |
[141] |
-0.61[142] |
-0.32[143] |
-0.45[144] |
-0.41[145] |
-0.46[146] |
-5.31[147] |
22 |
POLR2K |
DNA-directed RNA polymerases I, II, and III subunit RPABC4 |
[148] |
-0.92[149] |
-0.20[150] |
-0.26[151] |
-0.06[152] |
-0.26[153] |
-0.66[154] |
23 |
POLR2G |
DNA-directed RNA polymerase II subunit RPB7 |
[155] |
-0.50[156] |
-0.35[157] |
-0.81[158] |
-0.26[159] |
-0.49[160] |
-1.21[161] |
24 |
DCTD |
Deoxycytidylate deaminase |
[162] |
0.56[163] |
0.69[164] |
-1.44[165] |
0.00[166] |
0.55[167] |
0.49[168] |
25 |
POLR3GL |
DNA-directed RNA polymerase III subunit RPC7-like |
[169] |
-2.04[170] |
-1.34[171] |
-1.48[172] |
-0.96[173] |
-1.19[174] |
-1.22[175] |
26 |
POLR2C |
DNA-directed RNA polymerase II subunit RPB3 |
[176] |
1.49[177] |
1.47[178] |
1.00[179] |
0.66[180] |
0.78[181] |
0.16[182] |
27 |
DUT |
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
[183] |
0.29[184] |
0.57[185] |
0.08[186] |
0.46[187] |
1.11[188] |
-0.45[189] |
28 |
POLR2I |
DNA-directed RNA polymerase II subunit RPB9 |
[190] |
-0.92[191] |
-0.92[192] |
-0.96[193] |
-1.38[194] |
-1.40[195] |
-0.42[196] |
29 |
POLR3K |
DNA-directed RNA polymerase III subunit RPC10 |
[197] |
-0.64[198] |
-0.93[199] |
-1.05[200] |
-1.81[201] |
-1.20[202] |
-2.29[203] |
30 |
NT5C |
5'(3')-deoxyribonucleotidase, cytosolic type |
[204] |
-0.72[205] |
0.14[206] |
-0.90[207] |
-0.57[208] |
-0.68[209] |
-1.34[210] |
31 |
UPP1 |
Uridine phosphorylase 1 |
[211] |
-1.83[212] |
-2.03[213] |
-1.70[214] |
-0.87[215] |
-0.09[216] |
-1.57[217] |
32 |
DCTPP1 |
dCTP pyrophosphatase 1 |
[218] |
1.68[219] |
1.50[220] |
0.87[221] |
-0.67[222] |
-0.04[223] |
-1.20[224] |
33 |
RRM2 |
Ribonucleoside-diphosphate reductase subunit M2 |
[225] |
2.25[226] |
2.25[227] |
1.78[228] |
3.01[229] |
2.94[230] |
-0.23[231] |
34 |
POLR2B |
DNA-directed RNA polymerase II subunit RPB2 |
[232] |
1.89[233] |
2.14[234] |
2.11[235] |
2.00[236] |
2.59[237] |
1.57[238] |
35 |
POLR1C |
DNA-directed RNA polymerases I and III subunit RPAC1 |
[239] |
0.57[240] |
0.41[241] |
-0.68[242] |
-0.23[243] |
-0.11[244] |
-0.43[245] |
36 |
POLR2D |
DNA-directed RNA polymerase II subunit RPB4 |
[246] |
0.92[247] |
0.92[248] |
0.25[249] |
0.49[250] |
0.61[251] |
0.18[252] |
37 |
NME3 |
Nucleoside diphosphate kinase 3 |
[253] |
-1.21[254] |
-1.27[255] |
0.49[256] |
-0.94[257] |
-0.71[258] |
-0.54[259] |
38 |
POLR3E |
DNA-directed RNA polymerase III subunit RPC5 |
[260] |
1.81[261] |
1.76[262] |
0.65[263] |
-0.05[264] |
-0.02[265] |
0.63[266] |
39 |
UCK1 |
Uridine-cytidine kinase 1 |
[267] |
-0.13[268] |
0.57[269] |
0.03[270] |
0.17[271] |
0.78[272] |
0.81[273] |
40 |
UCKL1 |
Uridine-cytidine kinase-like 1 |
[274] |
1.63[275] |
1.75[276] |
-0.32[277] |
0.53[278] |
-0.31[279] |
0.26[280] |
41 |
RRM1 |
Ribonucleoside-diphosphate reductase large subunit |
[281] |
2.14[282] |
1.54[283] |
2.28[284] |
2.95[285] |
2.95[286] |
0.70[287] |
42 |
POLR1E |
DNA-directed RNA polymerase I subunit RPA49 |
[288] |
-0.04[289] |
-0.17[290] |
1.76[291] |
-0.69[292] |
0.46[293] |
-0.08[294] |
43 |
DCK |
Deoxycytidine kinase |
[295] |
0.25[296] |
0.63[297] |
-0.14[298] |
0.94[299] |
1.33[300] |
-1.27[301] |
44 |
POLR2A |
DNA-directed RNA polymerase II subunit RPB1 |
[302] |
3.40[303] |
1.80[304] |
2.84[305] |
3.05[306] |
3.33[307] |
2.41[308] |
45 |
TK1 |
Thymidine kinase, cytosolic |
[309] |
2.58[310] |
1.71[311] |
1.36[312] |
2.15[313] |
2.20[314] |
-0.93[315] |
46 |
POLR3C |
DNA-directed RNA polymerase III subunit RPC3 |
[316] |
0.16[317] |
-0.35[318] |
-0.40[319] |
1.19[320] |
0.54[321] |
-0.36[322] |
47 |
NME6 |
Nucleoside diphosphate kinase 6 |
[323] |
-0.08[324] |
-0.05[325] |
0.31[326] |
-0.50[327] |
-0.88[328] |
-0.52[329] |
48 |
NME7 |
Nucleoside diphosphate kinase 7 |
[330] |
-1.04[331] |
-0.91[332] |
-0.67[333] |
0.42[334] |
-0.12[335] |
-0.83[336] |
49 |
ENPP1 |
Ectonucleotide
pyrophosphatase/phosphodiesterase family member 1 |
1.67[337] |
2.59[338] |
2.59[339] |
0.69[340] |
-1.70[341] |
3.50[342] |
50 |
DPYD |
Dihydropyrimidine dehydrogenase [NADP(+)] |
[343] |
-4.30[344] |
-3.47[345] |
2.21[346] |
1.64[347] |
0.85[348] |
4.00[349] |
51 |
PNPT1 |
Polyribonucleotide nucleotidyltransferase 1, mitochondrial |
[350] |
1.60[351] |
2.11[352] |
2.34[353] |
1.34[354] |
2.00[355] |
1.56[356] |
52 |
POLR3D |
DNA-directed RNA polymerase III subunit RPC4 |
[357] |
1.33[358] |
1.64[359] |
0.98[360] |
0.70[361] |
0.43[362] |
-0.61[363] |
53 |
POLR3H |
DNA-directed RNA polymerase III subunit RPC8 |
[364] |
1.49[365] |
0.79[366] |
1.62[367] |
1.34[368] |
1.36[369] |
1.64[370] |
54 |
UMPS |
Uridine 5'-monophosphate synthase |
[371] |
2.20[372] |
2.33[373] |
1.86[374] |
1.43[375] |
1.94[376] |
2.25[377] |
55 |
RRM2B |
Ribonucleoside-diphosphate reductase subunit M2 B |
[378] |
1.90[379] |
1.94[380] |
0.80[381] |
1.90[382] |
1.59[383] |
1.07[384] |
56 |
UCK2 |
Uridine-cytidine kinase 2 |
[385] |
2.11[386] |
1.86[387] |
1.94[388] |
2.75[389] |
2.59[390] |
0.82[391] |
57 |
POLR2J3 |
DNA-directed RNA polymerase II subunit RPB11-b2 |
[392] |
-4.93[393] |
-5.17[394] |
-3.23[395] |
-5.24[396] |
-2.75[397] |
-3.01[398] |
58 |
TK2 |
Thymidine kinase 2, mitochondrial |
[399] |
0.73[400] |
1.03[401] |
-0.12[402] |
1.21[403] |
1.98[404] |
2.72[405] |
59 |
POLR3A |
DNA-directed RNA polymerase III subunit RPC1 |
[406] |
2.62[407] |
2.93[408] |
2.27[409] |
2.06[410] |
2.01[411] |
1.61[412] |
60 |
POLR3F |
DNA-directed RNA polymerase III subunit RPC6 |
[413] |
0.61[414] |
1.06[415] |
0.53[416] |
0.91[417] |
0.69[418] |
-0.75[419] |
61 |
UPRT |
Uracil phosphoribosyltransferase homolog |
[420] |
-0.02[421] |
-0.61[422] |
-8.77[423] |
0.42[424] |
0.20[425] |
0.03[426] |
62 |
CTPS2 |
CTP synthase 2 |
[427] |
2.07[428] |
1.85[429] |
2.43[430] |
1.88[431] |
1.60[432] |
1.07[433] |
63 |
ENPP3 |
Ectonucleotide
pyrophosphatase/phosphodiesterase family member 3 |
0.74[434] |
2.72[435] |
-2.61[436] |
-3.17[437] |
-5.42[438] |
-1.37[439] |
64 |
POLR3G |
DNA-directed RNA polymerase III subunit RPC7 |
[440] |
-0.50[441] |
0.03[442] |
0.67[443] |
0.08[444] |
0.17[445] |
-1.13[446] |
65 |
POLR1B |
DNA-directed RNA polymerase I subunit RPA2 |
[447] |
3.00[448] |
2.83[449] |
2.34[450] |
2.13[451] |
2.62[452] |
2.75[453] |
66 |
POLR3B |
DNA-directed RNA polymerase III subunit RPC2 |
[454] |
0.93[455] |
1.44[456] |
1.36[457] |
1.49[458] |
1.54[459] |
2.38[460] |
67 |
POLA2 |
DNA polymerase alpha subunit B |
[461] |
1.31[462] |
0.81[463] |
1.42[464] |
2.41[465] |
2.61[466] |
-0.22[467] |
68 |
PRIM1 |
DNA primase small subunit |
[468] |
1.34[469] |
2.53[470] |
2.90[471] |
2.05[472] |
2.54[473] |
-0.29[474] |
69 |
POLD1 |
DNA polymerase delta catalytic subunit |
[475] |
2.52[476] |
2.62[477] |
3.48[478] |
2.72[479] |
3.37[480] |
1.28[481] |
70 |
PRIM2 |
DNA primase large subunit |
[482] |
1.94[483] |
1.62[484] |
1.28[485] |
2.08[486] |
2.21[487] |
-0.97[488] |
71 |
CAD |
CAD protein |
[489] |
3.99[490] |
3.76[491] |
4.25[492] |
4.04[493] |
4.04[494] |
2.85[495] |
72 |
POLR1A |
DNA-directed RNA polymerase I subunit RPA1 |
[496] |
4.17[497] |
3.08[498] |
2.96[499] |
3.51[500] |
3.42[501] |
2.86[502] |
73 |
POLD3 |
DNA polymerase delta subunit 3 |
[503] |
1.84[504] |
1.58[505] |
2.59[506] |
3.01[507] |
3.39[508] |
1.60[509] |
74 |
POLE |
DNA polymerase epsilon catalytic subunit A |
[510] |
3.71[511] |
4.20[512] |
4.30[513] |
3.63[514] |
4.54[515] |
3.55[516] |
75 |
POLE2 |
DNA polymerase epsilon subunit 2 |
[517] |
1.37[518] |
2.03[519] |
3.07[520] |
2.05[521] |
2.48[522] |
-0.54[523] |
76 |
POLA1 |
DNA polymerase alpha catalytic subunit |
[524] |
2.67[525] |
2.65[526] |
3.25[527] |
3.88[528] |
3.74[529] |
2.28[530] |
77 |
POLR2J2 |
DNA-directed RNA polymerase II subunit RPB11-b1 |
[531] |
-3.69[532] |
-3.14[533] |
-1.12[534] |
-4.56[535] |
-1.45[536] |
-2.14[537] |
78 |
ENTPD1 |
Ectonucleoside triphosphate diphosphohydrolase 1 |
[538] |
3.41[539] |
4.02[540] |
3.68[541] |
2.46[542] |
3.65[543] |
3.86[544] |
79 |
CMPK2 |
UMP-CMP kinase 2, mitochondrial |
[545] |
-0.26[546] |
-1.91[547] |
[548] |
-5.86[549] |
0.22[550] |
2.63[551] |
80 |
NT5M |
5'(3')-deoxyribonucleotidase, mitochondrial |
[552] |
0.15[553] |
1.57[554] |
1.14[555] |
2.23[556] |
0.96[557] |
-0.65[558] |
81 |
POLR1H |
|
[559] |
[560] |
[561] |
[562] |
[563] |
[564] |
[565] |
82 |
POLR1F |
|
[566] |
[567] |
[568] |
[569] |
[570] |
[571] |
[572] |
83 |
ENTPD3 |
Ectonucleoside triphosphate diphosphohydrolase 3 |
[573] |
[574] |
[575] |
[576] |
[577] |
[578] |
[579] |
84 |
CTPS1 |
CTP synthase 1 |
[580] |
[581] |
[582] |
[583] |
[584] |
[585] |
[586] |
85 |
MIR3658 |
|
[587] |
[588] |
[589] |
[590] |
[591] |
[592] |
[593] |
86 |
MIR1914 |
|
[594] |
[595] |
[596] |
[597] |
[598] |
[599] |
[600] |
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