WP_PROLACTIN_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | PPIB | Peptidyl-prolyl cis-trans isomerase B | [8] | -2.35[9] | -1.86[10] | -2.31[11] | -3.60[12] | -3.59[13] | -1.93[14] |
3 | PPIA | Peptidyl-prolyl cis-trans isomerase A | [15] | 0.43[16] | 0.84[17] | 1.07[18] | -0.27[19] | 0.33[20] | 0.27[21] |
4 | CTSD | Cathepsin D | [22] | 0.53[23] | 0.14[24] | 0.06[25] | 0.08[26] | -1.35[27] | 1.22[28] |
5 | YWHAZ | 14-3-3 protein zeta/delta | [29] | -0.04[30] | 0.08[31] | 0.29[32] | 0.87[33] | -0.07[34] | -0.99[35] |
6 | ITGB1 | Integrin beta-1 | [36] | 0.77[37] | 1.06[38] | 1.09[39] | 1.43[40] | 1.99[41] | 0.81[42] |
7 | NFKBIA | NF-kappa-B inhibitor alpha | [43] | -0.52[44] | -2.04[45] | -2.53[46] | -3.55[47] | -1.19[48] | -0.49[49] |
8 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [50] | 0.14[51] | 0.08[52] | 0.69[53] | -0.02[54] | 0.45[55] | -0.32[56] |
9 | YWHAG | 14-3-3 protein gamma | [57] | 0.74[58] | 0.47[59] | 0.42[60] | 0.68[61] | 0.48[62] | -0.69[63] |
10 | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 | [64] | -0.45[65] | -0.51[66] | 0.00[67] | -3.33[68] | -1.30[69] | -0.95[70] |
11 | JUN | Transcription factor AP-1 | [71] | 0.05[72] | -1.23[73] | -1.06[74] | -1.74[75] | -0.69[76] | -1.16[77] |
12 | FOS | Proto-oncogene c-Fos | [78] | -5.48[79] | -3.95[80] | -4.71[81] | -6.20[82] | -4.65[83] | -0.65[84] |
13 | AKT1 | RAC-alpha serine/threonine-protein kinase | [85] | 0.62[86] | 0.65[87] | -0.53[88] | -0.09[89] | 0.42[90] | 0.41[91] |
14 | STAT3 | Signal transducer and activator of transcription 3 | [92] | 1.09[93] | -0.14[94] | 0.49[95] | 0.21[96] | -0.04[97] | 3.06[98] |
15 | MYC | Myc proto-oncogene protein | [99] | 0.97[100] | 0.90[101] | -1.24[102] | -2.82[103] | 0.03[104] | -1.35[105] |
16 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [106] | -0.39[107] | -0.45[108] | 0.02[109] | -0.58[110] | 0.41[111] | -0.54[112] |
17 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [113] | 0.59[114] | 0.54[115] | 1.30[116] | -0.88[117] | 0.09[118] | -1.05[119] |
18 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [120] | 0.98[121] | 1.68[122] | 1.53[123] | 0.85[124] | 1.97[125] | 1.91[126] |
19 | GRB2 | Growth factor receptor-bound protein 2 | [127] | 1.73[128] | 1.84[129] | 1.85[130] | 0.52[131] | 0.92[132] | 0.95[133] |
20 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [134] | 0.46[135] | -0.19[136] | 0.82[137] | 2.50[138] | 0.71[139] | 1.60[140] |
21 | SHC1 | SHC-transforming protein 1 | [141] | 1.70[142] | 2.19[143] | 2.16[144] | 2.62[145] | 2.59[146] | 1.43[147] |
22 | RELA | Transcription factor p65 | [148] | 0.67[149] | 0.43[150] | 0.47[151] | -0.09[152] | 0.30[153] | -0.23[154] |
23 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [155] | 0.47[156] | 1.15[157] | 2.31[158] | -0.22[159] | 1.13[160] | 1.75[161] |
24 | JAK1 | Tyrosine-protein kinase JAK1 | [162] | 1.05[163] | 0.80[164] | 0.88[165] | 0.59[166] | 1.72[167] | 2.18[168] |
25 | FLNA | Filamin-A | [169] | 4.67[170] | 3.40[171] | 0.34[172] | 5.51[173] | 4.63[174] | 2.81[175] |
26 | NFKBIB | NF-kappa-B inhibitor beta | [176] | -0.63[177] | -0.53[178] | -0.31[179] | -1.85[180] | -1.02[181] | -1.08[182] |
27 | CASP3 | Caspase-3 | [183] | 0.67[184] | 1.61[185] | -1.04[186] | -0.93[187] | 0.55[188] | -0.15[189] |
28 | HRAS | GTPase HRas | [190] | -0.47[191] | -0.91[192] | -1.81[193] | -0.98[194] | -0.71[195] | -2.01[196] |
29 | SOCS3 | Suppressor of cytokine signaling 3 | [197] | -3.60[198] | -3.75[199] | -2.13[200] | -0.83[201] | -1.42[202] | 0.78[203] |
30 | MAPK1 | Mitogen-activated protein kinase 1 | [204] | 2.25[205] | 2.65[206] | 2.38[207] | 1.81[208] | 1.95[209] | 2.43[210] |
31 | PXN | Paxillin | [211] | 1.54[212] | 1.53[213] | 1.46[214] | 2.08[215] | 2.53[216] | 0.30[217] |
32 | PTK2 | Focal adhesion kinase 1 | [218] | 1.27[219] | 2.03[220] | 2.30[221] | 1.91[222] | 1.60[223] | 1.41[224] |
33 | PTPN1 | Tyrosine-protein phosphatase non-receptor type 1 | [225] | 1.65[226] | 1.59[227] | 1.01[228] | 1.79[229] | 1.57[230] | 0.34[231] |
34 | MAPK14 | Mitogen-activated protein kinase 14 | [232] | 2.01[233] | 2.35[234] | 1.82[235] | 1.65[236] | 1.61[237] | 1.93[238] |
35 | VAV2 | Guanine nucleotide exchange factor VAV2 | [239] | 1.84[240] | 2.36[241] | 1.74[242] | -0.57[243] | 0.34[244] | 1.16[245] |
36 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [246] | 0.06[247] | 0.45[248] | 1.44[249] | 2.03[250] | 2.02[251] | 3.65[252] |
37 | MAPK8 | Mitogen-activated protein kinase 8 | [253] | -0.91[254] | 0.77[255] | -0.46[256] | -0.94[257] | -0.60[258] | 0.14[259] |
38 | SIRPA | Tyrosine-protein phosphatase non-receptor type substrate 1 | [260] | -1.45[261] | -4.51[262] | 0.62[263] | -2.51[264] | 1.49[265] | 2.27[266] |
39 | SOS1 | Son of sevenless homolog 1 | [267] | 0.44[268] | 2.24[269] | 1.64[270] | 0.81[271] | 0.53[272] | 1.19[273] |
40 | ELK1 | ETS domain-containing protein Elk-1 | [274] | 0.22[275] | -1.65[276] | 0.67[277] | 0.24[278] | 1.31[279] | 0.48[280] |
41 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [281] | 2.91[282] | 2.00[283] | 3.06[284] | 1.22[285] | 1.31[286] | 0.81[287] |
42 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [288] | 1.21[289] | 1.15[290] | 0.84[291] | -0.28[292] | 1.11[293] | 1.10[294] |
43 | IRF1 | Interferon regulatory factor 1 | [295] | 0.03[296] | -0.17[297] | -0.14[298] | 1.22[299] | 0.70[300] | 1.48[301] |
44 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [302] | 0.07[303] | 0.54[304] | 1.01[305] | -7.17[306] | -1.67[307] | 0.47[308] |
45 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [309] | 2.41[310] | 2.90[311] | 3.41[312] | 0.67[313] | 1.72[314] | 0.36[315] |
46 | CISH | Cytokine-inducible SH2-containing protein | [316] | -2.37[317] | -1.92[318] | -1.81[319] | -2.68[320] | -3.64[321] | 1.75[322] |
47 | MAPK9 | Mitogen-activated protein kinase 9 | [323] | 1.76[324] | 2.26[325] | 2.21[326] | 1.68[327] | 1.62[328] | 1.16[329] |
48 | MAPK3 | Mitogen-activated protein kinase 3 | [330] | 2.39[331] | 2.70[332] | 2.64[333] | 0.39[334] | 0.89[335] | -0.39[336] |
49 | GSK3B | Glycogen synthase kinase-3 beta | [337] | 1.80[338] | 1.71[339] | 2.17[340] | 1.78[341] | 2.09[342] | 1.81[343] |
50 | STAT5B | Signal transducer and activator of transcription 5B | [344] | 1.89[345] | 1.79[346] | 2.39[347] | 1.52[348] | 1.14[349] | 2.27[350] |
51 | SRC | Proto-oncogene tyrosine-protein kinase Src | [351] | 3.56[352] | 3.81[353] | 2.71[354] | 2.36[355] | 2.02[356] | -0.20[357] |
52 | SOCS2 | Suppressor of cytokine signaling 2 | [358] | -0.27[359] | -2.54[360] | -4.40[361] | 0.62[362] | -4.62[363] | 2.30[364] |
53 | NEK3 | Serine/threonine-protein kinase Nek3 | [365] | 0.57[366] | 2.25[367] | 1.78[368] | -1.38[369] | -1.31[370] | -0.32[371] |
54 | MTOR | Serine/threonine-protein kinase mTOR | [372] | 3.07[373] | 4.35[374] | 3.81[375] | 2.65[376] | 3.21[377] | 4.10[378] |
55 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [379] | [380] | [381] | [382] | [383] | [384] | [385] |
56 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1.75[386] | 2.52[387] | 2.58[388] | 1.02[389] | 1.66[390] | 1.81[391] | |
57 | IRS1 | Insulin receptor substrate 1 | [392] | 2.63[393] | 2.34[394] | 3.66[395] | 1.67[396] | 1.74[397] | 2.77[398] |
58 | STAT5A | Signal transducer and activator of transcription 5A | [399] | -1.41[400] | 0.03[401] | -1.01[402] | -0.88[403] | 0.36[404] | 0.89[405] |
59 | PAK1 | Serine/threonine-protein kinase PAK 1 | [406] | 0.53[407] | 0.03[408] | 2.34[409] | -1.89[410] | 2.37[411] | 0.92[412] |
60 | IRS2 | Insulin receptor substrate 2 | [413] | -5.11[414] | [415] | -2.10[416] | -0.70[417] | 3.61[418] | 3.04[419] |
61 | SOCS1 | Suppressor of cytokine signaling 1 | [420] | -0.91[421] | 0.22[422] | 0.39[423] | -1.83[424] | -2.73[425] | -0.81[426] |
62 | FYN | Tyrosine-protein kinase Fyn | [427] | 1.48[428] | -6.85[429] | 1.61[430] | 1.44[431] | 3.45[432] | 1.62[433] |
63 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.16[434] | 2.06[435] | 2.15[436] | 1.09[437] | 1.78[438] | 2.56[439] | |
64 | GAB2 | GRB2-associated-binding protein 2 | [440] | 2.10[441] | 2.16[442] | 2.30[443] | 0.89[444] | 1.46[445] | 1.19[446] |
65 | PIAS3 | E3 SUMO-protein ligase PIAS3 | [447] | 1.84[448] | 1.30[449] | 2.49[450] | 2.68[451] | 2.86[452] | 1.42[453] |
66 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | [454] | [455] | [456] | [457] | [458] | [459] | [460] |
67 | JAK2 | Tyrosine-protein kinase JAK2 | [461] | 0.76[462] | 1.03[463] | 0.48[464] | 0.73[465] | 1.81[466] | 3.36[467] |
68 | NOS2 | Nitric oxide synthase, inducible | [468] | 0.56[469] | [470] | -5.52[471] | -4.89[472] | -5.30[473] | -6.66[474] |
69 | PRLR | Prolactin receptor | [475] | 1.38[476] | 1.82[477] | 5.57[478] | -5.04[479] | -3.42[480] | 4.56[481] |
70 | TEC | Tyrosine-protein kinase Tec | [482] | -1.62[483] | -1.75[484] | -1.26[485] | 1.31[486] | 0.21[487] | 2.24[488] |
71 | CBL | E3 ubiquitin-protein ligase CBL | [489] | 4.99[490] | 4.20[491] | 4.31[492] | 5.10[493] | 5.07[494] | 4.41[495] |
72 | VAV1 | Proto-oncogene vav | [496] | -7.96[497] | -2.86[498] | -4.68[499] | -6.12[500] | -6.90[501] | 1.83[502] |
73 | ZAP70 | Tyrosine-protein kinase ZAP-70 | [503] | 1.54[504] | 2.03[505] | -4.31[506] | -5.58[507] | -3.75[508] | 2.81[509] |
74 | AGAP2 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 | 3.27[510] | 4.58[511] | 2.14[512] | -3.46[513] | 1.37[514] | 1.64[515] | |
75 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [516] | [517] | [518] | 1.31[519] | -3.10[520] | 4.75[521] | |
76 | PRL | Prolactin | [522] | [523] | [524] | [525] | [526] | [527] | [528] |