WP_PRION_DISEASE_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HSP90B1 | Endoplasmin | [1] | -1.00[2] | 0.16[3] | -0.36[4] | -0.60[5] | -0.61[6] | -0.19[7] |
2 | HSPA5 | 78 kDa glucose-regulated protein | [8] | -0.16[9] | -0.58[10] | -0.79[11] | -1.03[12] | -0.87[13] | -0.50[14] |
3 | PDIA3 | Protein disulfide-isomerase A3 | [15] | -0.04[16] | -0.82[17] | -0.92[18] | -0.22[19] | -0.46[20] | -0.92[21] |
4 | STAT3 | Signal transducer and activator of transcription 3 | [22] | 0.84[23] | -1.15[24] | 0.13[25] | 0.52[26] | -0.15[27] | 2.24[28] |
5 | PRNP | Major prion protein | [29] | 1.76[30] | 0.99[31] | -4.91[32] | 1.67[33] | 2.39[34] | -0.10[35] |
6 | RAD21 | Double-strand-break repair protein rad21 homolog | [36] | 0.73[37] | 1.63[38] | 2.26[39] | 2.33[40] | 2.02[41] | 0.21[42] |
7 | RXRA | Retinoic acid receptor RXR-alpha | [43] | 0.23[44] | -0.45[45] | 0.92[46] | 0.29[47] | 0.02[48] | 1.98[49] |
8 | CASP3 | Caspase-3 | [50] | 0.42[51] | 0.61[52] | -1.40[53] | -0.62[54] | 0.44[55] | -0.97[56] |
9 | MAPK1 | Mitogen-activated protein kinase 1 | [57] | 2.00[58] | 1.65[59] | 2.01[60] | 2.12[61] | 1.83[62] | 1.61[63] |
10 | SMC3 | Structural maintenance of chromosomes protein 3 | [64] | -0.88[65] | 1.29[66] | 2.28[67] | 0.69[68] | 1.18[69] | -0.11[70] |
11 | PTK2 | Focal adhesion kinase 1 | [71] | 1.02[72] | 1.02[73] | 1.94[74] | 2.22[75] | 1.48[76] | 0.60[77] |
12 | ELK1 | ETS domain-containing protein Elk-1 | [78] | -0.03[79] | -2.65[80] | 0.31[81] | 0.55[82] | 1.20[83] | -0.33[84] |
13 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [85] | 0.96[86] | 0.15[87] | 0.47[88] | 0.03[89] | 1.00[90] | 0.29[91] |
14 | CTCF | Transcriptional repressor CTCF | [92] | 1.50[93] | 0.96[94] | 1.67[95] | 1.20[96] | 1.04[97] | 0.34[98] |
15 | TBP | TATA-box-binding protein | [99] | 0.06[100] | -0.13[101] | -0.78[102] | -0.81[103] | 0.05[104] | -1.24[105] |
16 | CHD2 | Chromodomain-helicase-DNA-binding protein 2 | [106] | 1.82[107] | 2.08[108] | 2.76[109] | 2.00[110] | 2.24[111] | 2.21[112] |
17 | MAPK3 | Mitogen-activated protein kinase 3 | [113] | 2.14[114] | 1.70[115] | 2.27[116] | 0.70[117] | 0.78[118] | -1.21[119] |
18 | RFX5 | DNA-binding protein RFX5 | [120] | 1.56[121] | 1.41[122] | 1.99[123] | 2.05[124] | 2.30[125] | 0.54[126] |
19 | EP300 | Histone acetyltransferase p300 | [127] | 3.01[128] | 2.12[129] | 3.54[130] | 2.85[131] | 2.96[132] | 2.59[133] |
20 | FYN | Tyrosine-protein kinase Fyn | [134] | 1.23[135] | -7.86[136] | 1.24[137] | 1.75[138] | 3.33[139] | 0.80[140] |
21 | SPI1 | Transcription factor PU.1 | [141] | -8.86[142] | [143] | -9.92[144] | -9.38[145] | -10.13[146] | -0.74[147] |
22 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [148] | 2.01[149] | 2.68[150] | 3.70[151] | 2.82[152] | 2.82[153] | 2.18[154] |
23 | BATF | Basic leucine zipper transcriptional factor ATF-like | [155] | 0.02[156] | -1.47[157] | -8.28[158] | -9.48[159] | [160] | -3.18[161] |
24 | FGFR1 | Fibroblast growth factor receptor 1 | [162] | 4.87[163] | 2.69[164] | 4.88[165] | 5.33[166] | 4.66[167] | 1.50[168] |
25 | IRF4 | Interferon regulatory factor 4 | [169] | -4.54[170] | -4.69[171] | -4.78[172] | -4.03[173] | -5.08[174] | 0.45[175] |
26 | MEF2C | Myocyte-specific enhancer factor 2C | [176] | -2.82[177] | -2.18[178] | 3.32[179] | 5.88[180] | 1.93[181] | 5.12[182] |
27 | BCL2 | Apoptosis regulator Bcl-2 | [183] | -2.57[184] | 2.35[185] | -4.52[186] | 2.05[187] | 1.82[188] | 3.07[189] |
28 | POU2F2 | POU domain, class 2, transcription factor 2 | [190] | 2.01[191] | 1.07[192] | 2.17[193] | 2.26[194] | 4.72[195] | 3.17[196] |
29 | NCAM1 | Neural cell adhesion molecule 1 | [197] | 1.85[198] | -2.75[199] | -2.79[200] | 5.30[201] | 6.40[202] | 4.45[203] |
30 | BCL11A | B-cell lymphoma/leukemia 11A | [204] | -0.33[205] | [206] | -0.38[207] | 3.62[208] | [209] | 2.14[210] |
31 | PAX5 | Paired box protein Pax-5 | [211] | -3.04[212] | [213] | 1.98[214] | [215] | [216] | 2.98[217] |
32 | EBF1 | Transcription factor COE1 | [218] | [219] | [220] | [221] | [222] | [223] | [224] |
33 | MIR3610 | [225] | [226] | [227] | [228] | [229] | [230] | [231] | |
34 | MIR3652 | [232] | [233] | [234] | [235] | [236] | [237] | [238] | |
35 | CASP12 | Inactive caspase-12 | [239] | [240] | [241] | [242] | [243] | [244] | [245] |
36 | MIR3175 | [246] | [247] | [248] | [249] | [250] | [251] | [252] | |
37 | MIR1281 | [253] | [254] | [255] | [256] | [257] | [258] | [259] |