WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 0.01[1] | 0.10[2] | 0.09[3] | -0.59[4] | -0.57[5] | -0.79[6] | |
2 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [7] | 0.42[8] | -0.92[9] | -3.27[10] | -3.42[11] | -0.08[12] | -1.29[13] |
3 | LTA4H | Leukotriene A-4 hydrolase | [14] | -0.40[15] | 0.28[16] | 0.42[17] | -2.05[18] | -0.78[19] | -0.98[20] |
4 | HRAS | GTPase HRas | [21] | -1.43[22] | -2.08[23] | -2.53[24] | -2.38[25] | -1.81[26] | -2.12[27] |
5 | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 | [28] | -2.07[29] | -2.95[30] | -0.48[31] | -0.22[32] | -0.06[33] | 1.38[34] |
6 | RB1 | Retinoblastoma-associated protein | [35] | 0.79[36] | 1.35[37] | 2.25[38] | 0.84[39] | 1.95[40] | 2.02[41] |
7 | GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | [42] | -0.35[43] | 0.49[44] | 1.34[45] | 0.16[46] | 1.16[47] | 1.98[48] |
8 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | [49] | 0.08[50] | 1.23[51] | 1.13[52] | 0.13[53] | 1.16[54] | 1.88[55] |
9 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | [56] | 2.37[57] | 4.05[58] | 3.81[59] | -0.65[60] | 0.62[61] | 3.04[62] |
10 | ALOX5AP | Arachidonate 5-lipoxygenase-activating protein | [63] | -2.44[64] | -4.23[65] | -2.49[66] | -1.58[67] | -1.34[68] | 0.21[69] |
11 | TBXAS1 | Thromboxane-A synthase | [70] | -3.39[71] | -1.28[72] | -4.13[73] | -0.79[74] | -1.46[75] | 2.20[76] |
12 | PTGDS | Prostaglandin-H2 D-isomerase | [77] | 0.07[78] | 0.31[79] | -8.22[80] | -1.61[81] | -0.71[82] | 1.44[83] |
13 | ALOX5 | Arachidonate 5-lipoxygenase | [84] | -1.30[85] | -6.59[86] | -6.17[87] | -8.56[88] | -6.52[89] | 3.36[90] |
14 | MAPK11 | Mitogen-activated protein kinase 11 | [91] | -0.60[92] | -0.64[93] | -1.19[94] | -1.08[95] | 1.70[96] | 0.71[97] |
15 | LTC4S | Leukotriene C4 synthase | [98] | -3.34[99] | -1.79[100] | -2.82[101] | -7.25[102] | -3.13[103] | 1.09[104] |
16 | PTGIS | Prostacyclin synthase | [105] | -1.98[106] | -0.80[107] | 3.51[108] | -0.31[109] | 6.41[110] | 5.39[111] |
17 | CYSLTR1 | Cysteinyl leukotriene receptor 1 | [112] | [113] | [114] | [115] | [116] | [117] | 0.71[118] |
18 | PTGER1 | Prostaglandin E2 receptor EP1 subtype | [119] | -0.42[120] | -2.11[121] | -3.75[122] | -6.19[123] | -1.06[124] | -1.35[125] |
19 | PTGES | Prostaglandin E synthase | [126] | 0.87[127] | -2.93[128] | -2.48[129] | 1.89[130] | 5.18[131] | -0.82[132] |
20 | ALOX15B | Arachidonate 15-lipoxygenase B | [133] | -5.90[134] | [135] | 0.95[136] | -8.54[137] | 0.09[138] | 0.51[139] |
21 | PTGER2 | Prostaglandin E2 receptor EP2 subtype | [140] | [141] | [142] | 0.90[143] | 3.36[144] | 2.96[145] | 1.94[146] |
22 | PTGER4 | Prostaglandin E2 receptor EP4 subtype | [147] | -4.46[148] | -5.99[149] | 3.12[150] | -0.54[151] | -0.51[152] | 3.52[153] |
23 | ADCY3 | Adenylate cyclase type 3 | [154] | 1.04[155] | -0.15[156] | 3.51[157] | 3.31[158] | 5.62[159] | 4.06[160] |
24 | ALOX12 | Arachidonate 12-lipoxygenase, 12S-type | [161] | 0.20[162] | 0.20[163] | -0.50[164] | -0.59[165] | -0.41[166] | 1.37[167] |
25 | PTGS1 | Prostaglandin G/H synthase 1 | [168] | 0.93[169] | -5.93[170] | -3.85[171] | 1.25[172] | 4.86[173] | 3.52[174] |
26 | IGFBP5 | Insulin-like growth factor-binding protein 5 | [175] | 1.22[176] | -2.38[177] | 0.98[178] | 9.87[179] | 2.94[180] | 8.29[181] |
27 | PTGS2 | Prostaglandin G/H synthase 2 | [182] | [183] | -2.99[184] | -2.40[185] | 1.43[186] | 8.03[187] | 3.38[188] |
28 | ALOX15 | Arachidonate 15-lipoxygenase | [189] | 1.19[190] | -2.82[191] | 2.10[192] | -3.19[193] | -1.96[194] | -0.39[195] |
29 | PLA2G4A | Cytosolic phospholipase A2 | [196] | -0.15[197] | -2.65[198] | 5.79[199] | 2.07[200] | 6.62[201] | 4.90[202] |
30 | PTGER3 | Prostaglandin E2 receptor EP3 subtype | [203] | -2.33[204] | [205] | [206] | 4.47[207] | 2.30[208] | 5.19[209] |
31 | PRXL2B | [210] | [211] | [212] | [213] | [214] | [215] | [216] |