WP_PI3KAKTMTOR_VITD3_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 LDHA L-lactate dehydrogenase A chain [1] -0.56[2] -0.05[3] 0.09[4] 0.04[5] -0.27[6] -0.10[7]
2 AKT1 RAC-alpha serine/threonine-protein kinase [8] -0.79[9] -0.46[10] -1.55[11] 0.00[12] 0.32[13] -0.60[14]
3 MYC Myc proto-oncogene protein [15] -0.44[16] -0.22[17] -2.25[18] -2.74[19] -0.07[20] -2.35[21]
4 HLA-DRA HLA class II histocompatibility antigen, DR alpha chain [22] -14.14[23] [24] -14.59[25] -5.70[26] -7.33[27] -0.92[28]
5 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial -1.65[29] -1.11[30] -0.09[31] -0.49[32] -0.65[33] -0.20[34]
6 RELA Transcription factor p65 [35] -0.74[36] -0.68[37] -0.55[38] -0.01[39] 0.20[40] -1.23[41]
7 RXRA Retinoic acid receptor RXR-alpha [42] -0.93[43] -0.57[44] 0.27[45] 0.06[46] 0.03[47] 1.80[48]
8 SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 [49] 3.75[50] 1.36[51] -5.17[52] -1.69[53] 0.78[54] -1.64[55]
9 GSK3B Glycogen synthase kinase-3 beta [56] 0.39[57] 0.59[58] 1.15[59] 1.86[60] 1.99[61] 0.81[62]
10 MTOR Serine/threonine-protein kinase mTOR [63] 1.66[64] 3.24[65] 2.79[66] 2.73[67] 3.11[68] 3.10[69]
11 TSC2 Tuberin [70] 0.94[71] 1.03[72] 1.71[73] 1.25[74] 2.07[75] 1.73[76]
12 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.25[77] 0.95[78] 1.13[79] 1.18[80] 1.68[81] 1.56[82]
13 TSC1 Hamartin [83] 1.02[84] 2.24[85] 2.38[86] 2.11[87] 2.61[88] 2.40[89]
14 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 [90] 2.16[91] 3.17[92] 3.19[93] 3.09[94] 1.43[95] 1.50[96]
15 HK3 Hexokinase-3 [97] -8.71[98] -8.08[99] -9.00[100] -5.45[101] -8.35[102] 2.62[103]
16 PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 [104] 4.38[105] 4.99[106] 5.45[107] 3.00[108] 2.84[109] -0.01[110]
17 IL10 Interleukin-10 [111] -2.74[112] -2.43[113] -2.26[114] -1.93[115] -2.10[116] -1.94[117]
18 CD86 T-lymphocyte activation antigen CD86 [118] [119] [120] -5.03[121] -4.05[122] -5.77[123] 1.00[124]
19 CYP24A1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [125] 7.27[126] 2.96[127] -2.69[128] 4.16[129] -2.35[130] -7.45[131]
20 VDR Vitamin D3 receptor [132] -1.03[133] -0.05[134] 0.58[135] 2.38[136] 4.01[137] 0.13[138]
21 IL12A Interleukin-12 subunit alpha [139] -2.28[140] [141] -0.23[142] -1.49[143] 0.60[144] -3.53[145]
22 CD80 T-lymphocyte activation antigen CD80 [146] [147] [148] -5.58[149] -1.10[150] -1.87[151] 2.27[152]
[1]
ref_hepatocyte LDHA
Mean 277
Standard deviation 1.5e+02
Values 1.4e+02 2.5e+02 5.4e+02 2e+02 2.5e+02
[2]
HepG2 LDHA
Mean 762
Standard deviation 74
Values 8.1e+02 7.1e+02
[3]
HepG2.C3A LDHA
Mean 652
Standard deviation 1.7e+02
Values 7.7e+02 5.3e+02
[4]
HuH.7 LDHA
Mean 696
Standard deviation 62
Values 6.9e+02 6.3e+02 7.6e+02
[5]
SNU475 LDHA
Mean 505
Standard deviation 20
Values 5.2e+02 4.9e+02
[6]
THLE LDHA
Mean 372
Standard deviation 35
Values 3.5e+02 4e+02
[7]
liver LDHA
Mean 467
Standard deviation 2.8e+02
Values 2.1e+02 2.5e+02 7.3e+02 6.8e+02
[8]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[9]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[10]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[11]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[12]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[13]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[14]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[15]
ref_hepatocyte MYC
Mean 29.9
Standard deviation 34
Values 89 1.4 23 15 20
[16]
HepG2 MYC
Mean 88.8
Standard deviation 53
Values 52 1.3e+02
[17]
HepG2.C3A MYC
Mean 62.6
Standard deviation 15
Values 52 73
[18]
HuH.7 MYC
Mean 14.7
Standard deviation 2.6
Values 14 18 13
[19]
SNU475 MYC
Mean 7.93
Standard deviation 1.4
Values 8.9 6.9
[20]
THLE MYC
Mean 46
Standard deviation 10
Values 39 53
[21]
liver MYC
Mean 10.6
Standard deviation 6
Values 5.5 5.9 18 13
[22]
ref_hepatocyte HLA-DRA
Mean 28.7
Standard deviation 43
Values 6.7 1e+02 33 0 1.6
[23]
HepG2 HLA-DRA
Mean 0.00643
Standard deviation 0.0091
Values 0.013 0
[24]
HepG2.C3A HLA-DRA
Mean 0
Standard deviation 0
Values 0 0
[25]
HuH.7 HLA-DRA
Mean 0.00273
Standard deviation 0.0047
Values 0 0 0.0082
[26]
SNU475 HLA-DRA
Mean 0.979
Standard deviation 0.57
Values 1.4 0.58
[27]
THLE HLA-DRA
Mean 0.289
Standard deviation 0.31
Values 0.51 0.069
[28]
liver HLA-DRA
Mean 27.5
Standard deviation 9.7
Values 16 26 29 39
[29]
ref_hepatocyte PDHA1
Mean 24.9
Standard deviation 8.4
Values 16 20 25 25 38
[30]
HepG2 PDHA1
Mean 32
Standard deviation 3.7
Values 35 29
[31]
HepG2.C3A PDHA1
Mean 28.2
Standard deviation 0.42
Values 28 28
[32]
HuH.7 PDHA1
Mean 55
Standard deviation 18
Values 67 34 64
[33]
SNU475 PDHA1
Mean 31.4
Standard deviation 0.34
Values 31 32
[34]
THLE PDHA1
Mean 25.6
Standard deviation 3
Values 24 28
[35]
liver PDHA1
Mean 39.1
Standard deviation 23
Values 17 22 54 63
[36]
ref_hepatocyte RELA
Mean 16
Standard deviation 11
Values 35 8.1 15 9.8 12
[37]
HepG2 RELA
Mean 38.7
Standard deviation 4.7
Values 35 42
[38]
HepG2.C3A RELA
Mean 24.3
Standard deviation 6.4
Values 20 29
[39]
HuH.7 RELA
Mean 25.6
Standard deviation 2.6
Values 23 25 29
[40]
SNU475 RELA
Mean 28.2
Standard deviation 0.33
Values 28 28
[41]
THLE RELA
Mean 29.7
Standard deviation 4
Values 27 32
[42]
liver RELA
Mean 12.3
Standard deviation 8.7
Values 5.7 4.1 19 20
[43]
ref_hepatocyte RXRA
Mean 14.5
Standard deviation 6.1
Values 9.4 18 22 15 7.5
[44]
HepG2 RXRA
Mean 30.9
Standard deviation 2.8
Values 29 33
[45]
HepG2.C3A RXRA
Mean 23.9
Standard deviation 6.1
Values 20 28
[46]
HuH.7 RXRA
Mean 41.2
Standard deviation 10
Values 30 51 42
[47]
SNU475 RXRA
Mean 26.9
Standard deviation 8.3
Values 21 33
[48]
THLE RXRA
Mean 23.9
Standard deviation 7.5
Values 19 29
[49]
liver RXRA
Mean 91.4
Standard deviation 37
Values 1.2e+02 72 1.3e+02 49
[50]
ref_hepatocyte SLC2A3
Mean 7.61
Standard deviation 15
Values 1.5 1.6 0.66 34 0.19
[51]
HepG2 SLC2A3
Mean 414
Standard deviation 0.7
Values 4.1e+02 4.1e+02
[52]
HepG2.C3A SLC2A3
Mean 47.6
Standard deviation 5.9
Values 52 43
[53]
HuH.7 SLC2A3
Mean 0.499
Standard deviation 0.18
Values 0.36 0.71 0.43
[54]
SNU475 SLC2A3
Mean 4.19
Standard deviation 2
Values 5.6 2.7
[55]
THLE SLC2A3
Mean 21.1
Standard deviation 0.92
Values 22 20
[56]
liver SLC2A3
Mean 4.42
Standard deviation 1.7
Values 5.2 5.9 1.9 4.8
[57]
ref_hepatocyte GSK3B
Mean 4.16
Standard deviation 1.7
Values 4.9 2.1 2.7 5.2 5.9
[58]
HepG2 GSK3B
Mean 22.1
Standard deviation 6
Values 26 18
[59]
HepG2.C3A GSK3B
Mean 15.3
Standard deviation 2.3
Values 17 14
[60]
HuH.7 GSK3B
Mean 21.8
Standard deviation 5.6
Values 15 26 24
[61]
SNU475 GSK3B
Mean 26.9
Standard deviation 2.6
Values 25 29
[62]
THLE GSK3B
Mean 26.7
Standard deviation 2.9
Values 25 29
[63]
liver GSK3B
Mean 13.2
Standard deviation 3.2
Values 16 15 14 8.6
[64]
ref_hepatocyte MTOR
Mean 3.34
Standard deviation 0.62
Values 4.3 3.2 3.5 2.6 3.1
[65]
HepG2 MTOR
Mean 42.7
Standard deviation 6.3
Values 47 38
[66]
HepG2.C3A MTOR
Mean 76.8
Standard deviation 17
Values 65 89
[67]
HuH.7 MTOR
Mean 54.5
Standard deviation 17
Values 41 50 73
[68]
SNU475 MTOR
Mean 39.4
Standard deviation 0.66
Values 40 39
[69]
THLE MTOR
Mean 46.6
Standard deviation 4.9
Values 43 50
[70]
liver MTOR
Mean 51.8
Standard deviation 18
Values 62 72 34 39
[71]
ref_hepatocyte TSC2
Mean 3.2
Standard deviation 0.13
Values 3.2 3.4 3.2 3.1 3.1
[72]
HepG2 TSC2
Mean 24.9
Standard deviation 3.4
Values 22 27
[73]
HepG2.C3A TSC2
Mean 16
Standard deviation 4.7
Values 13 19
[74]
HuH.7 TSC2
Mean 24.6
Standard deviation 4
Values 21 24 29
[75]
SNU475 TSC2
Mean 13.5
Standard deviation 5
Values 10 17
[76]
THLE TSC2
Mean 21.8
Standard deviation 1.7
Values 21 23
[77]
liver TSC2
Mean 19.2
Standard deviation 2.2
Values 22 19 17 18
[78]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 0.94 1.2 2.3 2.6
[79]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 4.3 2.1
[80]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 9.6 8
[81]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 7 12 10
[82]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 6.8 8.1
[83]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[84]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 13 15 6.1 6
[85]
ref_hepatocyte TSC1
Mean 1.81
Standard deviation 0.96
Values 2.1 1.1 0.7 3.1 2.1
[86]
HepG2 TSC1
Mean 14.8
Standard deviation 1.6
Values 16 14
[87]
HepG2.C3A TSC1
Mean 20.9
Standard deviation 3.3
Values 19 23
[88]
HuH.7 TSC1
Mean 22.2
Standard deviation 4.3
Values 18 26 22
[89]
SNU475 TSC1
Mean 13.9
Standard deviation 2.8
Values 12 16
[90]
THLE TSC1
Mean 18
Standard deviation 3.2
Values 16 20
[91]
liver TSC1
Mean 17.4
Standard deviation 1.8
Values 17 20 17 16
[92]
ref_hepatocyte PRKAA2
Mean 0.754
Standard deviation 0.84
Values 0.23 0.24 0.1 2 1.2
[93]
HepG2 PRKAA2
Mean 13.6
Standard deviation 4
Values 16 11
[94]
HepG2.C3A PRKAA2
Mean 16.6
Standard deviation 1.4
Values 18 16
[95]
HuH.7 PRKAA2
Mean 16.2
Standard deviation 6.6
Values 9.7 23 16
[96]
SNU475 PRKAA2
Mean 11.4
Standard deviation 0.77
Values 11 12
[97]
THLE PRKAA2
Mean 3.29
Standard deviation 0.6
Values 3.7 2.9
[98]
liver PRKAA2
Mean 3.87
Standard deviation 1.2
Values 5 4 4.3 2.2
[99]
ref_hepatocyte HK3
Mean 0.594
Standard deviation 0.77
Values 0.17 1.8 1 0 0.036
[100]
HepG2 HK3
Mean 0.00573
Standard deviation 0.0081
Values 0 0.011
[101]
HepG2.C3A HK3
Mean 0.00536
Standard deviation 0.0076
Values 0.011 0
[102]
HuH.7 HK3
Mean 0.00273
Standard deviation 0.0047
Values 0 0 0.0082
[103]
SNU475 HK3
Mean 0.0241
Standard deviation 0.0053
Values 0.02 0.028
[104]
THLE HK3
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[105]
liver HK3
Mean 6.61
Standard deviation 1.6
Values 8.3 7.5 4.7 6
[106]
ref_hepatocyte PFKFB4
Mean 0.54
Standard deviation 0.67
Values 0.25 0.19 0.45 1.7 0.1
[107]
HepG2 PFKFB4
Mean 45.5
Standard deviation 9.5
Values 52 39
[108]
HepG2.C3A PFKFB4
Mean 42
Standard deviation 12
Values 33 51
[109]
HuH.7 PFKFB4
Mean 55.6
Standard deviation 10
Values 53 67 47
[110]
SNU475 PFKFB4
Mean 7.66
Standard deviation 0.44
Values 8 7.4
[111]
THLE PFKFB4
Mean 6.27
Standard deviation 1.8
Values 7.6 5
[112]
liver PFKFB4
Mean 0.973
Standard deviation 0.3
Values 1.3 0.84 0.61 1.2
[113]
ref_hepatocyte IL10
Mean 0.495
Standard deviation 0.35
Values 0.95 0.36 0.6 0 0.57
[114]
HepG2 IL10
Mean 0.299
Standard deviation 0.17
Values 0.18 0.42
[115]
HepG2.C3A IL10
Mean 0.224
Standard deviation 0.14
Values 0.32 0.13
[116]
HuH.7 IL10
Mean 0.243
Standard deviation 0.091
Values 0.16 0.34 0.23
[117]
SNU475 IL10
Mean 0.23
Standard deviation 0.0042
Values 0.23 0.23
[118]
THLE IL10
Mean 0.187
Standard deviation 0.022
Values 0.17 0.2
[119]
liver IL10
Mean 0.233
Standard deviation 0.024
Values 0.25 0.21 0.21 0.26
[120]
ref_hepatocyte CD86
Mean 0.389
Standard deviation 0.38
Values 0.61 0.85 0.48 0 0
[121]
HepG2 CD86
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A CD86
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 CD86
Mean 0.0281
Standard deviation 0.02
Values 0.0094 0.026 0.049
[124]
SNU475 CD86
Mean 0.0418
Standard deviation 0.02
Values 0.056 0.028
[125]
THLE CD86
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[126]
liver CD86
Mean 1.41
Standard deviation 0.3
Values 1.3 1.9 1.2 1.2
[127]
ref_hepatocyte CYP24A1
Mean 0.344
Standard deviation 0.69
Values 0 0 0 1.6 0.15
[128]
HepG2 CYP24A1
Mean 215
Standard deviation 90
Values 1.5e+02 2.8e+02
[129]
HepG2.C3A CYP24A1
Mean 6.56
Standard deviation 2.9
Values 8.6 4.5
[130]
HuH.7 CYP24A1
Mean 0.126
Standard deviation 0.11
Values 0.019 0.24 0.11
[131]
SNU475 CYP24A1
Mean 10.9
Standard deviation 10
Values 18 3.8
[132]
THLE CYP24A1
Mean 0.109
Standard deviation 0.079
Values 0.053 0.16
[133]
liver CYP24A1
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[134]
ref_hepatocyte VDR
Mean 0.333
Standard deviation 0.23
Values 0.19 0.39 0.41 0.038 0.63
[135]
HepG2 VDR
Mean 0.657
Standard deviation 0.019
Values 0.64 0.67
[136]
HepG2.C3A VDR
Mean 0.783
Standard deviation 0.23
Values 0.94 0.62
[137]
HuH.7 VDR
Mean 1.17
Standard deviation 0.57
Values 1.3 0.56 1.7
[138]
SNU475 VDR
Mean 3.08
Standard deviation 3
Values 5.2 0.97
[139]
THLE VDR
Mean 8.71
Standard deviation 1.4
Values 7.8 9.7
[140]
liver VDR
Mean 0.658
Standard deviation 0.17
Values 0.54 0.56 0.63 0.9
[141]
ref_hepatocyte IL12A
Mean 0.149
Standard deviation 0.3
Values 0.69 0.057 0 0 0
[142]
HepG2 IL12A
Mean 0.125
Standard deviation 0.091
Values 0.06 0.19
[143]
HepG2.C3A IL12A
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 IL12A
Mean 0.299
Standard deviation 0.11
Values 0.41 0.2 0.29
[145]
SNU475 IL12A
Mean 0.0941
Standard deviation 0.011
Values 0.086 0.1
[146]
THLE IL12A
Mean 0.367
Standard deviation 0.0081
Values 0.36 0.37
[147]
liver IL12A
Mean 0.0235
Standard deviation 0.047
Values 0 0 0.094 0
[148]
ref_hepatocyte CD80
Mean 0.0435
Standard deviation 0.06
Values 0 0.11 0.1 0 0
[149]
HepG2 CD80
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A CD80
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 CD80
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[152]
SNU475 CD80
Mean 0.0359
Standard deviation 0.015
Values 0.025 0.046
[153]
THLE CD80
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[154]
liver CD80
Mean 0.381
Standard deviation 0.28
Values 0.61 0.64 0.12 0.15