WP_PURINE_METABOLISM_AND_RELATED_DISORDERS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AOX1 Aldehyde oxidase [1] -3.34[2] -3.62[3] -9.81[4] -4.31[5] -2.97[6] 1.23[7]
2 APRT Adenine phosphoribosyltransferase [8] -0.74[9] -0.61[10] -0.79[11] -1.57[12] -1.06[13] -2.70[14]
3 PNP Purine nucleoside phosphorylase [15] -0.32[16] -1.16[17] -0.33[18] -0.85[19] 0.24[20] -2.96[21]
4 PAICS Multifunctional protein ADE2 [22] 1.83[23] 2.17[24] 2.15[25] 1.37[26] 1.80[27] -0.95[28]
5 ADSL Adenylosuccinate lyase [29] 0.49[30] 0.59[31] 1.18[32] 0.02[33] -0.21[34] -2.27[35]
6 ATIC Bifunctional purine biosynthesis protein PURH [36] 1.47[37] 1.22[38] 1.37[39] 0.63[40] 0.66[41] -2.28[42]
7 TPMT Thiopurine S-methyltransferase [43] -1.30[44] -0.62[45] -1.89[46] -0.39[47] -1.09[48] -1.16[49]
8 MAT2A S-adenosylmethionine synthase isoform type-2 [50] 0.84[51] 1.08[52] 1.07[53] 1.83[54] 1.76[55] -0.14[56]
9 GART Trifunctional purine biosynthetic protein adenosine-3 [57] 1.14[58] 0.82[59] 0.44[60] 1.17[61] 1.19[62] -1.52[63]
10 DGUOK Deoxyguanosine kinase, mitochondrial [64] -0.40[65] -0.47[66] -0.53[67] -0.30[68] -0.68[69] -2.73[70]
11 ITPA Inosine triphosphate pyrophosphatase [71] 0.25[72] 0.25[73] -1.26[74] 0.09[75] -1.08[76] -2.75[77]
12 PRPS1 Ribose-phosphate pyrophosphokinase 1 [78] [79] [80] [81] [82] [83] [84]
13 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase [85] -0.50[86] -0.40[87] 0.78[88] 0.99[89] 0.68[90] -2.85[91]
14 XDH Xanthine dehydrogenase/oxidase [92] -9.75[93] -8.69[94] -2.99[95] -6.39[96] -4.66[97] 1.76[98]
15 RRM2B Ribonucleoside-diphosphate reductase subunit M2 B [99] 1.56[100] 1.63[101] 0.65[102] 2.01[103] 1.51[104] -0.56[105]
16 IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 [106] 2.23[107] 1.43[108] 1.37[109] 3.06[110] 2.23[111] -2.26[112]
17 PPAT Amidophosphoribosyltransferase [113] 1.56[114] 2.01[115] 2.32[116] 1.74[117] 2.00[118] -0.73[119]
18 PFAS Phosphoribosylformylglycinamidine synthase [120] 3.08[121] 2.55[122] 3.49[123] 3.17[124] 3.17[125] 0.54[126]
19 ADA Adenosine deaminase [127] 1.49[128] 0.53[129] -1.29[130] 2.92[131] 0.07[132] -2.03[133]
20 AMPD1 AMP deaminase 1 [134] [135] [136] -0.81[137] -0.85[138] -2.21[139] [140]
21 GRM5 Metabotropic glutamate receptor 5 [141] [142] [143] [144] [145] [146] [147]
22 ADSS2 [148] [149] [150] [151] [152] [153] [154]
[1]
ref_hepatocyte AOX1
Mean 166
Standard deviation 2e+02
Values 25 4.8e+02 2.5e+02 12 68
[2]
HepG2 AOX1
Mean 28.7
Standard deviation 3.3
Values 31 26
[3]
HepG2.C3A AOX1
Mean 22.6
Standard deviation 2.4
Values 24 21
[4]
HuH.7 AOX1
Mean 0.258
Standard deviation 0.25
Values 0.066 0.55 0.16
[5]
SNU475 AOX1
Mean 7.67
Standard deviation 6.2
Values 12 3.3
[6]
THLE AOX1
Mean 26.7
Standard deviation 2.8
Values 29 25
[7]
liver AOX1
Mean 1.12e+03
Standard deviation 5.3e+02
Values 1.1e+03 1.8e+03 5.6e+02 9.6e+02
[8]
ref_hepatocyte APRT
Mean 64.6
Standard deviation 34
Values 82 74 1.1e+02 20 41
[9]
HepG2 APRT
Mean 67.9
Standard deviation 11
Values 60 76
[10]
HepG2.C3A APRT
Mean 71
Standard deviation 2.4
Values 73 69
[11]
HuH.7 APRT
Mean 52.3
Standard deviation 21
Values 66 29 62
[12]
SNU475 APRT
Mean 19.9
Standard deviation 1.6
Values 19 21
[13]
THLE APRT
Mean 39
Standard deviation 2.5
Values 37 41
[14]
liver APRT
Mean 28.4
Standard deviation 29
Values 4 3.4 52 55
[15]
ref_hepatocyte PNP
Mean 30
Standard deviation 33
Values 86 12 26 2.3 23
[16]
HepG2 PNP
Mean 42.3
Standard deviation 2.8
Values 40 44
[17]
HepG2.C3A PNP
Mean 22.5
Standard deviation 12
Values 31 14
[18]
HuH.7 PNP
Mean 33.5
Standard deviation 12
Values 46 23 31
[19]
SNU475 PNP
Mean 15.3
Standard deviation 6.3
Values 20 11
[20]
THLE PNP
Mean 44.5
Standard deviation 6.2
Values 40 49
[21]
liver PNP
Mean 11
Standard deviation 6
Values 9.7 6.1 20 8.7
[22]
ref_hepatocyte PAICS
Mean 28.4
Standard deviation 8.1
Values 14 33 28 34 32
[23]
HepG2 PAICS
Mean 178
Standard deviation 24
Values 1.9e+02 1.6e+02
[24]
HepG2.C3A PAICS
Mean 215
Standard deviation 76
Values 2.7e+02 1.6e+02
[25]
HuH.7 PAICS
Mean 177
Standard deviation 52
Values 2.2e+02 1.2e+02 1.9e+02
[26]
SNU475 PAICS
Mean 67.2
Standard deviation 4.6
Values 70 64
[27]
THLE PAICS
Mean 124
Standard deviation 21
Values 1.1e+02 1.4e+02
[28]
liver PAICS
Mean 42.1
Standard deviation 21
Values 25 24 62 57
[29]
ref_hepatocyte ADSL
Mean 25
Standard deviation 12
Values 21 12 17 34 40
[30]
HepG2 ADSL
Mean 61.7
Standard deviation 4
Values 59 65
[31]
HepG2.C3A ADSL
Mean 63.3
Standard deviation 4.7
Values 67 60
[32]
HuH.7 ADSL
Mean 79.7
Standard deviation 15
Values 94 64 81
[33]
SNU475 ADSL
Mean 23.2
Standard deviation 2.7
Values 25 21
[34]
THLE ADSL
Mean 27.3
Standard deviation 7.7
Values 22 33
[35]
liver ADSL
Mean 14.9
Standard deviation 3.2
Values 11 16 14 18
[36]
ref_hepatocyte ATIC
Mean 24.9
Standard deviation 8.1
Values 28 14 19 32 32
[37]
HepG2 ATIC
Mean 121
Standard deviation 12
Values 1.1e+02 1.3e+02
[38]
HepG2.C3A ATIC
Mean 97.3
Standard deviation 10
Values 90 1e+02
[39]
HuH.7 ATIC
Mean 90.3
Standard deviation 22
Values 1.1e+02 65 1e+02
[40]
SNU475 ATIC
Mean 35.2
Standard deviation 3.4
Values 38 33
[41]
THLE ATIC
Mean 49.5
Standard deviation 10
Values 42 57
[42]
liver ATIC
Mean 14.7
Standard deviation 12
Values 4.1 5.3 21 29
[43]
ref_hepatocyte TPMT
Mean 23.4
Standard deviation 7.6
Values 32 29 14 18 24
[44]
HepG2 TPMT
Mean 16.8
Standard deviation 5.6
Values 21 13
[45]
HepG2.C3A TPMT
Mean 25.6
Standard deviation 12
Values 34 17
[46]
HuH.7 TPMT
Mean 8.85
Standard deviation 2.1
Values 11 6.6 9.3
[47]
SNU475 TPMT
Mean 16.4
Standard deviation 0.91
Values 16 17
[48]
THLE TPMT
Mean 13.9
Standard deviation 0.98
Values 13 15
[49]
liver TPMT
Mean 30.1
Standard deviation 12
Values 18 22 40 42
[50]
ref_hepatocyte MAT2A
Mean 23.3
Standard deviation 13
Values 14 16 44 15 27
[51]
HepG2 MAT2A
Mean 73.6
Standard deviation 11
Values 81 66
[52]
HepG2.C3A MAT2A
Mean 82.6
Standard deviation 22
Values 98 67
[53]
HuH.7 MAT2A
Mean 68.8
Standard deviation 31
Values 93 34 79
[54]
SNU475 MAT2A
Mean 75.8
Standard deviation 6
Values 80 72
[55]
THLE MAT2A
Mean 99.7
Standard deviation 1.6
Values 1e+02 99
[56]
liver MAT2A
Mean 61
Standard deviation 25
Values 34 46 78 86
[57]
ref_hepatocyte GART
Mean 21.4
Standard deviation 16
Values 33 7.1 8 17 43
[58]
HepG2 GART
Mean 83.2
Standard deviation 13
Values 74 92
[59]
HepG2.C3A GART
Mean 63.6
Standard deviation 1.3
Values 65 63
[60]
HuH.7 GART
Mean 40.7
Standard deviation 14
Values 50 25 48
[61]
SNU475 GART
Mean 44.2
Standard deviation 5.5
Values 48 40
[62]
THLE GART
Mean 61.8
Standard deviation 11
Values 54 69
[63]
liver GART
Mean 21.4
Standard deviation 7.5
Values 20 26 12 29
[64]
ref_hepatocyte DGUOK
Mean 21.4
Standard deviation 7.8
Values 32 23 23 16 12
[65]
HepG2 DGUOK
Mean 28.6
Standard deviation 0.085
Values 29 29
[66]
HepG2.C3A DGUOK
Mean 26
Standard deviation 0.71
Values 25 26
[67]
HuH.7 DGUOK
Mean 20.7
Standard deviation 8.1
Values 29 13 20
[68]
SNU475 DGUOK
Mean 15.9
Standard deviation 2.3
Values 14 18
[69]
THLE DGUOK
Mean 16.8
Standard deviation 0.74
Values 16 17
[70]
liver DGUOK
Mean 9.23
Standard deviation 8.2
Values 2.2 2.1 17 15
[71]
ref_hepatocyte ITPA
Mean 21
Standard deviation 5.1
Values 28 15 22 17 22
[72]
HepG2 ITPA
Mean 44
Standard deviation 4.2
Values 41 47
[73]
HepG2.C3A ITPA
Mean 42.1
Standard deviation 1.5
Values 41 43
[74]
HuH.7 ITPA
Mean 12.3
Standard deviation 5.6
Values 17 6 14
[75]
SNU475 ITPA
Mean 20.4
Standard deviation 4.7
Values 17 24
[76]
THLE ITPA
Mean 12.5
Standard deviation 2.1
Values 11 14
[77]
liver ITPA
Mean 8.99
Standard deviation 7.5
Values 2.4 2.6 16 15
[78]
ref_hepatocyte PRPS1
Mean 18.8
Standard deviation 5.2
Values 22 17 16 13 26
[79]
HepG2 PRPS1
Missing
[80]
HepG2.C3A PRPS1
Missing
[81]
HuH.7 PRPS1
Missing
[82]
SNU475 PRPS1
Missing
[83]
THLE PRPS1
Missing
[84]
liver PRPS1
Missing
[85]
ref_hepatocyte HPRT1
Mean 13.6
Standard deviation 5.4
Values 8.9 15 7.3 17 20
[86]
HepG2 HPRT1
Mean 16.9
Standard deviation 0.27
Values 17 17
[87]
HepG2.C3A HPRT1
Mean 17.3
Standard deviation 2.3
Values 19 16
[88]
HuH.7 HPRT1
Mean 32.8
Standard deviation 5.1
Values 38 28 32
[89]
SNU475 HPRT1
Mean 24.8
Standard deviation 3.3
Values 22 27
[90]
THLE HPRT1
Mean 27.5
Standard deviation 1.6
Values 26 29
[91]
liver HPRT1
Mean 5.44
Standard deviation 5.1
Values 1.1 1.6 7.1 12
[92]
ref_hepatocyte XDH
Mean 5.26
Standard deviation 5.8
Values 2.8 13 9.2 0 0.81
[93]
HepG2 XDH
Mean 0.0107
Standard deviation 0.0091
Values 0.0043 0.017
[94]
HepG2.C3A XDH
Mean 0.0215
Standard deviation 0.03
Values 0.043 0
[95]
HuH.7 XDH
Mean 0.929
Standard deviation 0.041
Values 0.91 0.98 0.9
[96]
SNU475 XDH
Mean 0.0574
Standard deviation 0.055
Values 0.096 0.019
[97]
THLE XDH
Mean 0.262
Standard deviation 0.11
Values 0.18 0.34
[98]
liver XDH
Mean 51.2
Standard deviation 29
Values 87 61 19 38
[99]
ref_hepatocyte RRM2B
Mean 5.12
Standard deviation 4.1
Values 2.8 2.6 1.6 7.3 11
[100]
HepG2 RRM2B
Mean 26.7
Standard deviation 1.8
Values 28 25
[101]
HepG2.C3A RRM2B
Mean 26.7
Standard deviation 5.2
Values 30 23
[102]
HuH.7 RRM2B
Mean 11.3
Standard deviation 1.7
Values 9.5 13 12
[103]
SNU475 RRM2B
Mean 18.9
Standard deviation 5.1
Values 15 23
[104]
THLE RRM2B
Mean 18.4
Standard deviation 0.84
Values 19 18
[105]
liver RRM2B
Mean 9.96
Standard deviation 2.3
Values 8.6 12 7.4 12
[106]
ref_hepatocyte IMPDH1
Mean 4.53
Standard deviation 3.3
Values 5.1 1.2 1.2 8.6 6.6
[107]
HepG2 IMPDH1
Mean 37.5
Standard deviation 10
Values 30 45
[108]
HepG2.C3A IMPDH1
Mean 20.5
Standard deviation 4.3
Values 17 24
[109]
HuH.7 IMPDH1
Mean 16.5
Standard deviation 2.6
Values 17 14 19
[110]
SNU475 IMPDH1
Mean 34.6
Standard deviation 1.1
Values 35 34
[111]
THLE IMPDH1
Mean 26.8
Standard deviation 3.7
Values 24 29
[112]
liver IMPDH1
Mean 2.72
Standard deviation 0.62
Values 3.4 2.2 2.2 3.1
[113]
ref_hepatocyte PPAT
Mean 3.8
Standard deviation 3
Values 1.8 1.7 1.5 7.8 6.1
[114]
HepG2 PPAT
Mean 19.7
Standard deviation 5
Values 23 16
[115]
HepG2.C3A PPAT
Mean 25.7
Standard deviation 7.5
Values 31 20
[116]
HuH.7 PPAT
Mean 26.6
Standard deviation 9.2
Values 30 16 34
[117]
SNU475 PPAT
Mean 11.6
Standard deviation 2.8
Values 14 9.6
[118]
THLE PPAT
Mean 19.1
Standard deviation 1.8
Values 18 20
[119]
liver PPAT
Mean 6.55
Standard deviation 0.98
Values 5.5 6.4 6.5 7.9
[120]
ref_hepatocyte PFAS
Mean 2.15
Standard deviation 0.73
Values 2.6 1.4 1.5 2.2 3.1
[121]
HepG2 PFAS
Mean 31.9
Standard deviation 2.2
Values 30 33
[122]
HepG2.C3A PFAS
Mean 21.1
Standard deviation 1.9
Values 22 20
[123]
HuH.7 PFAS
Mean 33.9
Standard deviation 17
Values 38 15 49
[124]
SNU475 PFAS
Mean 17.8
Standard deviation 1.9
Values 19 16
[125]
THLE PFAS
Mean 24.4
Standard deviation 5.7
Values 20 28
[126]
liver PFAS
Mean 8.96
Standard deviation 1.7
Values 10 9.8 6.5 9.5
[127]
ref_hepatocyte ADA
Mean 1.88
Standard deviation 0.53
Values 2.6 1.8 1.6 1.2 2.2
[128]
HepG2 ADA
Mean 9.29
Standard deviation 5.2
Values 5.6 13
[129]
HepG2.C3A ADA
Mean 4.58
Standard deviation 0.33
Values 4.8 4.3
[130]
HuH.7 ADA
Mean 1.08
Standard deviation 0.11
Values 0.96 1.1 1.1
[131]
SNU475 ADA
Mean 13
Standard deviation 2
Values 12 14
[132]
THLE ADA
Mean 2.48
Standard deviation 0.3
Values 2.7 2.3
[133]
liver ADA
Mean 1.32
Standard deviation 0.66
Values 0.69 0.81 1.9 1.9
[134]
ref_hepatocyte AMPD1
Mean 0.0195
Standard deviation 0.044
Values 0 0.098 0 0 0
[135]
HepG2 AMPD1
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A AMPD1
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 AMPD1
Mean 0.0156
Standard deviation 0.027
Values 0.047 0 0
[138]
SNU475 AMPD1
Mean 0.00992
Standard deviation 0.0075
Values 0.015 0.0046
[139]
THLE AMPD1
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[140]
liver AMPD1
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte GRM5
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 GRM5
Missing
[143]
HepG2.C3A GRM5
Missing
[144]
HuH.7 GRM5
Missing
[145]
SNU475 GRM5
Missing
[146]
THLE GRM5
Missing
[147]
liver GRM5
Missing
[148]
ref_hepatocyte ADSS2
Missing
[149]
HepG2 ADSS2
Missing
[150]
HepG2.C3A ADSS2
Missing
[151]
HuH.7 ADSS2
Missing
[152]
SNU475 ADSS2
Missing
[153]
THLE ADSS2
Missing
[154]
liver ADSS2
Missing